Download or read book Breaking the Appalachian Barrier written by John Hrastar and published by McFarland. This book was released on 2018-03-04 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1750 the Appalachian Mountains were a formidable barrier between the British colonies in the east and French territory in the west, passable only on foot or horseback. It took more than a century to break the mountain barrier and open the west to settlement. In 1751 a private Virginia company pioneered a road from Maryland to Ohio, challenging the French and Indians for the Ohio country. Several wars stalled the road, which did not start in earnest until after Ohio became a state in 1803. The stone-paved Cumberland Road--from Cumberland, Maryland, to Wheeling, Virginia--was complete by 1818 and over the next 30 years was traversed by Conestoga wagons and stagecoaches. The Baltimore and Ohio Railroad--the first general purpose railroad in the world--started in Baltimore in the 1820s and reached Wheeling by 1852, uniting east and west.

Download or read book Blood Spinal Cord and Brain Barriers in Health and Disease written by Hari Shanker Sharma and published by Elsevier. This book was released on 2003-12-21 with total page 623 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent research into the anatomy and pathophysiology of the blood-brain and blood-spinal cord barriers suggests that a breakdown in these barriers can result in several diseases affecting the central nervous system (CNS). This book presents new findings in the area of blood-brain barrier research that suggest barriers play important roles in health and disease conditions. It also discusses the development of new drugs that can modulate the barrier function in the CNS and may provide new approaches to treating neurological diseases such as Alzheimer's disease and other motor neuron diseases, as well as spinal cord trauma. Key Features * Presents the recent progress made in the research on the blood-brain and spinal cord barrier * Contains numerous illustrations of light and electron micrographs * Includes Foreword written by two eminent researchers in the field, Milton Brightman and Jorge Cervos-Navarro

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Download or read book Pharmacology of the Blood Brain Barrier Targeting CNS Disorders written by and published by Academic Press. This book was released on 2014-10-21 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume of Advances in Pharmacology presents pharmacology of the blood brain barrier, focusing on targeting CNS disorders. With a variety of chapters and the best authors in the field, the volume is an essential resource for pharmacologists, immunologists and biochemists alike. Contributions from the best authors in the field An essential resource for pharmacologists, immunologists, and biochemists

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Download or read book The Ocean and Cryosphere in a Changing Climate written by Intergovernmental Panel on Climate Change (IPCC) and published by Cambridge University Press. This book was released on 2022-04-30 with total page 755 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Intergovernmental Panel on Climate Change (IPCC) is the leading international body for assessing the science related to climate change. It provides policymakers with regular assessments of the scientific basis of human-induced climate change, its impacts and future risks, and options for adaptation and mitigation. This IPCC Special Report on the Ocean and Cryosphere in a Changing Climate is the most comprehensive and up-to-date assessment of the observed and projected changes to the ocean and cryosphere and their associated impacts and risks, with a focus on resilience, risk management response options, and adaptation measures, considering both their potential and limitations. It brings together knowledge on physical and biogeochemical changes, the interplay with ecosystem changes, and the implications for human communities. It serves policymakers, decision makers, stakeholders, and all interested parties with unbiased, up-to-date, policy-relevant information. This title is also available as Open Access on Cambridge Core.

Download or read book Overcoming Obstacles in Drug Discovery and Development written by Kan He and published by Elsevier. This book was released on 2023-05-18 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: Overcoming Obstacles in Drug Discovery and Development uses real-world case studies to illustrate how critical thinking and problem solving skills are applied in the discovery and development of drugs. It also shows how developing critical thinking to overcome issues plays an essential role in the process. Modern drug discovery and development is a highly complex undertaking that requires scientific and professional expertise to be successful. After the identification of a molecular entity for treating a medical condition, challenges inevitably arise during the subsequent development to understand and characterize the biological profile; feedback from scientists is used to fine-tune the molecular entity to obtain an effective and safe product. In this process, the discovery team may identify unexpected safety issues and new medical disorders for treatment by the molecular entity. Invariably inherent in this complex undertaking are miscues, mistakes, and unexpected problems that can derail development and throw timetables into disarray, potentially leading to failure in the development of a medically useful drug. Addressing critical unexpected problems during development often requires scientists to utilize critical thinking and imaginative problem-solving skills. Overcoming Obstacles in Drug Discovery and Development will be essential to young scientists to help learn the skills to successfully face challenges, learn from mistakes, and further develop critical thinking skills. It will also be beneficial to experienced researchers who can learn from the case studies of successful and unsuccessful drug development. Provides real-world case studies in drug discovery and the development of drugs Illustrates the use of critical thinking and problem solving in approaching preclinical and clinical problems in drug discovery and development Illustrates and analyses examples of successes and failures in drug discovery and development that have not previously been reported

Download or read book Journal written by American Chemical Society and published by . This book was released on 2002 with total page 1448 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Surfaces and Interfaces Physics and Electronics written by R.S. Bauer and published by Elsevier. This book was released on 2012-12-02 with total page 663 pages. Available in PDF, EPUB and Kindle. Book excerpt: Surfaces and Interfaces: Physics and Electronics covers the proceedings of the second Trieste ICTP-IUPAP Semiconductor Symposium, conducted at the International Center for Theoretical Physics in Trieste, Italy on August 30 to September 3, 1982. The book focuses on the processes, methodologies, reactions, and approaches involved in semiconductor physics. The selection first elaborates on the electronic properties and surface geometry of GaAs and ZnO surfaces; electronic structure of Si (III) surfaces; and photoemission studies of surface states on Si (III) 2X1. Discussions focus on consistency of different experiments, relating experiments to a theoretical model, quenching of surface states by hydrogen, inverse photoemission results, and basic data and models of the low-index ZnO surfaces. The text then examines Si (III) 2X1 studies by angle resolved photoemission; electronic surface states at steps in Si (III) 2X1; and a novel method for the study of optical properties of surfaces. The manuscript takes a look at spot profile analysis (LEED) of defects at silicon surfaces; chemisorption-induced defects at interfaces on compound semiconductors; and surface defects on semiconductors. The microscopic properties and behavior of silicide interfaces, recombination at semiconductor surfaces and interfaces, and dipoles, defects, and interfaces are also discussed. The selection is a highly recommended source of data for physicists and readers wanting to study semiconductor physics.

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Download or read book Endothelial Cell Culture written by Roy Bicknell and published by Cambridge University Press. This book was released on 1996-09-28 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of the Handbooks in Practical Animal Cell Biology is to provide practical workbooks for those involved in primary cell culture. Each volume addresses a different cell lineage, and contains an introductory section followed by individual chapters on the culture of specific differentiated cell types. The authors of each chapter are leading researchers in their fields and use their first-hand experience to present reliable techniques in a clear and thorough manner. Endothelial Cell Culture contains chapters on endothelial cells derived from 1) lung, 2) bone marrow, 3) brain, 4) mammary glands, 5) skin, 6) adipose tissue, 7) female reproductive system, and 8) synovium.

Download or read book Legislation on Foreign Relations Through written by United States and published by . This book was released on 1991 with total page 1268 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Skin Barrier Function written by T. Agner and published by Karger Medical and Scientific Publishers. This book was released on 2016-02-04 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although a very fragile structure, the skin barrier is probably one of the most important organs of the body. Inward/out it is responsible for body integrity and outward/in for keeping microbes, chemicals, and allergens from penetrating the skin. Since the role of barrier integrity in atopic dermatitis and the relationship to filaggrin mutations was discovered a decade ago, research focus has been on the skin barrier, and numerous new publications have become available. This book is an interdisciplinary update offering a wide range of information on the subject. It covers new basic research on skin markers, including results on filaggrin and on methods for the assessment of the barrier function. Biological variation and aspects of skin barrier function restoration are discussed as well. Further sections are dedicated to clinical implications of skin barrier integrity, factors influencing the penetration of the skin, influence of wet work, and guidance for prevention and saving the barrier. Distinguished researchers have contributed to this book, providing a comprehensive and thorough overview of the skin barrier function. Researchers in the field, dermatologists, occupational physicians, and related industry will find this publication an essential source of information.

Download or read book Energy Research Abstracts written by and published by . This book was released on 1985 with total page 672 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Economics of Energy Efficiency written by Steve Sorrell and published by Edward Elgar Publishing. This book was released on 2004 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines energy management practices within a wide range of public and private sector organisations.

Download or read book Renewable and Sustainable Energy II written by Nan Qi Ren and published by Trans Tech Publications Ltd. This book was released on 2012-05-14 with total page 3255 pages. Available in PDF, EPUB and Kindle. Book excerpt: This special collection contains selected papers from the International Conference on Energy and Environmental Protection (ICEEP 2012), held on the 23rd and 24th June, 2012, in Hohhot, China. The 590 peer-reviewed papers cover a wide area and are divided into: Chapter 1: Development and Utilization of Solar Energy; Chapter 2: Development and Utilization of Biomass Energy; Chapter 3: Development and Utilization of Wind Energy; Chapter 4: Nuclear Energy and other Energy Sources; Chapter 5: Energy Storage Technologies and Storage Batteries; Chapter 6: Energy-Saving Technology; Chapter 7: Hydrogen and Fuel Cells; Chapter 8: Energy Materials, Engineering Materials and Processing Technologies; Chapter 9: Energy Chemical Engineering; Chapter 10: Energy Security and Clean Use; Chapter 11: New Energy, New Energy Vehicles, Electric Vehicles; Chapter 12: Energy-Efficient Lighting Products and Technologies; Chapter 13: Green Building Materials and Energy-Saving Buildings

Download or read book Soviet Physics written by and published by . This book was released on 1973 with total page 1040 pages. Available in PDF, EPUB and Kindle. Book excerpt: