Download or read book Structural Virology written by Mavis Agbandje-McKenna and published by Royal Society of Chemistry. This book was released on 2010-11-11 with total page 389 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last ten years, much effort has been devoted to improving the biophysical techniques used in the study of viruses. This has resulted in the visualization of these large macromolecular assemblages at atomic level, thus providing the platform for functional interpretation and therapeutic design. Structural Virology covers a wide range of topics and is split into three sections. The first discusses the vast biophysical methodologies used in structural virology, including sample production and purification, confocal microscopy, mass spectrometry, negative-stain and cryo-electron microscopy, X-ray crystallography and nuclear magnetic resonance spectroscopy. The second discusses the role of virus capsid protein structures in determining the functional roles required for receptor recognition, cellular entry, capsid assembly, genome packaging and mechanisms of host immune system evasion. The last section discusses therapeutic strategies based on virus protein structures, including the design of antiviral drugs and the development of viral capsids as vehicles for foreign gene delivery. Each topic covered will begin with a review of the current literature followed by a more detailed discussion of experimental procedures, a step in the viral life cycle, or strategies for therapeutic development. With contributions from experts in the field of structural biology and virology this exceptional monograph will appeal to biomedical scientists involved in basic and /or applied research on viruses. It also provides up-to-date reference material for students entering the field of structural virology as well as scientists already familiar with the area.

Download or read book Gordis Epidemiology written by David D Celentano and published by Elsevier Health Sciences. This book was released on 2018-10-19 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the Department of Epidemiology at Johns Hopkins University and continuing in the tradition of award-winning educator and epidemiologist Dr. Leon Gordis, comes the fully revised 6th Edition of Gordis Epidemiology. This bestselling text provides a solid introduction to basic epidemiologic principles as well as practical applications in public health and clinical practice, highlighted by real-world examples throughout. New coverage includes expanded information on genetic epidemiology, epidemiology and public policy, and ethical and professional issues in epidemiology, providing a strong basis for understanding the role and importance of epidemiology in today's data-driven society. - Covers the basic principles and concepts of epidemiology in a clear, uniquely memorable way, using a wealth of full-color figures, graphs, charts, and cartoons to help you understand and retain key information. - Reflects how epidemiology is practiced today, with a new chapter organization progressing from observation and developing hypotheses to data collection and analyses. - Features new end-of-chapter questions for quick self-assessment, and a glossary of genetic terminology. - Provides more than 200 additional multiple-choice epidemiology self-assessment questions online. - Evolve Instructor Resources, including a downloadable image and test bank, are available to instructors through their Elsevier sales rep or via request at: https://evolve.elsevier.com

Download or read book SARS CoV 2 Spike Protein Convergent Evolution written by Daniele Focosi and published by Springer Nature. This book was released on 2021-10-11 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the current knowledge of the globally circulating SARS-CoV-2 variants, highlights their distinct genetic characteristics and associated conformational changes in the viral spike protein, and profoundly discusses the mechanisms of convergent evolution that led to the rise of these mutated strains at different geographic regions during the Covid-19 pandemic. Furthermore, the book explores how these variants do and may impact the efficacy of established neutralizing antibody-based (nAb) vaccines and therapeutics by analysing latest in vivo and in vitro clinical data. Finally, the author discusses ways on how nAb Covid-19 treatment derived immune escape of SARS-CoV-2 could be minimized in the future.

Download or read book The Ultimate College Student Health Handbook written by Jill Grimes and published by Skyhorse. This book was released on 2020-05-05 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: 2022 Bookauthority: Best College Ebooks of All Time: Winner 2022 American Writing Awards Nonfiction Health Category: Winner 2022 IAN Book of the Year Outstanding Non-Fiction Health/Medicine: Winner 2022 International Impact Book Award Winner 2021 Gold Medal Florida Authors & Publishers Association Presidents Award: Health Category 2021 Gold Medal Winner of the International Book Award: Health Category 2021 Silver Medal Winner of the Nautilus Award: Health, Healing, Wellness & Vitality 2021 Independent Press Award Distinguished Favorite: Health & Fitness 2021 New York City Big Book Award Distinguished Favorite in the Health & Fitness category 2021 Firebird Speak Up Talk Radio Winner 2021 Readers’ Favorite Gold Medal: Young Adult Nonfiction 2020 Gold Medal Winner of the Literary Titan Award 2020 American Book Fest Best Book Awards Winner: College Guides Consider this College Health 101—an award-winning guide to what students really want (or need) to know about their mental and physical health when they're away from home. College students facing their first illness, accident, or anxiety away from home often flip-flop between wanting to handle it themselves and wishing their parents could swoop in and fix everything. Advice from peers and “Dr. Google” can be questionable.The Ultimate College Student Health Handbook provides accurate, trustworthy, evidence-based medical information (served with a dose of humor) to reduce anxiety and stress and help set appropriate expectations for more than fifty common issues. What if you can’t sleep well (or can’t sleep at all) in your dorm room? What if a pill “gets stuck” in your throat? What if your roommate falls asleep (or passes out) wearing contacts, and wakes up with one painfully stuck? Your friend’s terrible sore throat isn’t Strep or Mono? What else could it be? What should you do for food poisoning? When do you really need X-rays for a sprained ankle or injured toe? What helps severe test anxiety or fear of public speaking? Dr. Jill Grimes has the answer to these questions and many more. Her guidebook is designed to help you: Decide if and when to seek medical help Know what to expect when you get there Plan for the worst-case scenario if you don’t seek help Learn how you can prevent this in the future Realize what you can do right now, before you see a doctor Understand the diagnostic and treatment options Got questions about tattoos, smoking, vaping, pot, and piercings? No worries, Dr. Grimes has covered those topics, too, as well as a few things you might not know about the use and abuse of stimulant (ADD) prescription medications. Pair this book with the DIY First Aid Kit detailed in the bonus section to help you, your roommates, and your friends have a healthier, happier semester!

Download or read book Revelation written by and published by Canongate Books. This book was released on 1999-01-01 with total page 60 pages. Available in PDF, EPUB and Kindle. Book excerpt: The final book of the Bible, Revelation prophesies the ultimate judgement of mankind in a series of allegorical visions, grisly images and numerological predictions. According to these, empires will fall, the "Beast" will be destroyed and Christ will rule a new Jerusalem. With an introduction by Will Self.

Download or read book National Strategy for the COVID 19 Response and Pandemic Preparedness written by Joseph R. Biden, Jr. and published by Simon and Schuster. This book was released on 2021-05-04 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ultimate guide for anyone wondering how President Joe Biden will respond to the COVID-19 pandemic—all his plans, goals, and executive orders in response to the coronavirus crisis. Shortly after being inaugurated as the 46th President of the United States, Joe Biden and his administration released this 200 page guide detailing his plans to respond to the coronavirus pandemic. The National Strategy for the COVID-19 Response and Pandemic Preparedness breaks down seven crucial goals of President Joe Biden's administration with regards to the coronavirus pandemic: 1. Restore trust with the American people. 2. Mount a safe, effective, and comprehensive vaccination campaign. 3. Mitigate spread through expanding masking, testing, data, treatments, health care workforce, and clear public health standards. 4. Immediately expand emergency relief and exercise the Defense Production Act. 5. Safely reopen schools, businesses, and travel while protecting workers. 6. Protect those most at risk and advance equity, including across racial, ethnic and rural/urban lines. 7. Restore U.S. leadership globally and build better preparedness for future threats. Each of these goals are explained and detailed in the book, with evidence about the current circumstances and how we got here, as well as plans and concrete steps to achieve each goal. Also included is the full text of the many Executive Orders that will be issued by President Biden to achieve each of these goals. The National Strategy for the COVID-19 Response and Pandemic Preparedness is required reading for anyone interested in or concerned about the COVID-19 pandemic and its effects on American society.

Download or read book Harlem Shuffle written by Colson Whitehead and published by Anchor. This book was released on 2021-09-14 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt: NEW YORK TIMES BESTSELLER • From the two-time Pulitzer Prize-winning author of The Underground Railroad and The Nickel Boys, this gloriously entertaining novel is “fast-paced, keen-eyed and very funny ... about race, power and the history of Harlem all disguised as a thrill-ride crime novel" (San Francisco Chronicle). "Ray Carney was only slightly bent when it came to being crooked..." To his customers and neighbors on 125th street, Carney is an upstanding salesman of reasonably priced furniture, making a decent life for himself and his family. He and his wife Elizabeth are expecting their second child, and if her parents on Striver's Row don't approve of him or their cramped apartment across from the subway tracks, it's still home. Few people know he descends from a line of uptown hoods and crooks, and that his façade of normalcy has more than a few cracks in it. Cracks that are getting bigger all the time. Cash is tight, especially with all those installment-plan sofas, so if his cousin Freddie occasionally drops off the odd ring or necklace, Ray doesn't ask where it comes from. He knows a discreet jeweler downtown who doesn't ask questions, either. Then Freddie falls in with a crew who plan to rob the Hotel Theresa—the "Waldorf of Harlem"—and volunteers Ray's services as the fence. The heist doesn't go as planned; they rarely do. Now Ray has a new clientele, one made up of shady cops, vicious local gangsters, two-bit pornographers, and other assorted Harlem lowlifes. Thus begins the internal tussle between Ray the striver and Ray the crook. As Ray navigates this double life, he begins to see who actually pulls the strings in Harlem. Can Ray avoid getting killed, save his cousin, and grab his share of the big score, all while maintaining his reputation as the go-to source for all your quality home furniture needs? Harlem Shuffle's ingenious story plays out in a beautifully recreated New York City of the early 1960s. It's a family saga masquerading as a crime novel, a hilarious morality play, a social novel about race and power, and ultimately a love letter to Harlem. But mostly, it's a joy to read, another dazzling novel from the Pulitzer Prize and National Book Award-winning Colson Whitehead. Look for Colson Whitehead’s new novel, Crook Manifesto!

Download or read book Preventable written by Andy Slavitt and published by St. Martin's Press. This book was released on 2021-06-15 with total page 199 pages. Available in PDF, EPUB and Kindle. Book excerpt: * NATIONAL BESTSELLER * “Painfully good. The book could have been called, ‘Outrageous.’ The story Andy Slavitt tells is not just about Trump’s monumental failures but also about the deeper ones that started long before, with our health system, our politics, and more.” --Atul Gawande, author of Being Mortal The definitive, behind-the-scenes look at the U.S. Coronavirus crisis from one of the most recognizable and influential voices in healthcare From former Biden Senior Advisor Andy Slavitt, Preventable is the definitive inside account of the United States' failed response to the Coronavirus pandemic. Slavitt chronicles what he saw and how much could have been prevented -- an unflinching investigation of the cultural, political, and economic drivers that led to unnecessary loss of life. With unparalleled access to the key players throughout the government on both sides of the aisle, the principal public figures, as well as the people working on the frontline involved in fighting the virus, Slavitt brings you into the room as fateful decisions are made and focuses on the people at the center of the political system, health care system, patients, and caregivers. The story that emerges is one of a country in which -- despite the heroics of many -- bad leadership, political and cultural fractures, and an unwillingness to sustain sacrifice light a fuse that is difficult to extinguish. Written in the tradition of The Big Short, Preventable continues Andy Slavitt’s important work of addressing the uncomfortable realities that brought America to this place. And, he puts forth the solutions that will prevent us from being here again, ensuring a better, stronger country for everyone.

Download or read book The Masque of the Red Death written by Edgar Allan Poe and published by Strelbytskyy Multimedia Publishing. This book was released on 2020-08-01 with total page 13 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The Masque of the Red Death", originally published as "The Mask of the Red Death: A Fantasy", is an 1842 short story by American writer Edgar Allan Poe. The story follows Prince Prospero's attempts to avoid a dangerous plague, known as the Red Death, by hiding in his abbey. He, along with many other wealthy nobles, hosts a masquerade ballwithin seven rooms of the abbey, each decorated with a different color. In the midst of their revelry, a mysterious figure disguised as a Red Death victim enters and makes his way through each of the rooms. Prospero dies after confronting this stranger, whose "costume" proves to contain nothing tangible inside it; the guests also die in turn. Poe's story follows many traditions of Gothic fiction and is often analyzed as an allegory about the inevitability of death, though some critics advise against an allegorical reading. Many different interpretations have been presented, as well as attempts to identify the true nature of the titular disease. The story was first published in May 1842 in Graham's Magazineand has since been adapted in many different forms, including a 1964 film starring Vincent Price.

Download or read book Your Next Home written by Common Brick Manufacturers' Association of America and published by . This book was released on 1925 with total page 74 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Red Book 2021 written by David W. Kimberlin and published by . This book was released on 2021-05-15 with total page 1100 pages. Available in PDF, EPUB and Kindle. Book excerpt: The AAP's authoritative guide on preventing, recognizing, and treating more than 200 childhood infectious diseases. Developed by the AAP's Committee on Infectious Diseases as well as the expertise of the CDC, the FDA, and hundreds of physician contributors.

Download or read book Lifelines written by Dr. Leana Wen and published by Metropolitan Books. This book was released on 2021-07-27 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: From medical expert Leana Wen, MD, Lifelines is an insider's account of public health and its crucial role—from opioid addiction to global pandemic—and an inspiring story of her journey from struggling immigrant to being one of Time’s 100 Most Influential People. “Public health saved your life today—you just don’t know it,” is a phrase that Dr. Leana Wen likes to use. You don’t know it because good public health is invisible. It becomes visible only in its absence, when it is underfunded and ignored, a bitter truth laid bare as never before by the devastation of COVID-19. Leana Wen—emergency physician, former Baltimore health commissioner, CNN medical analyst, and Washington Post contributing columnist—has lived on the front lines of public health, leading the fight against the opioid epidemic, outbreaks of infectious disease, maternal and infant mortality, and COVID-19 disinformation. Here, in gripping detail, Wen lays bare the lifesaving work of public health and its innovative approach to social ills, treating gun violence as a contagious disease, for example, and racism as a threat to health. Wen also tells her own uniquely American story: an immigrant from China, she and her family received food stamps and were at times homeless despite her parents working multiple jobs. That child went on to attend college at thirteen, become a Rhodes scholar, and turn to public health as the way to make a difference in the country that had offered her such possibilities. Ultimately, she insists, it is public health that ensures citizens are not robbed of decades of life, and that where children live does not determine whether they live.

Download or read book The Coronaviridae written by Stuart G. Siddell and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: Coronaviruses were recognized as a group of enveloped, RNA viruses in 1968 and accepted by the International Committee on the Taxonomy of Viruses as a separate family, the Coronaviridae, in 1975. By 1978, it had become evident that the coronavirus genomic RNA was infectious (i. e. , positive strand), and by 1983, at least the framework of the coronavirus replication strategy had been per ceived. Subsequently, with the application of recombinant DNA techniques, there have been remarkable advances in our understanding of the molecular biology of coronaviruses, and a mass of structural data concerning coronavirus genomes, mRNAs, and pro teins now exists. More recently, attention has been focused on the role of essential and accessory gene products in the coronavirus replication cyde and a molecular analysis of the structure-function relation ships of coronavirus proteins. Nevertheless, there are still large gaps in our knowledge, for instance, in areas such as the genesis of coronavirus subgenomic mRNAs or the function of the coronavirus RNA-dependent RNA polymerase. The diseases caused by coronaviruses have been known for much longer than the agents themselves. Possibly the first coronavirus-related disease to be recorded was feline infectious peritonitis, as early as 1912. The diseases associ ated with infectious bronchitis virus, transmissible gastroenteritis virus, and murine hepatitis virus were all well known before 1950.

Download or read book For Better written by Tara Parker-Pope and published by Penguin. This book was released on 2010-05-06 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: “The most credible and interesting marital self-help book of all time.”—Newsweek Editor of The Washington Post's Wellness Department and former New York Times columnist Tara Parker-Pope is one of the most popular and e-mailed journalists in the nation. In this eye-opening—and ultimately optimistic—look at marriage today, Parker-Pope reveals the heart behind the statistics to bust the myths and share the true secrets to marital happiness. Among her surprising findings: • most marriages today are succeeding • newlywed couples who don't fight are at a higher risk for divorce than those who do • how couples divide household chores influences how often they have sex Whatever their stage of life or marital status, readers will be fascinated and buoyed by this classic in the making.

Download or read book SARS CoV2 COVID 19 Pandemic Control and Prevention written by Laurens Holmes, Jr. and published by Taylor & Francis. This book was released on 2023-09-29 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first comprehensive text to provide not only a detailed explanation of how the SARS-CoV2 (COVID-19) virus is spread within human populations, but also an epidemiological analysis and interpretation of viral pandemics to enable better measures for prevention and control. Providing an introduction to the physiology of both the human immune system and the SARS-CoV2 virus, specifically the virus’s replicative potential and our own vulnerability, the book offers an in-depth understanding of how the pandemic evolved. It also highlights the aberrant epigenomic mechanistic process in pathogenic microbe’s replication and survival, implying gene and environment interaction that affected different populations. Citing a range of environmental conditions, from structural and systemic racism to malnutrition and low-socioeconomic status, the book examines how these factors exacerbated existing health disparities, resulting in a disproportionate burden of morbidity and mortality on certain social groups. Also providing invaluable guidance on how future iterations of this pandemic may be better prevented and controlled, this will be a defining book for students, researchers and professionals within Public Health and Clinical Medicine to better understand the SARS-CoV2 (COVID-19) virus, and how to protect the most vulnerable social groups.

Download or read book Frontiers in Econometrics written by Paul Zarembka and published by New York : Academic Press. This book was released on 1974 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: Model selection; Linear models; Multiple-equation models.

Download or read book Life s Edge written by Carl Zimmer and published by Pan Macmillan. This book was released on 2021-03-18 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: ‘This book is not just about life, but about discovery itself. It is about error and hubris, but also about wonder and the reach of science. And it is bookended with the ultimate question: How do we define the thing that defines us?’ – Siddhartha Mukherjee, author of The Gene We all assume we know what life is, but the more scientists learn about the living world – from protocells to brains, from zygotes to pandemic viruses – the harder they find it to locate the edges of life, where it begins and ends. What exactly does it mean to be alive? Is a virus alive? Is a foetus? Carl Zimmer investigates one of the biggest questions of all: What is life? The answer seems obvious until you try to seriously answer it. Is the apple sitting on your kitchen counter alive, or is only the apple tree it came from deserving of the word? If we can’t answer that question here on earth, how will we know when and if we discover alien life on other worlds? The question hangs over some of society’s most charged conflicts – whether a fertilized egg is a living person, for example, and when we ought to declare a person legally dead. Life’s Edge is an utterly fascinating investigation by one of the most celebrated science writers of our time. Zimmer journeys through the strange experiments that have attempted to recreate life. Literally hundreds of definitions of what that should look like now exist, but none has yet emerged as an obvious winner. Lists of what living things have in common do not add up to a theory of life. It’s never clear why some items on the list are essential and others not. Coronaviruses have altered the course of history, and yet many scientists maintain they are not alive. Chemists are creating droplets that can swarm, sense their environment, and multiply – have they made life in the lab? Whether he is handling pythons in Alabama or searching for hibernating bats in the Adirondacks, Zimmer revels in astounding examples of life at its most bizarre. He tries his own hand at evolving life in a test tube with unnerving results. Charting the obsession with Dr Frankenstein’s monster and how Coleridge came to believe the whole universe was alive, Zimmer leads us all the way into the labs and minds of researchers working on engineering life from the ground up.