Download or read book Corticotrophin ACTH written by Choh Hao Li and published by Elsevier. This book was released on 2012-12-02 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hormonal Proteins and Peptides: Corticotrophin (ACTH) is a collection of papers dealing with the chemistry and biology of adrenocorticotropic hormone (ACTH). One paper describes the structure-function studies made on ACTH, with reference to the steroidogenic activity of synthetic ACTH fragments and analogs. The paper also discusses the melanocyte-stimulating hormone (MSH) activity, as well as the behavioral effects among the extraadrenal properties of ACTH. Some problems related to ACTH receptors include the role of extracellular calcium and the characterization of ACTH receptors in fetal and adult human adrenocortical cells. Another paper describes ACTH synthesis in the pituitary and extrapituitary tissues. One paper analyzes the role of ACTH in the regulation process concerning the production of steroid hormones, particularly, on the generation of glucocorticoids. Glucocorticoids are the characteristic products of the zona fasciculata. Another paper shows that the steady-state level of ACTH synthesis and release are due to the effects of stimulatory factors such as CRF and inhibitory hormones (namely, the glucocorticoids on the corticotroph). The maintenance of responsiveness of ACTH-secreting cells (as a response to individual stress in humans) can be a manifestation of an inherent molecular characteristic. This collection will prove valuable to microbiologists, biotechnologists, and academicians connected with the biological sciences.
Download or read book A Time for Metabolism and Hormones written by Paolo Sassone-Corsi and published by Springer. This book was released on 2016-04-04 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent years have seen spectacular advances in the field of circadian biology. These have attracted the interest of researchers in many fields, including endocrinology, neurosciences, cancer, and behavior. By integrating a circadian view within the fields of endocrinology and metabolism, researchers will be able to reveal many, yet-unsuspected aspects of how organisms cope with changes in the environment and subsequent control of homeostasis. This field is opening new avenues in our understanding of metabolism and endocrinology. A panel of the most distinguished investigators in the field gathered together to discuss the present state and the future of the field. The editors trust that this volume will be of use to those colleagues who will be picking up the challenge to unravel how the circadian clock can be targeted for the future development of specific pharmacological strategies toward a number of pathologies.
Download or read book NIH state of the science statement on management of the clinically inapparent adrenal mass incidentaloma written by and published by . This book was released on 2002 with total page 32 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Hypothalamus Pituitary Adrenal Axis written by and published by Elsevier. This book was released on 2008-09-12 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: The hypothalamic-pituitary-adrenal axis controls reactions to stress and regulates various body processes such as digestion, the immune system, mood and sexuality, and energy usage. This volume focuses on the role it plays in the immune system and provides substantive experimental and clinical data to support current understanding in the field, and potential applications of this knowledge in the treatment of disease. * Evidence presented in this book suggests that the nervous, endocrine, and immune systems form the Neuroendoimmune Supersystem, which integrates all the biological functions of higher organisms both in health and disease for their entire life cycle. * Contributors include both the scientists who initiated the work on the HPA axis and on the autonomic nervous system, and those who joined the field later.
Download or read book The Pituitary written by Shlomo Melmed and published by Academic Press. This book was released on 2010-12-09 with total page 744 pages. Available in PDF, EPUB and Kindle. Book excerpt: The pituitary, albeit a small gland, is known as the "master gland" of the endocrine system and contributes to a wide spectrum of disorders, diseases, and syndromes. Since the publication of the second edition of The Pituitary, in 2002, there have been major advances in the molecular biology research of pituitary hormone production and action and there is now a better understanding of the pathogenesis of pituitary tumors and clinical syndromes resulting in perturbation of pituitary function. There have also been major advances in the clinical management of pituitary disorders. Medical researchers and practitioners now better understand the morbidity and mortality associated with pituitary hormone hyposecretion and hypersecretion. Newly developed drugs, and improved methods of delivering established drugs, are allowing better medical management of acromegaly and prolactinoma. These developments have improved the worldwide consensus around the definition of a "cure" for pituitary disease, especially hormone hypersecretion, and hence will improve the success or lack of success of various forms of therapy. It is therefore time for a new edition of The Pituitary. The third edition will continue to be divided into sections that summarize normal hypothalamic-pituitary development and function, hypothalamic-pituitary failure, and pituitary tumors; additional sections will describe pituitary disease in systemic disorders and diagnostic procedures, including imaging, assessment of the eyes, and biochemical testing. The first chapter will be completely new – placing a much greater emphasis on physiology and pathogenesis. Two new chapters will be added on the Radiation and Non-surgical Management of the Pituitary and Other Pituitary Lesions. Other chapters will be completely updated and many new author teams will be invited. The second edition published in 2002 and there have been incredible changes in both the research and clinical aspects of the pituitary over the past 8 years – from new advances in growth hormones to pituitary tumor therapy. Presents a comprehensive, translational source of information about the pituitary in one reference work Pituitary experts (from all areas of research and practice) take readers from the bench research (cellular and molecular mechanism), through genomic and proteomic analysis, all the way to clinical analysis (histopathology and imaging) and new therapeutic approaches Clear presentation by endocrine researchers of the cellular and molecular mechanisms underlying pituitary hormones and growth factors as well as new techniques used in detecting lesions (within the organ) and other systemic disorders Clear presentation by endocrinologists and neuroendocrine surgeons of how imaging, assessment of the eyes, and biochemical testing can lead to new therapeutic approaches
Download or read book Treatment of Multiple Sclerosis written by Richard A. Rudick and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiple sclerosis is one of the major current problems in neurol ogical practice. It remains incompletely understood, yet is a common cause of chronic disability in developed Western so cieties: Patients with the disease have difficulty understanding what has happened to them and become bewildered by the con trast between the evidently large body of knowledge concerning the clinical manifestations and course of the disease, and the conflicting views they so often receive from different specialists as to the best current management of their disease. As in so many disorders for which treatment is only partially effective, at best, "alternative" therapies abound. Dr. Rudick and Dr. Goodkin have extensive experience in the day-to-day management of multiple sclerosis at the Mellen Center for Multiple Sclerosis Treatment and Research, attached to the Cleveland Clinic. In this book they have assembled a group of experts from several countries and have provided a comprehensive review of the results of different treatments of the disease. Each treatment is considered in the light of its proposed scientific basis or mode of action, and in relation to ethical and trial design issues. This information deserves to be made widely available. As the treatment of multiple sclerosis enters a new era as a result of the new understanding of the cellular mechanisms of demyelination and the molecular biology of the immune response, this information about current treatments assumes additional importance. The book is of interest to all physicians concerned with the management of patients with the disease.
Download or read book Diagnostic Function Tests in Chemical Pathology written by P.T. Lascelles and published by Springer Science & Business Media. This book was released on 1990-03-31 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is written for hospital doctors, nurses, biochemists, medi cal laboratory scientific officers and phlebotomists involved with the biochemical investigation of patients. It is hoped, also, that general practitioners and medical students will find it of help. Whilst the vast majority of biochemical tests assess the level of constituents in blood and urine at a given point in time, an impor tant additional parameter is the assessment of physiological reserve function by means of loading tests, prOlonged fasting, exercise and clearance studies. The protocol and interpretation of response of each of these stress tests form the main basis of the text. An attempt has been made to be reasonably comprehensive in the range of tests described; hence, not only have some rather older ones been re tained, but also some very recently introduced ones included. It is appreciated that practice varies widely from laboratory to labora tory with respect to protocol, sample collection, methodology and quotation of reference ranges, and no doubt also from clinician to clinician, particularly regarding interpretation of results. In paedi atric work, micromethods will demand much smaller volumes of blood than those stated here, which relate generally to adult medi cine. The account, therefore, must be seen as a guide to practice rather than as a recipe; it is in no wayan attempt to standardise procedures, which depend on the local requirements.
Download or read book SAFE USES OF CORTISOL written by William McK. Jefferies and published by Charles C Thomas Publisher. This book was released on 2004-01-04 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Third Edition of this popular book brings up to date the material that so many readers found helpful in the previous editions. The text has been revised and reorganized with current chapters focusing on the history of cortisol use, sources of confusion regarding cortisol therapy, the significance of normal adrenocortical function, generally accepted uses of physiological dosage, viral infections, miscellaneous clinical conditions, and future directions for research and therapy. The author provides explanation and confirmation of the rationale for the effectiveness and safety of the uses of physiological dosages of cortisol in the treatment, not only of patients with rheumatoid arthritis and other autoimmune disorders, but also of patients with chronic allergies, chronic fatigue syndrome, gonadal dysfunction, infertility, shingles, acne, hirsutism, respiratory infections, and other less common disorders. It is a known fact that the influenza virus attacks the human body by impairing the production of the adrenocorticotropic hormone (ACTH), which, in turn, impairs the production of cortisol; the only hormone that is absolutely essential for life. In addition, within the past two years, a new infection has developed in central China and has been labeled Severe Acute Respiratory Syndrome (SARS). The ACTH hormone and the SARS epidemic is addressed, and it is hoped that this type of cortisol therapy will not only be helpful in the treatment of the various disorders mentioned but will lead to a better understanding of the factors that contribute to the development of these disorders and ultimately contribute towards their prevention.
Download or read book The Pituitary adrenocortical Function written by National Library of Medicine (U.S.) and published by . This book was released on 1950 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Evidence Based Medical Consultation E Book written by Daniel Steinberg and published by Elsevier Health Sciences. This book was released on 2007-10-30 with total page 545 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medical consultation is an integral part of the job description for many internal medicine specialists who practice in an inpatient setting. This concise, pocket-sized handbook helps you to provide timely and effective, evidence-based consultations for a full range of commonly encountered clinical situations. Each chapter provides evidence-based answers to common medical consultation questions, giving you the practical guidance you need to successfully manage hospitalized patients. A practical organization expedites access to the most relevant health concerns for every type of hospitalized patient. 20-25 clinical questions for each patient type, followed by brief, evidence-based answers, address the most common clinical scenarios requiring medical consultation. A thorough and systematic search of current literature ensures that each clinical recommendation is based on the best available evidence.
Download or read book The Adrenal Cortex written by Albert B. Eisenstein and published by . This book was released on 1967 with total page 712 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Core Topics in Endocrinology in Anaesthesia and Critical Care written by George M. Hall and published by Cambridge University Press. This book was released on 2010-04-01 with total page 203 pages. Available in PDF, EPUB and Kindle. Book excerpt: Core Topics in Endocrinology in Anesthesia and Critical Care provides a comprehensive, practical overview of the perioperative management of patients with endocrine disorders, giving clear diagnostic advice and management guidelines. This book considers the management of patients with endocrine disorders of the pituitary, thyroid, parathyroid and adrenal glands, including rarer disorders such as MEN syndrome. It then considers all aspects of the perioperative management of diabetic patients, including paediatric, obstetric and ambulatory patients. Finally it discusses endocrine disorders in the critically ill patient, covering such issues as the topical conundrum of glucose control and the management of diabetic metabolic acidosis, thyroid storm and myxoedema coma. Every chapter reviews the relevant anatomy and pathophysiology and the latest developments in defining the genetic causes are also considered where appropriate. Core Topics in Endocrinology in Anesthesia and Critical Care is an invaluable tool for all anaesthetists and intensivists in their daily clinical practice.
Download or read book The Cortisol Connection written by Shawn Talbott and published by Turner Publishing Company. This book was released on 2011-01-01 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: Why does stress make you fat? What can you ultimately do about it? Shawn Talbott answered these questions in THE CORTISOL CONNECTION. Cortisol is the body's main stress hormone, prompting our fight or flight mechanism when dealing with a highly stressful situation, like being chased by a lion. However, the human body was made to deal with short bursts of stress (like being chased by a lion), not prolonged, continuous levels of stress (like mortgage payments, project deadlines, and traffic jams). This kind of stress causes the body's cortisol levels to rise, and scientific research has shown that high cortisol levels are associated with obesity, diabetes, fatigue, and even Alzheimer's disease. This new edition describes the results of the latest research about the connection between cortisol and HSD, and cortisol and testosterone. If we keep cortisol and HSD and testosterone within normal ranges, we're able to maximize the metabolic effect of diet and exercise regimen – and improve weight loss. In the first edition, Talbott introduced his SENSE program, that teaches participants how to manage stress and reduce cortisol levels. The program has been refined in the second edition with the help of the new research and the results of Talbott's test of the SENSE program over the past 5 years – he know it works. For the past 5 years, he has been actively researching (and refining and tweaking) this popular program to make it more and more effective in helping people to lose weight. SENSE is a program that combines Stress management, Exercise, Nutrition, Supplementation, and Evaluation into a comprehensive and highly effective (yet easy to follow) program that delivers results. During these 5 years, Talbott has combined different dietary approaches with varied exercise regimens and myriad supplement combinations – until finding just the right combination that works best for the majority of people. This edition contains 25% new material and a revised program to help everyone manage cortisol, stress, and their weight.
Download or read book Consults in Obstetric Anesthesiology written by Suzanne K. W. Mankowitz and published by Springer. This book was released on 2018-11-15 with total page 628 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text addresses the need for a book specifically aimed at obstetric anesthesia and covers topics such as pulmonary, cardiac renal, hepatic, hematologic, neurologic, endocrine and other diseases. The real anesthetic challenge arises when patients present to Labor and Delivery with unusual or complicated medical problems and, in recent years, a few of the larger institutions have developed an Obstetric Anesthesiology Consultation Service to prepare for the management of these patients. While most pregnant women who present to Labor and Delivery require anesthetic intervention, they typically meet the anesthesiologist for the first time in labor. Since the majority of laboring women are healthy without significant comorbidities, this does not present much of a challenge to the anesthesiologist and the anesthetic management tends to be straight-forward with favorable outcomes. However, using this new model, the anesthesiologist has the opportunity to discuss the various treatment modalities and potentially suggest diagnostic testing to be performed prior to delivery, similar to the pre-operative testing that is done in other surgical environments.
Download or read book The Pituitary adrenocortical Function written by Army Medical Library (U.S.) and published by . This book was released on 1950 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Corticotropin Releasing Factor written by Errol B. De Souza and published by CRC Press. This book was released on 2018-01-18 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive summary of data from basic and clinical studies in support of a role for corticotropin-releasing factor (CRF) as a neurotransmitter in the mammalian central nervous system (CNS). It includes descriptions of the anatomy of CRF and its receptors in the CNS, as well as the characterization of CRF receptors and the second messenger systems mediating effects of CRF in the brain. It discusses the autonomic, behavioral, and electrophysiologic effects of CRF administration in the brain. This work also includes a section which covers the role of brain CRF in the etiology and pathophysiology of a variety of neurologic, psychiatric, and endocrine disorders. Endocrinologists, brain researchers, and neuroendocrinologists are among those who will find this reference both useful and interesting.
Download or read book Psychobiology of Stress written by Stefano Puglisi-Allegra and published by Springer Science & Business Media. This book was released on 1990-10-31 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: From a historical point of view the first studies on the response of the organism to stressful situations in general, and on the psychobiology of stress in particular, are probably those of Cannon and de la Paz, the physiologists who showed in 1911 that the adrenal medulla and the sympathetic system are involved in emergency situations. Cannon noted that the venous blood of cats frightened by barking dogs contained adrenaline, a response of the organism which was prevented by adrenalectomy or by section of the splanchnic nerve innervating the adrenal medulla. Cannon suggested that the adrenal medulla was acting in concert with the sympathetic nervous system, so that both systems were activated during stress. The role of the sympathetic system in response to stressful events was later emphasized by the experiments carried out by Maickel et al. (1967) and by Mason (1968): these authors clearly showed that stressors activate the sympathetic system causing it to release adrenaline and noradrenaline. This line of research may be contrasted with that carried out by Hans Selye, centered on of the adrenal cortex in the stress response. Selye's findings and theories originated the role the so-called hypothalamic - pituitary - adrenal cortex (HPA) model of stress: in short, during stress adrenocorticotropic hormone is released from cells of the anterior pituitary and elicits secretion of glucocorticoids from the adrenal cortex.
