Download or read book Metallo Drugs Development and Action of Anticancer Agents written by Astrid Sigel and published by Walter de Gruyter GmbH & Co KG. This book was released on 2018-02-05 with total page 588 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 18, entitled Metallo-Drugs: Development and Action of Anticancer Agents of the series Metal Ions in Life Sciences centers on biological, medicinal inorganic chemistry. The serendipitous discovery of the antitumor activity of cis-diamminodichloroplatinum(II) (cisplatin) by Barnett Rosenberg in the 1960s is a landmark in metallodrug-based chemotherapy. The success of cisplatin in the clinic, followed by oxaliplatin and carboplatin, along with their drawbacks relating mainly to resistance development and severe toxicity, initiated research on polynuclear platinum complexes and on Pt(IV) complexes as prodrugs. Furthermore, the indicated shortcomings led to the exploration of other transition and main group metal ions, among them Ru(II/III), Au(I/III), Ti(IV), V(IV/V), and Ga(III) including also the essential metal ions Fe(II/III), Cu(I/II), and Zn(II). Ionic as well as covalent and non-covalent interactions between structurally very different complexes and biomolecules like nucleic acids, proteins, and carbohydrates are studied and discussed with regard to their possible anticancer actions. Hence, MILS-18 summarizes the research at the forefront of medicinal inorganic chemistry, including studies on the next-generation, tailor-made anticancer drugs. All this and more is treated in an authoritative and timely manner in the 17 stimulating chapters of this book, written by 39 internationally recognized experts from 10 nations (from the US via Europe to China and Australia). The impact of this vibrant research area is manifested by more than 2700 references, nearly 150 illustrations (more than half in color) and several comprehensive tables. Metallo-Drugs: Development and Action of Anticancer Agents is an essential resource for scientists working in the wide range from enzymology, material sciences, analytical, organic, and inorganic biochemistry all the way through to medicine including the clinic ... not forgetting that it also provides excellent information for teaching.
Download or read book Biology of Copper Complexes written by John R. J. Sorenson and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 589 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1928, it was discovered that copper was essential for normal human metabolism. Ten years later, 1938, it was observed that patients with rheumatoid arthritis had a higher than normal serum copper concentration, which returned to normal wi th remission of this disease. Thirteen years later, it was found that copper complexes were effective in treating arthritic diseaseS. The first report that copper complexes had antiinflammatory activity in an animal model of in flammation appeared twenty-two years after the discovery of essen tiality. In 1976, it was suggested that the active forms of the anti arthritic drugs are their copper complexes formed in vivo. This suggestion was confirmed and extended in the interim with over 1000 recent publications, and many of these were addressed in the proceed ings of our first symposium, published in 1982. The present symposium was organized to present new normal physiological, nutritional, and biochemical aspects of essential metal loelement metabolism as well as variations in metabolism associated with disease states. In addition new data concerning antimicrobial, antiinflammatory, antiulcer, anticancer, anticarcinogenic, analgesic, and radioprotectant activities of copper complexes were presented. These activities are consistent with the notion that they represent the facilitation of normal copper-dependent metabolic processes in dis ease states. The presentations and interactive discussions that fol lowed are contained in these proceedings. John R. J. Sorenson Dedication These proceedings are dedicated to those who made this truly memorable scientific and social Arkansas experience possible.
Download or read book Computational Quantum Chemistry written by Masoud Soroush and published by Elsevier. This book was released on 2018-10-16 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: Computational Quantum Chemistry: Insights into Polymerization Reactions consolidates extensive research results, couples them with computational quantum chemistry (CQC) methods applicable to polymerization reactions, and presents those results systematically. CQC has advanced polymer reaction engineering considerably for the past two decades. The book puts these advances into perspective. It also allows you to access the most up-to-date research and CQC methods applicable to polymerization reactions in a single volume. The content is rigorous yet accessible to graduate students as well as researchers who need a reference of state-of-the-art CQC methods with polymerization applications. - Consolidates more than 10 years of theoretical polymerization reaction research currently scattered across journal articles - Accessibly presents CQC methods applicable to polymerization reactions - Provides researchers with a one-stop source of the latest theoretical developments in polymer reaction engineering
Download or read book Photofunctionalization of Molecular Switch Based on Pyrimidine Ring Rotation in Copper Complexes written by Michihiro Nishikawa and published by Springer Science & Business Media. This book was released on 2013-12-16 with total page 131 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a detailed description of photofunctionalization of molecular switch based on pyrimidine ring rotational isomerization in copper complexes bearing two bidentate ligands. The most important features of this work focus on the properties associated with the rotational isomerization based on the two possible coordination geometries at the copper center derived from two nitrogen atoms on the unsymmetrically substituted pyrimidine ring. The functions of systems such as dual emission and redox potential switching based on photo-driven rotation will be of particular interest to readers. Both the functions and the procedures for proving these phenomena are beneficial for the development of more functionalized systems based on material science, molecular science, nanoscience, nanotechnology, electrochemistry, photochemistry, coordination chemistry, physical chemistry, and related disciplines. The finding elucidated here holds promise for handling the photoprocesses of metal complexes, valid for both applications and novel properties. This system is expected make it possible to extract an electrochemical potential response from molecular switches, aiming to simulate the five senses of human beings at a single molecular level.
Download or read book The Chemistry of Organocopper Compounds written by Zvi Rappoport and published by John Wiley & Sons. This book was released on 2009-12-21 with total page 1183 pages. Available in PDF, EPUB and Kindle. Book excerpt: Copper in organic synthesis has seen a tremendous development over the past ten years. This text represents the most comprehensive survey on the use of Copper and Cuprates in organic synthesis. The first time that the Patai Series touches on Copper compounds, it contains contributions by leading experts, and delivers the quality expected from the Patai Series.
Download or read book Metal Ions in Biological Systems written by Helmut Sigel and published by CRC Press. This book was released on 2023-06-14 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes drug metal-ion interactions in the gut and deals with the deficiency of zinc and iron and their pharmacological use. It covers anti-inflammatory activities of copper and gold complexes and considers the role of metal ions and chelating agents in anti-viral chemotherapy.
Download or read book Copper and Zinc in Inflammatory and Degenerative Diseases written by K. D. Rainsford and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abnormal metabolism and distribution of both copper and zinc occurs in many inflammatory and degenerative diseases. The pattern of these changes varies at different stages of these diseases and with differing types of conditions. The corollary to this situation is the possibility of using drugs or metal complexes to modify both the perturbed status of copper and zinc and thus the disease states. This book comprehensively reviews the clinical and experimental data on the changes in copper and zinc status in different diseases and the use of various complexes of these metals or drugs to treat a diversity of inflammatory and degenerative conditions.
Download or read book Comprehensive Organic Synthesis written by and published by Newnes. This book was released on 2014-02-14 with total page 9815 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of Comprehensive Organic Synthesis—winner of the 2015 PROSE Award for Multivolume Reference/Science from the Association of American Publishers—builds upon the highly respected first edition in drawing together the new common themes that underlie the many disparate areas of organic chemistry. These themes support effective and efficient synthetic strategies, thus providing a comprehensive overview of this important discipline. Fully revised and updated, this new set forms an essential reference work for all those seeking information on the solution of synthetic problems, whether they are experienced practitioners or chemists whose major interests lie outside organic synthesis. In addition, synthetic chemists requiring the essential facts in new areas, as well as students completely new to the field, will find Comprehensive Organic Synthesis, Second Edition, Nine Volume Set an invaluable source, providing an authoritative overview of core concepts. Winner of the 2015 PROSE Award for Multivolume Reference/Science from the Association of American Publishers Contains more than170 articles across nine volumes, including detailed analysis of core topics such as bonds, oxidation, and reduction Includes more than10,000 schemes and images Fully revised and updated; important growth areas—including combinatorial chemistry, new technological, industrial, and green chemistry developments—are covered extensively
Download or read book Progress in Medicinal Chemistry written by and published by Elsevier. This book was released on 2011-09-22 with total page 595 pages. Available in PDF, EPUB and Kindle. Book excerpt: There are five main subject areas in this volume in the series on medicinal chemistry. The first is a review of the understanding of Alzheimer's disease and the development of drugs for its treatment; the second, looking at recent efforts in modifying a naturally occuring anticancer (campothecin) for chemotherapy; the third covers the problem of getting a drug to a specific site within the context of phosphates and phosphonates; a survey of sterilization using aldehydes for the destruction of microbes both inside and outside the human body is reviewed in the fourth; and the last chapter is an account of the progress made in the biologically active enantiomer for complex synthetic asymmetric drug molecules.
Download or read book Metal Oxo and Metal Peroxo Species in Catalytic Oxidations written by B. Meunier and published by Springer. This book was released on 2003-09-04 with total page 327 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is a description of the current knowledge on the different metal-oxo and metal-peroxo species involved in catalytic oxidations. The series contains critical reviews of the present position and future trends, and short and concise reports written by the world’s renowned experts.
Download or read book Food Additives in Europe 2000 written by and published by Nordic Council of Ministers. This book was released on 2002 with total page 708 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Photochemistry and Photophysics of Earth Abundant Transition Metal Complexes written by and published by Elsevier. This book was released on 2024-05-28 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Inorganic Chemstry serial highlights new advances in the field with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in Advances in Inorganic Chemistry serials - Updated release includes the latest information on Photochemistry and Photophysics of Earth-Abundant Transition Metal Complexes
Download or read book Medicinal and Biological Inorganic Chemistry written by Ajay Kumar Goswami and published by Walter de Gruyter GmbH & Co KG. This book was released on 2022-01-19 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book provides a detailed state-of-the-art overview of inorganic chemistry applied to medicinal chemistry and biology. It covers the newly emerging field of metals in medicine and the future of medicinal inorganic chemistry. It is an essential reading for every researcher and student in medicinal and bioinorganic chemistry.
Download or read book EPA 600 2 written by and published by . This book was released on 1978 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Removal of Heavy Metals from Industrial Wastewaters Using Insoluble Starch Xanthate written by Robert E. Wing and published by . This book was released on 1978 with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Research Reporting Series written by and published by . This book was released on 1978 with total page 558 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Chemical Drug Design written by Girish Kumar Gupta and published by Walter de Gruyter GmbH & Co KG. This book was released on 2016-10-10 with total page 327 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemical Drug Design provides a compact overview on recent advances in this rapidly developing field. With contributions on in silico drug design, natural product based compounds, as well as on ligand- and structure-based approaches, the authors present innovative methods and techniques for identifying and synthetically designing novel drugs.
