Download or read book Copper Carbenes and Nitrenes written by and published by . This book was released on 2009 with total page 299 pages. Available in PDF, EPUB and Kindle. Book excerpt: The development of synthetic reactions that are efficient for the construction of carbon-carbon and carbon-heteroatom bonds is an important goal in contemporary organic and inorganic synthetic chemistry. Late-transition metal carbenes and nitrenes serve as highly valuable synthetic intermediates for useful catalytic transformations such as the [2 + 1] addition to olefins to give cyclopropanes and aziridines respectively. The direct and selective functionalization of C-H bonds to C-C or C-N bonds is also known to proceed via the intermediacy of such key intermediates. The quest for the identification of such valuable catalytic intermediates has been proven difficult due to their general thermal instability and high reactivity. Herein we describe the isolation and characterization of discrete copper carbene and nitrene species that exhibit electrophilic character and can undergo catalytic group transfer reactions with nucleophilic substrates. The synthesis of a family of dinuclear copper(I) beta-diketiminate arene complexes that can activate organoazides has led to the stabilization of diverse nitrene [NR] ligands (R = aryl, aliphatic, acyl) and the crystallographic characterization of discrete dicopper nitrene complexes. The detailed synthetic studies allowed us to uncover a unique and an efficient copper catalyzed C-H amination protocol using organoazides as a nitrene precursor. High turnover numbers (900) can be achieved for the amination of ethylbenzene. A novel 'C-H' protected robust betadiketiminato copper(I) catalyst was synthesized and was found to catalyze nitrene [NR] insertion into C-H bonds of hydrocarbons, ethers and aldehydes. The rate of C-H amination is strongly correlated to the strength of the reacting C-H bond and was found dependent on the choice of nitrene [NR] substituent. Copper-catalyzed amination reactions of several C-H substrates with aryl azides and benzoyl azide were undertaken. The first three-coordinate Cu(II) primary amido species were isolated and characterized and were shown to be highly reactive towards C-H bonds. The ability to study metal-stabilized carbene and nitrene species provides many valuable insights towards its diverse reactivity pathways and opens an avenue for the development of novel catalytic processes.
Download or read book Heterocycles from Carbenes and Nitrenes written by Michael P. Doyle and published by Springer Nature. This book was released on 2023-08-09 with total page 381 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides researchers in the fields of organic chemistry, organometallic chemistry and homogeneous catalysis with an overview of recent developments in the applications of reactions involving carbene and nitrene intermediates directed to the synthesis of heterocyclic compounds. Multiple pathways through which diverse heterocyclic compounds are accessed occur from a variety of carbene and nitrene precursors through C-H/X-H insertions, cycloadditions, ylide transformations, rearrangements, and cascade reactions. Catalytic processes that form metallo-carbenes and nitrenes offer unparalleled chemo-, regio-, and stereo-selectivities. Insights are provided into the scope of these methodologies and the inherent control of catalyst ligands on reaction selectivities.
Download or read book Organic Reaction Mechanisms 2016 written by A. C. Knipe and published by . This book was released on 2020-01-14 with total page 872 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organic Reaction Mechanisms 2016, the 52nd annual volume in this highly successful and unique series, surveys research on organic reaction mechanisms described in the available literature dated 2016. The following classes of organic reaction mechanisms are comprehensively reviewed: * Reaction of Aldehydes and Ketones and their Derivatives * Reactions of Carboxylic, Phosphoric, and Sulfonic Acids and their Derivatives * Oxidation and Reduction * Carbenes and Nitrenes * Nucleophilic Aromatic Substitution * Electrophilic Aromatic Substitution * Carbocations * Nucleophilic Aliphatic Substitution * Carbanions and Electrophilic Aliphatic Substitution * Elimination Reactions * Polar Addition Reactions * Cycloaddition Reactions * Molecular Rearrangements
Download or read book Carbenes Nitrenes and Arynes written by Thomas Lonsdale Gilchrist and published by . This book was released on 1966 with total page 131 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Carbenes nitrenes and arynes written by T. L. Gilchrist and published by Springer. This book was released on 2012-06-17 with total page 131 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carbenes, nitrenes, and arynes are of great interest to chemists because of the central role they play, as the key intermediates, in a wide range of chemical reactions. Their study has illuminated many aspects of synthetic and mechanistic chemistry. Their organic chemistry has developed enormously over the last ten to fifteen years so that now a fairly clear pattern of reactions and reactivity, strikingly similar for all three, has emerged. Partly because of this, but also because of the many unsolved problems and gaps in our present knowledge, it now seems appropriate to present a comparative account of their chemistry. Our approach is a simple, descriptive one that nevertheless attempts to bring the reader as nearly up-to-date as possible; there is considerable emphasis on recent work in the text and the problems. We have been selective rather than comprehensive, have concentrated on underlying principles, and have tried to emphasize what can, and what cannot, reasonably be claimed on the basis of the available experimental evidence. (The development of this area of organic chemistry could weil serve as a cauti'onary tale in this respect. ) We have written the book primarily at the advanced student level but it should also be useful to postgraduates students and to more experienced chemists. Some of the problems are at a rather more advanced level, the aim being to extend the reader's knowledge and understanding and to direct him to some recent originalliterature.
Download or read book Copper N heterocyclic Carbenes written by Benjamin Richard Morris Lake and published by . This book was released on 2014 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Organometallic Chemistry of N heterocyclic Carbenes written by Han Vinh Huynh and published by John Wiley & Sons. This book was released on 2017-02-03 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Organometallic Chemistry of N-heterocyclic Carbenes describes various aspects of N-heterocyclic Carbenes (NHCs) and their transition metal complexes at an entry level suitable for advanced undergraduate students and above. The book starts with a historical overview on the quest for carbenes and their complexes. Subsequently, unique properties, reactivities and nomenclature of the four classical NHCs derived from imidazoline, imidazole, benzimidazole and 1,2,4-triazole are elaborated. General and historically relevant synthetic aspects for NHCs, their precursors and complexes are then explained. The book continues with coverage on the preparation and characteristics of selected NHC complexes containing the most common metals in this area, i.e. Ni, Pd, Pt, Ag, Cu, Au, Ru, Rh and Ir. The book concludes with an overview and outlook on the development of various non-classical NHCs beyond the four classical types. Topics covered include: Stabilization, dimerization and decomposition of NHCs Stereoelectronic properties of NHCs and their evaluation Diversity of NHCs Isomers of NHC complexes and their identification NMR spectroscopic signatures of NHC complexes normal, abnormal and mesoionic NHCs The Organometallic Chemistry of N-heterocyclic Carbenes is an essential resource for all students and researchers interested in this increasingly important and popular field of research.
Download or read book Computational Methods in Organometallic Catalysis written by Yu Lan and published by John Wiley & Sons. This book was released on 2021-03-24 with total page 672 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book includes a historical introduction to organometallic chemistry, a survey of mechanisms, and an extensive introduction to quantum mechanical computational methods.
Download or read book Aziridines and Epoxides in Organic Synthesis written by Andrei K. Yudin and published by John Wiley & Sons. This book was released on 2006-02-20 with total page 532 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aziridines and epoxides are among the most widely used intermediates in organic synthesis, acting as precursors to complex molecules due to the strains incorporated in their skeletons. Besides their importance as reactive intermediates, many biologically active compounds also contain these three-membered rings. Filling a gap in the literature, this clearly structured book presents the much needed information in a compact and concise way. The renowned editor has succeeded in gathering together excellent authors to cover synthesis, applications, and the biological aspects in equal depth. Divided roughly equally between aziridines and epoxides, the twelve chapters discuss: * Synthesis of aziridines * Nucleophilic ring-opening of aziridines and epoxides * Organic synthesis with aziridine building blocks * Vinyl aziridines in organic synthesis * Diastereoselective aziridination reagents * Synthetic aspects of aziridinomitocene chemistry * Biosynthesis of biologically important aziridines * Organic catalysis of epoxide and aziridine ring formation * Metal-mediated synthesis of epoxides * Asymmetric epoxide ring opening chemistry * Epoxides in complex molecule synthesis * Biological activity of epoxide-containing molecules A high-quality reference manual for academic and industrial chemists alike.
Download or read book Organic Reaction Mechanisms 2013 written by A. C. Knipe and published by John Wiley & Sons. This book was released on 2016-09-07 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organic Reaction Mechanisms 2013, the 49th annual volume in this highly successful and unique series, surveys research on organic reaction mechanisms described in the available literature dated 2013. The following classes of organic reaction mechanisms are comprehensively reviewed: Reaction of Aldehydes and Ketones and their Derivatives Reactions of Carboxylic, Phosphoric, and Sulfonic Acids and their Derivatives Oxidation and Reduction Carbenes and Nitrenes Nucleophilic Aromatic Substitution Electrophilic Aromatic Substitution Carbocations Nucleophilic Aliphatic Substitution Carbanions and Electrophilic Aliphatic Substitution Elimination Reactions Polar Addition Reactions Cycloaddition Reactions Molecular Rearrangements An experienced team of authors compile these reviews every year, so that the reader can rely on a continuing quality of selection and presentation.
Download or read book Copper in N Heterocyclic Chemistry written by Ananya Srivastava and published by Elsevier. This book was released on 2020-11-13 with total page 506 pages. Available in PDF, EPUB and Kindle. Book excerpt: Copper in N-Heterocyclic Chemistry provides an overview of copper-catalyzed synthesis and functionalization of N-heterocyclic compounds, covering all recent developments in a way that is ideal for researchers and students working in the area of synthetic organic chemistry and medicinal chemistry. The book explores N-heterocyclic compounds as unique structural units in the development of natural products and pharmaceuticals, along with the remarkable progress made in the area of high atom economic strategies, and more recently, copper-catalyzed C-H activation and its applications in organic synthesis. Readers will find troubleshooting protocols, as well as the advantages and limitations of each method discussed. As copper catalysts show versatile chemical reactivity in many aspects, including their oxidation states 0–3 are accessible and their ability to facilitate bond formations due to their ability to serve as Lewis acids, oxidizing agents and catalysts, this book is an ideal resource on the topics explored. Discusses novel synthetic methods developed over the past decade for copper-catalyzed synthesis of N-heterocyclic compounds Covers the most recent methodologies adapted in synthetic chemistry for applications in natural products and pharmaceuticals Includes troubleshooting protocols, as well as the advantages and limitations of each method discussed in detail
Download or read book Organic Reaction Mechanisms 2019 written by Mark G. Moloney and published by John Wiley & Sons. This book was released on 2023-03-13 with total page 708 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organic Reaction Mechanisms 2019, the 55th annual volume in this highly successful and unique series, surveys research on organic reaction mechanisms described in the available literature dated 2019. The following classes of organic reaction mechanisms are comprehensively reviewed: • Reaction of Aldehydes and Ketones and their Derivatives • Reactions of Carboxylic, Phosphoric, and Sulfonic Acids and their Derivatives • Oxidation and Reduction • Carbenes and Nitrenes • Nucleophilic Aromatic Substitution • Electrophilic Aromatic Substitution • Carbocations • Nucleophilic Aliphatic Substitution • Carbanions and Electrophilic Aliphatic Substitution • Elimination Reactions • Polar Addition Reactions • Cycloaddition Reactions • Molecular Rearrangements An experienced team of authors compile these reviews every year, so that the reader can rely on a continuing quality of selection and presentation.
Download or read book Organic Reaction Mechanisms 1978 written by A. C. Knipe and published by John Wiley & Sons. This book was released on 2008-04-30 with total page 732 pages. Available in PDF, EPUB and Kindle. Book excerpt: The only book series to summarize the latest progress on organic reaction mechanisms, Organic Reaction Mechanisms, 1978 surveys the development in understanding of the main classes of organic reaction mechanisms reported in the primary scientific literature in 1978. The 14th annual volume in this highly successful series highlights mechanisms of stereo-specific reactions. Reviews are compiled by a team of experienced editors and authors, allowing advanced undergraduates, graduate students, postdocs, and chemists to rely on the volume's continuing quality of selection and presentation.
Download or read book Organic Reaction Mechanisms 1974 written by A. R. Butler and published by John Wiley & Sons. This book was released on 2008-04-30 with total page 670 pages. Available in PDF, EPUB and Kindle. Book excerpt: The only book series to summarize the latest progress on organic reaction mechanisms, Organic Reaction Mechanisms, 1974 surveys the development in understanding of the main classes of organic reaction mechanisms reported in the primary scientific literature in 1974. The 10th annual volume in this highly successful series highlights mechanisms of stereo-specific reactions. Reviews are compiled by a team of experienced editors and authors, allowing advanced undergraduates, graduate students, postdocs, and chemists to rely on the volume's continuing quality of selection and presentation.
Download or read book Modern Catalytic Methods for Organic Synthesis with Diazo Compounds written by Michael P. Doyle and published by Wiley-Interscience. This book was released on 1998-01-19 with total page 680 pages. Available in PDF, EPUB and Kindle. Book excerpt: This much-needed resource brings together a wealth of procedures for the synthesis and practical use of diazocarbonyl compounds. It features methods for the preparation of important catalysts and for applications of diazocarbonyl compounds within each of the main transformation categories-including in-depth coverage of cyclopropanation, C-H and X-H insertion, Wolff rearrangement, ylide formation, aromatic cycloaddition and substitution, and many other useful reactions. Written by leading experts in the field, this book contains cutting-edge material on highly enantioselective transformations, and presents new ways of thinking about diazocarbonyl compounds and their applications, from donor-acceptor cyclopropanes in organic synthesis to macrocyclic cyclopropanation. Complete with illustrative examples of procedures in each chapter, clear diagrams, and a detailed bibliography, this practical reference gives readers the tools they need to put diazocarbonyl compounds to work for their own projects-an invaluable source of guidance for synthetic organic chemists, chemical scientists, and advanced students.
Download or read book Organic Reaction Mechanisms 2012 written by A. C. Knipe and published by John Wiley & Sons. This book was released on 2015-05-04 with total page 660 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organic Reaction Mechanisms 2012, the 48th annual volume in this highly successful and unique series, surveys research on organic reaction mechanisms described in the available literature dated 2012. The following classes of organic reaction mechanisms are comprehensively reviewed: Reaction of Aldehydes and Ketones and their Derivatives Reactions of Carboxylic, Phosphoric, and Sulfonic Acids and their Derivatives Oxidation and Reduction Carbenes and Nitrenes Nucleophilic Aromatic Substitution Electrophilic Aromatic Substitution Carbocations Nucleophilic Aliphatic Substitution Carbanions and Electrophilic Aliphatic Substitution Elimination Reactions Polar Addition Reactions Cycloaddition Reactions Molecular Rearrangements An experienced team of authors compiled these reviews, ensuring the quality of selection and presentation.
