Download or read book The Coordination Chemistry of Metalloenzymes written by I. Bertini and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt: Assembling a program in bioinorganic chemistry that is scientifi cally relevant, well defined, and self-consistent is not an easy task. In this attempt we decided to consider zinc enzymes, copper oxidases, cytochromes and cytochrome oxidase. The choice is in part due to the great attention that the current specialized literature devotes to these topics, which are now debated among chemists, biochemists, biophysicists, etc .. We believe that hydration reactions, hydrolytic and oxidative processes have much in common from the point of view of the reaction mechanisms, the comprehension of which represents a frontier of science. For these reasons these topics have been the subject of the NATO-ASI held at San Miniato, Pisa, Italy, from May 28 to June 8, 1982. We hope we can transfer here the main conclusions of what (we believe) was a very stimulating scientific meeting. We would like to thank the local saving bank, Cassa di Risparmio di San Miniato, for helping in many ways. The financial contribution from the European Research Office of the US Army, and from the Bruker Spectrospin s.r.l., Italy, is also acknowledged. The National Science Foundation of the United States has provided a travel grant to one of the participants from the U.S.A. We are grateful to the NATO Scientific Affairs Division which provided a grant to finance this Institute.

Download or read book Coordination chemistry inspired by metalloenzymes written by Frans Paap and published by . This book was released on 1987 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Coordination Chemistry of Metalloenzymes written by Ivano Bertini and published by Springer My Copy UK. This book was released on 1983 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Chemistry of Metalloproteins written by Joseph J. Stephanos and published by John Wiley & Sons. This book was released on 2014-07-22 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: Addresses the full gamut of questions in metalloprotein science Formatted as a question-and-answer guide, this book examines all major families of metal binding proteins, presenting our most current understanding of their structural, physicochemical, and functional properties. Moreover, it introduces new and emerging medical applications of metalloproteins. Readers will discover both the underlying chemistry and biology of this important area of research in bioinorganic chemistry. Chemistry of Metalloproteins features a building block approach that enables readers to master the basics and then advance to more sophisticated topics. The book begins with a general introduction to bioinorganic chemistry and metalloproteins. Next, it covers: Alkali and alkaline earth cations Metalloenzymes Copper proteins Iron proteins Vitamin B12 Chlorophyll Chapters are richly illustrated to help readers fully grasp all the chemical concepts that govern the biological action of metalloproteins. In addition, each chapter ends with a list of suggested original research articles and reviews for further investigation of individual topics. Presenting our most current understanding of metalloproteins, Chemistry of Metalloproteins is recommended for students and researchers in coordination chemistry, biology, and medicine. Each volume of the Wiley Series in Protein and Peptide Science addresses a specific facet of the field, reviewing the latest findings and presenting a broad range of perspectives. The volumes in this series constitute essential reading for biochemists, biophysicists, molecular biologists, geneticists, cell biologists, and physiologists as well as researchers in drug design and development, proteomics, and molecular medicine with an interest in proteins and peptides.

Download or read book The Coordination Chemistry of Metalloenzymes The Role of Metals in Reactions Involving Water Dioxygen and Related Species Volume 100 written by BERTINI, I (ED.) and published by . This book was released on 1983 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Transition Metals in Coordination Environments written by Ewa Broclawik and published by Springer. This book was released on 2019-03-16 with total page 532 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the electronic properties of transition metals in coordination environments. These properties are responsible for the unique and intricate activity of transition metal sites in bio- and inorganic catalysis, but also pose challenges for both theoretical and experimental studies. Written by an international group of recognized experts, the book reviews recent advances in computational modeling and discusses their interplay using experiments. It covers a broad range of topics, including advanced computational methods for transition metal systems; spectroscopic, electrochemical and catalytic properties of transition metals in coordination environments; metalloenzymes and biomimetic compounds; and spin-related phenomena. As such, the book offers an invaluable resource for all researchers and postgraduate students interested in both fundamental and application-oriented research in the field of transition metal systems.

Download or read book Sustaining Life on Planet Earth Metalloenzymes Mastering Dioxygen and Other Chewy Gases written by Peter M. H Kroneck and published by Springer. This book was released on 2015-02-23 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: MILS-15 provides an up-to-date review of the metalloenzymes involved in the activation, production, and conversion of molecular oxygen as well as the functionalization of the chemically inert gases methane and ammonia. Found either in aerobes (humans, animals, plants, microorganisms) or in anaerobes (so-called “impossible bacteria”) these enzymes employ preferentially iron and copper at their active sites, in order to conserve energy by redox-driven proton pumps, to convert methane to methanol, or ammonia to hydroxylamine or other compounds. When it comes to the light-driven production of molecular oxygen, the tetranuclear manganese cluster of photosystem II must be regarded as the key player. However, dioxygen can also be produced in the dark, by heme iron-dependent dismutation of oxyanions. Metalloenzymes Mastering Dioxygen and Other Chewy Gases is a vibrant research area based mainly on structural and microbial biology, inorganic biological chemistry, and environmental biochemistry. All this is covered in an authoritative manner in 7 stimulating chapters, written by 21 internationally recognized experts, and supported by nearly 1100 references, informative tables, and over 140 illustrations (many in color). MILS-15 provides excellent information for teaching; it is also closely related to MILS-14, The Metal-Driven Biogeochemistry of Gaseous Compounds in the Environment. Peter M. H. Kroneck is a bioinorganic chemist who is exploring the role of transition metals in biology, with a focus on functional and structural aspects of microbial iron, copper, and molybdenum enzymes and their impact on the biogeochemical cyles of nitrogen and sulfur. Martha E. Sosa Torres is an inorganic chemist, with special interests in magnetic properties of newly synthesized transition metal complexes and their reactivity towards molecular oxygen, applying kinetic, electrochemical, and spectroscopic techniques.

Download or read book Synthetic Coordination and Organometallic Chemistry written by Alexandr D. Garnovskii and published by CRC Press. This book was released on 2003-04-25 with total page 559 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference offers a clear and concise review of modern synthetic techniques of metal complexes as well as lesser known gas- and solid-phase synthesis, electrosynthesis, and microwave and ultrasonic treatment of the reaction system.

Download or read book Artificial Metalloenzymes and MetalloDNAzymes in Catalysis written by Montserrat Diéguez and published by John Wiley & Sons. This book was released on 2018-06-05 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: An important reference for researchers in the field of metal-enzyme hybrid catalysis Artificial Metalloenzymes and MetalloDNAzymes in Catalysis offers a comprehensive review of the most current strategies, developed over recent decades, for the design, synthesis, and optimization of these hybrid catalysts as well as material about their application. The contributors—noted experts in the field—present information on the preparation, characterization, and optimization of artificial metalloenzymes in a timely and authoritative manner. The authors present a thorough examination of this interesting new platform for catalysis that combines the excellent selective recognition/binding properties of enzymes with transition metal catalysts. The text includes information on the various applications of metal-enzyme hybrid catalysts for novel reactions, offers insights into the latest advances in the field, and contains an informative perspective on the future: Explores the development of artificial metalloenzymes, the modern and strongly evolving research field on the verge of industrial application Contains a comprehensive reference to the research area of metal-enzyme hybrid catalysis that has experienced tremendous growth in recent years Includes contributions from leading researchers in the field Shows how this new catalysis combines the selective recognition/binding properties of enzymes with transition metal catalysts Written for catalytic chemists, bioinorganic chemists, biochemists, and organic chemists, Artificial Metalloenzymes and MetalloDNAzymes in Catalysis offers a unique reference to the fundamentals, concepts, applications, and the most recent developments for more efficient and sustainable synthesis.

Download or read book Coordination Chemistry in Protein Cages written by Takafumi Ueno and published by John Wiley & Sons. This book was released on 2013-03-22 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sets the stage for the design and application of new protein cages Featuring contributions from a team of international experts in the coordination chemistry of biological systems, this book enables readers to understand and take advantage of the fascinating internal molecular environment of protein cages. With the aid of modern organic and polymer techniques, the authors explain step by step how to design and construct a variety of protein cages. Moreover, the authors describe current applications of protein cages, setting the foundation for the development of new applications in biology, nanotechnology, synthetic chemistry, and other disciplines. Based on a thorough review of the literature as well as the authors' own laboratory experience, Coordination Chemistry in Protein Cages Sets forth the principles of coordination reactions in natural protein cages Details the fundamental design of coordination sites of small artificial metalloproteins as the basis for protein cage design Describes the supramolecular design and assembly of protein cages for or by metal coordination Examines the latest applications of protein cages in biology and nanotechnology Describes the principles of coordination chemistry that govern self-assembly of synthetic cage-like molecules Chapters are filled with detailed figures to help readers understand the complex structure, design, and application of protein cages. Extensive references at the end of each chapter serve as a gateway to important original research studies and reviews in the field. With its detailed review of basic principles, design, and applications, Coordination Chemistry in Protein Cages is recommended for investigators working in biological inorganic chemistry, biological organic chemistry, and nanoscience.

Download or read book Molecular Electronic Structures of Transition Metal Complexes I written by David Michael P. Mingos and published by Springer Science & Business Media. This book was released on 2012-01-11 with total page 227 pages. Available in PDF, EPUB and Kindle. Book excerpt: J.P. Dahl: Carl Johan Ballhausen (1926–2010).- J.R. Winkler and H.B. Gray: Electronic Structures of Oxo-Metal Ions.- C.D. Flint: Early Days in Kemisk Laboratorium IV and Later Studies.- J.H. Palmer: Transition Metal Corrole Coordination Chemistry. A Review Focusing on Electronic Structural Studies.- W.C. Trogler: Chemical Sensing with Semiconducting Metal Phthalocyanines.- K.M. Lancaster: Biological Outer-Sphere Coordination.- R.K. Hocking and E.I. Solomon: Ligand Field and Molecular Orbital Theories of Transition Metal X-ray Absorption Edge Transitions.- K.B. Møller and N.E. Henriksen: Time-resolved X-ray diffraction: The dynamics of the chemical bond.

Download or read book Stability and Applications of Coordination Compounds written by Abhay Nanda Srivastva and published by BoD – Books on Demand. This book was released on 2020-07-08 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the current era of incessant developing needs for the betterment and ease in living style for humans, technology is seeking upgraded, well structured materials for utilization in various fields of human-wellness such as medication, energy, environment protection and cleaning, food security etc. In the same direction, chemists are doing very well at synthesizing compounds and materials from different groups of chemicals. Among them, coordination compounds also play a key role in serving humanity as these compounds have a wide range of applications in health care from antimicrobial to anticancer, bioengineering, bio-mimetic models, catalysis, photosensitized materials etc. Along with development of stable coordination compounds, their extensive structural studies are also in the main line of work for researchers. Twenty-nine authors from different countries have contributed their scientific views and work in magnifying the importance and scope of coordination compounds in the present book entitled “Stability and Applications of Coordination Compounds”. I hope that the book will achieve its target of supplementing the community of researchers and readers working in the field of coordination chemistry.

Download or read book Exploring the Influence of Metalloenzyme Active Sites on Metal Binding Pharmacophores written by David Pifer Martin and published by . This book was released on 2014 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carbonic anhydrase was used as a model system to examine the influence of metalloenzyme active site environments on coordination by metal-binding pharmacophores (MBPs). This dissertation will first discuss metalloenzymes as therapeutic targets, along with inhibitors of these enzymes that have gained FDA approval in Chapter 1. The characteristics of MBPs that have generally been implicated in the low clinical success rate of therapeutics targeting these enzymes are then discussed, followed by an explanation of how the use of a more diverse collection of MBPs can potentially solve these problems. The coordination of a series of novel MBPs inspired by Zn2+ sensors to Co2+, Ni2+, Cu2+, and Zn2+ will then be discussed in Chapter 2. These studies into the fundamental coordination chemistry of MBPs provide valuable information into the preferred binding modes of these molecules to active site metal ions. Inhibition of human carbonic anhydrase II (hCAII) by MBPs was investigated and those molecules showing activity were cocrystallized in the hCAII active site. The binding modes were then compared to those observed in small-molecule model complexes. Unexpected monodentate coordination by the O,S-donor ligand 3-hydroxy-2-methylpyran-4-thione is described in Chapter 3. Further studies using substituted derivatives of the 1-hydroxy-1H-pyridin-2-thione MBP are then discussed that show the monodentate coordination mode to be a result of interactions with the surrounding hCAII active site environment formed upon metal coordination. In Chapter 4, mutants of hCAII were then used to examine the influence of the metal coordination sphere on MBP binding. The affinity and binding mode of benzenesulfonamide, a prototypical hCAII inhibitor, to mutants containing altered coordination spheres will be discussed that show decreased binding affinity despite a common binding mode. Finally, in Chapter 5, a class of inhibitors that bind in the hCAII active site by hydrogen bonding to the metal-bound water molecule rather than direct coordination of the active site metal ion, are discussed.

Download or read book Advances in the Development of Artificial Metalloenzymes written by Tatjana N. Parac-Vogt and published by Frontiers Media SA. This book was released on 2019-11-05 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reactions catalyzed by metalloenzymes have great potential for applications in the biotechnology and pharmaceutical industries. While only a few of these enzymes have yet been used in such applications, in the last few decades numerous efficient, selective, environmentally friendly and economical synthetic analogues have been described, including supramolecular, polymeric, nanoparticulate and lowmolecular- weight organometallic complexes, and metal organic frameworks. In this Research Topic, we present a collection of original research and review articles that show significant recent advances made in the rational design of such artificial metalloenzymes.

Download or read book Coordination Chemistry written by D. Banerjea and published by Elsevier. This book was released on 2017-12-20 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt: Coordination Chemistry is a collection of invited lectures presented at the 20th International Conference on Coordination Chemistry held in Calcutta, India, on December 10-14, 1979, and organized by the International Union of Pure and Applied Chemistry in cooperation with India's National Science Academy and the Department of Science & Technology. The conference covers a wide range of topics relating to coordination chemistry, including the stereochemistry of coordination compounds; the mechanism of the base hydrolysis of octahedral cobalt(III) complexes; and metal chelates as anticancer agents. This book consists of 26 chapters and opens with a discussion on some developments in the stereochemistry of coordination complexes, including the creation of ""sepulchrate"" ions of cobalt, chromium, ruthenium, and platinum; the preparation of planar complexes containing ligands spanning trans-positions; and the separation of optical and configurational isomers of octahedral complexes containing unsymmetrical and asymmetric ligands. The following chapters explore complex chemistry and the mimicry of metalloenzymes; metal complexes with functionalized macrocyclic ligands; binuclear complexes in electron transfer reactions; and application of coordination chemistry in biology and medicine. The synthetic and structural chemistry of transition metals is also considered, along with linear free energy relationships in coordination chemistry. This monograph will be a valuable source of information for practitioners and research workers in the field of pure and applied chemistry, particularly coordination chemistry.

Download or read book Practical Approaches to Biological Inorganic Chemistry written by Robert R. Crichton and published by Elsevier. This book was released on 2019-09-10 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: Practical Approaches to Biological Inorganic Chemistry, Second Edition, reviews the use of spectroscopic and related analytical techniques to investigate the complex structures and mechanisms of biological inorganic systems that contain metals. Each chapter presents an overview of the technique, including relevant theory, a clear explanation of what it is, how it works, and how the technique is actually used to evaluate biological structures. New chapters cover Raman Spectroscopy and Molecular Magnetochemistry, but all chapters have been updated to reflect the latest developments in discussed techniques. Practical examples, problems and many color figures are also included to illustrate key concepts. The book is designed for researchers and students who want to learn both the basics and more advanced aspects of key methods in biological inorganic chemistry. Presents new chapters on Raman Spectroscopy and Molecular Magnetochemistry, as well as updated figures and content throughout Includes color images throughout to enable easier visualization of molecular mechanisms and structures Provides worked examples and problems to help illustrate and test the reader’s understanding of each technique Written by leading experts who use and teach the most important techniques used today to analyze complex biological structures

Download or read book Advances in Catalytic Activation of Dioxygen by Metal Complexes written by László I. Simándi and published by Springer Science & Business Media. This book was released on 2006-04-11 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: The subject of dioxygen activation and homogeneous catalytic oxidation by metal complexes has been in the focus of attention over the last 20 years. The widespread interest is illustrated by its recurring presence among the sessions and subject areas of important international conferences on various aspects of bioinorganic and coordination chemistry as well as catalysis. The most prominent examples are ICCC, ICBIC, EUROBIC, ISHC, and of course the ADHOC series of meetings focusing on the subject itself. Similarly, the number of original and review papers devoted to various aspects of dioxygen activation are on the rise. This trend is due obviously to the relevance of catalytic oxidation to biological processes such as dioxygen transport, and the action of oxygenase and oxidase enzymes related to metabolism. The structural and functional modeling of metalloenzymes, particularly of those containing iron and copper, by means of low-molecular complexes of iron, copper, ruthenium, cobalt, manganese, etc., have provided a wealth of indirect information helping to understand how the active centers of metalloenzymes may operate. The knowledge gained from the study of metalloenzyme models is also applicable in the design of transition metal complexes as catalytsts for specific reactions. This approach has come to be known as biomimetic or bioinspired catalysis and continues to be a fruitful and expanding area of research.