Download or read book Control Strategies for Closed loop Deep Brain Stimulation in Network Models of Parkinson s Disease written by John Fleming and published by . This book was released on 2021 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Towards Closed loop Stimulation for Treatment of Parkinson s Disease written by Patrick Gorzelic and published by . This book was released on 2010 with total page 99 pages. Available in PDF, EPUB and Kindle. Book excerpt: Treatment of Parkinson's Disease (PD) via deep brain stimulation (DBS) has gained much attention in recent years. The treatment uses a surgically implanted electrode to excite selected areas of a patient's brain with electronic stimulation, often yielding drastic improvements in PD symptoms. The method of stimulation is a simple one; the patient's subthalamic nucleus (STN) or internal segment of the globus pallidus (GPi) is subjected to a constant barrage of high frequency pulses, warranting continuous spiking activity of the area. Until this point, no other method of stimulation has been shown to work in practice. This work examines the possibility of using a less constant, more energy-efficient stimulation pattern, wherein the stimulation waveform is not simply pre-programmed for all time; it is calculated continuously through use of model-based feedback control. Specifically, a computational model of a neuronal network that plays a key role in the emergence of PD symptoms is employed to simulate the activity of the brain under the influence of feedback-controlled stimulation. Two control strategies are developed, and the results of each are presented and discussed. Important aspects pertaining to general simulation-based neuronal control that arise throughout the research are also commented on.
Download or read book Deep Brain Stimulation for Parkinson s Disease written by Gordon H. Baltuch and published by CRC Press. This book was released on 2007-03-19 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: Considered the largest breakthrough in the treatment of Parkinson's disease in the past 40 years, Deep Brain Stimulation (DBS) is a pioneering procedure of neurology and functional neurosurgery, forging enormous change and growth within the field. The first comprehensive text devoted to this surgical therapy, Deep Brain Stimulation for Parkinson's
Download or read book Closed loop Deep Brain Stimulation Algorithm for Parkinson s Disease Based on Reinforcement Learning and Basal Ganglia thalamus Network Dynamics written by 卓嘉虹 and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Towards Closed loop Optogenetic Control of Parkinson s Disease written by Kyle Reigh and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The treatment of Parkinson's disease with electrical stimulation has become common with the application of deep brain stimulation (DBS). This method of applying an open-loop, high frequency pulsed signal to the patients subthalamic nucleus (STN) or global pallidus interior (GPi) succeeds in improving thalamic response to sensorimotor inputs. However, it is a method that can be further improved. One way that this may be possible is through the use of optogenetics. With the application light-sensitive channelrhodopsin-2 (ChR2), an ionic current can be generated by controlled illumination of the neuron.This thesis first analyzes potential computational neuronal models that can be used to successfully design a controller that would improve on current techniques. An analytic solution for the reduced order neuron model is found via an AFT solution technique to verify the numerical simulation of the model and further analyze the dynamics of the system. An optogenetics model is then acquired and observed in detail in order to apply it to the neuron model. Finally, multiple control strategies, including PID, linear compensator application, and pulsed stimulation, are explored and discussed in an effort to alleviate Parkinson's symptoms.
Download or read book Deep Brain Stimulation written by Peter Bain and published by OUP Oxford. This book was released on 2009-03-05 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: Deep brain stimulation (DBS) is increasingly used for the treatment of patients with severe Parkinson's disease and other movement disorders, but the technique and science behind it is still poorly understood by most clinicians. This book is intended to provide an overview of the use of deep brain stimulation for movement disorders and provide an introduction to the developing arena of DBS for psychiatric disease. The first part of the book covers the varying surgical techniques involved in implanting electrodes into various deep nuclei within the brain. The neurophysiological techniques involved in this process and the complex issue of programming the implanted stimulator in order to optimise therapeutic efficacy and minimise stimulation induced adverse effects. The second part of the book describes how to select appropriate patients for DBS and describes the results of DBS treatment for Parkinson's disease, dystonia and various tremors, as well as psychiatric conditions. Edited by three of the world's leading experts in the DBS field, this pocketbook will provide neurologists, trainees and specialist nurses with an overview of the therapeutics use of DBS
Download or read book Stereotactic and Functional Neurosurgery written by Nader Pouratian and published by Springer Nature. This book was released on 2020-02-28 with total page 563 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text presents a comprehensive and state-of the-art approach to stereotactic and functional neurosurgery. Overarching sections include achieving stereotactic precision, defining trajectories and targets, the biophysics of stereotactic therapies, diseases and targets, and the future of functional neurosurgery. Each section is designed to be inclusive of all relevant topics, serving as an unbiased resource to new clinicians in this field or established clinicians that are aiming to better understand complementary methods. Importantly, each section and the associated chapters can be used by basic and translational scientists as well as engineers and industry to better understand and deliver innovation to the field. Chapters within each section methodically analyze traditional and recently emerging concepts and techniques; address underlying principles with examples drawn from specific diseases and applications; and cover patient selection, target selection, available stereotactic methods, nuanced surgical methods, and clinical evidence across treatment options. Written by experts in each area, Stereotactic and Functional Neurosurgery is a definitive guide to the latest developments in stereotactic targeting, electrode implantation, surgical treatment of neurological and psychiatric disorders, the renaissance of stereotactic lesions, and the frontier of restorative neurosurgery for a variety of disorders that have no other therapeutic options.
Download or read book Towards the Next Generation of Deep Brain Stimulation Therapies Technological Advancements Computational Methods and New Targets written by George C. McConnell and published by Frontiers Media SA. This book was released on 2021-10-04 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Closed Loop Systems for Next Generation Neuroprostheses written by Timothée Levi and published by Frontiers Media SA. This book was released on 2018-04-26 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: Millions of people worldwide are affected by neurological disorders which disrupt the connections within the brain and between brain and body causing impairments of primary functions and paralysis. Such a number is likely to increase in the next years and current assistive technology is yet limited. A possible response to such disabilities, offered by the neuroscience community, is given by Brain-Machine Interfaces (BMIs) and neuroprostheses. The latter field of research is highly multidisciplinary, since it involves very different and disperse scientific communities, making it fundamental to create connections and to join research efforts. Indeed, the design and development of neuroprosthetic devices span/involve different research topics such as: interfacing of neural systems at different levels of architectural complexity (from in vitro neuronal ensembles to human brain), bio-artificial interfaces for stimulation (e.g. micro-stimulation, DBS: Deep Brain Stimulation) and recording (e.g. EMG: Electromyography, EEG: Electroencephalography, LFP: Local Field Potential), innovative signal processing tools for coding and decoding of neural activity, biomimetic artificial Spiking Neural Networks (SNN) and neural network modeling. In order to develop functional communication with the nervous system and to create a new generation of neuroprostheses, the study of closed-loop systems is mandatory. It has been widely recognized that closed-loop neuroprosthetic systems achieve more favorable outcomes for users then equivalent open-loop devices. Improvements in task performance, usability, and embodiment have all been reported in systems utilizing some form of feedback. The bi-directional communication between living neurons and artificial devices is the main final goal of those studies. However, closed-loop systems are still uncommon in the literature, mostly due to requirement of multidisciplinary effort. Therefore, through eBook on closed-loop systems for next-generation neuroprostheses, we encourage an active discussion among neurobiologists, electrophysiologists, bioengineers, computational neuroscientists and neuromorphic engineers. This eBook aims to facilitate this process by ordering the 25 contributions of this research in which we highlighted in three different parts: (A) Optimization of different blocks composing the closed-loop system, (B) Systems for neuromodulation based on DBS, EMG and SNN and (C) Closed-loop BMIs for rehabilitation.
Download or read book Delays and Interconnections Methodology Algorithms and Applications written by Giorgio Valmorbida and published by Springer Nature. This book was released on 2019-10-02 with total page 315 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains advances on the theory and applications of time-delay systems with particular focus on interconnected systems. The methods for stability analysis and control design are based on time-domain and frequency-domain approaches, for continuous-time and sampled-data systems, linear and nonlinear systems. This volume is a valuable source of reference for control practitioners, graduate students, and scientists researching practical as well as theoretical solutions to a variety of control problems inevitably influenced by the presence of time delays. The contents are organized in three parts: Interconnected Systems analysis, Modeling and and Analysis for Delay systems, and Stabilization and Control Strategies for Delay Systems. This volume presents a selection of 19 contributions presented in the 4th DelSys Workshop which took place in Gif-sur-Yvette, France November 25-27, 2015.
Download or read book Closed Loop Neuroscience written by Ahmed El Hady and published by Academic Press. This book was released on 2016-09-08 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Closed Loop Neuroscience addresses the technical aspects of closed loop neurophysiology, presenting the implementation of these approaches spanning several domains of neuroscience, from cellular and network neurophysiology, through sensory and motor systems, and then clinical therapeutic devices. Although closed-loop approaches have long been a part of the neuroscientific toolbox, these techniques are only now gaining popularity in research and clinical applications. As there is not yet a comprehensive methods book addressing the topic as a whole, this volume fills that gap, presenting state-of-the-art approaches and the technical advancements that enable their application to different scientific problems in neuroscience. - Presents the first volume to offer researchers a comprehensive overview of the technical realities of employing closed loop techniques in their work - Offers application to in-vitro, in-vivo, and hybrid systems - Contains an emphasis on the actual techniques used rather than on specific results obtained - Includes exhaustive protocols and descriptions of software and hardware, making it easy for readers to implement the proposed methodologies - Encompasses the clinical/neuroprosthetic aspect and how these systems can also be used to contribute to our understanding of basic neurophysiology - Edited work with chapters authored by leaders in the field from around the globe – the broadest, most expert coverage available
Download or read book Sliding Mode Control in Electro Mechanical Systems written by Vadim Utkin and published by CRC Press. This book was released on 2017-12-19 with total page 503 pages. Available in PDF, EPUB and Kindle. Book excerpt: Apply Sliding Mode Theory to Solve Control Problems Interest in SMC has grown rapidly since the first edition of this book was published. This second edition includes new results that have been achieved in SMC throughout the past decade relating to both control design methodology and applications. In that time, Sliding Mode Control (SMC) has continued to gain increasing importance as a universal design tool for the robust control of linear and nonlinear electro-mechanical systems. Its strengths result from its simple, flexible, and highly cost-effective approach to design and implementation. Most importantly, SMC promotes inherent order reduction and allows for the direct incorporation of robustness against system uncertainties and disturbances. These qualities lead to dramatic improvements in stability and help enable the design of high-performance control systems at low cost. Written by three of the most respected experts in the field, including one of its originators, this updated edition of Sliding Mode Control in Electro-Mechanical Systems reflects developments in the field over the past decade. It builds on the solid fundamentals presented in the first edition to promote a deeper understanding of the conventional SMC methodology, and it examines new design principles in order to broaden the application potential of SMC. SMC is particularly useful for the design of electromechanical systems because of its discontinuous structure. In fact, where the hardware of many electromechanical systems (such as electric motors) prescribes discontinuous inputs, SMC becomes the natural choice for direct implementation. This book provides a unique combination of theory, implementation issues, and examples of real-life applications reflective of the authors’ own industry-leading work in the development of robotics, automobiles, and other technological breakthroughs.
Download or read book Adaptive Deep Brain Stimulation for Parkinson s Disease written by Simon Little and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Clinical and Ethical Practice of Neuromodulation Deep Brain Stimulation and Beyond written by Markus Christen and published by Frontiers Media SA. This book was released on 2018-01-15 with total page 84 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuromodulation is among the fastest-growing areas of medicine, involving many diverse specialties and affecting hundreds of thousands of patients with numerous disorders worldwide. It can briefly be described as the science of how electrical, chemical, and mechanical interventions can modulate the nervous system function. A prominent example of neuromodulation is deep brain stimulation (DBS), an intervention that reflects a fundamental shift in the understanding of neurological and psychiatric diseases: namely as resulting from a dysfunctional activity pattern in a defined neuronal network that can be normalized by targeted stimulation. The application of DBS has grown remarkably and more than 130,000 patients worldwide have obtained a DBS intervention in the past 30 years—most of them for treating movement disorders. This Frontiers Research Topics provides an overview on the current discussion beyond basic research in DBS and other brain stimulation technologies. Researchers from various disciplines, who are working on broader clinical, ethical and social issues related to DBS and related neuromodulation technologies, have contributed to this research topic.
Download or read book Pathological Synchronization in Neuronal Populations written by Alessio Franci and published by . This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the first part of this thesis, motivated by the development of deep brain stimulation for Parkinson's disease, we consider the problem of reducing the synchrony of a neuronal population via a closed-loop electrical stimulation. This, under the constraints that only the mean membrane voltage of the ensemble is measured and that only one stimulation signal is available (mean-field feedback). The neuronal population is modeled as a network of interconnected Landau-Stuart oscillators controlled by a linear single-input single-output feedback device. Based on the associated phase dynamics, we analyze existence and robustness of phase-locked solutions, modeling the pathological state, and derive necessary conditions for an effective desynchronization via mean-field feedback. Sufficient conditions are then derived for two control objectives: neuronal inhibition and desynchronization. Our analysis suggests that, depending on the strength of feedback gain, a proportional mean-field feedback can either block the collective oscillation (neuronal inhibition) or desynchronize the ensemble.In the second part, we explore two possible ways to analyze related problems on more biologically sound models. In the first, the neuronal population is modeled as the interconnection of nonlinear input-output operators and neuronal synchronization is analyzed within a recently developed input-output approach. In the second, excitability and synchronizability properties of neurons are analyzed via the underlying bifurcations. Based on the theory of normal forms, a novel reduced model is derived to capture the behavior of a large class of neurons remaining unexplained in other existing reduced models.
Download or read book Connectomic Deep Brain Stimulation written by Andreas Horn and published by Academic Press. This book was released on 2021-09-10 with total page 602 pages. Available in PDF, EPUB and Kindle. Book excerpt: Connectomic Deep Brain Stimulation (DBS) covers this highly efficacious treatment option for movement disorders such as Parkinson's Disease, Essential Tremor and Dystonia. The book examines its impact on distributed brain networks that span across the human brain in parallel with modern-day neuroimaging concepts and the connectomics of the brain. It asks several questions, including which cortical areas should DBS electrodes be connected in order to generate the highest possible clinical improvement? Which connections should be avoided? Could these connectomic insights be used to better understand the mechanism of action of DBS? How can they be transferred to individual patients, and more. This book is suitable for neuroscientists, neurologists and functional surgeons studying DBS. It provides practical advice on processing strategies and theoretical background, highlighting and reviewing the current state-of-the-art in connectomic surgery. - Written to provide a "hands-on" approach for neuroscience graduate students, as well as medical personnel from the fields of neurology and neurosurgery - Includes preprocessing strategies (such as co-registration, normalization, lead localization, VTA estimation and fiber-tracking approaches) - Presents references (key articles, books and protocols) for additional detailed study - Provides data analysis boxes in each chapter to help with data interpretation
Download or read book Modeling Analysis and Control of Parkinson s Disease Utilizing Deep Brain Stimulation System written by and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
