Download or read book Contemporary Topics in Molecular Immunology Vol 8 written by and published by . This book was released on 1981 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Contemporary Topics in Molecular Immunology written by F. P. Inman and published by Springer Science & Business Media. This book was released on 2013-11-22 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: There are many unanswered questions regarding the molecular nature of antibodies, components of complement, and other substances which participate in the immune response. The list of substances which need to be analyzed chemically is increasing. Plasma cell products, of course, have long been of great interest because the most prevalent ones are immunoglobulins. Other cell types, however, are the source of the broad spectrum of additional substances which classically fall into the sanctum of the molecular immunologist. It is these substances, and especially those more recently discovered, which are responsible for the broadening investigative interests of immunologists. In this volume we have provided you with descriptions of research being done with immunoglobulins and with complement. Additionally, we have in cluded two reports that deal with molecules which are among the more recent acquisitions of the molecular immunologist. The components of complement are known to react in a cascading manner which results in the lysis of cellular antigens. The first step in the classical pathway requires the activation of CI by the antibody-antigen aggregates. This volume of Contemporary Topics in Molecular Immunology begins with the report of Reid and Porter which describes their investigation of the mechanism of activation of C I. Their descriptions of C I q and of the reaction of C I with immunoglobulins are especially intriguing. It is clearly apparent from their report that activation of the components of complement is a complex phenome non.
Download or read book Contemporary Topics in Molecular Immunology written by R. A. Reisfeld and published by Springer Science & Business Media. This book was released on 2013-12-01 with total page 439 pages. Available in PDF, EPUB and Kindle. Book excerpt: New information is developing so rapidly in the entire field of immunology that one is unable to remain abreast of all advancing fronts. In many cases, consider able information has accumulated as the result of the efforts of many investigators, but the conclusions from the various laboratories have not been summarized recently in a comprehensible manner. One such situation has to do with work on IgD. An up-to-date report on this immunoglobulin was included in Volume 10f this series, but since that time there has been considerable progress in the deter mination of its structure and function. In the present volume Leslie and Martin have reviewed the accomplishments of recent years and the problems remaining to be solved. New information regarding the concentration of IgD in body fluids in normal and disease states is presented. Studies of the ontogeny of surface IgD in animals are described, and the fmdings imply that it may be important in the primary immune response. The role of IgD on lymphocyte surfaces is thoroughly discussed especially in terms of stimulating or suppressive combinations of signals delivered to the lymphocyte by agents which bind or alter the surface rt:ceptors. The authors conclude by proposing a model for plasma-cell differentiation which accounts fo~ the existence of triple Ig-bearing cells, many IgM-IgD-bearing cells, and the low percentage of cells bearing a single isotype. Sometimes the serum of an individual contains abnormally large amounts of two distinct, homogeneous populations of immunoglobulins.
Download or read book Contemporary Topics in Molecular Immunology written by Gordon Ada and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: A series of volumes devoted to molecular immunology will contain, for the most part, articles which attempt to explain immunological phenomena in terms of the behavior and properties of particular molecules. Many of the articles in this volume do this. At the same time, there are many instances-and this is particularly so in the case of immunology-where phenomena must first be described and interpreted in terms of the properties and behavior of cells. Most of us would hope that in due course a fuller understanding will be forthcoming. This volume starts off with such a contribution. Perhaps the most fascinat ing problem in immunology is how diversity is generated. There are two broad proposals: (1) that complete information exists ab initio (the germ-line theory), and (2) that there is initially a limited amount of information, and diversity is generated by somatic mutation. The issue is unresolved, but Cunningham has taken many of the data which have previously been used to support the germ-line theory and shows that the interpretations are not always clear-cut and can frequently be used to support another possibility-that new specificities may arise after stimulation of appropriate cells by antigens. And he has produced experimental evidence to support this notion. On the other hand, there can be little doubt that to a considerable degree the specificity of the immune response is determined by the selection by antigen of cells with receptors of appropriate specificity. This is essentially a surface phenomenon.
Download or read book Contemporary Topics in Molecular Immunology written by H. Eisen and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunochemistry, recently rechristened molecular immunology, has been pre occupied throughout its long history with the structure and function of antibodies and the specificity of antibody-antigen reactions. With the recent X-ray diffrac of several crystallized immunoglobulin (Ig) fragments and a whole tion analyses Ig molecule, the three-dimensional structure of antibodies and their ligand combining sites has been realized, marking the concluding stages of a phase of immunological research that can be traced back at least 75 years. At the same time chemically minded immunologists have been moving in new directions. A substantial beginning in one direction has been made with the purification of messenger RNAs (mRNAs) for Ig chains. Hybridization of these RNAs (or their DNA copies made with the enzyme reverse transcriptase) to cell DNA is beginning to provide convincing estimates of the number of germ-line Ig genes. And some hybridization studies have already yielded suggestive evidence for translocation of V and C genes from separate to contiguous positions in DNA isolated from cells at different stages of differentiation. Moreover, in vitro trans lation of Ig mRNAs has revealed a remarkably hydrophobic stretch of about 20 amino acids at the N-terminus of the nascent Ig chain. This extra piece is absent in the Ig extracted from or secreted by plasma cells, presumably because it is rapidly cleaved from the "preimmunoglobulin" chain within the cell, but the extra piece probably plays a key role in directing the synthesis of prelg to the cell's secretory pathway.
Download or read book Contemporary Topics in Molecular Immunology written by R. Porter and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: The distinction between molecular immunology and immunobiology is neces sarily arbitrary. The most rapid progress is usually made in the blurred area between the two, when the chemist is aware of the full significance of the biological problems, and the biologist is alert to the contribution that a knowl edge of molecular structure can be made to their solution. The range of scientific disciplines able to contribute to research in immunology, which this approach brings, is reflected in the present volume. Protein chemists worked out the arrangement of the polypeptide chains and the amino acid sequences of antibodies and X-ray crystallographers the three dimensional structure, but more precise definition of the amino acid side chain positions in the combining site is required for an understanding of the subtleties of antibody specificity. That this can be achieved with physical techniques such as nuclear magnetic resonance has been shown by R. A. Dwek, and in his chapter he summarizes these results with a minimum of technical detail. The immune response has been shown to be dependent on complex cellular interactions and further progress will be facilitated by investigation of the molecular basis of these interactions. This necessitates study of the structure and organization of the molecules in the surfaces of lymphocytes and other cells.
Download or read book Contemporary Topics in Molecular Immunology written by R. Reisfeld and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: This series was originally entitled Contemporary Topics in Immunochemistry, and Volume 1 bearing that name was published. Upon its editorial review and while charting the development of future volumes, the editors began to sense that the word "Immunochemistry" was somewhat restrictive according to its present interpretation. Accompanying the expansion of knowledge in immuno biology is a demand for explanations in molecular terms. Since the intent of the series is to focus attention on research at the molecular level in any aspect of immunology, the editors and publisher felt the term "Immunochemistry" should be replaced with "Molecular Immunology." Thus, the series now bears a revised appellation, Contemporary Topics in Molecular Immunology. The editors feel this more accurately reflects the intended breath of the series. An apology is offered to writers, librarians, and other catalogers for the inconvenience this change will cause. F. P. Inman General Editor Athens, Georgia March,1973 vii Preface The earliest explorers into immunology were at once confronted by myriad molecular riddles which became increasingly complex as immunochemical tech niques resolved one question only to raise scores of others. Even as our knowledge of cellular immunology was growing remarkably fast, during the past two decades exciting experiments delineated the molecular structure of immuno globulins. These joint advances not only shaped the Gestalt of present-day immunology, but paved the way for an incisive molecular approach to the challenges of research.
Download or read book Contemporary Topics in Molecular Immunology written by and published by . This book was released on 1972 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Contemporary Topics in Immunobiology written by John J. Marchalonis and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: The problem that virtually all cells have in discriminating between "self" and "non-self" molecules and cells has been considered at great length in immuno biology. However, cells that clearly are incapable of carrying out mammalian type immune functions can exhibit exquisite specificity in their capacity to discriminate among syngeneic, allogeneic, and xenogeneic cells. In this volume of Contemporary Topics in Immunobiology we have chosen to consider the general problem of self/non-self discrimination as it is manifest in recognition reactions of plants and invertebrates and in the evolutionary development of the immune response of vertebrates. A broad, many-faceted approach is taken toward fundamental issues in immunobiology in order to develop innovative concepts of receptor function as well as to delineate traditional views. The capacity of plants to discriminate between self and non-self is addressed in Chapter 1 by R. B. Knox and Adrienne E. Clarke. These authors provide examples of cell-cell recognition in plants that parallel those occurring in in vertebrates and vertebrates. In general, tolerance (acceptance) of grafts is re stricted to plants within closely related genera. Recognition is mediated by callus cells, which proliferate at wound surfaces in higher plants, and there is a correlation between cell and tissue type and antigenic markers detectable with the use of mammalian antibodies. Certain flowering plants exhibit precise discrimination in fertilization, when pollen must be from the same species, but fertilization occurs only if the pollen is genetically non-self.
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1993 with total page 1608 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Oligodendroglia written by William Norton and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: This series has addressed a constituency of scientists possessing biochemical background with the goal of providing them with specialized reviews of neu robiological interest. Since its initiation, neurochemistry and neuroscience have come of age, and the editors initiate with this volume the concept of a central theme. It is planned that each subsequent volume will also be topical. We note with sadness the passing of Dr. Henry Mahler who served as an advisory editor since the initiation of this series. He played a major role in building the bridge between biochemistry and neurochemistry and will be missed. Weare pleased to welcome two new editors, Drs. William Norton and Bruce McEwen. B. W. Agranoff M. H. Aprison vii FOREWORD Oligodendroglia constitute one of the three principal cell types of the central nervous system. These cells, together with their elaborated membranes, account for at least 25 percent of the dry mass of an adult rat brain and an even greater percentage of the central nervous system of larger animals.
Download or read book Scientific and Technical Books and Serials in Print written by and published by . This book was released on 1989 with total page 1216 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Endotoxin written by H. Friedman and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 689 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is based on the proceedings of the International Symposium on Bacterial Endotoxins held in Japan. May 11-14. 1988 and sponsored by the International Endotoxin Society and the International Society for Immuno pharmacology. Speakers and participants of this symposium provided new information concerning fundamental and clinical aspects of endotoxin research conducted over the last half decade or so. Advances have been made in understanding the structure and nature of endotoxin molecules and their effects on a wide variety of both cellular and subcellular aspects, of immunity. metabolism and physiology. both in vivo and in vitro. Endotoxins are constituents of gram negative bacteria. Since their original discovery in the nineteenth century. many laboratories studied their chemical composition. their physico- and immunochemica1 properties. as well as their pharmacological and physiological effects on the host. Much is now known about the chemical structure of the endotoxins. There is also a grow ing body of information concerning the multiple effects of endotoxins on the host including immune mechanisms. Some effects have been found to be benefi cial to the host and endotoxins are being used more frequently to induce important mediators of immunity as well as increasing resistance against infections by many microorganisms as well as inhibiting growth of tumors in experimental animal models and in man.
Download or read book Applications written by Z. Deyl and published by Elsevier. This book was released on 2000-04-01 with total page 477 pages. Available in PDF, EPUB and Kindle. Book excerpt: Applications
Download or read book Molecular Basis of Biological Degradative processes written by Richard Berlin and published by Elsevier. This book was released on 2012-12-02 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Basis of Biological Degradative Processes contains the proceedings of the 1977 symposium held at the University of Connecticut Health Science Center. The papers focus on the molecular mechanisms underlying the biological degradation, including the relationship between the lysosome and tissue remodeling and the role of this organelle in processing intra- and extracellular material. The book also explores the specific application of the lysosome concept to the description of deficiency diseases of lipid catabolism. Organized into 12 chapters, this book begins with an overview of the mechanisms underlying cell death and its control, along with possible experimental models for its study, nutrient deficiencies during prenatal development, and congenital diseases resulting from zinc, magnesium, and manganese deficiencies. It explains the clinical lysosome deficiencies, the early phase of blood coagulation, cascade events in the activation and function of mast cells, activation of plasminogen and its involvement in the production of localized extracellular proteolysis, and proteolytic events in viral replication. Chapters on human neutrophil elastase and the protease-pathogenesis model of pulmonary emphysema; dissolution mechanism of apatite crystals during dental caries and bone resorption; and degradative processes of bone follow. This book is a valuable resource for biologists, physiologists, and those involved in basic and applied research in ""catabolic"" processes.
Download or read book List of Journals Indexed in Index Medicus written by National Library of Medicine (U.S.) and published by . This book was released on 1994 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: Issues for 1977-1979 include also Special List journals being indexed in cooperation with other institutions. Citations from these journals appear in other MEDLARS bibliographies and in MEDLING, but not in Index medicus.
Download or read book Immunology and Epidemiology written by Geoffrey W. Hoffmann and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: In February 1985 a small international meeting of scientists took place at the recreation resort of the Polish Academy of Sci ences in Mogilany, near Cracow, Poland. The initiative for holding the workshop came from a working meeting on mathematical immunology and related topics at the International Institute for Applied Sys tems Analysis in Laxenburg, Austria, in November 1983. In addition to representatives of IIASA, delegates of the IIASA National Member Organizations (NMO) of Czechoslovakia, Italy, and the soviet Union took part in that working meeting. The participants came to the conclusion that IIASA could play an important role in facilitating the development of research in this field. The first step that they recommended to I IASA was to organize a workshop on mathematical immunology. The purpose of the workshop was to review the progress that has been made in applying mathematics to problems in immunology and to explore ways in which further progress might be achieved, especially by more efficient interactions between scientists working in mathematical and experimental immunology. Some National Member Organizations contributed to the success of the workshop by nominat ing further participants working in this or related fields. For instance, thanks to a suggestion of the British NMO, the meeting also included analyses of the interactions between the immune state of a population and epidemiological phenomena. There were 33 participants at Mogilany from 11 countries, namely Canada, Czechoslovakia, Federal Republic of Germany, Hungary, Japan, Netherlands, Poland, Sweden, united Kingdom, USA, and USSR.
