Download or read book Contemporary Topics in Molecular Immunology V 3 written by G. L. Ada and published by . This book was released on 1974 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Contemporary Topics in Molecular Immunology written by Gordon Ada and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: A series of volumes devoted to molecular immunology will contain, for the most part, articles which attempt to explain immunological phenomena in terms of the behavior and properties of particular molecules. Many of the articles in this volume do this. At the same time, there are many instances-and this is particularly so in the case of immunology-where phenomena must first be described and interpreted in terms of the properties and behavior of cells. Most of us would hope that in due course a fuller understanding will be forthcoming. This volume starts off with such a contribution. Perhaps the most fascinat ing problem in immunology is how diversity is generated. There are two broad proposals: (1) that complete information exists ab initio (the germ-line theory), and (2) that there is initially a limited amount of information, and diversity is generated by somatic mutation. The issue is unresolved, but Cunningham has taken many of the data which have previously been used to support the germ-line theory and shows that the interpretations are not always clear-cut and can frequently be used to support another possibility-that new specificities may arise after stimulation of appropriate cells by antigens. And he has produced experimental evidence to support this notion. On the other hand, there can be little doubt that to a considerable degree the specificity of the immune response is determined by the selection by antigen of cells with receptors of appropriate specificity. This is essentially a surface phenomenon.
Download or read book Contemporary Topics in Molecular Immunology written by R. Porter and published by . This book was released on 2014-01-15 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Contemporary Topics in Molecular Immunology written by F. P. Inman and published by Springer Science & Business Media. This book was released on 2013-11-22 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: There are many unanswered questions regarding the molecular nature of antibodies, components of complement, and other substances which participate in the immune response. The list of substances which need to be analyzed chemically is increasing. Plasma cell products, of course, have long been of great interest because the most prevalent ones are immunoglobulins. Other cell types, however, are the source of the broad spectrum of additional substances which classically fall into the sanctum of the molecular immunologist. It is these substances, and especially those more recently discovered, which are responsible for the broadening investigative interests of immunologists. In this volume we have provided you with descriptions of research being done with immunoglobulins and with complement. Additionally, we have in cluded two reports that deal with molecules which are among the more recent acquisitions of the molecular immunologist. The components of complement are known to react in a cascading manner which results in the lysis of cellular antigens. The first step in the classical pathway requires the activation of CI by the antibody-antigen aggregates. This volume of Contemporary Topics in Molecular Immunology begins with the report of Reid and Porter which describes their investigation of the mechanism of activation of C I. Their descriptions of C I q and of the reaction of C I with immunoglobulins are especially intriguing. It is clearly apparent from their report that activation of the components of complement is a complex phenome non.
Download or read book Contemporary Topics in Molecular Immunology written by R. Porter and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: The distinction between molecular immunology and immunobiology is neces sarily arbitrary. The most rapid progress is usually made in the blurred area between the two, when the chemist is aware of the full significance of the biological problems, and the biologist is alert to the contribution that a knowl edge of molecular structure can be made to their solution. The range of scientific disciplines able to contribute to research in immunology, which this approach brings, is reflected in the present volume. Protein chemists worked out the arrangement of the polypeptide chains and the amino acid sequences of antibodies and X-ray crystallographers the three dimensional structure, but more precise definition of the amino acid side chain positions in the combining site is required for an understanding of the subtleties of antibody specificity. That this can be achieved with physical techniques such as nuclear magnetic resonance has been shown by R. A. Dwek, and in his chapter he summarizes these results with a minimum of technical detail. The immune response has been shown to be dependent on complex cellular interactions and further progress will be facilitated by investigation of the molecular basis of these interactions. This necessitates study of the structure and organization of the molecules in the surfaces of lymphocytes and other cells.
Download or read book Contemporary Topics in Molecular Immunology written by F. Inman and published by . This book was released on 2014-01-15 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Contemporary Topics in Molecular Immunology written by and published by . This book was released on 1973 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Contemporary Topics in Molecular Immunology written by R. Reisfeld and published by . This book was released on 2014-01-15 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Contemporary Topics in Molecular Immunology V 6 written by G. L. Ada and published by . This book was released on 1977 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Contemporary Topics in Molecular Immunology written by H. Eisen and published by . This book was released on 2014-01-15 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Contemporary Topics in Molecular Immunology written by W. J. Mandy (Ed) and published by . This book was released on 1972 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Contemporary Topics in Molecular Immunology written by Gordon Ada and published by . This book was released on 1974-09-01 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Contemporary Topics in Molecular Immunology written by F. Inman and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: recipients and acceptance of allografts can be made. The authors have the experi ence and ability to bridge the entire field of transplantation and their article encompasses both clinical and immunochemical data in this area. Their data show clearly that matches for the DR antigens are more important than those at the ABC loci in determination of graft survival. Additional relevant factors, in cluding autoimmunity and other B-cell antigens, are discussed and correlated with graft survival. The authors also present pathology data concerning the distribution of HLA-DR antigens in various tissues. These data indicate a fruitful area for future investigations on the chemical aspects of the various antigens encoded within the human MHC. Do changes in the structure of lymphocyte surface glycoproteins, especially changes in their carbohydrate portions, occur during normal lymphoid differen tiation? Information about this question is limited, and pertinent data are avail able for only a few proteins. Three of the proteins are major glycoprotein con stituents of rodent thymocyte membranes: the Thy-! antigen, a glycosylated leukocyte sialoglycoprotein called W3/13, and a high-molecular-weight glycopro tein known as the leukocyte-common antigen. In his contribution, Pink thor oughly characterizes these glycoproteins and discusses the evidence that the structures change when a thymocyte differentiates into a mature, peripheral T cell. A comparison is drawn between lymphocyte glycoprotein changes and those that occur during red blood cell differentiation. The reader will find Pink's discourse informative and provocative. Mast cells, basophils, and related tumor lines bind IgE with very high affinity.
Download or read book Contemporary Topics in Molecular Immunology written by F. P. Inman and published by Springer. This book was released on 1975-09-01 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: There are many unanswered questions regarding the molecular nature of antibodies, components of complement, and other substances which participate in the immune response. The list of substances which need to be analyzed chemically is increasing. Plasma cell products, of course, have long been of great interest because the most prevalent ones are immunoglobulins. Other cell types, however, are the source of the broad spectrum of additional substances which classically fall into the sanctum of the molecular immunologist. It is these substances, and especially those more recently discovered, which are responsible for the broadening investigative interests of immunologists. In this volume we have provided you with descriptions of research being done with immunoglobulins and with complement. Additionally, we have in cluded two reports that deal with molecules which are among the more recent acquisitions of the molecular immunologist. The components of complement are known to react in a cascading manner which results in the lysis of cellular antigens. The first step in the classical pathway requires the activation of CI by the antibody-antigen aggregates. This volume of Contemporary Topics in Molecular Immunology begins with the report of Reid and Porter which describes their investigation of the mechanism of activation of C I. Their descriptions of C I q and of the reaction of C I with immunoglobulins are especially intriguing. It is clearly apparent from their report that activation of the components of complement is a complex phenome non.
Download or read book Contemporary Topics in Molecular Immunology written by F. P. Inman and published by Springer Science & Business Media. This book was released on 2013-03-14 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: Included in this volume is a broad range of topics. Immunology is such a diverse field that many of the subspecialties overlap, and one finds it convenient and necessary to integrate information from several of them. We try to focus on the molecular aspects of immunology as much as is reasonable, but some con tributions consist of ablend of molecular and cellular immunology and even immunopathology. This is as it should be, since information at the molecular level often provides an explanation of phenomena observed at other levels. Myelin basic protein holds the interest of immunologists because it is impli cated in the induction of the autoimmune disease called experimental allergie encephalomyelitis (EAE). Although much biochemical and immunological information about this protein has been uncovered, it is not understood how such an inaccessible self-antigen can serve as the focal point in the central ner vous system for myelin basic protein-specific EAE-inducing T cells. Day dis cusses the problem by first reviewing the sequences of the proteins from several species and the antigenicity of the proteins and peptides derived from them. The reader is then led into a thorough discussion of the immunological relation ships that do and do not influence development of the encephalitis. From this discussion, the author promulgates the bystander model as the best overall mechanism to explain why different fragments of the highly conserved protein are needed by various species to give rise to the same type of localized central nervous system disease.
Download or read book Contemporary Topics in Molecular Immunology Vol 8 written by and published by . This book was released on 1981 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Contemporary Topics in Immunobiology written by Max Cooper and published by Springer. This book was released on 2012-03-19 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: Contemporary immunobiology is an ever-diversifying field that embraces many aspects of cellular and humoral immune responsiveness. This includes the phylogeny, ontogeny, induction, regulation, expression, and differentiation of the immune-cell series, as well as the relationship of these to the pathogenesis of many disease processes. It is clearly beyond the limitations of each volume in this series to comprehensively cover progress in each of these fields. Three general areas of contemporary investigations are discussed in the current issue: cellular events of B cell differentiation, including antigen recognition and respon siveness of B lymphocytes; regulation of the immune response by T cells, and the roles of this regulatory system in allotype suppression and in autoimm unity; and the genetic control of immune responses and its possible relation to disease pathogenesis. Analysis of responsiveness of B lymphocytes has been greatly aided by the availability of athymic nude mice. The immunological responsiveness of these mice to a wide range of stimuli has been reviewed and analyzed by H. H. Wortis. This article concludes with the provocative thesis that in the future "nudes will supply new rather than confirmatory data . . . (especially regarding) the develop ment of neoplasia. " In contrast to the studies on the congenitally athymic mice, G. F.
