Download or read book Consommation chronique de benzodiaz pines et d clin cognitif chez le sujet g de plus de 65 ans written by Thibault Mura and published by . This book was released on 2009 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt: La prévalence de consommation de benzodiazépine est estimée à 10 à 20% chez les sujets âgés. Seules trois études, présentant des résultats divergents, se sont intéressées au lien entre consommation chronique de benzodiazépines et déclin cognitif. L'objectif de notre étude était de déterminer si la consommation chronique de benzodiazépine est associée à une accélération du déclin cognitif avec l'âge, chez les sujets de plus de 65 ans. Notre étude a porté sur 1 449 sujets de plus de 65 ans issus de la cohorte des trois cités, recrutées dans les villes de Bordeaux et Montpellier, en France, entre 1999 et 2001, sur la base d'un tirage au sort sur la liste électorale. Les données cognitives et celles concernant la consommation de benzodiazépine des sujets ont été colligées à l'inclusion, puis lors des vistes de suivis à 2, 4 et 7 ans. 1 282 consommateurs chroniques ayant présenté une reprise de benzodiazépine à chacune des quatre visites ont été comparés à 167 sujets non consommateurs n'ayant présentés aucune prise de benzodiazépine lors des visites de suivi. Le déclin cognitif a été analysé à l'aide d'un modèle multivarié non linéaire à variable latente pour données longitudinales. Les résulats de 5 tests neuropsychologiques ont été utilisés: le Mini Mental state Examination, l'Isaacs set test, les test de rétention visuelle de Benton, et les deux parties A et B du Trail Making Test. La consommation chronique de benzodiazépines était associée à un bas niveau cognitif (ß=0,024 p=0,006). Aucune association n'était retrouvée entre cette consommation et la vitesse du déclin cognitif (ß*âge = 0,005 pvalue=0,445). Nos résulats suggèrent que la consommation de benzodiazépines n'est pas le facteur de risque de déclin cognitif avec l'âge

Download or read book Probl mes pos s par la consommation des benzodiaz pines chez les personnes g es written by Marie Leroy and published by . This book was released on 2015 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: De par une population française de plus en plus vieillissante, la consommation des benzodiazépines est devenue un réel problème de santé publique. Au 1er janvier 2015, la classe des 65 ans et plus représente plus de 12,3 millions d'habitants parmi les 66 millions d'habitants que compte la France. De plus, 11,5 millions de français ont consommé au moins une benzodiazépine et environ 20% des 12 millions de personnes âgées consomment de façon chronique des hypnotiques ou anxiolytiques. Les conditions physiologiques normales de l'âge les rendent naturellement plus vulnérables aux risques liés à l'utilisation de ces molécules. Ainsi, les chutes, les accidents de la route et les troubles cognitifs sont des cas fréquemment rencontrés. En effet, la consommation de benzodiazépines chez le sujet âgé a un retentissement non négligeable sur le fonctionnement mnésique. Plusieurs mécanismes biochimiques sont impliqués mais tous les types et stades de mémoires ne semblent pas être atteints de la même manière. De plus, des études récentes montrent un lien probable entre la consommation des benzodiazépines et la maladie d'Alzheimer mais il convient de rester prudent sur les données obtenues car aucune certitude n'a encore été établie. Enfin, du fait de l'importance de leur consommation en France, des effets indésirables non négligeables qu'elles génèrent et de certains usages problématiques, les benzodiazépines font l'objet, depuis de nombreuses années, d'une attention particulière des autorités sanitaires en particulier de l'ANSM.

Download or read book Effet de l initiation d un traitement par benzodiaz pine sur le d clin cognitif chez la personne g e written by Marie-Sara Marchand and published by . This book was released on 2013 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: La France est un des pays où la consommation de psychotropes et notamment celle de benzodiazépines (BZD) est la plus élevée. Chez les sujets âgés, l’utilisation au long cours de BZD est associée à un risque accru de présenter différents événements graves, notamment un risque accru de démence. Le mécanisme expliquant cette association n’est pas élucidé, et l’effet des BZD sur les performances cognitives, en particulier à long-terme, reste controversé. L’objectif principal de cette étude était d’étudier l’association entre l’exposition incidente aux BZD et l’évolution du déclin cognitif chez des sujets initialement non déments. La population d’étude était issue de la cohorte PAQUID, réalisée chez des sujets de 65 ans et plus résidant en Dordogne et Gironde et offrant jusqu’à 20 ans de suivi. Parmi les sujets non utilisateurs de BZD à l’inclusion et non déments au suivi à 3 ans (T3) dans la cohorte PAQUID, 102 exposés incidents aux BZD et 715 non exposés à T3 ont été identifiés. L’évolution de leurs fonctions cognitives a été étudiée en considérant les résultats obtenus au Mini Mental Status Examination (MMSE) et à l’Isaac Set Test (IST) aux visites de suivi réalisées tous les 2-3 ans après T3 (T5 à T20). L’association entre l’exposition incidente aux BZD et l’évolution des performances cognitives a été étudiée à l’aide de modèles non linéaires mixtes considérant un processus latent comme variable à expliquer. Des analyses secondaires portant sur l’évolution de la symptomatologie dépressive, des troubles du sommeil et de l’anxiété ont été réalisées afin d’étudier un éventuel biais protopathique. L’exposition incidente aux BZD n’était pas associée à une différence d’évolution des performances cognitives des sujets évaluées au regard du MMSE ou de l’IST, ni à court-terme ni au long-terme. L’analyse secondaire n’a pas mis en évidence de différence d’évolution de la symptomatologie dépressive, des troubles du sommeil ou de l’anxiété, qui aurait pu témoigner d’un possible biais protopathique dans l’association entre BZD et démence. Indépendamment du risque de démence, l’initiation après 65 ans d’un traitement par BZD ne paraissait pas associée à un risque accru de dégradation des performances cognitives à long terme.

Download or read book Computers and Games for Mental Health and Well Being written by Yasser Khazaal and published by Frontiers Media SA. This book was released on 2018-07-12 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent years have seen important developments in the computer and game industry, including the emergence of the concept of serious games. It is hypothesized that tools such as games, virtual reality, or applications for smartphones may foster learning, enhance motivation, promote behavioral change, support psychotherapy, favor empowerment, and improve some cognitive functions. Computers and games may create supports for training or help people with cognitive, emotional, or behavioral change. Games take various formats, from board games to informatics to games with interactive rules of play. Similarly, computer tools may vary widely in format, from self-help or assisted computerized training to virtual reality or applications for smartphones. Some tools that may be helpful for mental health were specifically designed for that goal, whereas others were not. Gamification of computer-related products and games with a numeric format tend to reduce the gap between games and computers tools and increase the conceptual synergy in such fields. Games and computer design share an opportunity for creativity and innovation to help create, specifically design, and assess preventive or therapeutic tools. Computers and games share a design conception that allows innovative approaches to overcome barriers of the real world by creating their own rules. Yet, despite the potential interest in such tools to improve treatment of mental disorders and to help prevent them, the field remains understudied and information is under-disseminated in clinical practice. Some studies have shown, however, that there is potential interest and acceptability of tools that support various vehicles, rationales, objectives, and formats. These tools include traditional games (e.g., chess games), popular electronic games, board games, computer-based interventions specifically designed for psychotherapy or cognitive training, virtual reality, apps for smartphones, and so forth. Computers and games may offer a true opportunity to develop, assess, and disseminate new prevention and treatment tools for mental health and well-being. Currently, there is a strong need for state-of-the-art information to answer questions such as the following: Why develop such tools for mental health and well-being? What are the potential additions to traditional treatments? What are the best strategies or formats to improve the possible impact of these tools? Are such tools useful as a first treatment step? What is the potential of a hybrid model of care that combines traditional approaches with games and/or computers as tools? What games and applications have already been designed and studied? What is the evidence from previous studies? How can such tools be successfully designed for mental health and well-being? What is rewarding or attractive for patients in using such treatments? What are the worldwide developments in the field? Are some protocols under development? What are the barriers and challenges related to such developments? How can these tools be assessed, and how can the way that they work, and for whom, be measured? Are the potential benefits of such products specific, or can these additions be attributed to nonspecific factors? What are the users’ views on such tools? What are the possible links between such tools and social networks? Is there a gap between evidence-based results and market development? Are there any quality challenges? What future developments and studies are needed in the field?

Download or read book Clinical Chronopharmacology written by Alain Reinberg and published by CRC Press. This book was released on 1990-07 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: Periodical and predictable changes in biological susceptibility and response to a large variety of chemical agents, including drugs and food, have been documented since the early 1970s. This book provides a survey of clinically-documented research in chronopharmacology.

Download or read book Molecular Mechanisms of Hormone Action written by Gesellschaft für Biologische Chemie. Colloquium and published by . This book was released on 1989 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book An Introduction to Differential Manifolds written by Jacques Lafontaine and published by Springer. This book was released on 2015-07-29 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is an introduction to differential manifolds. It gives solid preliminaries for more advanced topics: Riemannian manifolds, differential topology, Lie theory. It presupposes little background: the reader is only expected to master basic differential calculus, and a little point-set topology. The book covers the main topics of differential geometry: manifolds, tangent space, vector fields, differential forms, Lie groups, and a few more sophisticated topics such as de Rham cohomology, degree theory and the Gauss-Bonnet theorem for surfaces. Its ambition is to give solid foundations. In particular, the introduction of “abstract” notions such as manifolds or differential forms is motivated via questions and examples from mathematics or theoretical physics. More than 150 exercises, some of them easy and classical, some others more sophisticated, will help the beginner as well as the more expert reader. Solutions are provided for most of them. The book should be of interest to various readers: undergraduate and graduate students for a first contact to differential manifolds, mathematicians from other fields and physicists who wish to acquire some feeling about this beautiful theory. The original French text Introduction aux variétés différentielles has been a best-seller in its category in France for many years. Jacques Lafontaine was successively assistant Professor at Paris Diderot University and Professor at the University of Montpellier, where he is presently emeritus. His main research interests are Riemannian and pseudo-Riemannian geometry, including some aspects of mathematical relativity. Besides his personal research articles, he was involved in several textbooks and research monographs.

Download or read book Minimum competence in scientific English written by Sue Blattes and published by L'Editeur : EDP Sciences. This book was released on 2003 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cet ouvrage, devenu célèbre sous son sigle MCSE, a déjà été utilisé par plus de 50 000 étudiants, chercheurs, professionnels. L'objectif est de lire et écrire des textes en anglais scientifique avec facilité et pertinence. L'ouvrage est conçu pour que l'apprenant devienne un véritable utilisateur de l'anglais. La méthode originale repose sur l'analyse des fonctions et structures nécessaires : measurement, frequency, comparison, modification, link words, time, cause and consequence, hypothesis, modality, purpose and process, impersonal forms, compound nouns and adjectives. Dans chaque unit, des tests d'auto-évaluation permettent de se situer et de construire son parcours de formation, d'abord en définissant ses objectifs à l'aide des key points et du lexis, puis, de façon plus personnalisée, en puisant dans les examples in context, checkpoints (back to basics, word web), web search, FAQs... MCSE est l'outil de base d'une méthode qui comprend aussi d'autres outils dans la même collection (Listening Comprehension for Scientiflc English et Speaking Skills in Scientitic English). L'ouvrage est destiné à tout apprenant de niveau baccalauréat qui désire acquérir une réelle compétence dans l'écriture et la lecture de textes en anglais scientifique.

Download or read book Biological Rhythm Research written by A. Sollberger and published by . This book was released on 1965 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Endocrine Rhythms written by Dorothy T. Krieger and published by . This book was released on 1979 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Burn Care and Treatment written by Marc G. Jeschke and published by Springer Nature. This book was released on 2020-12-21 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of this practical guide offers a comprehensive summary of the most important and most immediate therapeutic approaches in the assessment and treatment of burn injuries. Taking into account age-specific needs in pediatric, adult, and elderly burn patients, several chapters on key issues – such as pre-hospital treatment, wound care and infection control, burn nursing, critical care, burn reconstructive surgery and rehabilitation for burn victims – have now been updated. In addition, the book has been supplemented with the latest information on fluid resuscitation, organ support for burn patients, necrotizing soft tissue infections, and TEN/SJS. Written in a concise manner, the updated edition of this book provides essential guidelines for optimal care to improve patient outcomes, and thus will be a valuable reference resource for physicians, surgeons, residents, nurses, and other burn care providers.​

Download or read book Unidentified written by Robert Salas and published by Career Press. This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1969 the U.S. Air Force issued a statement that read' "No UFO reported, investigated and evaluated by the Air Force was ever an indication of threat to our national security." This statement is patently false. It has been proven untrue by the testimony of many military officers and airmen and documentation of incidents involving UFOs and nuclear weapons, testimonies of which the U.S. Air Force was fully aware. Unidentified details many of these testimonies, some for the first time. As partial justification for its position, the Air Force cites a University of Colorado study that was contracted and paid for by federal funds. Unidentified reveals how this study was actually just another part of the plan to cover up the reality of the UFO phenomenon. For the first time, Unidentified publishes evidence that the investigators for the Colorado study knew about the UFO-related missile shutdown incidents but did not investigate them or include them in their final report.

Download or read book Textbook on Endocrinology written by and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Lost Secrets of the Sacred Ark written by Laurence Gardner and published by HarperCollins UK. This book was released on 2004 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Ark of the Covenant is the source of one of the deepest mysteries of the Western world. Laurence Gardner has accessed Rosicrucian archives to reveal where the Ark is, what it is and how this lost secret of the distant past has led to the phenomenal new science of space-time manipulation.

Download or read book Perinatal Stress Mood and Anxiety Disorders written by Anita Riecher-Rössler and published by Karger Medical and Scientific Publishers. This book was released on 2005-01-01 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt: The twelve articles included offer a comprehensive up-to-date overview of the most relevant research and treatment considerations in this neglected field. A brief, though very interesting introduction to the history of psychiatry of motherhood is followed by the discussion of the old question if perinatal disorders are specific entities and if they should have a specific place in our classification systems. This book is aimed primarily at clinicians, teachers and researchers from the fields of psychiatry (adult as well as child and adolescent psychiatry), obstetrics and gynaecology, paediatrics, psychology, psychotherapy, neurobiology and psychoneuroendocrinology as well as their students and learners.

Download or read book Principles of Critical Care Third Edition written by HALL and published by McGraw Hill Professional. This book was released on 2005-08-04 with total page 1821 pages. Available in PDF, EPUB and Kindle. Book excerpt: The classic text in critical care medicine! The 3rd Edition of this classic text is streamlined and focused on the needs of the working critical care physician and features important new treatment strategies. Organized by organ systems, this text, the only critical care source that includes evidence-based learning, guides physicians from initial patient assessment and differential diagnosis through therapeutic plan.

Download or read book Handbook of physiology written by William Ferguson Hamilton and published by . This book was released on 1963 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: