Download or read book Conjugation Reactions In Drug Metabolism written by Gerard J. Mulder and published by CRC Press. This book was released on 1990-02-21 with total page 423 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text investigates the molecular biology of conjugation, and the subsequent activity of the transfered genes "in vivo". Conjugation may be very important when considering biotransformations, as expression of transfered genes may allow organisms to metabolize certain substrates.
Download or read book Conjugation Deconjugation Reactions in Drug Metabolism and Toxicity written by Frederick C. Kauffman and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: In-depth coverage of advances in molecular biology, indicating the importance of drug and xenobiotic conjugates as transport forms of biologically active compounds. Part One describes molecular events associated with the expression and regulation of transferases and hydrolases involved in Phase II drug conjugation and deconjugation. Part Two deals with the regulation of Phase II conjugation, while Part Three critically reviews the importance of drug conjugates in pharmacology and toxicology. An up-to-date source of information of broad interest to pharmacologists and toxicologists.
Download or read book Conjugation Reactions in Drug Metabolism written by Gerard J. Mulder and published by . This book was released on 1990 with total page 413 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Conjugation deconjugation Reactions in Drug Metabolism and Toxicity written by Frederick C. Kauffman and published by . This book was released on 1994 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in molecular biology describing important enzyme systems involved in drug conjugation and deconjugation reactions and recent work indicating the importance of drug and xenobiotic conjugates as transport forms of biologically active compounds are reviewed comprehensively. Part One describes molecular events associated with the expression and regulation of transferases and hydrolases involved in Phase II drug conjugation and deconjugation. Part Two deals with the regulation of Phase II conjugation, and Part Three reviews critically the importance of drug conjugates in pharmacology and toxicology. This volume is an up-to-date source of information on this topic and will be of broad interest to pharmacologists and toxicologists.
Download or read book Drug Metabolism written by Corina Ionescu and published by Springer Science & Business Media. This book was released on 2006-02-28 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Metabolism: Current Concepts provides a comprehensive understanding of the processes that take place following ingestion of a medicinal agent or xenobiotic, with an emphasis on the crucial role of metabolism (biotransformation). How a sound knowledge of these phenomena is incorporated into the design of effective new drug candidates is also explained. The user-friendly text focuses on concepts rather than extraneous details and is supported by many illustrated examples of biotransformations as well as frequent references to current critical reviews and articles highlighting the nature of research objectives in this vibrant area of medicinal development. The final topic on strategies for drug design relies on the background provided by the rest of the book. This book is ideally suited as an advanced text for courses in drug metabolism for students of medicine, pharmacy, pharmacology, biochemistry; and for courses in drug design and drug delivery for students of medicinal chemistry. It is also appropriate for professional seminars or courses that relate to the fate of a drug in the body, drug interactions, adverse reactions and drug design.
Download or read book Conjugation deconjugation Reactions in Drug Metabolism and Toxicity written by Frederick C. Kauffman and published by . This book was released on 1994 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sulfotransferase enzymes/genetic regulation of the subcellular localization & expression of glucuronidase/etc.
Download or read book Conjugation Reactions in Drug Metabolism written by Gerard J. Mulder and published by . This book was released on 1990 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This text investigates the molecular biology of conjugation, and the subsequent activity of the transfered genes ""in vivo"". Conjugation may be very important when considering biotransformations, as expression of transfered genes may allow organisms to metabolize certain substrates.
Download or read book Introduction to Drug Metabolism written by G. Gordon Gibson and published by Nelson Thornes. This book was released on 2001 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: Of drug-metabolising reactions. p. 25.
Download or read book Conjugation Deconjugation Reactions in Drug Metabolism and Toxicity written by Frederick C. Kauffman and published by Springer. This book was released on 2011-12-10 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt: In-depth coverage of advances in molecular biology, indicating the importance of drug and xenobiotic conjugates as transport forms of biologically active compounds. Part One describes molecular events associated with the expression and regulation of transferases and hydrolases involved in Phase II drug conjugation and deconjugation. Part Two deals with the regulation of Phase II conjugation, while Part Three critically reviews the importance of drug conjugates in pharmacology and toxicology. An up-to-date source of information of broad interest to pharmacologists and toxicologists.
Download or read book Drug Metabolism written by Jack P. Uetrecht and published by CRC Press. This book was released on 2007-06-21 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt: In order to understand drug metabolism at its most fundamental level, pharmaceutical scientists must be able to analyze drug compound structures and predict possible metabolic pathways in order to avoid the risk of adverse reactions that lead to the withdrawal of a drug from the market. This comprehensive textbook will aid in guiding students throu
Download or read book Conjugation Deconjugation Reactions in Drug Metabolism and Toxicity written by Frederick C. Kauffman and published by Springer. This book was released on 1994-05-26 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt: In-depth coverage of advances in molecular biology, indicating the importance of drug and xenobiotic conjugates as transport forms of biologically active compounds. Part One describes molecular events associated with the expression and regulation of transferases and hydrolases involved in Phase II drug conjugation and deconjugation. Part Two deals with the regulation of Phase II conjugation, while Part Three critically reviews the importance of drug conjugates in pharmacology and toxicology. An up-to-date source of information of broad interest to pharmacologists and toxicologists.
Download or read book Introduction to Drug Metabolism written by G. GORDON GIBSON AND PAUL SKETT and published by Springer. This book was released on 2013-12-11 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: This introduction to the mechanisms by which the body metabolizes and excretes administered drugs is directed at advanced undergraduate biochemists, pharmacologists, pre-clinical medical students and advanced undergraduate/postgraduate toxicologists.
Download or read book The Biochemistry of Drug Metabolism written by Bernard Testa and published by . This book was released on 2008 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Offering a conceptual and factual presentation of the metabolism of drugs and other xenobiotics, these two volumes distinctly focus on the biochemistry, with an emphasis on xenobiotic-metabolizing enzymes, their reactions and regulations. The first volume is divided into three parts. Part One begins by introducing xenobiotics in the broad context of physiological metabolism, and continues with an overview of the processes of drug disposition and metabolism. It then goes on to summarize the macroscopic and microscopic locations of drug ...
Download or read book Introduction to Drug Metabolism written by G. Gordon Gibson and published by Springer. This book was released on 2013-11-11 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although the scientific literature on drug metabolism is extensive, it suffers from the disadvantage that the material is diffuse and consists largely of specialist monographs dealing with particular aspects of the subject. In addi tion, although there are a few excellent texts on drug metabolism in print, these tend to be earlier publications and hence do not take into account the many recent advances in this area. Our motivations for writing this book therefore arose from the clear need for a recent and cohesive introductory text on this subject, specifically designed to cater for the needs of undergraduate and postgraduate students. Much of the subject matter in this text is derived from various courses on drug metabolism given at the University of Surrey and the University of Glasgow to basic science students in pharmacology, biochemistry, nutrition and nursing studies, to pre-clinical medical students and to under graduate and post-graduate students in toxicology. Therefore, it is our inten tion that this text will serve as a primer in drug metabolism to a variety of students in the life sciences taking courses in this subject. The term 'drug metabolism' in its broadest sense may be considered as the absorption, distribution, biotransformation and excretion of drugs. To cover all these facets of drug metabolism in a single text is a voluminous task and therefore we have focused primarily on the biotransformation aspects of the subject.
Download or read book Microsomes and Drug Oxidations written by Volker Ullrich and published by Elsevier. This book was released on 2013-10-22 with total page 805 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microsomes and Drug Oxidations is a record of the proceedings of the Third International Symposium on Microsomes and Drug Oxidations, held in Berlin, Germany in July 1976. The compendium provides an overview of knowledge on the oxidative metabolism of drugs, carcinogens, and various other environmental chemicals. Topics discussed include lipid structure of liver microsomal membranes; interactions between cytochrome p-450 and nadphcytochrome p-450 reductase in the microsomal membrane; impact of drug monoxygenases in clinical pharmacology; and the manner in which oxygen participates in mixed-function oxidation reactions. Pharmacologists, toxicologists, biochemists, and researchers in the pharmaceutical industry will find the book highly insightful.
Download or read book Drug Metabolism in Drug Design and Development written by Donglu Zhang and published by John Wiley & Sons. This book was released on 2007-11-16 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: The essentials of drug metabolism vital to developing new therapeutic entities Information on the metabolism and disposition of candidate drugs is a critical part of all aspects of the drug discovery and development process. Drug metabolism, as practiced in the pharmaceutical industry today, is a complex, multidisciplinary field that requires knowledge of sophisticated analytical technologies and expertise in mechanistic and kinetic enzymology, organic reaction mechanism, pharmacokinetic analysis, animal physiology, basic chemical toxicology, preclinical pharmacology, and molecular biology. With chapters contributed by experts in their specific areas, this reference covers: * Basic concepts of drug metabolism * The role of drug metabolism in the pharmaceutical industry * Analytical techniques in drug metabolism * Common experimental approaches and protocols Drug Metabolism in Drug Design and Development emphasizes practical considerations such as the data needed, the experiments and analytical methods typically employed, and the interpretation and application of data. Chapters highlight facts, common protocols, detailed experimental designs, applications, and limitations of techniques. This is a comprehensive, hands-on reference for drug metabolism researchers as well as other professionals involved in pre-clinical drug discovery and development.
Download or read book Pharmacology and Therapeutics written by Scott A. Waldman and published by Saunders. This book was released on 2009 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Everything you need to know about all of today's drugs in a coherent, easy-to-use format - from the underlying science through innovation, translation, regulation, and clinical implementation. This multimedia resource fills a critical need for a more clinically focused, user-friendly pharmacology reference. Evidence-based therapeutic guidelines facilitate decision making; and coverage of pharmacogenetics and pharmacogenomics, regenerative pharmacology, stem cell therapies, and the emerging field of individualized medicine keeps you at the forefront of the latest developments.
