Download or read book Conference on Nonhuman Primate Toxicology written by Clem O. Miller and published by . This book was released on 1968 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Toxicity Testing in the 21st Century written by National Research Council and published by National Academies Press. This book was released on 2007-10-05 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in molecular biology and toxicology are paving the way for major improvements in the evaluation of the hazards posed by the large number of chemicals found at low levels in the environment. The National Research Council was asked by the U.S. Environmental Protection Agency to review the state of the science and create a far-reaching vision for the future of toxicity testing. The book finds that developing, improving, and validating new laboratory tools based on recent scientific advances could significantly improve our ability to understand the hazards and risks posed by chemicals. This new knowledge would lead to much more informed environmental regulations and dramatically reduce the need for animal testing because the new tests would be based on human cells and cell components. Substantial scientific efforts and resources will be required to leverage these new technologies to realize the vision, but the result will be a more efficient, informative and less costly system for assessing the hazards posed by industrial chemicals and pesticides.
Download or read book Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on 1968 with total page 932 pages. Available in PDF, EPUB and Kindle. Book excerpt: Includes subject section, name section, and 1968-1970, technical reports.
Download or read book Nonhuman Primates I written by Thomas C. Jones and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: The International Life Sciences Institute (ILSI) was estab lished in 1978 to stimulate and support scientific research and educational programs related to nutrition, toxicology, and food safety, and to encourage cooperation in these programs among scientists in universities, industry, and government agencies to assist in the resolution of health and safety issues. To supplement and enhance these efforts, ILSI has made a major commitment to supporting programs to harmonize toxicologic testing, to advance a more uniform interpreta tion of bioassay results worldwide, to promote a common understanding of lesion classifications, and to encourage wide discussion of these topics among scientists. The Mo nographs on the Pathology of Laboratory Animals are de signed to facilitate communication among those involved in the safety testing of foods, drugs, and chemicals. The complete set will cover all organ systems and is intended for use by pathologists, toxicologists, and others con cerned with evaluating toxicity and carcinogenicity stu dies. The international nature of the project - as reflected in the composition of the editorial board and the diversity of the authors and editors -strengthens our expectations that understanding and cooperation will be improved worldwide through the series. Alex Malaspina President International Life Sciences Institute Preface This book, on Nonhuman Primates, is the eleventh volume of a set pre pared under the sponsorship of the International Life Sciences Institute (ILSI).
Download or read book National Library of Medicine Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on 1971 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: First multi-year cumulation covers six years: 1965-70.
Download or read book Classes of Pesticides written by Wayland J. Hayes Jr. and published by Elsevier. This book was released on 2013-10-22 with total page 465 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Pesticide Toxicology, Volume 3: Classes of Pesticides focuses on the properties, toxicity, classes, and reactions of pesticides. The selection first offers information on carbamate insecticides, nitro compounds and related phenolic pesticides, and synthetic organic rodenticides. Discussions focus on miscellaneous synthetic organic rodenticides, fluoroacetic acid and its derivatives, mononitrophenols, dinitrophenols, classification of carbamates, and toxicology of anticholinesterase carbamates. The book then examines herbicides and fungicides and related compounds. Topics include nitrogen heterocyclic fungicides not otherwise classified, hydrazines, hydrozones, and diazo fungicides, anilino and nitrobenzenoid fungicides, antibiotics and botanicals, organic phosphorus herbicides, carbamate herbicides, and herbicidal oils and simple aliphatics. The publication elaborates on miscellaneous pesticides, including repellents, synthetic molluscicides, inhibitors of chitin synthesis, chemosterilants, and synthetic acaricides. The selection is a valuable source of data for researchers interested in pesticide toxicology.
Download or read book A Textbook Of SPECT in Neurology and Psychiatry written by Peter P. Deyn and published by John Libbey Eurotext. This book was released on 1997 with total page 586 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive colour atlas provides a state-of-the-art view of Single Photon Emission Computerised Tomography (SPECT) in relation to its application in the fields of nuclear medicine and psychiatry. The broad range of topics covered by experts in the fields of nuclear medicine, neurology and psychiatry from all over the world, reflects the most recent evolution in functional neuroimaging with clinical neuropsychiatric sciences. The book is organised with respect to clinical indication, which implies that whenever possible methodological problems related to clinical indication are categorised under the relevant topic. It is designed to stimulate discussion of some issues of paramount importance for the present and future development of this interdisciplinary modality for the study of patients with diseases of the central nervous system. This textbook is an important tool to all nuclear physicians, neurologists and psychiatrists and will serve as a guide towards the optimal application of SPECT in diagnosis, study of pathophysiology and therapeutic follow-up in neuropsychiatric illnesses.
Download or read book Animal Models in Toxicology written by Shayne C. Gad and published by CRC Press. This book was released on 2016-04-05 with total page 1140 pages. Available in PDF, EPUB and Kindle. Book excerpt: Animal Models in Toxicology is a single-source reference for the use of animal models in toxicology. Chapters cover nine species used in toxicology and experimental biology. With contributions from experts in toxicology, toxicological pathology, and species-specific metabolism, each of these chapters provides an excellent introductory "course" alon
Download or read book The Baboon in Biomedical Research written by John L. VandeBerg and published by Springer Science & Business Media. This book was released on 2009-06-04 with total page 405 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nonhuman primates have played critical roles in biomedical research, and they are among the few animals whose use in research continues to increase. The scienti?c value of nonhuman primates derives from their close phylogenetic proximity to man and their consequent anatomic, physiologic, and genetic similarities to man. Only nonhuman primates can provide adequate models for many complex physiological and disease processes of humans. The baboon is a relative newcomer to the repertoire of nonhuman primates used in biomedical research. However, in less than 50 years since its ?rst use in the U. S. , it has become one of the most popular laboratory primate species. It is larger than the other widely used monkey species, making it advantageous for many types of experiments and technological developments. It is extraordinarily hardy and highly fecund in captivity. It closely resembles humans in a variety of physiological and disease processes, such as cholesterol metabolism, early stages of atherosclerosis, and alcoholic liver disease. Its chromosomes closely resemble those of humans, and many genes of the two species lie in the same chromosomal order. Among all primates, baboons are the most widely used models for the genetics of susceptibility to complex diseases and they are the ?rst nonhuman primate for which a framework genetic linkage map was established. In addition, the baboon genome is currently being sequenced, and as a result the utility of this species for biomedical research will be dramatically increased.
Download or read book Behavioral Sex Differences in Nonhuman Primates written by Gary Mitchell and published by . This book was released on 1979 with total page 566 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Nonhuman Primate in Nonclinical Drug Development and Safety Assessment written by Joerg Bluemel and published by Academic Press. This book was released on 2015-03-13 with total page 716 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Nonhuman Primate in Drug Development and Safety Assessment is a valuable reference dedicated to compiling the latest research on nonhuman primate models in nonclinical safety assessment, regulatory toxicity testing and translational science. By covering important topics such as study planning and conduct, inter-species genetic drift, pathophysiology, animal welfare legislation, safety assessment of biologics and small molecules, immunotoxicology and much more, this book provides scientific and technical insights to help you safely and successfully use nonhuman primates in pharmaceutical toxicity testing. A comprehensive yet practical guide, this book is intended for new researchers or practicing toxicologists, toxicologic pathologists and pharmaceutical scientists working with nonhuman primates, as well as graduate students preparing for careers in this area. - Covers important topics such as species selection, study design, experimental methodologies, animal welfare and the 3Rs (Replace, Refine and Reduce), social housing, regulatory guidelines, comparative physiology, reproductive biology, genetic polymorphisms and more - Includes practical examples on techniques and methods to guide your daily practice - Offers a companion website with high-quality color illustrations, reference values for safety assessment and additional practical information such as study design considerations, techniques and procedures and dosing and sampling volumes
Download or read book Nonhuman Primates written by National Research Council (U.S.). Committee on Conservation of Nonhuman Primates and published by . This book was released on 1975 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Nonhuman Primates written by and published by National Academies. This book was released on 1975 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Preclinical Safety Evaluation of Biopharmaceuticals written by Joy A. Cavagnaro and published by John Wiley & Sons. This book was released on 2013-03-07 with total page 1012 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The goal is to provide a comprehensive reference book for the preclinicaldiscovery and development scientist whose responsibilities span target identification, lead candidate selection, pharmacokinetics, pharmacology, and toxicology, and for regulatory scientists whose responsibilities include the evaluation of novel therapies." —From the Afterword by Anthony D. Dayan Proper preclinical safety evaluation can improve the predictive value, lessen the time and cost of launching new biopharmaceuticals, and speed potentially lifesaving drugs to market. This guide covers topics ranging from lead candidate selection to establishing proof of concept and toxicity testing to the selection of the first human doses. With chapters contributed by experts in their specific areas, Preclinical Safety Evaluation of Biopharmaceuticals: A Science-Based Approach to Facilitating Clinical Trials: Includes an overview of biopharmaceuticals with information on regulation and methods of production Discusses the principles of ICH S6 and their implementation in the U.S., Europe, and Japan Covers current practices in preclinical development and includes a comparison of safety assessments for small molecules with those for biopharmaceuticals Addresses all aspects of the preclinical evaluation process, including: the selection of relevant species; safety/toxicity endpoints; specific considerations based upon class; and practical considerations in the design, implementation, and analysis of biopharmaceuticals Covers transitioning from preclinical development to clinical trials This is a hands-on, straightforward reference for professionals involved in preclinical drug development, including scientists, toxicologists, project managers, consultants, and regulatory personnel.
Download or read book A Comprehensive Guide to Toxicology in Preclinical Drug Development written by Ali S. Faqi and published by Academic Press. This book was released on 2012-10-18 with total page 903 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Comprehensive Guide to Toxicology in Preclinical Drug Development is a resource for toxicologists in industry and regulatory settings, as well as directors working in contract resource organizations, who need a thorough understanding of the drug development process. Incorporating real-life case studies and examples, the book is a practical guide that outlines day-to-day activities and experiences in preclinical toxicology. This multi-contributed reference provides a detailed picture of the complex and highly interrelated activities of preclinical toxicology in both small molecules and biologics. The book discusses discovery toxicology and the international guidelines for safety evaluation, and presents traditional and nontraditional toxicology models. Chapters cover development of vaccines, oncology drugs, botanic drugs, monoclonal antibodies, and more, as well as study development and personnel, the role of imaging in preclinical evaluation, and supporting materials for IND applications. By incorporating the latest research in this area and featuring practical scenarios, this reference is a complete and actionable guide to all aspects of preclinical drug testing. - Chapters written by world-renowned contributors who are experts in their fields - Includes the latest research in preclinical drug testing and international guidelines - Covers preclinical toxicology in small molecules and biologics in one single source
Download or read book Challenges in Nonhuman Primate Research in the 21st Century written by Gerhard F. Weinbauer and published by Waxmann Verlag. This book was released on 2013 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: In continuation of the Covance Primate Symposium Series, the 19th Covance Primate Symposium took place in Münster on 23rd & 24th of May 2012. Altogether, 70 participants representing 43 organisations, gathered for this symposium. The 2012 Primate Symposium focussed on ?Challenges in Nonhuman Primate Research in the 21st Century?. The broad participation and the lively discussions during the symposium underlined the timeliness and importance of this topic. Expert speakers covered four major topics, i.e. biosimilars development: regulatory implications, key considerations and next steps, optimizing nonhuman primate use in nonclinical safety assessment, trends in nonhuman primate developmental & reproductive toxicology (DART) and juvenile toxicity evaluation, and relevance and importance of nonhuman primate models in regulatory toxicology. The development of biosimilar has taken up speed considerably and meanwhile needs to be considered a significant factor of potential drug development, yet there are still some uncertainties und guidelines are under development. With the increased focus on biopharmaceuticals and the associated increase for using nonhuman primates being the relevant animal model, it became necessary to optimize the use of this animal model, e.g. refine study designs and animals numbers but still execute meaningful preclinical studies. It appears that significant progress has been achieved in that context. In the area of nonhuman primate DART and juvenile toxicity evaluation, recent guideline changes had a major impact on species selection, and the experimental design plus the timing of these studies within the preclinical programmes. Finally, given the increasing regulations and justficiations of using nonhuman primates as experimental models. It is paramount to understand the essential and indispensable role that nonhuman primates can play in drug safety evaluation and medical drug development.
Download or read book Hayes Principles and Methods of Toxicology Sixth Edition written by A. Wallace Hayes and published by CRC Press. This book was released on 2014-10-10 with total page 2186 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hayes’ Principles and Methods of Toxicology has long been established as a reliable reference to the concepts, methodologies, and assessments integral to toxicology. The new sixth edition has been revised and updated while maintaining the same high standards that have made this volume a benchmark resource in the field. With new authors and new chapters that address the advances and developments since the fifth edition, the book presents everything toxicologists and students need to know to understand hazards and mechanisms of toxicity, enabling them to better assess risk. The book begins with the four basic principles of toxicology—dose matters, people differ, everything transforms, and timing is crucial. The contributors discuss various agents of toxicity, including foodborne, solvents, crop protection chemicals, radiation, and plant and animal toxins. They examine various methods for defining and measuring toxicity in a host of areas, including genetics, carcinogenicity, toxicity in major body systems, and the environment. This new edition contains an expanded glossary reflecting significant changes in the field. New topics in this edition include: The importance of dose–response Systems toxicology Food safety The humane use and care of animals Neurotoxicology The comprehensive coverage and clear writing style make this volume an invaluable text for students and a one-stop reference for professionals.
