Download or read book Conceptual Background and Bioenergetic Mitochondrial Aspects of Oncometabolism written by Guido Kroemer and published by . This book was released on 2014 with total page 509 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Conceptual Background and Bioenergetic Mitochondrial Aspects of Oncometabolism written by and published by Elsevier. This book was released on 2014-05-23 with total page 565 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 542 of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This new volume covers research methods providing a theoretical overview on metabolic alterations of cancer cells and a series of protocols that can be employed to study oncometabolism, in vitro, ex vivo and in vivo. Malignant cells exhibit metabolic changes when compared to their normal counterparts, owing to both genetic and epigenetic alterations. Although such a metabolic rewiring has recently been indicated as "yet another" general hallmark of cancer, accumulating evidence suggests that the metabolic alterations of each neoplasm rather represent a molecular signature that intimately accompanies, and hence cannot be severed from, all facets of malignant transformation. - Continues the legacy of this premier serial with quality chapters authored by leaders in the field - Covers research methods in biomineralization science - Provides theoretical overview on metabolic alterations of cancer cells, and a series of protocols that can be employed to study oncometabolism, in vitro, ex vivo and in vivo

Download or read book Conceptural Background and Bioenergetic Mitochondrial Aspects on Oncometabolism written by Lorenzo Ed Galluzzi and published by . This book was released on 2014 with total page 1051 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Cell wide Metabolic Alterations Associated with Malignancy written by and published by Academic Press. This book was released on 2014-06-07 with total page 403 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods providing a a theoretical overview on metabolic alterations of cancer cells and a series of protocols that can be employed to study oncometabolism, in vitro, ex vivo and in vivo. Malignant cells exhibit metabolic changes when compared to their normal counterparts, owing to both genetic and epigenetic alterations. Although such a metabolic rewiring has recently been indicated as "yet another" general hallmark of cancer, accumulating evidence suggests that the metabolic alterations of each neoplasm rather represent a molecular signature that intimately accompanies, and hence cannot be severed from, all facets of malignant transformation. - Continues the legacy of this premier serial with quality chapters authored by leaders in the field - Covers research methods in biomineralization science - Contains sections on such topics providing a a theoretical overview on metabolic alterations of cancer cells and a series of protocols that can be employed to study oncometabolism, in vitro, ex vivo and in vivo.

Download or read book Natural Products and Brain Energy Metabolism Astrocytes in Neurodegenerative Diseases Volume I written by Fushun Wang and published by Frontiers Media SA. This book was released on 2022-11-11 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Medicinal Chemistry of Anticancer Drugs written by Carmen Avendaño and published by Elsevier. This book was released on 2015-06-11 with total page 767 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medicinal Chemistry of Anticancer Drugs, Second Edition, provides an updated treatment from the point of view of medicinal chemistry and drug design, focusing on the mechanism of action of antitumor drugs from the molecular level, and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents. Antitumor chemotherapy is a very active field of research, and a huge amount of information on the topic is generated every year. Cytotoxic chemotherapy is gradually being supplemented by a new generation of drugs that recognize specific targets on the surface or inside cancer cells, and resistance to antitumor drugs continues to be investigated. While these therapies are in their infancy, they hold promise of more effective therapies with fewer side effects. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book provides a sorely needed update from the point of view of medicinal chemistry and drug design. - Presents information in a clear and concise way using a large number of figures - Historical background provides insights on how the process of drug discovery in the anticancer field has evolved - Extensive references to primary literature

Download or read book Inter Organellar Ca2 Signaling in Health and Disease Part B written by and published by Academic Press. This book was released on 2021-08-12 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: International Review of Cell and Molecular Biology reviews and details current advances in cell and molecular biology. The IRCMB series has a worldwide readership, maintaining a high standard by publishing invited articles on important and timely topics that are authored by prominent cell and molecular biologists. The articles published in IRCMB have a high impact and an average cited half-life of 9 years. This great resource ranks high amongst scientific journals dealing with cell biology. - Publishes only invited review articles on selected topics - Authored by established and active cell and molecular biologists and drawn from international sources - Offers a wide range of perspectives on specific subjects

Download or read book Methods in Systems Biology written by Daniel Jameson and published by Academic Press. This book was released on 2011-09-26 with total page 775 pages. Available in PDF, EPUB and Kindle. Book excerpt: Systems biology is a term used to describe a number of trends in bioscience research and a movement that draws on those trends. This volume in the Methods in Enzymology series comprehensively covers the methods in systems biology. With an international board of authors, this volume is split into sections that cover subjects such as machines for systems biology, protein production and quantification for systems biology, and enzymatic assays in systems biology research. This volume in the Methods in Enzymology series comprehensively covers the methods in systems biology With an international board of authors, this volume is split into sections that cover subjects such as machines for systems biology, protein production and quantification for systems biology, and enzymatic assays in systems biology research

Download or read book Mitochondrial Function written by William S. Allison and published by . This book was released on 2009 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Hydrogen Peroxide and Cell Signaling Part B written by and published by Academic Press. This book was released on 2013-07-15 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This is the second of three volumes on hydrogen peroxide and cell signaling, and includes chapters on such topics as the cellular steady-state of H2O2, evaluating peroxiredoxin sensitivity towards inactivation by peroxide substrates, and peroxiredoxins as preferential targets in H2O2-induced signaling.

Download or read book 3D Bioprinting for Reconstructive Surgery written by Daniel J. Thomas and published by Woodhead Publishing. This book was released on 2017-11-14 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: 3D Bioprinting for Reconstructive Surgery: Techniques and Applications examines the combined use of materials, procedures and tools necessary for creating structural tissue constructs for reconstructive purposes. Offering a broad analysis of the field, the first set of chapters review the range of biomaterials which can be used to create 3D-printed tissue constructs. Part Two looks at the techniques needed to prepare biomaterials and biological materials for 3D printing, while the final set of chapters examines application-specific examples of tissues formed from 3D printed biomaterials. 3D printing of biomaterials for tissue engineering applications is becoming increasingly popular due to its ability to offer unique, patient-specific parts—on demand—at a relatively low cost. This book is a valuable resource for biomaterials scientists, biomedical engineers, practitioners and students wishing to broaden their knowledge in the allied field. - Discusses new possibilities in tissue engineering with 3D printing - Presents a comprehensive coverage of the materials, techniques and tools needed for producing bioprinted tissues - Reviews emerging technologies in addition to commercial techniques

Download or read book Translational Endocrinology of Bone written by Gerard Karsenty and published by Academic Press. This book was released on 2012-12-31 with total page 247 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of model organisms together with the power of genetics has profoundly affected our understanding of the physiology of one organ, the skeleton, in two distinct but complementary ways. This is the first translational reference to focus on these major conceptual advances in bone biology and their development in the clinic. Several advances have already been translated into therapies and others are being tested for diseases as different as osteoporosis, type-2 diabetes, and hypo-fertility. This book is a timely reference for both basic and clinical researchers in bone biology and endocrinology. - Summarizes the latest research and translational applications of how the varied growth and development of bone affects appetite, metabolism, reproduction, and a wide range of endocrine functions - Provides a common language for bone biologists, endocrinologists, osteologists, and other researchers, such as neuroscientists, who study appetite, fuel metabolism and diabetes, to discuss the development of translational research and new therapeutic strategies for bone, metabolic, and neuro-endocrine diseases - Saves researchers and clinicians time in quickly accessing the very latest details on a broad range of bone research and therapeutics, as opposed to searching through thousands of journal articles

Download or read book Intra and Intermolecular Interactions between Non covalently Bonded Species written by Elliot R. Bernstein and published by Elsevier. This book was released on 2020-09-10 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: The study of gases, clusters, liquids, and solids as units or systems, eventually focuses on the properties of these systems as governed by interactions between atoms, molecules, and radicals that are not covalently bonded to one another. The stereo/spatial properties of molecular species themselves are similarly controlled, with such interactions found throughout biological, polymeric, and cluster systems and are a central feature of chemical reactions. Nevertheless, these interactions are poorly described and characterized, with efforts to do so, usually based on a particular quantum or even classical mechanical procedure, obscuring the fundamental nature of the interactions in the process. Intra- and Intermolecular Interactions Between Noncovalently Bonded Species addresses this issue directly, defining the nature of the interactions and discussing how they should and should not be described. It reviews both theoretical developments and experimental procedures in order to explore interactions between nonbonded entities in such a fundamental manner as to elucidate their nature and origins. Drawing attention to the extensive experience of its editor and team of expert authors, Intra- and Intermolecular Interactions Between Noncovalently Bonded Species is an indispensable guide to the foundational knowledge, latest advances, most pressing challenges, and future directions for all those whose work is influenced by these interactions. - Comprehensively describes the nature of interactions between nonbonded species in biological systems, liquids, crystals, clusters, and in particular, water. - Combines fundamental, theoretical, background information based on various approximations with the knowledge of experimental techniques. - Outlines interactions clearly and consistently with a particular focus on frequency and time-resolved spectroscopies as applied to these interactions.

Download or read book Chemistry of Plant Phosphorus Compounds written by Arlen Frank and published by Elsevier. This book was released on 2013-06-03 with total page 688 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a high level reference source for scientists engaged in any aspect of plant research - chemistry, biochemistry or physiology - with primary focus on the chemistry of phosphorus-containing compounds that occur naturally in the plant kingdom, and specifically in the higher plants (Plantae). The book is comprehensive with respect to nomenclature, physical properties, and distribution worldwide. There are many tables of actual data on phosphorus compounds occurring in whole plants and parts of plants. The tables provide detailed data that is needed by the food industry, agriculture, etc as many of the phosphorus compounds are common to both plants and animals. Two appendices cover other aspects including changes in phosphorus-containing compounds during germination and their accumulation during growth and senescence. The final sections of the book comprise separate indexes of plants, compounds and authors. - Comprehensive examination of phosphorus compounds found in plants - Extensive tables listing types of compounds and their occurrence in plants including: Nomenclature; Occurrence; Physical Properties; Synthesis; Hydrolysis; Phosphorylation; Extraction; Separation and Analysis - Easy to use indexes of plants, compounds and authors

Download or read book Green Approaches in Medicinal Chemistry for Sustainable Drug Design written by Bimal Banik and published by Elsevier. This book was released on 2024-05-31 with total page 699 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extensive experimentation and high failure rates are a well-recognized downside to the drug discovery process, with the resultant high levels of inefficiency and waste producing a negative environmental impact. Sustainable and Green Approaches in Medicinal Chemistry 2e reveals how medicinal chemistry can play a direct role in addressing this issue. After providing essential context to the growth of green chemistry in relation to drug discovery, the book goes on to identify a broad range of practical techniques and useful insights, revealing how medicinal chemistry techniques can be used to improve efficiency, mitigate failure and increase the environmental benignity of the entire drug discovery process. Drawing on the knowledge of a global team of experts, Sustainable and Green Approaches in Medicinal Chemistry, Second Edition encourages the growth of green medicinal chemistry, and supports medicinal chemists, drug discovery researchers, pharmacologists and all those in related fields across both academia and industry in integrating these approaches into their own work. This second volume of the second edition includes the development of nanoparticles and nanocomposites, as well as the application of ultrasound and microwave-induced methods; studies solventless synthesis; defines the role of steroids; studies reactions in aqueous solution; identifies enzyme-mediated reactions; investigates ionic liquids and deep eutectic solvents; explores natural products; investigates solid supports; realizes the effects of salts; focuses on combinatorial chemistry; develops one-pot methods; analyzes multi-component reactions; investigates dipole moment values; and examines computer-assisted methods. - Highlights the need for adoption of sustainable and green chemistry pathways in drug development - Reveals risk factors associated with the drug development process and the ways sustainable approaches can help address these - Identifies novel and cost effective green medicinal chemistry approaches for improved efficiency and sustainability

Download or read book Elsevier s Integrated Review Biochemistry written by John W. Pelley, PhD and published by Elsevier Health Sciences. This book was released on 2011-11-30 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: Effectively merge basic science and clinical skills with Elsevier's Integrated Review Biochemistry, by John W. Pelley, PhD. This concise, high-yield title in the popular Integrated Review Series focuses on the core knowledge in biochemistry while linking that information to related concepts from other basic science disciplines. Case-based questions at the end of each chapter enable you to gauge your mastery of the material, and a color-coded format allows you to quickly find the specific guidance you need. Online access via www.studentconsult.com - included with your purchase - allows you to conveniently access the book's complete text and illustrations online as well as relevant content from other Student Consult titles. This concise and user-friendly reference provides crucial guidance for the early years of medical training and USMLE preparation. Spend more time reviewing and less time searching thanks to an extremely focused, "high-yield" presentation. Gauge your mastery of the material and build confidence with both case-based, andUSMLE-style questions that provide effective chapter review and quick practice for your exams. Access the full contents online at www.studentconsult.com where you'll find the complete text and illustrations, "Integration Links" to bonus content in other Student Consult titles, an interactive community center with a wealth of additional resources, and much more! Grasp and retain vital concepts more easily thanks to a color-coded format, succinct,text, key concept boxes, and dynamic illustrations that facilitate learning in a highly visual approach. Effectively review for problem-based courses with the help of text boxes that help you clearly see the clinical relevance of the material. Great for visual learners!

Download or read book Comprehensive Biophysics written by and published by Academic Press. This book was released on 2012-04-12 with total page 3533 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biophysics is a rapidly-evolving interdisciplinary science that applies theories and methods of the physical sciences to questions of biology. Biophysics encompasses many disciplines, including physics, chemistry, mathematics, biology, biochemistry, medicine, pharmacology, physiology, and neuroscience, and it is essential that scientists working in these varied fields are able to understand each other's research. Comprehensive Biophysics, Nine Volume Set will help bridge that communication gap. Written by a team of researchers at the forefront of their respective fields, under the guidance of Chief Editor Edward Egelman, Comprehensive Biophysics, Nine Volume Set provides definitive introductions to a broad array of topics, uniting different areas of biophysics research - from the physical techniques for studying macromolecular structure to protein folding, muscle and molecular motors, cell biophysics, bioenergetics and more. The result is this comprehensive scientific resource - a valuable tool both for helping researchers come to grips quickly with material from related biophysics fields outside their areas of expertise, and for reinforcing their existing knowledge. Biophysical research today encompasses many areas of biology. These studies do not necessarily share a unique identifying factor. This work unites the different areas of research and allows users, regardless of their background, to navigate through the most essential concepts with ease, saving them time and vastly improving their understanding The field of biophysics counts several journals that are directly and indirectly concerned with the field. There is no reference work that encompasses the entire field and unites the different areas of research through deep foundational reviews. Comprehensive Biophysics fills this vacuum, being a definitive work on biophysics. It will help users apply context to the diverse journal literature offering, and aid them in identifying areas for further research Chief Editor Edward Egelman (E-I-C, Biophysical Journal) has assembled an impressive, world-class team of Volume Editors and Contributing Authors. Each chapter has been painstakingly reviewed and checked for consistent high quality. The result is an authoritative overview which ties the literature together and provides the user with a reliable background information and citation resource