Download or read book Computational Framework for Small Animal SPECT Imaging written by Sang Hyeb Lee and published by . This book was released on 2015 with total page 137 pages. Available in PDF, EPUB and Kindle. Book excerpt: Small animal Single Photon Emission Computed Tomography (SPECT) has been an invaluable asset in biomedical science since this non-invasive imaging technique allows the longitudinal studies of animal models of human diseases. However, the image degradation caused by non-stationary collimator-detector response and single photon emitting nature of SPECT makes it difficult to provide a quantitative measure of 3D radio-pharmaceutical distribution inside the patient. Moreover, this problem exacerbates when an intra-peritoneal X-ray contrast agent is injected into a mouse for low-energy radiotracers. In this dissertation, we design and develop a complete computational framework for the entire SPECT scan procedure from the radio-pharmaceutical injection, image acquisition, attenuation and scatter correction, and to the image reconstruction. Using this framework, we solve several challenging problems in small animal SPECT imaging. In particular, we perform an in-depth analysis of photon attenuation and scatter in small SPECT imaging and evaluate the performance of correction methods under various imaging circumstances in terms of image quality and computational complexity. Furthermore, we propose various techniques to accelerate correction methods using computational accelerators. This research also implements and validates a solution for solving the cross-talk contamination problem in I-123 and I-125 by using the ratio of detected low and high energy I-123 activity to separate the mixed low energy I-123 and I-125 activities using our simulation framework. Iterative reconstruction methods produce an accurate image using an accurate system matrix model of the image acquisition process at the expense of computational time. This research examines and proposes various techniques for accelerating the analytic system matrix generation for 3D SPECT.
Download or read book Small Animal SPECT Imaging written by Matthew A. Kupinski and published by Springer Science & Business Media. This book was released on 2007-05-27 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Small-Animal SPECT Imaging is an edited work derived from the first workshop on Small-Animal SPECT Imaging held January 14-16, 2004 at the University of Arizona, Tucson, AZ, USA. The overall goal of the meeting and therefore this volume is to promote information exchange and collaboration between the research groups developing systems for small-animal applications. Topics include the biomedical significance of small-animal imaging, an overview of detector technologies including scintillation cameras and semi-conductor arrays, imager design and data acquisition systems, animal handling and anesthesia issues, objective assessment of image quality, and system modeling and reconstruction algorithms.
Download or read book Small Animal Imaging written by Fabian Kiessling and published by Springer. This book was released on 2017-05-22 with total page 871 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook is a practical guide to the use of small animal imaging in preclinical research that will assist in the choice of imaging modality and contrast agent and in study design, experimental setup, and data evaluation. All established imaging modalities are discussed in detail, with the assistance of numerous informative illustrations. While the focus of the new edition remains on practical basics, it has been updated to encompass a variety of emerging imaging modalities, methods, and applications. Additional useful hints are also supplied on the installation of a small animal unit, study planning, animal handling, and cost-effective performance of small animal imaging. Cross-calibration methods and data postprocessing are considered in depth. This new edition of Small Animal Imaging will be an invaluable aid for researchers, students, and technicians involved in research into and applications of small animal imaging.
Download or read book Small Animal Imaging written by Fabian Kiessling and published by Springer Science & Business Media. This book was released on 2010-11-29 with total page 589 pages. Available in PDF, EPUB and Kindle. Book excerpt: Small animal imaging has been recognized as an important tool in preclinical research. Nevertheless, the results of non-invasive imaging are often disappointing owing to choice of a suboptimal imaging modality and/or shortcomings in study design, experimental setup, and data evaluation. This textbook is a practical guide to the use of non-invasive imaging in preclinical research. Each of the available imaging modalities is discussed in detail, with the assistance of numerous informative illustrations. In addition, many useful hints are provided on the installation of a small animal unit, study planning, animal handling, and the cost-effective performance of small animal imaging. Cross-calibration methods, data postprocessing, and special imaging applications are also considered in depth. This is the first book to cover all the practical basics in small animal imaging, and it will prove an invaluable aid for researchers, students, and technicians.
Download or read book Handbook of Small Animal Imaging written by George C. Kagadis and published by CRC Press. This book was released on 2018-09-03 with total page 602 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of small animal models in basic and preclinical sciences constitutes an integral part of testing new pharmaceutical agents prior to their application in clinical practice. New imaging and therapeutic approaches need to be tested and validated first in animals before application to humans. Handbook of Small Animal Imaging: Preclinical Imaging, Therapy, and Applications collects the latest information about various imaging and therapeutic technologies used in preclinical research into a single source. Useful to established researchers as well as newcomers to the field, this handbook shows readers how to exploit and integrate these imaging and treatment modalities and techniques into their own research. The book first presents introductory material on small animal imaging, therapy, and research ethics. It next covers ionizing radiation and nonionizing radiation methods in small animal imaging, hybrid imaging, and imaging agents. The book then addresses therapeutic research platforms and image quantification, explaining how to ensure accurate measurements of high-quality data. It concludes with an overview of many small animal imaging and therapy applications that demonstrate the strength of the techniques in biomedical fields.
Download or read book Physics of PET and SPECT Imaging written by Magnus Dahlbom and published by CRC Press. This book was released on 2017-02-17 with total page 519 pages. Available in PDF, EPUB and Kindle. Book excerpt: PET and SPECT imaging has improved to such a level that they are opening up exciting new horizons in medical diagnosis and treatment. This book provides a complete introduction to fundamentals and the latest progress in the field, including an overview of new scintillator materials and innovations in photodetector development, as well as the latest system designs and image reconstruction algorithms. It begins with basics of PET and SPECT physics, followed by technology advances and computing methods, quantitative techniques, multimodality imaging, instrumentation, pre-clinical and clinical imaging applications.
Download or read book Ultra high resolution Small animal SPECT Imaging written by Frans van der Have and published by . This book was released on 2007 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Development of a Combined MicroSPECT CT System for Small Animal Imaging written by Mingshan Sun and published by . This book was released on 2006 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular Imaging of Small Animals written by Habib Zaidi and published by Springer. This book was released on 2014-05-27 with total page 762 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines the fundamental concepts of multimodality small-animal molecular imaging technologies and their numerous applications in biomedical research. Driven primarily by the widespread availability of various small-animal models of human diseases replicating accurately biological and biochemical processes in vivo, this is a relatively new yet rapidly expanding field that has excellent potential to become a powerful tool in biomedical research and drug development. In addition to being a powerful clinical tool, a number of imaging modalities including but not limited to CT, MRI, SPECT and PET are also used in small laboratory animal research to visualize and track certain molecular processes associated with diseases such as cancer, heart disease and neurological disorders in living small animal models of disease. In vivo small-animal imaging is playing a pivotal role in the scientific research paradigm enabling to understand human molecular biology and pathophysiology using, for instance, genetically engineered mice with spontaneous diseases that closely mimic human diseases.
Download or read book Quantitative Imaging in Small Animals Using SPECT CT written by Andrew Bing Hwang and published by . This book was released on 2006 with total page 552 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Ultra high resolution small animal SPECT imaging written by Have and published by . This book was released on 2007 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Computational Intelligence in Medical Imaging written by G. Schaefer and published by CRC Press. This book was released on 2009-03-24 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: CI Techniques & Algorithms for a Variety of Medical Imaging SituationsDocuments recent advances and stimulates further researchA compilation of the latest trends in the field, Computational Intelligence in Medical Imaging: Techniques and Applications explores how intelligent computing can bring enormous benefit to existing technology in medical
Download or read book Dual Modality CT SPECT Scanner for Small Animal Imaging written by Alexander Vyacheslavovich Stolin and published by . This book was released on 2007 with total page 205 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work describes the design and performance of a dual-modality system for small animal imaging combining a high spatial resolution SPECT component with an x-ray CT component. All components are mounted on a barrel type gantry which is able to rotate in 0.001 degrees increments about the animal. The SPECT subsystem consists of a four custom-built gamma cameras. The cameras can be equipped with either parallel hole or pinhole collimators depending on the study in question. The cameras can be operated in pairs to implement a unique half-cone geometry setup in order to decrease the overall acquisition time as well as maximize spatial resolution. The intrinsic spatial and energy resolutions of the gamma detectors are measured to be 1.75 mm and 17.9% respectively. Novel type of pinhole collimators was introduced. Square shape aperture with pyramid shape acceptance volume collimator was characterized both theoretically and experimentally. This type of a collimator allows for about 23% of efficiency increase without significant reduction in spatial resolution. The x-ray CT subsystem combines various interchangeable microfocus x-ray sources with either a high resolution CCD based detector or a flat panel Hamamatsu C7940 CMOS array. The CCD detector employs a 7k by 4k Phillips CCD chip with dimensions of 5 cm x 9 cm, large enough to require no minification between the gadolinium oxysulfate phosphor and the chip. The both subsystems have been installed and successfully used in phantom imaging and in a variety of small animal studies. Spatial resolutions of 50 mum for CT and 0.9 mm for SPECT have been achieved for live animal imaging. The scanner is able to obtain a lower resolution CT set in 4.5 minutes and SPECT data set in 30 minutes.
Download or read book Characterization of a Small Animal SPECT Platform for Use in Preclinical Translational Research written by Dustin Ryan Osborne and published by . This book was released on 2011 with total page 227 pages. Available in PDF, EPUB and Kindle. Book excerpt: Imaging Iodine-125 requires an increased focus on developing an understanding of how fundamental processes used by imaging systems work to provide quantitative output for the imaging system. Isotopes like I-125 pose specific imaging problems that are a result of low energy emissions as well as how closely spaced those emissions are in the spectrum. This work seeks to characterize the performance of a small animal SPECT-CT imaging system with respect to imaging I-125 for use in a preclinical translational research environment and to understand how the performance of this system relates to critical applications such as attenuation and scatter correction. The specific aims of this work examined several key areas of system function and performance with respect to I-125 imaging. The first aim examined the geometric SPECT calibration routine used for the Inveon imaging system with a particular focus on determining the accuracy of the calibration as well as the robustness of the algorithm under routine and adverse imaging conditions. The second aim was to characterize detector uniformity issues that may arise by comparing the uniformity performance of the system with both I-125 and Co-57 as well as examining the possibility of altering the acquisition method for normalization scans to increase the uniformity performance. The third aim sought to optimize the energy window used for acquisition of I-125 data and to determine the effects the selection of the window had on valid and scatter events. The fourth aim used the optimized windows, determined by the third aim, to assess the performance of a reconstruction algorithm, currently under development, that corrects for attenuation and scatter effects. The fifth and final aim of this work sought to assess the feasibility acquiring SPECT-CT data simultaneously and to assess the quality of data that could be achieved if simultaneous acquisition of the two imaging modalities was, in fact, possible. This work met these aims by performing an extensive series of studies examining the response of the system to I-125 imaging. These included multiple series of phantom imaging using both manufacturer as well as custom-designed sources for use with measurements involving I-125 and Co-57. Statistics from over 60 datasets with analysis in greater than 480 regions of interest were used for the analysis of attenuation and scatter correction data alone. The final study involving simultaneous SPECT-CT acquisition required modification of the imaging hardware to enable this type of data collection as well as development of a reconstruction algorithm to correctly handle the CT data acquired in a step-and-shoot helical mode. A number of key findings resulted from this work including the validation of the calibration routine of this imaging system, even under non-ideal imaging conditions for both the SPECT and CT modalities. Uniformity performance with I-125 was found to be a challenge with this imaging system but reductions in performance compared to other isotopes were not significant enough to introduce severe artifacts into the image data. Optimization of I-125 parameters resulted in improvements of the processed data indicating that the recommended settings provided by the manufacturer could be altered to provide results that better balance between minimizing scatter effects and maximizing detection of valid events. Assessment of the proposed scatter and attenuation correction algorithm for this system showed marked improvement as compared to data processed without these corrections. The final study of simultaneous SPECT-CT imaging proved this acquisition method to be feasible on a commercial system with minimal The primary conclusions drawn from this study indicate that the system is adequate for imaging with I-125 when care is taken to properly maintain the system as well as keeping sources current and properly centered in the scanner field of view during calibration. The study strongly illustrates the necessity of compensating any data collected using I-125 for attenuation and scatter effects; with some regions showing greater than 25% attenuation and approximately 30% improvement in quantitative values for scatter affected regions with the corrections applied. The study also concludes that simultaneous SPECT-CT is feasible with minor adjustments to a commercial platform.
Download or read book Brieven van Albert Kuyle 1904 1958 aan George Impens written by and published by . This book was released on 1954 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book SPECT System for Small Animal Imaging with a Single Photon Counting Pixel Detector written by Giovanni Mettivier and published by . This book was released on 2004 with total page 91 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Advances in Visual Computing written by Richard Boyle and published by Springer. This book was released on 2006-11-17 with total page 936 pages. Available in PDF, EPUB and Kindle. Book excerpt: The two volume set LNCS 4291 and LNCS 4292 constitutes the refereed proceedings of the Second International Symposium on Visual Computing, ISVC 2006, held in Lake Tahoe, NV, USA in November 2006. The 65 revised full papers and 56 poster papers presented together with 57 papers of ten special tracks were carefully reviewed and selected from more than 280 submissions. The papers cover the four main areas of visual computing.
