Download or read book Computational Explorations of Dopamine Dysfunction in Autism Spectrum Disorders written by and published by . This book was released on 2001 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autism is a developmental disorder characterized by a diverse set of behavioral characteristics, including social difficulties, seizures, motor abnormalities, executive dysfunction, and problems of inflexibility and overselectivity in learning. The breadth of this behavioral profile has made identifying the underlying neural mechanisms difficult for researchers seeking an explanation. An examination of the various roles played by the dopamine (DA) system in learning, attention, and cognitive control uncovers a surprising connection between DA and the symptoms of autism. DA abnormalities are associated with motor problems, repetitive behaviors, seizures, poor implicit learning, learning to follow eye gaze, and executive dysfunction. Led by these facts, I hypothesize that impaired interactions between DA and the prefrontal cortex (PFC) can explain many of the behavioral patterns observed in autism. Under my account, the PFC actively maintains context information that modulates processing in other brain areas so as to produce behavior appropriate for the current setting or situation. The DA system provides a mechanism for learning when PFC contents should be updated to support shifting task contingencies. I hypothesize that inflexibility in the updating of PFC contents, caused by dysfunctional DA/PFC interactions, is at the heart of many behaviors seen in autism. In this document I demonstrate the viability of this hypothesis by perturbing the updating of PFC in five computational models of healthy cognition, covering five distinct behavioral domains, producing autistic patterns of performance in all five cases through this common biological deficit. Specifically, I show how abnormal DA/PFC interactions can explain executive dysfunction, differences during the learning of category structures, impaired implicit learning, difficulties utilizing contextual information to disambiguate homographs, and overselective behavior in people with autism. Thus, I offer a unifying biological account of phenomena that have previously been treated separately in the autism literature and demonstrate the usefulness of the tools of computational modeling in this endeavour.

Download or read book Principles of Frontal Lobe Function written by Donald T. Stuss and published by Oxford University Press, USA. This book was released on 2013-01-31 with total page 799 pages. Available in PDF, EPUB and Kindle. Book excerpt: Principles of Frontal Lobe Function, Second Edition is an expanded volume, divided into 9 sections representing major research and clinical disciples, including new topics such as social neuroscience. This book will provide clinicians, researchers, and students with the most current information as the mystery of the frontal lobes is unraveled.

Download or read book Current Issues in Developmental Disorders written by Chloë R. Marshall and published by Psychology Press. This book was released on 2013 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cognitive development in children is a highly complex process which, while remarkably resilient, can be disrupted in a variety of ways. This volume focuses on two types of neurodevelopmental disorder: syndromic conditions such as fragile X syndrome, Down syndrome, Williams syndrome and velocardiofacial syndrome; and non-syndromic conditions including dyslexia, specific language impairment, autism spectrum disorder and attention deficit hyperactivity disorder. This book provides a state-of-the-art review of current research and covers key topics across the full range of developmental disorders. Topics covered include: diagnosis and comorbidity genetics longitudinal studies computational models distinguishing disorder from disadvantage language and culture the modern beginnings of research into developmental disorders The book also looks at how the study of developmental disorders has contributed to our understanding of typical development, and themes emerge that are common across chapters, including intervention and education, and the neurobiological bases of developmental disorders. The result is a fascinating and thought-provoking volume that will be indispensable to advanced students, researchers and practitioners in the fields of developmental psychology, neuropsychology, speech and language therapy, and developmental disorders.

Download or read book Neural Engineering Techniques for Autism Spectrum Disorder written by Ayman S. El-Baz and published by Academic Press. This book was released on 2021-07-16 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neural Engineering for Autism Spectrum Disorder, Volume One: Imaging and Signal Analysis Techniques presents the latest advances in neural engineering and biomedical engineering as applied to the clinical diagnosis and treatment of Autism Spectrum Disorder (ASD). Advances in the role of neuroimaging, infrared spectroscopy, sMRI, fMRI, DTI, social behaviors and suitable data analytics useful for clinical diagnosis and research applications for Autism Spectrum Disorder are covered, including relevant case studies. The application of brain signal evaluation, EEG analytics, feature selection, and analysis of blood oxygen level-dependent (BOLD) signals are presented for detection and estimation of the degree of ASD. Presents applications of Neural Engineering and other Machine Learning techniques for the diagnosis of Autism Spectrum Disorder (ASD) Includes in-depth technical coverage of imaging and signal analysis techniques, including coverage of functional MRI, neuroimaging, infrared spectroscopy, sMRI, fMRI, DTI, and neuroanatomy of autism Covers Signal Analysis for the detection and estimation of Autism Spectrum Disorder (ASD), including brain signal analysis, EEG analytics, feature selection, and analysis of blood oxygen level-dependent (BOLD) signals for ASD Written to help engineers, computer scientists, researchers and clinicians understand the technology and applications of Neural Engineering for the detection and diagnosis of Autism Spectrum Disorder (ASD)

Download or read book Educational Neuroscience written by Denis Mareschal and published by John Wiley & Sons. This book was released on 2013-12-31 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: Educational Neuroscience presents a series of readings from educators, psychologists, and neuroscientists that explore the latest findings in developmental cognitive neurosciences and their potential applications to education. Represents a new research area with direct relevance to current educational practices and policy making Features individual chapters written collaboratively by educationalist, psychologists, and neuroscientists to ensure maximum clarity and relevance to a broad range of readers Edited by a trio of leading academics with extensive experience in the field

Download or read book Autism Spectrum Disorders Developmental Trajectories Neurobiological Basis Treatment Update Volume 2 written by Roberto Canitano and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Download or read book Translational Neuropsychopharmacology written by Trevor W. Robbins and published by Springer. This book was released on 2016-09-22 with total page 503 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers wide areas of animal and human psychopharmacology with clinical utility in the treatment of psychiatric and neurological (e.g Alzheimer's disease) disorders. The main theme is to develop a new paradigm for drug discovery that questions the claim that animal models or assays fail adequately to predict Phase 3 clinical trials. A new paradigm is advocated that stresses the importance of intermediate staging points between these extremes that depend on suitable translation of findings from animal studies to Phase 1 or Phase 2 studies utilising experimental medicine.

Download or read book Obsessive compulsive Disorder written by Christopher Pittenger and published by Oxford University Press. This book was released on 2017 with total page 777 pages. Available in PDF, EPUB and Kindle. Book excerpt: Obsessive-compulsive disorder (OCD) affects one person in 40 and can cause great suffering. This volume provides the first comprehensive summary of our understanding of this enigmatic condition, summarizing current work ranging from genetics and neurobiology through cognitive psychology, treatment, personal experiences, and societal implications.

Download or read book Autism Spectrum Disorders in Adults written by Bernardo Barahona Corrêa and published by Springer. This book was released on 2017-04-13 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book a group of international experts guide the reader through the clinical features of adults with autism spectrum disorders, describe the care needs of patients and their families, explain the evolution of the disorders into old age, and highlight what can be done to help. Detailed attention is paid to the medical and psychiatric problems of adults with these disorders and the approach to their education and professional integration. In addition, expert neuroscientists summarize current views on the neurobiology of autism. Autism spectrum disorders are devastating neurodevelopmental disorders. Although diagnosis and therapeutic interventions usually take place in infancy, they are chronic lifelong conditions. Surprisingly, the literature on autism spectrum disorders in adults is scarce. Moreover, most mental health professionals working with adults have little training in autism, and adult mental health services around the world are rarely prepared to address the needs of these patients, which tend to increase with age. This book therefore fills a crucial gap in the literature and will prove useful for all who care for and deal with adults in the Autistic Spectrum.

Download or read book ADI R written by Michael Rutter and published by . This book was released on 2013 with total page 64 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Autism Spectrum Disorders written by David Amaral and published by Oxford University Press. This book was released on 2011-05-01 with total page 1445 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autism is an emerging area of basic and clinical research, and has only recently been recognized as a major topic in biomedical research. Approximately 1 in 150 children are diagnosed as autistic, so it is also an intense growth area in behavioral and educational treatments. Financial resources have begun to be raised for more comprehensive research and an increasing number of scientists are becoming involved in autism research. In many respects, autism has become a model for conducting translational research on a psychiatric disorder. This text provides a comprehensive summary of all current knowledge related to the behavioral, experiential, and biomedical features of the autism spectrum disorders including major behavioral and cognitive syndromology, common co-morbid conditions, neuropathology, neuroimmunology, and other neurological correlates such as seizures, allergy and immunology, gastroenterology, infectious disease, and epidemiology. Edited by three leading researchers, this volume contains over 80 chapters and nine shorter commentaries by thought leaders in the field, making the book a virtual "who's who" of autism research. This carefully developed book is a comprehensive and authoritative reference for what we know in this area as well as a guidepost for the next several years in all areas of autism research.

Download or read book Epigenetics in Human Disease written by Trygve Tollefsbol and published by Academic Press. This book was released on 2012-07-26 with total page 617 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epigenetics is one of the fastest growing fields of sciences, illuminating studies of human diseases by looking beyond genetic make-up and acknowledging that outside factors play a role in gene expression. The goal of this volume is to highlight those diseases or conditions for which we have advanced knowledge of epigenetic factors such as cancer, autoimmune disorders and aging as well as those that are yielding exciting breakthroughs in epigenetics such as diabetes, neurobiological disorders and cardiovascular disease. Where applicable, attempts are made to not only detail the role of epigenetics in the etiology, progression, diagnosis and prognosis of these diseases, but also novel epigenetic approaches to the treatment of these diseases. Chapters are also presented on human imprinting disorders, respiratory diseases, infectious diseases and gynecological and reproductive diseases. Since epigenetics plays a major role in the aging process, advances in the epigenetics of aging are highly relevant to many age-related human diseases. Therefore, this volume closes with chapters on aging epigenetics and breakthroughs that have been made to delay the aging process through epigenetic approaches. With its translational focus, this book will serve as valuable reference for both basic scientists and clinicians alike. Comprehensive coverage of fundamental and emergent science and clinical usage Side-by-side coverage of the basis of epigenetic diseases and their treatments Evaluation of recent epigenetic clinical breakthroughs

Download or read book Sensory Processing Across the Lifespan A 25 Year Initiative to Understand Neurophysiology Behaviors and Treatment Effectiveness for Sensory Processing written by Lucy Jane Miller and published by Frontiers Media SA. This book was released on 2021-06-04 with total page 143 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Computational Psychiatry written by A. David Redish and published by MIT Press. This book was released on 2016-12-09 with total page 425 pages. Available in PDF, EPUB and Kindle. Book excerpt: Psychiatrists and neuroscientists discuss the potential of computational approaches to address problems in psychiatry including diagnosis, treatment, and integration with neurobiology. Modern psychiatry is at a crossroads, as it attempts to balance neurological analysis with psychological assessment. Computational neuroscience offers a new lens through which to view such thorny issues as diagnosis, treatment, and integration with neurobiology. In this volume, psychiatrists and theoretical and computational neuroscientists consider the potential of computational approaches to psychiatric issues. This unique collaboration yields surprising results, innovative synergies, and novel open questions. The contributors consider mechanisms of psychiatric disorders, the use of computation and imaging to model psychiatric disorders, ways that computation can inform psychiatric nosology, and specific applications of the computational approach. Contributors Susanne E. Ahmari, Huda Akil, Deanna M. Barch, Matthew Botvinick, Michael Breakspear, Cameron S. Carter, Matthew V. Chafee, Sophie Denève, Daniel Durstewitz, Michael B. First, Shelly B. Flagel, Michael J. Frank, Karl J. Friston, Joshua A. Gordon, Katia M. Harlé, Crane Huang, Quentin J. M. Huys, Peter W. Kalivas, John H. Krystal, Zeb Kurth-Nelson, Angus W. MacDonald III, Tiago V. Maia, Robert C. Malenka, Sanjay J. Mathew, Christoph Mathys, P. Read Montague, Rosalyn Moran, Theoden I. Netoff, Yael Niv, John P. O'Doherty, Wolfgang M. Pauli, Martin P. Paulus, Frederike Petzschner, Daniel S. Pine, A. David Redish, Kerry Ressler, Katharina Schmack, Jordan W. Smoller, Klaas Enno Stephan, Anita Thapar, Heike Tost, Nelson Totah, Jennifer L. Zick

Download or read book The Oxford Handbook of Metamemory written by John Dunlosky and published by Oxford University Press. This book was released on 2016 with total page 593 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Oxford Handbook of Metamemory investigates the human ability to evaluate and control learning and information retrieval processes. Each chapter in this authoritative guide highlights a different facet of metamemory research, including classical metamemory judgments; applications of metamemory research to the classroom and courtroom; and cutting-edge perspectives on continuing debates and theory. Chapters also provide broad historical overviews of each research area and discussions of promising directions for future research. The breadth and depth of coverage on offer in this Handbook make it ideal for seminars on metamemory or metacognition. It would also be a valuable supplement for advanced courses on cognitive psychology, of use especially to graduate students and more seasoned researchers who are interested in exploring metamemory for the first time.

Download or read book The Comorbidities of Epilepsy written by Marco Mula and published by Academic Press. This book was released on 2019-04-20 with total page 413 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epilepsy is one of most frequent neurological disorders affecting about 50 million people worldwide and 50% of them have at least another medical problem in comorbidity; sometimes this is a the cause of the epilepsy itself or it is due to shared neurobiological links between epilepsy and other medical conditions; other times it is a long-term consequence of the antiepileptic drug treatment. The Comorbidities of Epilepsy offers an up-to-date, comprehensive overview of all comorbidities of epilepsy (somatic, neurological and behavioral), by international authorities in the field of clinical epileptology, with an emphasis on epidemiology, pathophysiology, diagnosis and management. This book includes also a critical appraisal of the methodological aspects and limitations of current research on this field. Pharmacological issues in the management of comorbidities are discussed, providing information on drug dosages, side effects and interactions, in order to enable the reader to manage these patients safely. The Comorbidities of Epilepsy is aimed at all health professionals dealing with people with epilepsy including neurologists, epileptologists, psychiatrists, clinical psychologists, epilepsy specialist nurses and clinical researchers. Provides a comprehensive overview of somatic, neurological and behavioral co-morbidities of epilepsy Discusses up-to-date management of comorbidities of epilepsy Written by a group of international experts in the field

Download or read book The Human Nervous System written by George Paxinos and published by Academic Press. This book was released on 2012-12-02 with total page 1211 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Human Nervous System is a definitive account of human neuroanatomy, with a comprehensive coverage of the brain, spinal cord, and peripheral nervous system. The cytoarchitecture, chemoarchitecture, connectivity, and major functions of neuronal structures are examined by acknowledged authorities in the field, such as: Alheid, Amaral, Armstrong, Beitz, Burke, de Olmos, Difiglia, Garey, Gerrits, Gibbins, Holstege, Kaas, Martin, McKinley, Norgren, Ohye, Paxinos, Pearson, Pioro, Price, Saper, Sasaki, Schoenen, Tadork, Voogd, Webster, Zilles, and their associates. Large, clearly designed 8-1/2" x 11" format 35 information-packed chapters 500 photomicrographs and diagrams 6,200 bibliographic entries Table of contents for every chapter Exceptionally cross-referenced Detailed subject index Substantial original research work Mini atlases of some brain regions