Download or read book Computational Approaches in Molecular Radiation Biology written by Matesh N. Varma and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Office of Health and Environmental Research (OHER) has supported and continues to support development of computational approaches in biology and medicine. OHER's Radiological and Chemical Physics Program initiated development of computational approaches to determine the effects produced by radiation of different quality (such as high energy electrons, protons, helium and other heavy ions, etc. ) in a variety of materials of biological interest-such as water, polymers and DNA; these include molecular excitations and sub-excitations and the production of ionization and their spatial and temporal distribution. In the past several years, significant advances have been made in computational methods for this purpose. In particular, codes based on Monte Carlo techniques have ·been developed that provide a realistic description of track-structure produced by charged particles. In addition, the codes have become sufficiently sophisticated so that it is now possible to calculate the spatial and temporal distribution of energy deposition patterns in small volumes of subnanometer and nanometer dimensions. These dimensions or resolution levels are relevant for our understanding of mechanisms at the molecular level by which radiations affect biological systems. Since the Monte Carlo track structure codes for use in radiation chemistry and radiation biology are still in the developmental stage, a number of investigators have been exploring different strategies for improving these codes.
Download or read book Physical and Chemical Mechanisms in Molecular Radiation Biology written by William A. Glass and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fundamental understanding of the production of biological effects by ionizing radiation may well be one of the most important scientific objectives of mankind; such understanding could lead to the effective and safe utilization of the nuclear energy option. In addition, this knowledge will be of immense value in such diverse fields as radiation therapy and diagnosis and in the space program. To achieve the above stated objective, the U. S. Department of Energy (DOE) and its predecessors embarked upon a fundamental interdisciplinary research program some 35 years ago. A critical component of this program is the Radiological and Chemical Physics Program (RCPP). When the RCPP was established, there was very little basic knowledge in the fields of physics, chemistry, and biology that could be directly applied to understanding the effects of radiation on biological systems. Progress of the RCPP program in its first 15 years was documented in the proceedings of a conference held at Airlie, Virginia, in 1972. At this conference, it was clear that considerable progr:ess had been made in research on the physical and chemical processes in well-characterized systems that could be used to understand biological effects. During this period of time, most physical knowledge was obtained for the gas phase because the technology and instru mentation had not progressed to the point that measurements could be made in liquids more characteristic of biological materials.
Download or read book Structural Biology in Drug Discovery written by Jean-Paul Renaud and published by John Wiley & Sons. This book was released on 2020-01-09 with total page 1367 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the most comprehensive and up-to-date overview of structure-based drug discovery covering both experimental and computational approaches, Structural Biology in Drug Discovery: Methods, Techniques, and Practices describes principles, methods, applications, and emerging paradigms of structural biology as a tool for more efficient drug development. Coverage includes successful examples, academic and industry insights, novel concepts, and advances in a rapidly evolving field. The combined chapters, by authors writing from the frontlines of structural biology and drug discovery, give readers a valuable reference and resource that: Presents the benefits, limitations, and potentiality of major techniques in the field such as X-ray crystallography, NMR, neutron crystallography, cryo-EM, mass spectrometry and other biophysical techniques, and computational structural biology Includes detailed chapters on druggability, allostery, complementary use of thermodynamic and kinetic information, and powerful approaches such as structural chemogenomics and fragment-based drug design Emphasizes the need for the in-depth biophysical characterization of protein targets as well as of therapeutic proteins, and for a thorough quality assessment of experimental structures Illustrates advances in the field of established therapeutic targets like kinases, serine proteinases, GPCRs, and epigenetic proteins, and of more challenging ones like protein-protein interactions and intrinsically disordered proteins
Download or read book Springer Handbook of Atomic Molecular and Optical Physics written by Gordon W. F. Drake and published by Springer Science & Business Media. This book was released on 2007-02-05 with total page 1505 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprises a comprehensive reference source that unifies the entire fields of atomic molecular and optical (AMO) physics, assembling the principal ideas, techniques and results of the field. 92 chapters written by about 120 authors present the principal ideas, techniques and results of the field, together with a guide to the primary research literature (carefully edited to ensure a uniform coverage and style, with extensive cross-references). Along with a summary of key ideas, techniques, and results, many chapters offer diagrams of apparatus, graphs, and tables of data. From atomic spectroscopy to applications in comets, one finds contributions from over 100 authors, all leaders in their respective disciplines. Substantially updated and expanded since the original 1996 edition, it now contains several entirely new chapters covering current areas of great research interest that barely existed in 1996, such as Bose-Einstein condensation, quantum information, and cosmological variations of the fundamental constants. A fully-searchable CD- ROM version of the contents accompanies the handbook.
Download or read book Laser Driven Particle Acceleration Towards Radiobiology and Medicine written by Antonio Giulietti and published by Springer. This book was released on 2016-05-04 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book deals with the new method of laser-driven acceleration for application to radiation biophysics and medicine. It provides multidisciplinary contributions from world leading scientist in order to assess the state of the art of innovative tools for radiation biology research and medical applications of ionizing radiation. The book contains insightful contributions on highly topical aspects of spatio-temporal radiation biophysics, evolving over several orders of magnitude, typically from femtosecond and sub-micrometer scales. Particular attention is devoted to the emerging technology of laser-driven particle accelerators and their application to spatio-temporal radiation biology and medical physics, customization of non-conventional and selective radiotherapy and optimized radioprotection protocols.
Download or read book Interaction of Radiation with Matter written by Hooshang Nikjoo and published by Taylor & Francis. This book was released on 2016-04-19 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interaction of Radiation with Matter focuses on the physics of the interactions of ionizing radiation in living matter and the Monte Carlo simulation of radiation tracks. Clearly progressing from an elementary level to the state of the art, the text explores the classical physics of track description as well as modern aspects based on condensed mat
Download or read book Neutrons in Biology written by Benno P. Schoenborn and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 453 pages. Available in PDF, EPUB and Kindle. Book excerpt: This compendium presents some of the major applications of neutron scattering techniques to problems in biology. It is a record of the papers presented at the Neutrons in Biology Conference, the third in an occasional series held to highlight progress in the field and to provide a focus for future direction. The strength ofthe neutron scattering technique remains principally in the manipula tion of scattering density through hydrogen and deuterium atoms. The development ofad vanced detectors, innovative instrument and beamline components, and sophisticated data acquisition systems through the 1970s and early 1980s provided a sound foundation for the technique. With continued development, some of the exotic and expensive equipment has become affordable by the medium-sized facilities, thereby broadening the user base considerably. Despite problems with the major neutron sources in the late 1980s and early 1990s, some spectacular results have been achieved. Whilst the high and medium flux beam reac tors will continue to make a major impact in the field, the results from the first experi ments, and the planned developments on spallation neutron sources, clearly indicate that the technique has enormous potential.
Download or read book Biology of Root Formation and Development written by Arie Altman and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains the majority of the presentations of the Second International Symposium on the Biology of Root Formation and Development that was hcld in Jerusa lem, Israel, June 23---28, 1996. Following the First Symposium on the Biology of Adventi tious Root Formation, held in Dallas. USA, 1993, we perceived the need to include all kinds of roots, not only the shoot-borne ones. The endogenous signals that control root formation. and the subsequent growth and development processes, are very much alike, re gardless of the sites and sources of origin of the roots. Therefore, we included in the Sec ond Symposium contributions on both shoot-borne (i.e., adventitious) roots and root-borne (i.e., lateral) roots. Plant roots have remained an exciting and an intriguing field of sciencc. During thc years that followed the first symposium, an exceptional proliferation of interest in root biology has developed, associated with the intensive research activity in this field and the contemporary developments in the understanding of root function and development. New methods have been applied, and old ideas and interprctations werc rccxamined. Alto gether, it became necessary to update our viewpoints and to expand them.
Download or read book The Molecular Theory of Radiation Biology written by K. H Chadwick and published by . This book was released on 1981-02-01 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Plant Polyphenols 2 written by Georg G. Gross and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 911 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume summarizes current research on the influence of plant polyphenols on human health, promoting collaboration between chemists and biologists to improve our understanding of their biological significance, and expanding the possibilities for their use.
Download or read book Energy Research Abstracts written by and published by . This book was released on 1993 with total page 922 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Microdosimetric Response of Physical and Biological Systems to Low and High LET Radiations written by Yigal Horowitz and published by Elsevier. This book was released on 2006-06-07 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the aims of this book was to focus the attention of specialists to the diversity of the effects of the ionising radiation on biological and physical systems. Special emphasis has been placed on the exquisite complexities/differences introduced by high ionisation density versus low ionisation density irradiation in both biological and physical systems (Scholz – Chapter 1, Horowitz – Chapter 2, Olko – Chapter 3). As well we wanted to point out the need for novel experimental and theoretical approaches required to advance the important fields of micro and nanodosimetry. Important first steps have already been taken, for example, the accelerated application of semiconductor detectors in their various forms to microdosimetry and as well to practical, important applications in the radiation dosimetry of oncological procedures (Rosenfeld – Chapter 6). The vast number of applications of TLD to radiation dosimetry are not neglected; a special chapter is devoted to the application of TLDs to medical dosimetry applications (Mobit and Kron – Chapter 7) as well as a tutorial approach in an additional chapter to the cavity theories required to extrapolate dose from the detector medium to the tissue medium (Mobit and Sandison - Chapter 5). One of the major features of this book is the intensive, in depth, coverage of the theory and modelling of TL both from the solid state physics point of view (Chen – Chapter 4) and the microdosimetic point of view (Horowitz – Chapter 2 and Olko – Chapter 3). The many puzzling, quaint, quizzical features of TL science can now be understood in the framework of these advanced theoretical models, explained in straightforward, understandable terms. · Quantifies/unifies the effects of ionising radiation in both the biological and physical systems · Authoritative treatment of applications of semiconductor detectors and thermoluminescence dosemeters in medica l radiation dosimetry · Basic and advanced aspects of microdosimetry applied to both biological and physical systems · In-depth review of the effects of the density of ionising radiation in tsl and osl · Concise and elegant treatment of cavity theory in medical oncological dosimetry · Comprehensive review of this important interdisciplinary field including hundreds of ilustrations and references
Download or read book Computational Techniques for Analytical Chemistry and Bioanalysis written by Philippe B. Wilson and published by Royal Society of Chemistry. This book was released on 2020-12-10 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work will serve as a definitive overview of the field of computational simulation as applied to analytical chemistry and biology, drawing on recent advances as well as describing essential, established theory for graduates and postgraduate researchers.
Download or read book DNA Damage and Double Strand Breaks written by and published by Elsevier. This book was released on 2022-11-03 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt: DNA Damage and Double Strand Breaks, Volume 51 in The Enzymes series, highlights new advances in the field, with this new volume presenting interesting chapters that provide an update on female and male genital schistosomiasis and a call to integrate efforts to escalate diagnosis, treatment and awareness in endemic and non-endemic settings, vertebrates as uninfected disseminators of helminth eggs and larvae, and combatting anthelmintic resistance in ruminants. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in The Enzymes series
Download or read book Radiobiology Textbook written by Sarah Baatout and published by Springer Nature. This book was released on 2023-09-23 with total page 687 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access textbook focuses on the various aspects of radiobiology. The goal of radiobiological research is to better understand the effects of radiation exposure at the cellular and molecular levels in order to determine the impact on health. This book offers a unique perspective, by covering not only radiation biology but also radiation physics, radiation oncology, radiotherapy, radiochemistry, radiopharmacy, nuclear medicine, space radiation biology & physics, environmental and human radiation protection, nuclear emergency planning, molecular biology and bioinformatics, as well as the ethical, legal and social considerations related to radiobiology. This range of disciplines contributes to making radiobiology a broad and rather complex topic. This textbook is intended to provide a solid foundation to those interested in the basics and practice of radiobiological science. It is a learning resource, meeting the needs of students, scientists and medical staff with an interest in this rapidly evolving discipline, as well as a teaching tool, with accompanying teaching material to help educators.
Download or read book Microdosimetry and Its Applications written by H.H. Rossi and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 333 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microdosimetry and Its Applications is an advanced textbook presenting the fundamental concepts and numerical aspects of the absorption of energy by matter exposed to ionizing radiation. It is the only comprehensive work on the subject that can be considered definitive. It provides a deeper understanding of the initial phase of the interaction of ionizing radiation with matter, especially biological matter, and its consequences.
Download or read book The Cumulative Book Index written by and published by . This book was released on 1999 with total page 2520 pages. Available in PDF, EPUB and Kindle. Book excerpt:
