Download or read book Computational Agent based Modeling of Surgical Vocal Fold Injury and Repair written by Aman Garg and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "Voice disorders affect about one in ten adults at some point in their lifetime. Vocal fold scarring can result from surgical excision of benign and malignant vocal fold lesions. The elicited inflammation and healing response is complex and dynamic. It involves immune and repair cells (e.g., neutrophils, macrophages, fibroblasts) and molecules (e.g., inflammatory cytokines, damage-associated molecular pattern molecules) to locate damaged tissue, eliminate the necrotic cells and debris, and produce extracellular matrix substances for eventual tissue repair. A mechanistic understanding of the vocal fold injury and repair process will help in identifying the effective treatments for iatrogenic vocal fold scarring from surgery.The overall goal of this thesis was to develop computational agent-based models (ABM) that could numerically simulate the dynamics of major cellular and molecular components involved in surgical vocal fold injury and repair. The first research goal was to phenotype and enumerate immune and repair cells in surgically injured rat vocal folds up to 4 weeks after surgical injury. Viable cells were isolated from harvested vocal folds and were stained for cell surface markers specific to neutrophils, macrophages, endothelial cells and fibroblasts. Multi-parametric flow cytometry was then conducted to count the number of cells for each cell population in the vocal fold samples. The second research goal was to calibrate and validate existing agent-based models of vocal fold injury and repair (VF-ABM) with the flow cytometry data. Global sensitive analysis using Random Forests were first employed to identify the most influential model parameters on the outputs of cell numbers. The Robust Parameter Estimation (ROPE) algorithm from the package of Statistical Parameter Optimization Tool for Python (SPOTPY) was then used to calibrate VF-ABM for early time points from Day 1 to Day 5 of the flow cytometry data. Subsequently, VF-ABM were run 100 times to generate 95% confidence intervals for model evaluation. VF-ABM predicted outputs were considered accurate if the empirical data points were within the 95% confidence intervals of simulated outputs. Cell population quantities were calculated for Day 7, Week 2 and Week 4 respectively against the empirical flow cytometry data. Predicted cell populations reached 100% accuracy for Day 7. Although VF-ABM generated qualitative trends of cell population comparable to those of Weeks 2 and 4, the corresponding empirical data values fell outside of the 95% confidence intervals. Results from the flow cytometry study provided quantitative and time-dependent data on major cell populations involved in surgical vocal fold injury. Results from the model verification informed the area of improvements for the next generation of VF-ABM. This thesis contributes to the development of a computational tool that would better inform clinicians in prescribing treatments for patients with voice disorders." --

Download or read book Advanced HPC based Computational Modeling in Biomechanics and Systems Biology written by Mariano Vázquez and published by Frontiers Media SA. This book was released on 2019-04-04 with total page 449 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Download or read book ECAI 2020 written by G. De Giacomo and published by IOS Press. This book was released on 2020-09-11 with total page 3122 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the proceedings of the 24th European Conference on Artificial Intelligence (ECAI 2020), held in Santiago de Compostela, Spain, from 29 August to 8 September 2020. The conference was postponed from June, and much of it conducted online due to the COVID-19 restrictions. The conference is one of the principal occasions for researchers and practitioners of AI to meet and discuss the latest trends and challenges in all fields of AI and to demonstrate innovative applications and uses of advanced AI technology. The book also includes the proceedings of the 10th Conference on Prestigious Applications of Artificial Intelligence (PAIS 2020) held at the same time. A record number of more than 1,700 submissions was received for ECAI 2020, of which 1,443 were reviewed. Of these, 361 full-papers and 36 highlight papers were accepted (an acceptance rate of 25% for full-papers and 45% for highlight papers). The book is divided into three sections: ECAI full papers; ECAI highlight papers; and PAIS papers. The topics of these papers cover all aspects of AI, including Agent-based and Multi-agent Systems; Computational Intelligence; Constraints and Satisfiability; Games and Virtual Environments; Heuristic Search; Human Aspects in AI; Information Retrieval and Filtering; Knowledge Representation and Reasoning; Machine Learning; Multidisciplinary Topics and Applications; Natural Language Processing; Planning and Scheduling; Robotics; Safe, Explainable, and Trustworthy AI; Semantic Technologies; Uncertainty in AI; and Vision. The book will be of interest to all those whose work involves the use of AI technology.

Download or read book Computational Surgery and Dual Training written by Marc Garbey and published by Springer Science & Business Media. This book was released on 2009-12-16 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: The future of surgery is intrinsically linked to the future of computational sciences: the medical act will be computer assisted at every single step, from planning to post-surgery recovery and through the surgical procedure itself. Looking back at the history of surgery, surgery practice has changed drama- cally with the extensive use of revolutionary techniques, such as medical imaging, laparoscopy, endoscopy, sensors and actuators, and robots. This trend is dependent on the use of computer processing, computational method, and virtualization. Computational surgery will not only improve the ef?ciency and quality of surgery, but will also give new access to very complex operations that require extreme precision and minimum intrusion. Such examples are today’s inoperable cancer tumors that have invaded critical tissues or nervous centers. In order for this milestone to be reached quicker and more ef?ciently, surgeons will have to become very familiar with computing methods, such as image analysis, augmented re- ity, and/or robotics. It will be critical for surgeons to assimilate computers in their training, understand how computers work, understand the limitations/advantages of these computer tools, and be able to interpret computer imaging and simulations.

Download or read book Voice Quality written by John H. Esling and published by Cambridge University Press. This book was released on 2019-06-20 with total page 327 pages. Available in PDF, EPUB and Kindle. Book excerpt: Offers a new model of vocal tract articulation that explains laryngeal and oral voice quality, both auditorily and visually, through language examples and familiar voices.

Download or read book Vocal Fold Scar written by Jaime Eaglin Moore and published by . This book was released on 2016-05-13 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vocal fold scar remains one of the most demanding and, in some ways, frustrating challenges of laryngology and voice therapy. Treatments for this complex condition are inconsistent and often produce suboptimal results. Yet, while hopes for full recovery remain slim, surgical methods and improving technologies, along with improved therapy techniques, have combined to yield better and better outcomes; and further advances are on the horizon. In this new book, Moore, Sataloff, and Hawshaw have collaborated with world leaders in laryngology and speech-language pathology to compile the latest information on the pathophysiology of vocal fold scar, treatments, procedures and, importantly, look at the promising directions in research. The authors introduce the various causes and sequelae of scar, examine anatomy and pathophysiology, and take the reader through diagnostic procedures. Thereafter, they review preoperative therapy options and providing practical guidance on surgical methods including medialization, techniques for freeing the epithelium, management of sulcus, grafting, and the use of lasers. The book discusses tissue engineering and newer treatment options, including epidermal growth factor (EGF) and transforming growth factor-beta 1 (TGF- 1). The book summarizes the state of the art in diagnosis and treatment of vocal fold scar and should be valuable for any clinician who cares for the patient with this vexing problem."

Download or read book Global Sensitivity Analysis written by Andrea Saltelli and published by John Wiley & Sons. This book was released on 2008-02-28 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Complex mathematical and computational models are used in all areas of society and technology and yet model based science is increasingly contested or refuted, especially when models are applied to controversial themes in domains such as health, the environment or the economy. More stringent standards of proofs are demanded from model-based numbers, especially when these numbers represent potential financial losses, threats to human health or the state of the environment. Quantitative sensitivity analysis is generally agreed to be one such standard. Mathematical models are good at mapping assumptions into inferences. A modeller makes assumptions about laws pertaining to the system, about its status and a plethora of other, often arcane, system variables and internal model settings. To what extent can we rely on the model-based inference when most of these assumptions are fraught with uncertainties? Global Sensitivity Analysis offers an accessible treatment of such problems via quantitative sensitivity analysis, beginning with the first principles and guiding the reader through the full range of recommended practices with a rich set of solved exercises. The text explains the motivation for sensitivity analysis, reviews the required statistical concepts, and provides a guide to potential applications. The book: Provides a self-contained treatment of the subject, allowing readers to learn and practice global sensitivity analysis without further materials. Presents ways to frame the analysis, interpret its results, and avoid potential pitfalls. Features numerous exercises and solved problems to help illustrate the applications. Is authored by leading sensitivity analysis practitioners, combining a range of disciplinary backgrounds. Postgraduate students and practitioners in a wide range of subjects, including statistics, mathematics, engineering, physics, chemistry, environmental sciences, biology, toxicology, actuarial sciences, and econometrics will find much of use here. This book will prove equally valuable to engineers working on risk analysis and to financial analysts concerned with pricing and hedging.

Download or read book Vocal Fold Injection written by Byung-Joo Lee and published by Springer Nature. This book was released on 2021-09-07 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides step-by-step illustrated descriptions of diverse vocal fold injection techniques, including some not previously described. The aim is to provide laryngologists in general, and especially those who are less experienced, with the detailed understanding and guidance needed in order to achieve optimal outcomes. Highly experienced experts describe approaches via the transoral, transnasal, and transcutaneous routes and offer guidance on indications, injection materials, pre- and postoperative care, and the management of complications. Special considerations that must be borne in mind when employing different vocal fold injection techniques, in different settings, are also carefully explained. In offering comprehensive, up-to-date information on this minimally invasive and cost-effective procedure, Vocal Fold Injection will be an essential aid for practitioners.

Download or read book Index Medicus written by and published by . This book was released on 2004 with total page 1780 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.

Download or read book Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research written by National Research Council and published by National Academies Press. This book was released on 2003-08-22 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: Expanding on the National Research Council's Guide for the Care and Use of Laboratory Animals, this book deals specifically with mammals in neuroscience and behavioral research laboratories. It offers flexible guidelines for the care of these animals, and guidance on adapting these guidelines to various situations without hindering the research process. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research offers a more in-depth treatment of concerns specific to these disciplines than any previous guide on animal care and use. It treats on such important subjects as: The important role that the researcher and veterinarian play in developing animal protocols. Methods for assessing and ensuring an animal's well-being. General animal-care elements as they apply to neuroscience and behavioral research, and common animal welfare challenges this research can pose. The use of professional judgment and careful interpretation of regulations and guidelines to develop performance standards ensuring animal well-being and high-quality research. Guidelines for the Care and Use of Mammals in Neuroscience and Behavioral Research treats the development and evaluation of animal-use protocols as a decision-making process, not just a decision. To this end, it presents the most current, in-depth information about the best practices for animal care and use, as they pertain to the intricacies of neuroscience and behavioral research.

Download or read book Injection Laryngoplasty written by Giuseppe Bergamini and published by Springer. This book was released on 2015-10-20 with total page 103 pages. Available in PDF, EPUB and Kindle. Book excerpt: This well-illustrated book provides step-by-step guidance on the various techniques – microlaryngoscopic, fiberoptic endoscopic and transcutaneous – that can be employed for the purpose of injection laryngoplasty, a surgical procedure in which a foreign material is injected into the vocal fold. The anatomy and function of the region are first explained, with identification of the causes and means of evaluation of glottic and neoglottic insufficiency. Advice is then provided on the choice of material for injection laryngoplasty, including absorbable and long-lasting options, on the basis of careful analysis that takes into account both the recent literature and the authors’ own experiences. Detailed descriptions of the surgical indications and different procedures follow and for ease of reference, clear flow charts on diagnosis and indications are also included. The book concludes with chapters on the use of injection laryngoplasty specifically in the pediatric population and on postoperative care and speech therapy following the procedure. Injection Laryngoplasty will provide valuable assistance to all surgeons wishing to perform this kind of surgery.

Download or read book Converging Technologies for Improving Human Performance written by Mihail C. Roco and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 477 pages. Available in PDF, EPUB and Kindle. Book excerpt: M. C. Roco and W.S. Bainbridge In the early decades of the 21st century, concentrated efforts can unify science based on the unity of nature, thereby advancing the combination of nanotechnology, biotechnology, information technology, and new technologies based in cognitive science. With proper attention to ethical issues and societal needs, converging in human abilities, societal technologies could achieve a tremendous improvement outcomes, the nation's productivity, and the quality of life. This is a broad, cross cutting, emerging and timely opportunity of interest to individuals, society and humanity in the long term. The phrase "convergent technologies" refers to the synergistic combination of four major "NBIC" (nano-bio-info-cogno) provinces of science and technology, each of which is currently progressing at a rapid rate: (a) nanoscience and nanotechnology; (b) biotechnology and biomedicine, including genetic engineering; (c) information technology, including advanced computing and communications; (d) cognitive science, including cognitive neuroscience. Timely and Broad Opportunity. Convergence of diverse technologies is based on material unity at the nanoscale and on technology integration from that scale.

Download or read book Oral and Maxillofacial Surgery for the Clinician written by Krishnamurthy Bonanthaya and published by Springer Nature. This book was released on 2021 with total page 1965 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is an open access book with CC BY 4.0 license. This comprehensive open access textbook provides a comprehensive coverage of principles and practice of oral and maxillofacial surgery. With a range of topics starting from routine dentoalveolar surgery to advanced and complex surgical procedures, this volume is a meaningful combination of text and illustrations including clinical photos, radiographs, and videos. It provides guidance on evidence-based practices in context to existing protocols, guidelines and recommendations to help readers deal with most clinical scenarios in their daily surgical work. This multidisciplinary textbook is meant for postgraduate trainees, young practicing oral surgeons and experienced clinicians, as well as those preparing for university and board certification exams. It also aids in decision-making, the implementation of treatment plans and the management of complications that may arise. This book is an initiative of Association of Oral and Maxillofacial Surgeons of India (AOMSI) to its commitment to academic medicine. As part of this commitment, this textbook is in open access to help ensure widest possible dissemination to readers across the world. ; Open access Unique presentation with contents divided into color-coded core competency gradations Covers all aspects of oral and maxillofacial surgery Supplemented with videos of all commonly carried out procedures as operative video Every chapter or topic concludes with "future perspective" and addresses cutting edge advances in each area Every topic has a pull out box that provides the most relevant systematic reviews/ key articles to every topic.

Download or read book Smoking and Health written by United States. Surgeon General's Advisory Committee on Smoking and Health and published by . This book was released on 1964 with total page 406 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Enabling America written by Institute of Medicine and published by National Academies Press. This book was released on 1997-11-24 with total page 423 pages. Available in PDF, EPUB and Kindle. Book excerpt: The most recent high-profile advocate for Americans with disabilities, actor Christopher Reeve, has highlighted for the public the economic and social costs of disability and the importance of rehabilitation. Enabling America is a major analysis of the field of rehabilitation science and engineering. The book explains how to achieve recognition for this evolving field of study, how to set priorities, and how to improve the organization and administration of the numerous federal research programs in this area. The committee introduces the "enabling-disability process" model, which enhances the concepts of disability and rehabilitation, and reviews what is known and what research priorities are emerging in the areas of: Pathology and impairment, including differences between children and adults. Functional limitationsâ€"in a person's ability to eat or walk, for example. Disability as the interaction between a person's pathologies, impairments, and functional limitations and the surrounding physical and social environments. This landmark volume will be of special interest to anyone involved in rehabilitation science and engineering: federal policymakers, rehabilitation practitioners and administrators, researchers, and advocates for persons with disabilities.

Download or read book Voice Disorders and their Management written by Margaret Fawcus and published by Springer. This book was released on 2013-11-11 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since this book was first published, four years ago, there has been a considerable upsurge of interest in the field of both normal and abnormal voice production. Tangible evidence of this lies in the publication of the Journal of Voice in the United States, and in the UK the formation of the British Voice Association. This organization has attracted an increasing membership from professionals involved in all aspects of voice care and use - actors and singers, laryngologists and speech therapists, teachers and phoneticians. The Association holds regular study days, holds an annual two-day symposium, and publishes a Newsletter which attracts entries from this broad spectrum of professionals. We have also seen an increase in the number of specialist voice clinics, and in the two final chapters in this book a contrast is presented between such a specialist setting and the more typical clinic that operates in the majority of general hospitals. This last chapter now contains a breakdown of voice referrals over an eight-year period, which must represent a unique published study in this country. There still remains, however, little research into the management of voice disorders. There is clearly a need for more efficacy studies into specific treatment methods, and the single case-study designs developed in the field of aphasia would seem to be appropriate here.

Download or read book Reproductomics written by José A. Horcajadas and published by Academic Press. This book was released on 2018-07-23 with total page 425 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent advances in genomic and omics analysis have triggered a revolution affecting nearly every field of medicine, including reproductive medicine, obstetrics, gynecology, andrology, and infertility treatment. Reproductomics: The –Omics Revolution and Its Impact on Human Reproductive Medicine demonstrates how various omics technologies are already aiding fertility specialists and clinicians in characterizing patients, counseling couples towards pregnancy success, informing embryo selection, and supporting many other positive outcomes. A diverse range of chapters from international experts examine the complex relationship between genomics, transcriptomics, proteomics, and metabolomics and their role in human reproduction, identifying molecular factors of clinical significance. With this book Editors Jaime Gosálvez and José A. Horcajadas have provided researchers and clinicians with a strong foundation for a new era of personalized reproductive medicine. Thoroughly discusses how genomics and other omics approaches aid clinicians in various areas of reproductive medicine Identifies specific genomic and molecular factors of translational value in treating infertility and analyzing patient data Features chapter contributions by leading international experts