Download or read book Liver Disease in Children written by Frederick J. Suchy and published by Cambridge University Press. This book was released on 2021-03-18 with total page 875 pages. Available in PDF, EPUB and Kindle. Book excerpt: Liver disease in children is increasing in prevalence, placing a huge burden on healthcare systems and often requiring long-term management. Offering an integrative approach to the science and clinical practice of pediatric hepatology, this is the definitive reference text for improved diagnosis and treatment strategies. In the new edition of this authoritative text, chapters have been thoroughly revised in line with major advances in the field, such as recognizing the increased frequency of fatty liver disease, and how genetic testing has the potential to establish earlier diagnoses for a variety of diseases. Disorders covered include cholestasis, metabolic disorders and hepatitis, with their presentation across the spectrum of infancy, childhood and adolescence discussed. The indications and surgical aspects of liver transplant are explained and post-transplant care is described in detail. This is a valuable resource for pediatricians, hepatologists, gastroenterologists and all clinicians involved in the care of children with liver diseases.

Download or read book High Resolution Imaging in Microscopy and Ophthalmology written by Josef F. Bille and published by Springer. This book was released on 2019-08-13 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book provides a comprehensive overview of the application of the newest laser and microscope/ophthalmoscope technology in the field of high resolution imaging in microscopy and ophthalmology. Starting by describing High-Resolution 3D Light Microscopy with STED and RESOLFT, the book goes on to cover retinal and anterior segment imaging and image-guided treatment and also discusses the development of adaptive optics in vision science and ophthalmology. Using an interdisciplinary approach, the reader will learn about the latest developments and most up to date technology in the field and how these translate to a medical setting. High Resolution Imaging in Microscopy and Ophthalmology – New Frontiers in Biomedical Optics has been written by leading experts in the field and offers insights on engineering, biology, and medicine, thus being a valuable addition for scientists, engineers, and clinicians with technical and medical interest who would like to understand the equipment, the applications and the medical/biological background. Lastly, this book is dedicated to the memory of Dr. Gerhard Zinser, co-founder of Heidelberg Engineering GmbH, a scientist, a husband, a brother, a colleague, and a friend.

Download or read book The Extracellular Matrix an Overview written by Robert Mecham and published by Springer Science & Business Media. This book was released on 2011-02-16 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: Knowledge of the extracellular matrix (ECM) is essential to understand cellular differentiation, tissue development, and tissue remodeling. This volume of the series “Biology of Extracellular Matrix” provides a timely overview of the structure, regulation, and function of the major macromolecules that make up the extracellular matrix. It covers topics such as collagen types and assembly of collagen-containing suprastructures, basement membrane, fibronectin and other cell-adhesive glycoproteins, proteoglycans, microfibrils, elastin, fibulins and matricellular proteins, such as thrombospondin. It also explores the concept that ECM components together with their cell surface receptors can be viewed as intricate nano-devices that allow cells to physically organize their 3-D-environment. Further, the role of the ECM in human disease and pathogenesis is discussed as well as the use of model organisms in elucidating ECM function.

Download or read book Mechanics of Biological Systems written by Seungman Park and published by Morgan & Claypool Publishers. This book was released on 2019-11-06 with total page 135 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is an introduction to the mechanical properties, the force generating capacity, and the sensitivity to mechanical cues of the biological system. To understand how these qualities govern many essential biological processes, we also discuss how to measure them. However, before delving into the details and the techniques, we will first learn the operational definitions in mechanics, such as force, stress, elasticity, viscosity and so on. This book will explore the mechanics at three different length scales – molecular, cellular, and tissue levels – sequentially, and discuss the measurement techniques to quantify the intrinsic mechanical properties, force generating capacity, mechanoresponsive processes in the biological systems, and rupture forces.

Download or read book Functional Tissue Engineering written by Farshid Guilak and published by Springer Science & Business Media. This book was released on 2003-07-09 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: -Softcover reprint of a successful hardcover reference (370 copies sold) -Price to be accessible to the rapidly increasing population of students and investigators in the field of tissue engineering -Chapters written by well-known researchers discuss issues in functional tissue engineering as well as provide guidelines and a summary of the current state of technology

Download or read book Material Parameter Identification and Inverse Problems in Soft Tissue Biomechanics written by Stéphane Avril and published by Springer. This book was released on 2016-10-12 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt: The articles in this book review hybrid experimental-computational methods applied to soft tissues which have been developed by worldwide specialists in the field. People developing computational models of soft tissues and organs will find solutions for calibrating the material parameters of their models; people performing tests on soft tissues will learn what to extract from the data and how to use these data for their models and people worried about the complexity of the biomechanical behavior of soft tissues will find relevant approaches to address this complexity.

Download or read book Mechanotransduction written by and published by Academic Press. This book was released on 2014-07-29 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: Progress in Molecular Biology and Translational Science provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology. It contains contributions from leaders in their fields and abundant references. Volume 126 features in-depth reviews that focus on the tools required to investigate mechanotransduction. Additional chapters focus on how we can use these tools to answer fundamental questions about the interaction of physical forces with cell biology, morphogenesis, and function of mature structures. Chapters in the volume are authored by a unique combination of cell biologists and engineers, providing a range of perspectives on mechanotransduction. - Provides a unique combination of perspectives from biologists and engineers - Engaging to people of many training backgrounds

Download or read book NASH and Systemic Complications written by Ronit Shiri-Sverdlov and published by Mdpi AG. This book was released on 2022-01-28 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nonalcoholic fatty liver disease (NAFLD) is known as the hepatic manifestation of the metabolic syndrome, and while most patients develop simple steatosis, up to one-third can develop nonalcoholic steatohepatitis (NASH). NASH is a chronic inflammatory condition of the liver that can further progress to fibrosis and cirrhosis, which may eventually lead to liver failure and death. While we have increased our mechanistic knowledge regarding the pathogenesis of NASH within the last decade, treatment options are still limited and liver biopsies have remained the gold standard for diagnosis. To achieve major clinical breakthroughs for NASH patients, it is not sufficient to use a single animal model, since each model has specific limitations. Furthermore, we should rely more on alternative models such as organ-on-a-chip, which will enable us to explore unknown aspects of disease pathogenesis much faster and serve as clinically relevant surrogates for murine models. Another important direction for the improvement of patient health is to pay more attention to extrahepatic, organ-specific and systemic effects, which are associated with NASH. The articles in this Special Issue include an up-to-date overview of the rapidly developing technologies, novel targets for intervention and insights in the field in NASH. Additionally, these articles describe the major challenges in the field, strategies to overcome them and suggestions for future directions. To improve patient's outcome, clinicians, as well as scientists with biomedical, nutrition, physics and mathematics backgrounds, should join forces. Although challenges remain, the future of the field seems promising as these novel technologies and developments are expected to lead to progress in NASH.

Download or read book Pediatric Hepatology and Liver Transplantation written by Lorenzo D'Antiga and published by Springer. This book was released on 2019-04-29 with total page 829 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the first to provide balanced examination of both pediatric liver disease and liver transplantation – two topics that are inherently related, given that most chronic liver disorders eventually require organ replacement. The different forms of liver disease encountered in the pediatric age group are first discussed in a series of disease-specific chapters that have a reader-friendly, uniform structure covering pathophysiology, diagnostic and treatment algorithms, clinical cases, and transition to adult care. Key topics in the field of liver transplantation are then addressed. Examples include indications and contraindications, surgical techniques and complications, immunosuppression, in pediatric liver transplantation, acute and chronic rejection and allograft dysfunction, and CMV and EBV infection in transplant recipients, long-term graft injury and tolerance. A section on pediatric hepatology across the world includes chapters presenting the features and management of pediatric liver disease in South-America, Africa and Asia. A closing section considers what the future holds for pediatric liver disease and its management, including novel genetic testing, cell therapy and gene therapy. Pediatric Hepatology and Liver Transplantation will be of value for a range of practitioners, from residents making their first approach to pediatric liver disease through to specialists working in transplantation centers.

Download or read book Mathematical Cardiac Electrophysiology written by Piero Colli Franzone and published by Springer. This book was released on 2014-10-30 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the main mathematical and numerical models in computational electrocardiology, ranging from microscopic membrane models of cardiac ionic channels to macroscopic bidomain, monodomain, eikonal models and cardiac source representations. These advanced multiscale and nonlinear models describe the cardiac bioelectrical activity from the cell level to the body surface and are employed in both the direct and inverse problems of electrocardiology. The book also covers advanced numerical techniques needed to efficiently carry out large-scale cardiac simulations, including time and space discretizations, decoupling and operator splitting techniques, parallel finite element solvers. These techniques are employed in 3D cardiac simulations illustrating the excitation mechanisms, the anisotropic effects on excitation and repolarization wavefronts, the morphology of electrograms in normal and pathological tissue and some reentry phenomena. The overall aim of the book is to present rigorously the mathematical and numerical foundations of computational electrocardiology, illustrating the current research developments in this fast-growing field lying at the intersection of mathematical physiology, bioengineering and computational biomedicine. This book is addressed to graduate student and researchers in the field of applied mathematics, scientific computing, bioengineering, electrophysiology and cardiology.

Download or read book LED Based Photoacoustic Imaging written by Mithun Kuniyil Ajith Singh and published by Springer Nature. This book was released on 2020-04-07 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights the use of LEDs in biomedical photoacoustic imaging. In chapters written by key opinion leaders in the field, it covers a broad range of topics, including fundamentals, principles, instrumentation, image reconstruction and data/image processing methods, preclinical and clinical applications of LED-based photoacoustic imaging. Apart from preclinical imaging studies and early clinical pilot studies using LED-based photoacoustics, the book includes a chapter exploring the opportunities and challenges of clinical translation from an industry perspective. Given its scope, the book will appeal to scientists and engineers in academia and industry, as well as medical experts interested in the clinical applications of photoacoustic imaging.

Download or read book Normal and Pathological Anatomy of the Shoulder written by Gregory I. Bain and published by Springer. This book was released on 2015-05-05 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: ​This cutting-edge monograph on advanced clinical anatomy and pathoanatomy of the shoulder, written by the world’s leading authors, reflects recent significant advances in understanding of anatomy and pathology. It is beautifully illustrated with exquisite photographs of anatomical specimens, and images from arthroscopy, histology, and radiology complete the picture. The accompanying text brings out the clinical, biomechanical, and functional relevance and focuses on aspects important to the high-performance athlete. In addition, the book closely assesses how each component of the normal anatomy responds to trauma, disease, and degeneration. The finer points of the pathoanatomy are demonstrated with clinical cases, histology, radiology, arthroscopy, and open surgery. The text details how the pathoanatomy affects the patient presentation, clinical examination, and imaging. It is also explained how the pathology affects the natural history and the outcome of physical therapy and influences recommendations for surgical treatments. This book will be of immense value both to trainees and to specialists who manage disorders of the shoulder, including orthopedic surgeons, sports physicians, and physiotherapists. It will also be of great interest to anatomists and pathologists.

Download or read book Viscoelastic Solids 1998 written by Roderic S. Lakes and published by CRC Press. This book was released on 2017-11-22 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: Viscoelastic Solids covers the mathematical theory of viscoelasticity and physical insights, causal mechanisms, and practical applications. The book: presents a development of the theory, addressing both transient and dynamic aspects as well as emphasizing linear viscoelasticity synthesizes the structure of the theory with the aim of developing physical insight illustrates the methods for the solution of stress analysis problems in viscoelastic objects explores experimental methods for the characterization of viscoelastic materials describes the phenomenology of viscoelasticity in a variety of materials, including polymers, metals, high damping alloys, rock, piezoelectric materials, cellular solids, dense composite materials, and biological materials analyzes high damping and extremely low damping provides the theory of viscoelastic composite materials, including examples of various types of structure and the relationships between structure and mechanical properties contains examples on the use of viscoelastic materials in preventing and alleviating human suffering Viscoelastic Solids also demonstrates the use of viscoelasticity for diverse applications, such as earplugs, gaskets, computer disks, satellite stability, medical diagnosis, injury prevention, vibration abatement, tire performance, sports, spacecraft explosions, and music.

Download or read book Vascular Liver Disease written by Laurie D. DeLeve and published by Springer Science & Business Media. This book was released on 2011-03-23 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vascular Liver Disease: Mechanisms and Management covers all of the disease entities that stem from abnormalities that affect the hepatic vasculature. This multi-authored text includes the mechanisms and management of intrahepatic vascular disease, including the most common cause of vascular disease of the liver, cirrhosis. Other less common diseases of the liver vasculature are also covered such as sinusoidal obstruction syndrome (previously known as veno-occlusive disease), portal vein thrombosis, the Budd-Chiari syndrome and congenital vascular malformations. These entities, although rare, are a challenge to physicians and physician scientists. Although many textbooks have been written on the consequences of cirrhosis on the liver vasculature, this is the only volume that focuses on the liver vasculature as a separate entity, providing an innovative approach to liver disease management. Vascular Liver Disease: Mechanisms and Management will be of great value to clinical investigators and basic scientists interested in the liver circulation as well as clinical gastroenterologists and hepatologists, hepatobiliary surgeons and transplant surgeons, and to interventional radiologists with a particular interest in the liver.

Download or read book Cardiovascular Mechanics written by Michel R. Labrosse and published by CRC Press. This book was released on 2018-09-13 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: The objective of this book is to illustrate in specific detail how cardiovascular mechanics stands as a common pillar supporting such different clinical successes as drugs for high blood pressure, prosthetic heart valves and coronary artery bypass grafting, among others. This information is conveyed through a comprehensive treatment of the overarching principles and theories that are behind mechanobiological processes, aortic and arterial mechanics, atherosclerosis, blood and microcirculation, hear valve mechanics, as well as medical devices and drugs. Examines all major theoretical and practical aspects of mechanical forces related to the cardiovascular system. Discusses a unique coverage of mechanical changes related to an aging cardiovascular system. Provides an overview of experimental methods in cardiovascular mechanics. Written by world-class researchers from Canada, the US and EU. Extensive references are provided at the end of each chapter to enhance further study. Michel R. Labrosse is the founder of the Cardiovascular Mechanics Laboratory at the University of Ottawa, where he is a full professor within the Department of Mechanical Engineering. He has been an active researcher in academia along with being heavily associated with the University of Ottawa Heart Institute. He has authored or co-authored over 90 refereed communications, and supervised or co-supervised over 40 graduate students and post-docs.

Download or read book Handbook of Biomaterial Properties written by William Murphy and published by Springer. This book was released on 2016-06-11 with total page 676 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides tabular and text data relating to normal and diseased tissue materials and materials used in medical devices. Comprehensive and practical for students, researchers, engineers, and practicing physicians who use implants, this book considers the materials aspects of both implantable materials and natural tissues and fluids. Examples of materials and topics covered include titanium, elastomers, degradable biomaterials, composites, scaffold materials for tissue engineering, dental implants, sterilization effects on material properties, metallic alloys, and much more. Each chapter author considers the intrinsic and interactive properties of biomaterials, as well as their appropriate applications and historical contexts. Now in an updated second edition, this book also contains two new chapters on the cornea and on vocal folds, as well as updated insights, data, and citations for several chapters.

Download or read book Muscle Foods written by Burdette C. Breidenstein and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 585 pages. Available in PDF, EPUB and Kindle. Book excerpt: Traditionally, in the food industry, there has been a distinction made among meat, poultry, seafood, and game. Meat has historically been defined as the edible flesh of animals. This basically referred only to the red meats, namely, beef, lamb, pork, and veal, including both fresh and processed products as well as variety or glandular meats. It has been recognized more recently that all foods derived from muscle, or muscle foods, have basically the same or similar characteristics in physical and chemical properties. Tberefore, it is logical to exarnine and consider all muscle foods under one cover. Tbis book, therefore, is an attempt to address the various attributes of red meat, poultry, fish, and game under the single heading of muscle foods and to note any differences where they might OCCUT. It is of interest that of the 10 top V. S. meat companies in 1990, 8 of them were dealing with poultry as well as red meats and that 4 of the 10 were also involved with seafoods. Tbis lends impetus to the inclusion of all three in a book such as this. Furthermore, the rapid increase in consumption of poultry meat to approximately 30 kg (65 pounds) per capita and seafoods to 7 kg (16 pounds) per capita compared to beef at 34 kg (75 pounds) and pork at 30 kg (65 pounds), whereas veal and lamb/mutton represent only 0.