Download or read book Angiogenesis Assays written by Carolyn A. Staton and published by John Wiley & Sons. This book was released on 2007-01-11 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: Angiogenesis, the development of new blood vessels from the existing vasculature, is essential for physiological growth and over 18,000 research articles have been published describing the role of angiogenesis in over 70 different diseases, including cancer, diabetic retinopathy, rheumatoid arthritis and psoriasis. One of the most important technical challenges in such studies has been finding suitable methods for assessing the effects of regulators of eh angiogenic response. While increasing numbers of angiogenesis assays are being described both in vitro and in vivo, it is often still necessary to use a combination of assays to identify the cellular and molecular events in angiogenesis and the full range of effects of a given test protein. Although the endothelial cell - its migration, proliferation, differentiation and structural rearrangement - is central to the angiogenic process, it is not the only cell type involved. the supporting cells, the extracellular matrix and the circulating blood with its cellular and humoral components also contribute. In this book, experts in the use of a diverse range of assays outline key components of these and give a critical appraisal of their strengths and weaknesses. Examples include assays for the proliferation, migration and differentiation of endothelial cells in vitro, vessel outgrowth from organ cultures, assessment of endothelial and mural cell interactions, and such in vivo assays as the chick chorioallantoic membrane, zebrafish, corneal, chamber and tumour angiogenesis models. These are followed by a critical analysis of the biological end-points currently being used in clinical trials to assess the clinical efficacy of anti-angiogenic drugs, which leads into a discussion of the direction future studies should take. This valuable book is of interest to research scientists currently working on angiogenesis in both the academic community and in the biotechnology and pharmaceutical industries. Relevant disciplines include cell and molecular biology, oncology, cardiovascular research, biotechnology, pharmacology, pathology and physiology.

Download or read book Advances in Solid State Fermentation written by S. Roussos and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 641 pages. Available in PDF, EPUB and Kindle. Book excerpt: G.HAINNAUX Departement Milieu et Activites Agricoles, Centre ORSTOM, 911 Avenue d' Agropolis, B.P. 5045, 34032 Montpellier Cedex , France. Solid state fermentation, popularly abbreviated as SSF, is currently investigated by many groups throughout the world. The study of this technique was largely neglected in the past in European and Western countries and there is now a high demand for SSF, meaning in food, environment, agricultural, phannaceutical and many other biotechnological applications. It gives me satisfaction to note that the importance of this technique was realised at my department way back in 1975 since then, our team has put concentrated efforts on developing this technique. xvii Foreword Advances in Solid State Fermentation Foreword M. PUYGRENIER Agropolis Valorisation, Avenue d' Agropolis, 34394 Montpellier Cedex 5, France. On the name of the Scientific Community, I would like to express the wish that this International Symposium on SSF should be successful. Solid State Fermentation is part of biotechnology research. It consists on seeding solid culture medium with bacteria or fungi (filamentous or higher) and on producing, in this medium (solid components and exudates) metabolites and high value products. In fact, this process is very old. In older industries such the food and agricultural, this technique has been extensively used. An example of this is the production of pork sausages and Roquefort cheese. Pharmaceutical industry could make extensive use of SSF in the production of secondary metabolites of many kinds and development in this direction is soon expected.

Download or read book Concepts and Principles of Pharmacology written by James E. Barrett and published by Springer Nature. This book was released on 2019-12-24 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: Celebrating 100 years of HEP, this volume will discuss key pharmacological discoveries and concepts of the past 100 years. These discoveries have dramatically changed the medical treatment paradigms of many diseases and these concepts have and will continue to shape discovery of new medicinies. Newly evolving technologies will similarly be discussed as they will shape the future of the pharmacology and, accordingly, medical therapy.

Download or read book The Social Biology of Microbial Communities written by Institute of Medicine and published by National Academies Press. This book was released on 2013-01-10 with total page 633 pages. Available in PDF, EPUB and Kindle. Book excerpt: Beginning with the germ theory of disease in the 19th century and extending through most of the 20th century, microbes were believed to live their lives as solitary, unicellular, disease-causing organisms . This perception stemmed from the focus of most investigators on organisms that could be grown in the laboratory as cellular monocultures, often dispersed in liquid, and under ambient conditions of temperature, lighting, and humidity. Most such inquiries were designed to identify microbial pathogens by satisfying Koch's postulates.3 This pathogen-centric approach to the study of microorganisms produced a metaphorical "war" against these microbial invaders waged with antibiotic therapies, while simultaneously obscuring the dynamic relationships that exist among and between host organisms and their associated microorganisms-only a tiny fraction of which act as pathogens. Despite their obvious importance, very little is actually known about the processes and factors that influence the assembly, function, and stability of microbial communities. Gaining this knowledge will require a seismic shift away from the study of individual microbes in isolation to inquiries into the nature of diverse and often complex microbial communities, the forces that shape them, and their relationships with other communities and organisms, including their multicellular hosts. On March 6 and 7, 2012, the Institute of Medicine's (IOM's) Forum on Microbial Threats hosted a public workshop to explore the emerging science of the "social biology" of microbial communities. Workshop presentations and discussions embraced a wide spectrum of topics, experimental systems, and theoretical perspectives representative of the current, multifaceted exploration of the microbial frontier. Participants discussed ecological, evolutionary, and genetic factors contributing to the assembly, function, and stability of microbial communities; how microbial communities adapt and respond to environmental stimuli; theoretical and experimental approaches to advance this nascent field; and potential applications of knowledge gained from the study of microbial communities for the improvement of human, animal, plant, and ecosystem health and toward a deeper understanding of microbial diversity and evolution. The Social Biology of Microbial Communities: Workshop Summary further explains the happenings of the workshop.

Download or read book Exploration of the Seas written by National Research Council and published by National Academies Press. This book was released on 2003-11-04 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the summer of 1803, Thomas Jefferson sent Meriwether Lewis and William Clark on a journey to establish an American presence in a land of unqualified natural resources and riches. Is it fitting that, on the 200th anniversary of that expedition, the United States, together with international partners, should embark on another journey of exploration in a vastly more extensive region of remarkable potential for discovery. Although the oceans cover more than 70 percent of our planet's surface, much of the ocean has been investigated in only a cursory sense, and many areas have not been investigated at all. Exploration of the Seas assesses the feasibility and potential value of implementing a major, coordinated, international program of ocean exploration and discovery. The study committee surveys national and international ocean programs and strategies for cooperation between governments, institutions, and ocean scientists and explorers, identifying strengths, weaknesses, and gaps in these activities. Based primarily on existing documents, the committee summarizes priority areas for ocean research and exploration and examines existing plans for advancing ocean exploration and knowledge.

Download or read book Microbes The Foundation Stone of the Biosphere written by Christon J. Hurst and published by Springer Nature. This book was released on 2021-05-01 with total page 684 pages. Available in PDF, EPUB and Kindle. Book excerpt: This collection of essays discusses fascinating aspects of the concept that microbes are at the root of all ecosystems. The content is divided into seven parts, the first of those emphasizes that microbes not only were the starting point, but sustain the rest of the biosphere and shows how life evolves through a perpetual struggle for habitats and niches. Part II explains the ways in which microbial life persists in some of the most extreme environments, while Part III presents our understanding of the core aspects of microbial metabolism. Part IV examines the duality of the microbial world, acknowledging that life exists as a balance between certain processes that we perceive as being environmentally supportive and others that seem environmentally destructive. In turn, Part V discusses basic aspects of microbial symbioses, including interactions with other microorganisms, plants and animals. The concept of microbial symbiosis as a driving force in evolution is covered in Part VI. In closing, Part VII explores the adventure of microbiological research, including some reminiscences from and perspectives on the lives and careers of microbe hunters. Given its mixture of science and philosophy, the book will appeal to scientists and advanced students of microbiology, evolution and ecology alike.

Download or read book Handbook of Food Preservation written by M. Shafiur Rahman and published by CRC Press. This book was released on 2007-07-16 with total page 1088 pages. Available in PDF, EPUB and Kindle. Book excerpt: The processing of food is no longer simple or straightforward, but is now a highly inter-disciplinary science. A number of new techniques have developed to extend shelf-life, minimize risk, protect the environment, and improve functional, sensory, and nutritional properties. The ever-increasing number of food products and preservation techniques cr

Download or read book Ecology of Harmful Algae written by E. Granéli and published by Springer Science & Business Media. This book was released on 2007-10-04 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: Harmful algal can cause a variety of deleterious effects, including the poisoning of fish and shellfish, habitat disruptions for many organisms, water discoloration, beach fouling, and even toxic effects for humans. In this volume, international experts provide an in-depth analysis of harmful algae topics and offer a comprehensive synthesis of the latest research in the field.

Download or read book An Introduction to Phytoplanktons Diversity and Ecology written by Ruma Pal and published by Springer. This book was released on 2014-05-16 with total page 175 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book , ‘An Introduction to Phytoplanktons - Diversity and Ecology’ is very useful as it covers wide aspects of phytoplankton study including the general idea about cyanobacteria and algal kingdom. It contains different topics related to very basic idea of phytoplanktons such as, types ,taxonomic description and the key for identification etc. Together with it, very modern aspects of phytoplankton study including different methodologies needed for research students of botany, ecology, limnology and environmental biology are also included. The first chapter is very basic and informative and describes algal and phytoplankton classification, algal pigments, algal bloom and their control, algal toxins, wetlands algae, ecological significance of phytoplanktons etc. A general key for identification of common phytoplankton genera is also included for students who will be able to identify these genera based on the light microscopic characters. In Chapters 2-4, different aspects of phytoplankton research like primary productivity, community pattern analysis and their ecological parameter analysis have been discussed with detailed procedures. Statistical analysis is also discussed in detail. Chapter 5 includes case studies related to review, phytoplankton diversity and dynamics.

Download or read book Bioenergetic Processes of Cyanobacteria written by Guenter A. Peschek and published by Springer Science & Business Media. This book was released on 2011-05-26 with total page 733 pages. Available in PDF, EPUB and Kindle. Book excerpt: This publication is unique among a number of books on cyanobacteria because it focuses on the bioenergetics of these widespread organisms which are the evolutionary prerequisite for the development of all higher forms of life on our "blue" planet. The book primarily addresses questions of energy conversion by the fundamental bioenergetic processes: (oxygenic) photosynthesis, (aerobic) respiration, and (anaerobic) fermentation which uniquely occur together in these prokaryotic cells. Thermophilic cyanobacteria offer the most suitable material for high resolution structure analyses of Photosystem I and II and other electron transport complexes by X-ray crystallography (for example, at present the structure of Photosystem II at atomic resolution is only known for these organisms). These achievements during the last decade represent a milestone in our understanding of the complexes which are crucial for solar energy exploitation through photosynthetic water splitting. The present work represents an ambitious attempt to achieve the goal of a synoptic state-of-the-art picture by casting together the mosaics of detailed knowledge described by leading experts in the field. It contains 24 chapters written by 35 authors from Europe, USA, India and Japan. The book is aimed at reaching a broad audience ranging from students to experienced scientists. The editors wish all readers a pleasant and stimulating journey through the fascinating “world” of the bioenergetics of cyanobacteria and sincerely hope that this book will not only be of great value for the experts but also entice young people into this exciting research area with the aim to address successfully the challenging problems of high relevance that are still waiting for a satisfactory answer.

Download or read book Minimal Selfhood and the Origins of Consciousness written by Rupert Glasgow and published by BoD – Books on Demand. This book was released on 2018-07-10 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Minimal Selfhood and the Origins of Consciousness, R.D.V. Glasgow seeks to ground the logical roots of consciousness in what he has previously called the 'minimal self'. The idea is that elementary forms of consciousness are logically dependent not, as is commonly assumed, on ownership of an anatomical brain or nervous system, but on the intrinsic reflexivity that defines minimal selfhood. The aim of the book is to trace the logical pathway by which minimal selfhood gives rise to the possible appearance of consciousness. It is argued that in specific circumstances it thus makes sense to ascribe elementary consciousness to certain predatory single-celled organisms such as amoebae and dinoflagellates as well as to some of the simpler animals. Such an argument involves establishing exactly what those specific circumstances are and determining how elementary consciousness differs in nature and scope from its more complex manifestations.

Download or read book Environmental Technologies to Treat Nitrogen Pollution written by Francisco J. Cervantes and published by IWA Publishing. This book was released on 2009-06-30 with total page 449 pages. Available in PDF, EPUB and Kindle. Book excerpt: Environmental Technologies to Treat Nitrogen Pollution provides a thorough understanding of the principles and applications of environmental technologies to treat nitrogen contamination. The main focus is on water and wastewater treatment, with additional coverage of leachates and off-gasses. The book brings together an up-to-date compilation of the main physical, chemical and biological processes demanded for the removal of nitrogenous contaminants from water, wastewater, leachates and off-gasses. It includes a series of chapters providing a deep and broad knowledge of the principles and applications required for the treatment of nitrogen pollution. Each chapter has been prepared by recognized specialists across the range of different aspects involved in the removal of nitrogenous contaminants from industrial discharges. Environmental Technologies to Treat Nitrogen Pollution is the first book to provide a complete review of all the different processes used for the global management of nitrogen pollution. It also contains updated information about strategies to achieve nitrogen recovery and reuse in different industrial sectors. Several case studies document the application of different environmental technologies to manage nitrogen pollution. This book will be of interest to lecturers and graduate students in the following subject areas: Environmental Engineering, Environmental Biotechnology, wastewater treatment plant design, water pollution control, contaminants recovery and reuse. The book will also be an attractive reference for environmental engineering consultants.

Download or read book Drug Discovery and Evaluation written by Hans G. Vogel and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 790 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference book contains a comprehensive selection of the most frequently used assays for reliably detecting pharmacological effects of potential drugs, including tests for cardiovascular, analgesic, psychotropic, metabolic, endocrine, respiratory, renal, and immunomodulatory activities. Each of the over 700 assays comprises a detailed protocol with the purpose and rationale of the method, a description of the experimental procedure, a critical assessment of the results and their pharmacological and clinical relevance, and pertinent references. Identification of specific tests is facilitated by the enclosed CD-ROM which allows for a quick and full text research. An appendix with guidelines and legal regulations for animal experiments in various countries will help to plan these experiments properly in accordance with the welfare of laboratory animals.

Download or read book Life in Extreme Environments written by Ricardo Amils Pibernat and published by Springer Science & Business Media. This book was released on 2007-07-21 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an intriguing look at how life can adapt to many different extreme environments. It addresses the limits for life development and examines different strategies used by organisms to adapt to different extreme environments.

Download or read book Highway and Urban Environment written by G.M. Morrison and published by Springer Science & Business Media. This book was released on 2007-09-19 with total page 582 pages. Available in PDF, EPUB and Kindle. Book excerpt: With half of the world’s population now living in urban areas, and rapid urbanization continuing apace, it is essential that the growth of urban areas is supported by the development of adequate and sustainable infrastructure. This work offers comprehensive coverage of critical issues on the highway and urban environment which are key to understanding sustainability in the world's expanding urban areas.

Download or read book Desk Encyclopedia of Microbiology written by Moselio Schaechter and published by Academic Press. This book was released on 2010-04-19 with total page 1277 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Desk Encyclopedia of Microbiology, Second Edition is a single-volume comprehensive guide to microbiology for the advanced reader. Derived from the six volume e-only Encyclopedia of Microbiology, Third Edition, it bridges the gap between introductory texts and specialized reviews. Covering topics ranging from the basic science of microbiology to the current "hot" topics in the field, it will be invaluable for obtaining background information on a broad range of microbiological topics, preparing lectures and preparing grant applications and reports. The most comprehensive single-volume source providing an overview of microbiology to non-specialists Bridges the gap between introductory texts and specialized reviews Provides concise and general overviews of important topics within the field making it a helpful resource when preparing for lectures, writing reports, or drafting grant applications

Download or read book Biomaterials Fabrication and Processing Handbook written by Paul K. Chu and published by CRC Press. This book was released on 2008-03-27 with total page 720 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume focuses on a variety of production and processing aspects of the latest biomaterials. It discusses how scaffolds are used in tissue engineering and describes common implant materials, such as hard tissue, blood contacting, and soft tissue. The book also examines the important role nanotechnology plays in the preparation of drugs, protein delivery, tissue engineering, cardiovascular biomaterials, hard tissue replacements, biosensors, and bio-MEMS. With contributions from renowned international experts and extensive reference lists in each chapter, this book provides detailed, practical information to produce biomaterials and employ them in biomedicine.