Download or read book Sensing the Environment Regulation of Local and Global Homeostasis by the Skin s Neuroendocrine System written by Andrzej T. Slominski and published by Springer Science & Business Media. This book was released on 2012-06-02 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: The skin, the body’s largest organ, is strategically located at the interface with the external environment where it detects, integrates and responds to a diverse range of stressors, including solar radiation. It has already been established that the skin is an important peripheral neuroendocrine-immune organ that is closely networked with central regulatory systems. These capabilities contribute to the maintenance of peripheral homeostasis. Specifically, epidermal and dermal cells produce and respond to classical stress neurotransmitters, neuropeptides and hormones, production which is stimulated by ultraviolet radiation (UVR), biological factors (infectious and non-infectious) and other physical and chemical agents. Examples of local biologically active products are cytokines, biogenic amines (catecholamines, histamine, serotonin and N-acetyl-serotonin), melatonin, acetylocholine, neuropeptides including pituitary (proopiomelanocortin-derived ACTH, b-endorphin or MSH peptides, thyroid stimulating hormone) and hypothalamic (corticotropin-releasing factor and related urocortins, thyroid-releasing hormone) hormones, as well as enkephalins and dynorphins, thyroid hormones, steroids (glucocorticoids, mineralocorticoids, sex hormones, 7-δ steroids), secosteroids, opioids and endocannabinoids. The production of these molecules is hierarchical, organized along the algorithms of classical neuroendocrine axes such as the hypothalamic pituitary adrenal axis (HPA), hypothalamic-thyroid axis (HPT), serotoninergic, melatoninergic, catecholaminergic, cholinergic, steroid/secosteroidogenic, opioid and endocannabinoid systems. Disruptions of these axes or of communication between them may lead to skin and/or systemic diseases. These local neuroendocrine networks also serve to limit the effect of noxious environmental agents to preserve local and consequently global homeostasis. Moreover, the skin-derived factors/systems can also activate cutaneous nerve endings to alert the brain to changes in the epidermal or dermal environments, or alternatively to activate other coordinating centers by direct (spinal cord) neurotransmission without brain involvement. Furthermore, rapid and reciprocal communications between epidermal and dermal and adnexal compartments are also mediated by neurotransmission including antidromic modes of conduction. Lastly, skin cells and the skin as an organ coordinate and/or regulate not only peripheral but also global homeostasis.

Download or read book Tsunami Warning and Preparedness written by National Research Council and published by National Academies Press. This book was released on 2011-03-01 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many coastal areas of the United States are at risk for tsunamis. After the catastrophic 2004 tsunami in the Indian Ocean, legislation was passed to expand U.S. tsunami warning capabilities. Since then, the nation has made progress in several related areas on both the federal and state levels. At the federal level, NOAA has improved the ability to detect and forecast tsunamis by expanding the sensor network. Other federal and state activities to increase tsunami safety include: improvements to tsunami hazard and evacuation maps for many coastal communities; vulnerability assessments of some coastal populations in several states; and new efforts to increase public awareness of the hazard and how to respond. Tsunami Warning and Preparedness explores the advances made in tsunami detection and preparedness, and identifies the challenges that still remain. The book describes areas of research and development that would improve tsunami education, preparation, and detection, especially with tsunamis that arrive less than an hour after the triggering event. It asserts that seamless coordination between the two Tsunami Warning Centers and clear communications to local officials and the public could create a timely and effective response to coastal communities facing a pending tsuanami. According to Tsunami Warning and Preparedness, minimizing future losses to the nation from tsunamis requires persistent progress across the broad spectrum of efforts including: risk assessment, public education, government coordination, detection and forecasting, and warning-center operations. The book also suggests designing effective interagency exercises, using professional emergency-management standards to prepare communities, and prioritizing funding based on tsunami risk.

Download or read book Alzheimer s In America written by Maria Shriver and published by Free Press. This book was released on 2011-04-12 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Shriver Report: A Woman’s Nation Takes on Alzheimer’s will be the first comprehensive multi-disciplinary look at these questions at this transformational moment. The Report will digest the current trends in thinking about Alzheimer’s, examine cutting-edge medical research, look at societal impacts, and include a groundbreaking and comprehensive national poll. It will feature original photography and personal essays by men and women – some from the public arena with names you know, some from everyday America – sharing their personal struggles with the disease as patients, caregivers and family members.

Download or read book Senate Joint Resolutions written by Ohio. General Assembly. Senate and published by . This book was released on 1925 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Engineering written by Unesco and published by UNESCO. This book was released on 2010-01-01 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report reviews engineering's importance to human, economic, social and cultural development and in addressing the UN Millennium Development Goals. Engineering tends to be viewed as a national issue, but engineering knowledge, companies, conferences and journals, all demonstrate that it is as international as science. The report reviews the role of engineering in development, and covers issues including poverty reduction, sustainable development, climate change mitigation and adaptation. It presents the various fields of engineering around the world and is intended to identify issues and challenges facing engineering, promote better understanding of engineering and its role, and highlight ways of making engineering more attractive to young people, especially women.--Publisher's description.

Download or read book Delivering High Quality Cancer Care written by Committee on Improving the Quality of Cancer Care: Addressing the Challenges of an Aging Population and published by National Academies Press. This book was released on 2014-01-10 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the United States, approximately 14 million people have had cancer and more than 1.6 million new cases are diagnosed each year. However, more than a decade after the Institute of Medicine (IOM) first studied the quality of cancer care, the barriers to achieving excellent care for all cancer patients remain daunting. Care often is not patient-centered, many patients do not receive palliative care to manage their symptoms and side effects from treatment, and decisions about care often are not based on the latest scientific evidence. The cost of cancer care also is rising faster than many sectors of medicine--having increased to $125 billion in 2010 from $72 billion in 2004--and is projected to reach $173 billion by 2020. Rising costs are making cancer care less affordable for patients and their families and are creating disparities in patients' access to high-quality cancer care. There also are growing shortages of health professionals skilled in providing cancer care, and the number of adults age 65 and older--the group most susceptible to cancer--is expected to double by 2030, contributing to a 45 percent increase in the number of people developing cancer. The current care delivery system is poorly prepared to address the care needs of this population, which are complex due to altered physiology, functional and cognitive impairment, multiple coexisting diseases, increased side effects from treatment, and greater need for social support. Delivering High-Quality Cancer Care: Charting a New Course for a System in Crisis presents a conceptual framework for improving the quality of cancer care. This study proposes improvements to six interconnected components of care: (1) engaged patients; (2) an adequately staffed, trained, and coordinated workforce; (3) evidence-based care; (4) learning health care information technology (IT); (5) translation of evidence into clinical practice, quality measurement and performance improvement; and (6) accessible and affordable care. This report recommends changes across the board in these areas to improve the quality of care. Delivering High-Quality Cancer Care: Charting a New Course for a System in Crisis provides information for cancer care teams, patients and their families, researchers, quality metrics developers, and payers, as well as HHS, other federal agencies, and industry to reevaluate their current roles and responsibilities in cancer care and work together to develop a higher quality care delivery system. By working toward this shared goal, the cancer care community can improve the quality of life and outcomes for people facing a cancer diagnosis.

Download or read book Making Healthcare Safe written by Lucian L. Leape and published by Springer Nature. This book was released on 2021-05-28 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique and engaging open access title provides a compelling and ground-breaking account of the patient safety movement in the United States, told from the perspective of one of its most prominent leaders, and arguably the movement’s founder, Lucian L. Leape, MD. Covering the growth of the field from the late 1980s to 2015, Dr. Leape details the developments, actors, organizations, research, and policy-making activities that marked the evolution and major advances of patient safety in this time span. In addition, and perhaps most importantly, this book not only comprehensively details how and why human and systems errors too often occur in the process of providing health care, it also promotes an in-depth understanding of the principles and practices of patient safety, including how they were influenced by today’s modern safety sciences and systems theory and design. Indeed, the book emphasizes how the growing awareness of systems-design thinking and the self-education and commitment to improving patient safety, by not only Dr. Leape but a wide range of other clinicians and health executives from both the private and public sectors, all converged to drive forward the patient safety movement in the US. Making Healthcare Safe is divided into four parts: I. In the Beginning describes the research and theory that defined patient safety and the early initiatives to enhance it. II. Institutional Responses tells the stories of the efforts of the major organizations that began to apply the new concepts and make patient safety a reality. Most of these stories have not been previously told, so this account becomes their histories as well. III. Getting to Work provides in-depth analyses of four key issues that cut across disciplinary lines impacting patient safety which required special attention. IV. Creating a Culture of Safety looks to the future, marshalling the best thinking about what it will take to achieve the safe care we all deserve. Captivatingly written with an “insider’s” tone and a major contribution to the clinical literature, this title will be of immense value to health care professionals, to students in a range of academic disciplines, to medical trainees, to health administrators, to policymakers and even to lay readers with an interest in patient safety and in the critical quest to create safe care.

Download or read book The Investment Checklist written by Michael Shearn and published by John Wiley & Sons. This book was released on 2011-09-20 with total page 391 pages. Available in PDF, EPUB and Kindle. Book excerpt: A practical guide to making more informed investment decisions Investors often buy or sell stocks too quickly. When you base your purchase decisions on isolated facts and don't take the time to thoroughly understand the businesses you are buying, stock-price swings and third-party opinion can lead to costly investment mistakes. Your decision making at this point becomes dangerous because it is dominated by emotions. The Investment Checklist has been designed to help you develop an in-depth research process, from generating and researching investment ideas to assessing the quality of a business and its management team. The purpose of The Investment Checklist is to help you implement a principled investing strategy through a series of checklists. In it, a thorough and comprehensive research process is made simpler through the use of straightforward checklists that will allow you to identify quality investment opportunities. Each chapter contains detailed demonstrations of how and where to find the information necessary to answer fundamental questions about investment opportunities. Real-world examples of how investment managers and CEOs apply these universal principles are also included and help bring the concepts to life. These checklists will help you consider a fuller range of possibilities in your investment strategy, enhance your ability to value your investments by giving you a holistic view of the business and each of its moving parts, identify the risks you are taking, and much more. Offers valuable insights into one of the most important aspects of successful investing, in-depth research Written in an accessible style that allows aspiring investors to easily understand and apply the concepts covered Discusses how to think through your investment decisions more carefully With The Investment Checklist, you'll quickly be able to ascertain how well you understand your investments by the questions you are able to answer, or not answer, without making the costly mistakes that usually hinder other investors.

Download or read book Equity Growth and Community written by Chris Benner and published by Univ of California Press. This book was released on 2015-10-09 with total page 365 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the last several years, much has been written about growing economic challenges, increasing income inequality, and political polarization in the United States. Addressing these new realities in America's metropolitan regions, this book argues that a few lessons are emerging: first, inequity is bad for economic growth; second, bringing together the concerns of equity and growth requires concerted local action; and third, the fundamental building block for doing this is the creation of diverse and dynamic epistemic (or knowledge) communities, which help to overcome political polarization and to address the challenges of economic restructuring and social divides.

Download or read book Guide to Careers in World Affairs written by Laura J. Schisgall and published by . This book was released on 1987 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: Designed to help those who are considering a career that enables them to travel or live abroad or to work in an international field, this guide will be especially helpful to college and graduate school students, graduates with advanced degrees, professionals exploring alternative careers, and college-bound high school students, and will also be a useful resource for career counselors, job placement offices, and libraries. Listed are more than 250 sources of employment in international business, banking, finance, international law, journalism, consulting, nonprofit organizations, the United States government, the United Nations, and other international organizations. Each of the listings provides a brief description of the organization, the size of the professional staff, the number of professionals hired in the last year, qualifications for employment, internships where available, application procedures, and address. Also included are introductory essays by outstanding representatives of the different professions described, an annotated bibliography, and a listing of graduate programs. (BZ)

Download or read book Guide to the Presidency SET written by Michael Nelson and published by CQ Press. This book was released on 2007-07-02 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Guide to the Presidency is the leading reference source on the persons who have occupied the White House and on the institution of the presidency itself. Readers turn to this guide for its vast array of factual information about the institution and the presidents, as well as for its analytical chapters that explain the structure and operations of the office and the president's relationship to co-equal branches of government, Congress and the Supreme Court. This new edition is updated to include: A new chapter on presidential power Coverage of the expansion of presidential power under President George W. Bush

Download or read book City Diplomacy written by Sohaela Amiri and published by Springer Nature. This book was released on 2020-07-11 with total page 375 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edited volume provides an inclusive explanation of what, why, and how cities interact with global counterparts as well as with nation states, non-governmental organizations, and foreign publics. The chapters present theoretical and analytical approaches to the study of city diplomacy as well as case studies to capture the nuances of the practice. By bringing together a diverse group of authors in terms of their geographic location, academic and practitioner backgrounds, the volume speaks to multiple disciplines, including diplomacy, political science, communication, sociology, marketing and tourism.

Download or read book Plant Communication from an Ecological Perspective written by František Baluška and published by Springer Science & Business Media. This book was released on 2010-08-05 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the concept of allelopathy was introduced almost 100 years ago, research has led to an understanding that plants are involved in complex communicative interactions. They use a battery of different signals that convey plant-relevant information within plant individuals as well as between plants of the same species or different species. The 13 chapters of this volume discuss all these topics from an ecological perspective. Communication between plants allows them to share physiological and ecological information relevant for their survival and ?tness. It is obvious that in these very early days of ecological plant communication research we are illuminating only the ‘tip of iceberg’ of the communicative nature of higher plants. Nevertheless, knowledge on the identity and informative value of volatiles used by plants for communication is increasing with breath-taking speed. Among the most spectacular examples are sit- tions where plant emitters warn neighbours about a danger, increasing their innate immunity, or when herbivore-attacked plants attract the enemies of the herbivores (‘cry for help’ and ‘plant bodyguards’ concepts). It is becoming obvious that plants use not only volatile signals but also diverse water soluble molecules, in the case of plant roots, to safeguard their evolutionary success and accomplish self/non-self kin rec- nition. Importantly, as with all the examples of biocommunication, irrespective of whether signals and signs are transmitted via physical or chemical pathways, plant communication is a rule-governed and sign-mediated process.

Download or read book Foucault s Strata and Fields written by Maren Kusch and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 295 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, a large number of books and articles on Foucault has been published. Almost all of the book-size studies are expository and introductory. Indeed, there seems to be no other modern philosopher with reference to whom a comparable numberofintroductionshavebeen produced in such a short period. Most ofthe articles too provide over views, rather than critical assessments or rational reconstructions, even though there existsby now a small numberoffine papers also inthe two latter genres. Moreover, more often than not, writers on Foucault approach his work as part and parcel of so-called "postmodern" philo sophy. They concentrate on topics like the "death of the subject", the relation ofFoucault's work to. Derrida or Habermas, or its significance for postmodern art and culture. Without wanting to deny the merits, either of introductory exposi tions, or ofstudies that read Foucault as a postmodern thinker, it seems to me that these received perspectives have tended to leave central areas and aspects ofFoucault's work somewhat underexposed. As I see it, the most important of these areas are such as would suggest reading Fou cault from the vantage point of recent developments in the philosophy, sociology and history of science.

Download or read book Elsewhere written by Gabrielle Zevin and published by A&C Black. This book was released on 2006-01-01 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents a novel of hope, love, and redemption.

Download or read book How I Learnt to Speak in English written by Neetu Sugandh and published by Createspace Independent Publishing Platform. This book was released on 2016-10-27 with total page 110 pages. Available in PDF, EPUB and Kindle. Book excerpt: A true story as well as techniques and notes of someone who was rejected in her first job because of not being able to communicate in English fluently. Learn how she was appointed as a communication trainer in the same organization after a few months. What did she do? And, how did she do it? This book has her experience, notes, and techniques she followed to learn the language effectively in just a few months. The book is recommended for anyone who is interested in learning English in an easy and independent manner or refreshing their English basics quickly. It is also recommended for those who train on spoken English and want to understand their learners in a better way. It will not only make you learn but also keep you motivated to learn till you complete the book. The author has put special emphasis on learning minimal definitions and focusing on the correct usage of English. The English video game table or the wish list table is one its key features.

Download or read book A Modern History of German Criminal Law written by Thomas Vormbaum and published by Springer Science & Business Media. This book was released on 2013-10-01 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: Increasingly, international governmental networks and organisations make it necessary to master the legal principles of other jurisdictions. Since the advent of international criminal tribunals this need has fully reached criminal law. A large part of their work is based on comparative research. The legal systems which contribute most to this systemic discussion are common law and civil law, sometimes called continental law. So far this dialogue appears to have been dominated by the former. While there are many reasons for this, one stands out very clearly: Language. English has become the lingua franca of international legal research. The present book addresses this issue. Thomas Vormbaum is one of the foremost German legal historians and the book's original has become a cornerstone of research into the history of German criminal law beyond doctrinal expositions; it allows a look at the system’s genesis, its ideological, political and cultural roots. In the field of comparative research, it is of the utmost importance to have an understanding of the law’s provenance, in other words its historical DNA.