Download or read book Advances in Combination Therapy for Asthma and COPD written by Jan Lotvall and published by John Wiley & Sons. This book was released on 2011-12-12 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aimed at specialists in respiratory medicine, this new book comprehensively reviews the variety of agents currently available for treatment of asthma, COPD, and other airway diseases and covers practical guidelines as well as challenges and complications in their use. Advances in Combination Therapy for Asthma and COPD is the first book to address the complexity of multi-agent therapy and deal with management issues in an integrated fashion. A review of currently available agents and their applications, as well as new therapies soon to become available are outlined. Advantages of combined therapies and additional considerations that arise from multi-agent programs are highlighted.
Download or read book Combination Therapy for Asthma and Chronic Obstructive Pulmonary Disease written by Richard Martin and published by CRC Press. This book was released on 2000-04-18 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines the therapies used for treatment of asthma and chronic obstructive pulmonary disease (COPD) separately and in combination, covering beta-agonists, theophylline, leukotriene modifiers, and anticholinergics. Highlights the importance of specific time dosing of medications! Revealing what medications to use and when to prescribe them, Combination Therapy for Asthma and Chronic Obstructive Pulmonary Disease emphasizes anti-inflammatory therapy compares and contrasts the side effects and efficacy of titration and various combinations covers the steroid-sparing effect of combining inhaled corticosteroids and long-acting beta 2-agonists includes over 1100 references that clarify outcomes among several different agents details the mechanisms of inhaled glucocorticoid action and more! Written by clinicians who are experts in the pharmacological agents discussed, Combination Therapy for Asthma and Chronic Obstructive Pulmonary Disease is critical for pulmonologists, clinical immunologists/allergists, pharmacologists, internists, family practice physicians, pediatricians, and hospital interns and residents.
Download or read book ABC of COPD written by Graeme P. Currie and published by John Wiley & Sons. This book was released on 2010-11-04 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronic Obstructive Pulmonary Disease (COPD) is a progressive, largely irreversible lung condition characterised by airflow obstruction. Although cigarette smoking is the single most important risk factor in its development, other associations and risk factors are thought to have increasing relevance throughout the world. COPD is usually managed in primary care, although it is commonly under-diagnosed, and is one of the most common medical conditions necessitating admission to hospital. The second edition of the ABC of COPD provides the entire multidisciplinary team with a reliable, up-to-date and accessible account of COPD. Extensively updated by experienced clinicians - including new chapters on spirometry, inhalers, oxygen, death, dying and end of life issues - this ABC is an authoritative and practical guide for general practitioners, practice nurses, specialist nurses, medical students, paramedical staff, junior doctors, non-specialist doctors and all other health professionals working in both primary and secondary care.
Download or read book Chronic Obstructive Pulmonary Disease Exacerbations written by Jadwiga A. Wedzicha and published by CRC Press. This book was released on 2008-09-22 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronic Obstructive Pulmonary Disease Exacerbations covers the definition, diagnosis, epidemiology, mechanisms, and treatment associated with COPD exacerbations. This text also addresses imaging and how it plays a pivotal role in the diagnosis and study of exacerbations.Written by today's top experts, Chronic Obstructive Pulmonary Disease Exacerbat
Download or read book Pharmacotherapy in Chronic Obstructive Pulmonary Disease written by Bartolome R. Celli and published by CRC Press. This book was released on 2003-12-17 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: Placing specialists at the cutting-edge of therapeutic and biotechnological research, this reference reviews the extensive array of pharmaceutical options available for the management of patients with COPD. The book considers disease severity, dosing regimens, administration methods, and monitoring procedures, as well as medication-related side-eff
Download or read book Pharmacology and Therapeutics of Asthma and COPD written by Clive P. Page and published by Springer. This book was released on 2017-02-06 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: The present volume is supposed to be a major reference resource for chest physicians and those involved in the development of novel pharmaceutical entities for these diseases. Internationally recognized authorities review the most important new information on the advances in our understanding of the pathogenesis and treatment of these diseases, including the substantial advances in the topical delivery of inhaled medicines. Each chapter is extensively referenced, generously illustrated with clear diagrams and photographs, and represents a state-of-the-art review of this important area of respiratory medicine.
Download or read book Asthma and COPD written by Peter J. Barnes and published by Elsevier. This book was released on 2009-03-19 with total page 897 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Second Edition of Asthma and COPD: Basic Mechanisms and Clinical Management continues to provide a unique and authoritative comparison of asthma and COPD. Written and edited by the world's leading experts, it continues to be a comprehensive review of the most recent understanding of the basic mechanisms of both conditions, specifically comparing their etiology, pathogenesis, and treatments. * Each chapter considers Asthma and COPD in side-by-side contrast and comparison – not in isolation - in the context of mechanism, triggers, assessments, therapies, and clinical management * Presents the latest and most comprehensive understandings of the mechanisms of inflammation in both Asthma and COPD * Most extensive reference to primary literature on both Asthma and COPD in one source. * Easy-to-read summaries of the latest advances alongside clear illustrations
Download or read book Molecular Pharmacological Approach for the Optimisation of Combination Therapy of a Long acting 2 Agonist and a Corticosteroid in Chronic Obstructive Pulmonary Disease written by Christos Rossios and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Combination inhalers of long-acting ?2 agonists (LABAs) with inhaled corticosteroids (ICSs) are now widely used for the treatment of asthma. However, corticosteroid (CS) insensitivity can be a major barrier for the treatment of chronic obstructive pulmonary disease (COPD). Existing ICSs are less beneficial on the decline of lung function in the long term. Even at the cellular level, CSs are less effective in primary cells, peripheral blood mononuclear cells (PBMCs) obtained from COPD patients compared to PBMCs from healthy volunteers. High levels of oxidative stress in COPD have been reported to be involved in CS insensitivity. In addition, oxidative stress has been reported to affect the ?2 adrenergic receptor (?2AR) signalling itself. Here I hypothesise that oxidative stress affects the function of CSs and LABAs and/or their combination. Clarifying the molecular mechanism of this defect, will give new insights for the optimisation of the ideal CS/LABA combination therapy for the treatment of COPD.Primarily, pharmacological effects of fluticasone furoate (FF), a novel CS, were evaluated in various inflammation systems in respiratory cells and compared with those of currently available fluticasone propionate (FP) and budesonide (Bud). In the course of this study, FF was found to be a potent and long-acting CS. More importantly, the anti-inflammatory effects of FP were reduced under oxidative stress, whereas the effects of FF were not affected by oxidative stress. FF was also more effective on inhibiting cytokine release in PBMCs from COPD patients. Hence, this study demonstrated that FF is an oxidative stress insensitive CS.Furthermore, effects of oxidative stress on the function or signalling of LABAs were investigated. Salmeterol (SM)-induced cyclic AMP (cAMP) production was reduced under H2O2 treatment, while the effects of formoterol (FM) were not affected by H2O2. Under conditions of oxidative stress, SM also induced ?2AR internalisation, whereas FM did not. Cell signalling analysis showed that FM partially inhibited H2O2-induced Akt phosphorylation, a footprint of phosphoinositide-3 kinase (PI3K) activation, whereas SM did not. Furthermore, add-on treatment with FM could improve sensitivity of either Bud or FP in U937 cells, under simulative conditions of oxidative stress or PBMCs from COPD patients, but SM did not improve it. Moreover, vilanterol trifenatate (VT), also known as GW642444, a novel ultra LABA showed similar effects with FM, under oxidative stress. Thus, FM (and VT) is more robust than SM under oxidative stress conditions. Finally, the outcome of H2O2 on the anti-inflammatory effects of CS/LABA combination was evaluated. As concluded from the results above, FF and FM (or VT) were oxidative stress insensitive compounds. In fact, the combination of FF and VT, as well as a combination of mometasone furoate (MF) with FM showed the most potent anti-inflammatory effects under oxidative stress and in PBMCs from COPD patients. Consequently, the findings from this thesis might give new insights and support the development of new combination therapies for the treatment of chronic inflammatory airway diseases, where high levels of oxidative stress are seen.
Download or read book Molecular Pharmacological Approach for the Optimisation of Combination Therapy of a Long acting beta 2 Agonist and a Corticosteroid in Chronic Obstructive Pulmonary Disease written by and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Pharmacology and Therapeutics of Airway Disease written by Kian Fan Chung and published by CRC Press. This book was released on 2009-10-27 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written as a concise clinical reference guide covering the current and future airway disease treatments, this text encompasses: pathophysiology of respiratory tract diseasesthe methods of measuring airway and clinical responsesthe concepts upon which many treatments are used in COPD and asthma conditionsthe way in which these treatments work,
Download or read book Indacaterol written by Alexandre Trifilieff and published by Springer Science & Business Media. This book was released on 2013-11-19 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronic obstructive pulmonary disease (COPD) is a multi-component condition that results in increasingly limited airflow, usually associated with an abnormal inflammatory response of the lung. It constitutes a major public health burden worldwide, while only very few effective therapies are available. This book provides a comprehensive overview of the development of Onbrez Breezhaler, a newly approved once-daily inhaled β2 agonist for the treatment of COPD. It reviews the current pharmacotherapy for COPD and discusses topics such as the chemical design and the pre-clinical pharmacology of the molecule, the early clinical development, the INHANCE study (which provides a successful example of the use of an adaptive design in the confirmatory setting) and the Phase III clinical efficacy study, as well as the history and performance of the Breezhaler device. Finally, a list of emerging targets is included that could well offer future treatment options for COPD.
Download or read book New Drugs and Targets for Asthma and COPD written by T.T. Hansel and published by Karger Medical and Scientific Publishers. This book was released on 2010-08-31 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: Asthma, allergy and chronic obstructive lung disease are common throughout the world and are increasing in incidence, particularly in the developing world. This volume provides a state-of-the-art account of the identification of new targets and the development of new therapies for these conditions. Some 40 chapters by clinical academics and senior members of the pharmaceutical industry detail the latest breakthroughs in research and development. In asthma, a promising approach is the use of therapy directed against specific Th2 responses through biological antagonists of IL-5, IL-4 and IL-13. There have also been major advances in our understanding of innate immune responses to pathogen-associated molecular patterns, and in the area of Toll-like receptors. Up to date and comprehensive, this book will be of particular relevance to those working in the pharmaceutical industry (in preclinical research and clinical development), to academic researchers in the field of respiratory medicine, and to respiratory health care specialists.
Download or read book Chalk Talks in Internal Medicine written by Somnath Mookherjee and published by Springer Nature. This book was released on 2020-09-30 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides teaching scripts for medical educators in internal medicine and coaches them in creating their own teaching scripts. Every year, thousands of attending internists are asked to train the next generation of physicians to master a growing body of knowledge. Formal teaching time has become increasingly limited due to rising clinical workload, medical documentation requirements, duty hour restrictions, and other time pressures. In addition, today’s physicians-in-training expect teaching sessions that deliver focused, evidence-based content that is integrated into clinical workflow. In keeping with both time pressures and trainee expectations, academic internists must be prepared to effectively and efficiently teach important diagnostic and management concepts. A teaching script is a methodical and structured plan that aids in effective teaching. The teaching scripts in this book anticipate learners’ misconceptions, highlight a limited number of teaching points, provide evidence to support the teaching points, use strategies to engage the learners, and provide a cognitive scaffold for teaching the topic that the teacher can refine over time. All divisions of internal medicine (e.g. cardiology, rheumatology, and gastroenterology) are covered and a section on undifferentiated symptom-based presentations (e.g. fatigue, fever, and unintentional weight loss) is included. This book provides well-constructed teaching scripts for commonly encountered clinical scenarios, is authored by experienced academic internists and allows the reader to either implement them directly or modify them for their own use. Each teaching script is designed to be taught in 10-15 minutes, but can be easily adjusted by the reader for longer or shorter talks. Teaching Scripts in Internal Medicine is an ideal tool for internal medicine attending physicians and trainees, as well as physician’s assistants, nurse practitioners, and all others who teach and learn internal medicine.
Download or read book Severe Asthma written by Kian Fan Chung and published by European Respiratory Society. This book was released on 2019-06-01 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Severe asthma is a form of asthma that responds poorly to currently available medication, and its patients represent those with greatest unmet needs. In the last 10 years, substantial progress has been made in terms of understanding some of the mechanisms that drive severe asthma; there have also been concomitant advances in the recognition of specific molecular phenotypes. This ERS Monograph covers all aspects of severe asthma – epidemiology, diagnosis, mechanisms, treatment and management – but has a particular focus on recent understanding of mechanistic heterogeneity based on an analytic approach using various ‘omics platforms applied to clinically well-defined asthma cohorts. How these advances have led to improved management targets is also emphasised. This book brings together the clinical and scientific expertise of those from around the world who are collaborating to solve the problem of severe asthma.
Download or read book Analysis of Treatment of Respiratory Disease in the United Kingdom and United States written by Jordan R. Covvey and published by . This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: INTRODUCTION: Asthma and chronic obstructive pulmonary disease (COPD) affect 8% and 5% of the population, respectively, in the United Kingdom (UK) and the United States (USA). A variety of medicines are available but how they are utilised in real practice is not fully understood. The aim of this work was to describe and compare the treatment of asthma and COPD in the UK and USA. METHODS: Three retrospective databases (two administrative and one electronic health record datasets) were formed from sources in National Health Service (NHS) Scotland, NHS Forth Valley, Scotland, and Kentucky, USA. Several analyses were conducted, including mapping and evaluation of national medicine utilisation, evaluation of adherence/persistence with chronic therapy, classification of therapy against guideline recommendations, and appraisal of inhaled corticosteroid (ICS) prescribing. RESULTS: National medicine utilisation figures indicated an increasing preference over time for combination therapy with ICS and long-acting beta agonist (LABA) inhalers. Therapy for asthma demonstrated some unanticipated trends, with widespread use of high-dose combination therapy in up to one-third of patients and a lack of standardised therapy approach by clinicians at step 2/3. For COPD, spirometry data was unable to verify diagnosis in up to a quarter of patients, and approximately one-third of patients received unlicensed doses of combination therapy. Adherence and persistence with chronic medicine in both databases was better amongst women, with advancing age and with oral therapy. Direct comparisons between the UK and USA were difficult due to the different healthcare structures and methods for data collection, but doses of ICS in children appeared more aggressive in the USA. CONCLUSION: The treatment of respiratory disease can be optimised in several clinical areas, most notably with ICS prescribing. Further research and quality improvement measures are needed to improve the care of respiratory disease.
Download or read book Pediatric Respiratory Medicine written by Lynn Max Taussig and published by Elsevier Health Sciences. This book was released on 2008-01-01 with total page 1401 pages. Available in PDF, EPUB and Kindle. Book excerpt: This user-friendly text presents current scientific information, diagnostic approaches, and management strategies for the care of children with acute and chronic respiratory diseases. A consistent chapter format enables rapid and effortless location of the most current protocols on manifestations, etiologies, triggers, approaches to treatment, complications, and preventative strategies. Includes guidance on differential diagnosis to help determine which disease or condition the patient may have. Uses extensive color-coded algorithms to facilitate quick diagnosis, management, and treatment decisions. Provides the latest scientific information and diagnostic and management strategies for the care of children with respiratory illnesses. Presents cutting-edge coverage with new information on the biology of, and the influences on, the respiratory system during childhood, as well as the diagnosis and management of both common (ie, wheezing infant, cystic fibrosis, tuberculosis) and.
Download or read book Essential Clinical Anesthesia written by Charles Vacanti and published by Cambridge University Press. This book was released on 2011-07-11 with total page 1191 pages. Available in PDF, EPUB and Kindle. Book excerpt: The clinical practice of anesthesia has undergone many advances in the past few years, making this the perfect time for a new state-of-the-art anesthesia textbook for practitioners and trainees. The goal of this book is to provide a modern, clinically focused textbook giving rapid access to comprehensive, succinct knowledge from experts in the field. All clinical topics of relevance to anesthesiology are organized into 29 sections consisting of more than 180 chapters. The print version contains 166 chapters that cover all of the essential clinical topics, while an additional 17 chapters on subjects of interest to the more advanced practitioner can be freely accessed at www.cambridge.org/vacanti. Newer techniques such as ultrasound nerve blocks, robotic surgery and transesophageal echocardiography are included, and numerous illustrations and tables assist the reader in rapidly assimilating key information. This authoritative text is edited by distinguished Harvard Medical School faculty, with contributors from many of the leading academic anesthesiology departments in the United States and an introduction from Dr S. R. Mallampati. This book is your essential companion when preparing for board review and recertification exams and in your daily clinical practice.
