Download or read book Clinical Research Methodology and Evidence Based Medicine written by Ajit N Babu and published by Wolters kluwer india Pvt Ltd. This book was released on 2014-01-01 with total page 205 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research methodology is a discipline concerned with the scientific conception, design, implementation and analysis of research. Evidence-based medicine (EBM) is an approach for evaluating and applying medical knowledge, particularly that derived from original research, in the care of individual patients. This book strives to give the reader a sound introduction to these related subjects which form a continuum. In this revised and expanded second edition, existing areas have been treated in greater depth, more examples provided and a number of fresh topics added. New chapters now address the finer points of survey design, provide tips on effective scientific writing for publication and outline the process of drug discovery from product conception to marketing. With these modifications, the book provides a more holistic picture of EBM and clinical research, appealing to a broader audience of medical students, practicing physicians, nursing staff, new investigators and researchers in CRO as well as the pharmaceutical industry.
Download or read book Clinical Research Methodology and Evidence based Medicine written by Ajit N. Babu and published by Anshan Pub. This book was released on 2008 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is an introduction to the fields of research methodology and evidence-based medicine. The concept of evidence-based medicine has gathered international momentum and many seek to know how to practice it. This book focuses on both of these related areas, especially from the perspective of teaching the fundamentals.
Download or read book Research Methods written by Wendy L. Hurley and published by LWW. This book was released on 2011 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This research methods textbook distinguishes itself from other textbooks by providing a unique framework and perspective for users/students to establish the relevancy of research in their clinical practice. Many, if not most, students in professional preparation allied health care programs view the research methods/statistics course requirement of the curriculum as an obstacle to be overcome, or at best, as a necessary evil. Most research methods textbooks promote these notions because of the way they are presented. Of course, most times they are written by researchers or statisticians and are absolutely correct in presenting the theoretical underpinnings and mechanistic applications of the scientific method. They correctly present explanations as to why one type of methodology requires a certain type of statistical analysis based on the characteristics of the study population, the type of data collected, or the underlying assumptions pertinent to a specific statistical model. So, while technically beyond reproach, their failure is in establishing how and why research activity and understanding is integral to a professional practice"--Provided by publisher.
Download or read book Fundamentals of Evidence Based Medicine written by Kameshwar Prasad and published by Springer Science & Business Media. This book was released on 2013-08-16 with total page 165 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a basic book on evidence-based medicine (EBM). It starts with an introduction to the topic. It outlines the relationship between EBM and research and quality of care. Then It goes on to cover the most commonly used modules of EBM, i.e. therapy, diagnosis, prognosis and meta-analysis. Each module starts with an introduction to fundamental concepts, and description of the related research process, and then follows the critical appraisal of related type of research artcle. At the end, it covers the different systems of grading of level of evidence and strength of recommendations. The book also has three examples of critical appraisal on diagnosis, therapy, and meta-analysis.
Download or read book Foundations of Clinical Research written by Leslie G Portney and published by F.A. Davis. This book was released on 2020-01-16 with total page 696 pages. Available in PDF, EPUB and Kindle. Book excerpt: Become a successful evidence-based practitioner. How do you evaluate the evidence? Is the information accurate, relevant and meaningful for clinical decision making? Did the design fit the research questions and was the analysis and interpretation of data appropriate? Here are all the materials you need to take your first steps as evidence-based practitioners…how to use the design, data and analysis of research as the foundation for effective clinical decision making. You’ll find support every step of the way as you progress from the foundations of clinical research and concepts of measurement through the processes of designing studies and analyzing data to writing their own research proposal.
Download or read book Teaching Clinical Research Methodology by Example written by Jack Hirsh and published by Pmph-USA, Limited. This book was released on 2017 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: Teaching Clinical Research Methodology by Example has two principal objectives: (1) to tell the story of the research process in action and to provide a glimpse into the minds of the researchers responsible for some of the major advances (and setbacks) in modern medicine; (2) to explain the principles of evidence-based medicine by reviewing the research methods required to prove or disprove a theory. This text is written in a style accessible to health professionals who do not have a background in clinical epidemiology. The first section of the book, Causation, begins with an explanation of "casual" and "coincidental" associations and follows with examples: Smoking and lung cancer Dietary fats and coronary heart disease Cause and cure of peptic ulcers Viral infection and cancer of the cervix Vaccination and autism Venous obstruction as the cause of multiple sclerosis. The second section of the book explores prevention, treatment, and the ethical principles of clinical trials. Treatments presented include surgery for breast cancer, acute lymphoblastic leukemia, use of Viagra, stem cells in breast cancer, and the use of aspirin to treat heart attacks. Preventive measures discussed include vaccines, peri-menopausal hormone therapy, aspirin in the treatment of heart attacks, prevention of sudden death after heart attacks, stroke prevention, preventing fatal pulmonary embolism in surgical patients. Includes a chapter on assessing net clinical benefits of a treatment. Closes with a glossary of methodological terms.
Download or read book Evidence Based Medicine and the Changing Nature of Health Care written by Institute of Medicine and published by National Academies Press. This book was released on 2008-09-06 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drawing on the work of the Roundtable on Evidence-Based Medicine, the 2007 IOM Annual Meeting assessed some of the rapidly occurring changes in health care related to new diagnostic and treatment tools, emerging genetic insights, the developments in information technology, and healthcare costs, and discussed the need for a stronger focus on evidence to ensure that the promise of scientific discovery and technological innovation is efficiently captured to provide the right care for the right patient at the right time. As new discoveries continue to expand the universe of medical interventions, treatments, and methods of care, the need for a more systematic approach to evidence development and application becomes increasingly critical. Without better information about the effectiveness of different treatment options, the resulting uncertainty can lead to the delivery of services that may be unnecessary, unproven, or even harmful. Improving the evidence-base for medicine holds great potential to increase the quality and efficiency of medical care. The Annual Meeting, held on October 8, 2007, brought together many of the nation's leading authorities on various aspects of the issues - both challenges and opportunities - to present their perspectives and engage in discussion with the IOM membership.
Download or read book Principles of Research Methodology written by Phyllis G. Supino and published by Springer Science & Business Media. This book was released on 2012-06-22 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: Principles of Research Methodology: A Guide for Clinical Investigators is the definitive, comprehensive guide to understanding and performing clinical research. Designed for medical students, physicians, basic scientists involved in translational research, and other health professionals, this indispensable reference also addresses the unique challenges and demands of clinical research and offers clear guidance in becoming a more successful member of a medical research team and critical reader of the medical research literature. The book covers the entire research process, beginning with the conception of the research problem to publication of findings. Principles of Research Methodology: A Guide for Clinical Investigators comprehensively and concisely presents concepts in a manner that is relevant and engaging to read. The text combines theory and practical application to familiarize the reader with the logic of research design and hypothesis construction, the importance of research planning, the ethical basis of human subjects research, the basics of writing a clinical research protocol and scientific paper, the logic and techniques of data generation and management, and the fundamentals and implications of various sampling techniques and alternative statistical methodologies. Organized in thirteen easy to read chapters, the text emphasizes the importance of clearly-defined research questions and well-constructed hypothesis (reinforced throughout the various chapters) for informing methods and in guiding data interpretation. Written by prominent medical scientists and methodologists who have extensive personal experience in biomedical investigation and in teaching key aspects of research methodology to medical students, physicians and other health professionals, the authors expertly integrate theory with examples and employ language that is clear and useful for a general medical audience. A major contribution to the methodology literature, Principles of Research Methodology: A Guide for Clinical Investigators is an authoritative resource for all individuals who perform research, plan to perform it, or wish to understand it better.
Download or read book Clinical Epidemiology written by Diederick E. Grobbee and published by Jones & Bartlett Publishers. This book was released on 2014-01-23 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now updated with new data and examples throughout, Clinical Epidemiology: Principles, Methods, and Applications for Clinical Research, Second Edition is a comprehensive resource that introduces the reader to the basics of clinical epidemiology and explores the principles and methods that can be used to obtain quantitative evidence on the effects of interventions and on the diagnosis, etiology, and prognosis of disease. The everyday challenges of clinical research and the quantitative knowledge required to practice medicine are also examined, making this book a valuable reference for both graduate and undergraduate students in medicine and related disciplines, as well as for professionals involved in the design and conduct of clinical research.
Download or read book Clinical Research Methodologyand Evidence Based Medicine The Basics written by Ajit Babu and published by BI Publications Pvt Ltd. This book was released on 2008-01-01 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Advanced Handbook of Methods in Evidence Based Healthcare written by Andrew Stevens and published by SAGE. This book was released on 2001-01-02 with total page 540 pages. Available in PDF, EPUB and Kindle. Book excerpt: ′This handbook is an excellent reflection of the growing maturity and methodological sophistication of the field of Health Technology Assessment. The Handbook covers a spectrum of issues, from primary evidence (clinical trials) through reviews and meta-analysis, to identifying and filling gaps in the evidence. Up-to-date, clearly written, and well-edited, the handbook is a needed addition to any personal or professional library dealing with Health Technology Assessment.′ Professor David Banta, TNO Prevention and Health, The Netherlands ′This text presents the most advanced knowledge on methodology in health care research, and will form the backbone of many future studies′ - Paula Roberts, Nurse Researcher The `effectiveness revolution′ both in research and clinical practice, has tested available methods for health services research to the extreme. How far can observational methods, routine data and qualitative methods be used in health care evaluation? What cost and outcome measures are appropriate, and how should data be gathered? With the support of over two million pounds from the British Health Technology Assessment Research Programme, the research project for this Handbook has led to both a synthesis of all of the existing knowledge in these areas and an agenda for future debate and research. The chapters and their authors have been selected through a careful process of peer review and provide a coherent and complete approach to the field. The handbook has been a unique collaboration between internationally regarded clinicians, statisticians, epidemiologists, social scientists, health economists and ethicists. It provides the most advanced thinking and the most authoritative resource for a state of the art review of methods of evaluating health care and will be required reading for anyone involved in health services research and management.
Download or read book How to Read a Paper written by Trisha Greenhalgh and published by John Wiley & Sons. This book was released on 2010-11-18 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: How to Read a Paper describes the different types of clinical research reporting, and explains how to critically appraise the publications. The book provides the tools to find and evaluate the literature, and implement the findings in an evidence-based, patient-centered way. Written for anyone in the health care professions who has little or no knowledge of evidence-based medicine, it provides a clear understanding of the concepts and how to put them into practice at the basic, clinical level. Changes for the 4th edition The fourth edition will include two new chapters on important developments in health care research and delivery, but otherwise retains its original style, size, and scope. New chapter on quality improvement – describing papers on quality improvement projects using ebm methods; this will extend the readership to non clinical health care professionals working in hospitals and family practice, and to nurse specialists and practice nurses working in this field New chapter on complex interventions - how to set up research projects involving both qualitative and quantitative methodology (known as mixed methods) Thorough revision and updating of existing chapters and references New illustrations – diagrammatic representations of ebm concepts
Download or read book Small Clinical Trials written by Institute of Medicine and published by National Academies Press. This book was released on 2001-01-01 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical trials are used to elucidate the most appropriate preventive, diagnostic, or treatment options for individuals with a given medical condition. Perhaps the most essential feature of a clinical trial is that it aims to use results based on a limited sample of research participants to see if the intervention is safe and effective or if it is comparable to a comparison treatment. Sample size is a crucial component of any clinical trial. A trial with a small number of research participants is more prone to variability and carries a considerable risk of failing to demonstrate the effectiveness of a given intervention when one really is present. This may occur in phase I (safety and pharmacologic profiles), II (pilot efficacy evaluation), and III (extensive assessment of safety and efficacy) trials. Although phase I and II studies may have smaller sample sizes, they usually have adequate statistical power, which is the committee's definition of a "large" trial. Sometimes a trial with eight participants may have adequate statistical power, statistical power being the probability of rejecting the null hypothesis when the hypothesis is false. Small Clinical Trials assesses the current methodologies and the appropriate situations for the conduct of clinical trials with small sample sizes. This report assesses the published literature on various strategies such as (1) meta-analysis to combine disparate information from several studies including Bayesian techniques as in the confidence profile method and (2) other alternatives such as assessing therapeutic results in a single treated population (e.g., astronauts) by sequentially measuring whether the intervention is falling above or below a preestablished probability outcome range and meeting predesigned specifications as opposed to incremental improvement.
Download or read book Evidence based Research Methods for Chinese Medicine written by Siu-wai Leung and published by Springer. This book was released on 2016-11-24 with total page 201 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a practical guide to the evidence-based medicine (EBM) research methods that are applicable to Chinese medicine (CM). It includes 3 parts: clinical research, healthcare data research and laboratory research. In each chapter, it explains how to acquire, analyze and evaluate a specific kind of CM research result. Authors exemplify the most important methods with successful cases in transforming reliable data into new knowledge of CM. This book emphasizes the requirements for CM researchers to design and conduct CM studies by following the best available principles, standards and guidelines.
Download or read book Introduction to Research Methodology for Specialist Trainees written by P. M. Shaughn O'Brien and published by RCOG. This book was released on 2007 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is written for trainees in all subjects related to health. Research-orientated questions are incorporated into the majority of Royal College membership examinations; for example, in the OSCE station a research study or paper has to be criticised. Because of the nature of the editors' posts and their contacts there is naturally an emphasis on the specialist registrar trainee in obstetrics and gynaecology and many of the writers and thus the examples in the text are obstetric and gynaecological, however physicians, surgeons, midwives and nurses could readily use the book.
Download or read book Design and Analysis of Clinical Trials written by Shein-Chung Chow and published by John Wiley & Sons. This book was released on 2008-12-04 with total page 754 pages. Available in PDF, EPUB and Kindle. Book excerpt: Praise for the First Edition of Design and Analysis of Clinical Trials "An excellent book, providing a discussion of the clinical trial process from designing the study through analyzing the data, and to regulatory requirement . . . could easily be used as a classroom text to understand the process in the new drug development area." –Statistical Methods in Medicine A complete and balanced presentation now revised, updated, and expanded As the field of research possibilities expands, the need for a working understanding of how to carry out clinical trials only increases. New developments in the theory and practice of clinical research include a growing body of literature on the subject, new technologies and methodologies, and new guidelines from the International Conference on Harmonization (ICH). Design and Analysis of Clinical Trials, Second Edition provides both a comprehensive, unified presentation of principles and methodologies for various clinical trials, and a well-balanced summary of current regulatory requirements. This unique resource bridges the gap between clinical and statistical disciplines, covering both fields in a lucid and accessible manner. Thoroughly updated from its first edition, the Second Edition of Design and Analysis of Clinical Trials features new topics such as: Clinical trials and regulations, especially those of the ICH Clinical significance, reproducibility, and generalizability Goals of clinical trials and target population New study designs and trial types Sample size determination on equivalence and noninferiority trials, as well as comparing variabilities Also, three entirely new chapters cover: Designs for cancer clinical trials Preparation and implementation of a clinical protocol Data management of a clinical trial Written with the practitioner in mind, the presentation assumes only a minimal mathematical and statistical background for its reader. Instead, the writing emphasizes real-life examples and illustrations from clinical case studies, as well as numerous references-280 of them new to the Second Edition-to the literature. Design and Analysis of Clinical Trials, Second Edition will benefit academic, pharmaceutical, medical, and regulatory scientists/researchers, statisticians, and graduate-level students in these areas by serving as a useful, thorough reference source for clinical research.
Download or read book Pearls and Tricks in Pediatric Surgery written by Martin Lacher and published by Springer Nature. This book was released on 2020-10-29 with total page 522 pages. Available in PDF, EPUB and Kindle. Book excerpt: Providing core information on pediatric surgery, this book serves as a supplement to standard pediatric surgical textbooks. It offers pearls of wisdom that will help those who participate in pediatric surgical care, as well as to provide state-of-the-art insights based on physiological principles, literature reviews, and clinical experience. This book is an ideal tool to help readers prepare for questions they will be asked on ward rounds, in the OR, or in oral exams. The depth of exploration is intended for medical students, residents in pediatrics and pediatric surgery, pediatric surgical trainees, pediatric nurse practitioners, primary care pediatricians, and family practitioners.
