Download or read book Clinical and Genetic Aspects of Sudden Cardiac Death in the Practice of Sports Medicine written by Lynne Millar and published by Morgan & Claypool Publishers. This book was released on 2012 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sudden cardiac death is the leading cause of non-traumatic mortality in young (
Download or read book Cardiovascular Genetics and Genomics written by Dhavendra Kumar and published by Springer. This book was released on 2018-01-17 with total page 921 pages. Available in PDF, EPUB and Kindle. Book excerpt: This title reflects the exponential growth in the knowledge and information on this subject and defines the extensive clinical translation of cardiovascular genetics and genomics in clinical practice. This concise, clinically oriented text is targeted at a broad range of clinicians who manage patients and families with a wide range of heterogeneous inherited cardiovascular conditions. Cardiovascular Genetics and Genomics: Principles and Clinical Practice includes a concise and clear account on selected topics written by a team of leading experts on clinical cardiovascular genetics. Each chapter include key information to assist the clinician and case histories have been incorporated to reflect contemporary practice in clinical cardiovascular genetics and genomics. Therefore this will be of key importance to all professionals working in the discipline, from clinicians and trainees in cardiology, cardiac surgery, electrophysiology, immunology through geneticists, nursing staff and those involved in precision medicine.
Download or read book Clinical Approach to Sudden Cardiac Death Syndromes written by Ramon Brugada and published by Springer Science & Business Media. This book was released on 2010-01-18 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical cardiologists are encountering an important challenge in the caring of families with inherited cardiac diseases. The majority of the inherited cardiac diseases causing sudden death express themselves at variable ages in the form of altered muscle function (i.e hypertrophic or dilated cardiomyopathy) or in the form of arrhythmias (i.e. Brugada syndrome, long QT syndrome). However, it is not uncommon that the first sign of the disease may actually be sudden cardiac death, even before the identification of clear clinical abnormalities. In this last decade, with more than 50 new disease-associated genes identified, the possibility of genetic testing has opened a new opportunity to disease diagnosis and prevention. Clinical and genetic research is continuously on-going not only to identify those at risk, but to better define their level or risk still with limited success.
Download or read book Sports Cardiology An Issue of Clinics in Sports Medicine written by Robert W. Battle and published by Elsevier Health Sciences. This book was released on 2015-10-26 with total page 201 pages. Available in PDF, EPUB and Kindle. Book excerpt: A sports cardiologist evaluates affected athletes and suggests the most appropriate treatment options that may allow them to stay active in sports. This issue will discuss the following topics: Cardiovascular Adaptation and Remodeling to Rigorous Athletic Training, The Historical Perspective of Athletic Sudden Death, The ECG in Elite Athletes, The Management of Athletes with Congenital Heart Disease, Genetic testing in athletesThe Impact of Sports Cardiology on the Practice of Sports Medicine and many more!
Download or read book Sports Cardiology An Issue of Clinics in Sports Medicine E Book written by Peter Dean and published by Elsevier Health Sciences. This book was released on 2022-06-19 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this issue of Clinics in Sports Medicine, guest editor Dr. Peter Dean brings his considerable expertise to the topic of Sports Cardiology. Top experts in the field cover key topics such as the importance of surrounding the athlete with a "team;" pre-participation evaluation of the athlete; risk and causes of sudden death in athletes; non-cardiac diseases that mimic cardiac symptoms in young athletes; incorporating new heart rate monitors, wearables, and watches into sports cardiology practice; and more. - Contains 12 relevant, practice-oriented topics including differentiating between pathologic heart disease and an "athletic heart;" exercise stress testing in the athlete; myocarditis/COVID-19 and the athlete; sports participation and physical activity in patients with hypertrophic cardiomyopathy; sports participation and physical activity in patients with inherited arrhythmias and atrial fibrillation; and more. - Provides in-depth clinical reviews on sports cardiology, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
Download or read book Clinical and Molecular Aspects of Motor Neuron Disease written by Johnathan Cooper-Knock and published by Biota Publishing. This book was released on 2013-09-01 with total page 62 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this e-book, motor neuron disease (MND) shall refer to amyotrophic lateral sclerosis (ALS), the most common neurodegenerative disorder affecting both the upper and lower motor neurons. With the discovery of C9ORF72 expansions in approximately 10% of all MND cases, in certain populations, we stand at the brink of a new era of MND research and hopefully treatment facilitated by the ability to associate a relatively large group of patients with a similar disease mechanism. This review will summarise both current clinical management of MND and our present understanding of the molecular pathogenesis of MND. Study of C9ORF72-MND has the potential to rapidly advance both of these aspects in the coming years.
Download or read book The Molecular Biology of Neurofibromatosis Type 1 written by Meena Upadhyaya and published by Biota Publishing. This book was released on 2014-02-01 with total page 81 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurofibromatosis type 1 (NF1) is a common autosomal dominantly inherited, tumour predisposition syndrome affecting 1/3,000-4,000 individuals worldwide. This inherited disorder results from the mutational inactivation of the NF1 gene on human chromosome 17. The NF1 gene contains 61 exons that give rise to 12kb mRNA encoding neurofibromin. The 327kDa (2,818 amino acid) neurofibromin protein is expressed in most tissues and has a number of alternative isoforms. Neurofibromin is a tumour suppressor protein and down-regulates cellular Ras. Increased active Ras-GTP levels also stimulate the important PI3K/AKT/mTOR signalling pathway that protects cells from apoptosis. The major clinical featues of NF1 include multiple café-au-lait macules, skinfold freckles, iris Lisch nodules, and neurofibromas. The diagnostic criteria for clinical diagnosis have been well established. However, there are a small number of cases in which the diagnosis is not certain. The germline mutation rate for the NF1 gene is 10-fold higher than that observed for most other inherited diseases. Using a combination of different techniques, almost 95% of germline mutations can be detected. To date, only two firm genotype phenotype correlations have been reported. NF1 phenotype exhibits large variations within a family, evidence for modifying loci regulating the expression of an NF1 gene is beginning to emerge. We also are gaining knowledge on the molecular mechanisms associated with the development of different types of tumours. It is encouraging that the results of recent laboratory and clinical research are finally being translated into clinical trials. With the availability of high-throughput technologies, sophisticated animal models, and multi-centre clinical trials, the future for NF1 sufferers is looking optimistic. This book aims to provide an overview of the genetic and clinical aspects of NF1 and its role in both NF1-associated and sporadic tumour development. It emphasizes the recent developments in this field and some of the promising on-going clinical trials.
Download or read book Preventing Sudden Death in Sport Physical Activity written by American College of Sports Medicine and published by Jones & Bartlett Publishers. This book was released on 2016-03-14 with total page 470 pages. Available in PDF, EPUB and Kindle. Book excerpt: Preventing Sudden Death in Sport and Physical Activity, Second Edition examines the etiology, prevention, recognition, treatment, and return-to-play protocol of the common causes of sudden death in sport. Chapters are written by content area experts, offering a blend of clinical, scientific, and research expertise regarding each medical condition that is discussed.
Download or read book Sports Cardiology Essentials written by Christine E. Lawless and published by Springer Science & Business Media. This book was released on 2010-11-09 with total page 411 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents an invaluable symptoms-based approach to sports cardiology for sports medicine physicians, primary care physicians, and cardiologists. Edited by an authority in the field, the text offers sought-after insight on the cardiac health of athletes. Case studies are featured throughout to further understanding and the integration of concepts into daily practice. With contributions by both sports medicine physicians and cardiologists, this timely book bridges the gap between disciplines and is an unparalleled resource for those looking to effectively manage the cardiac health of active patients.
Download or read book Exercise And Sports Cardiology In 3 Volumes written by Paul Davis Thompson and published by World Scientific Publishing. This book was released on 2018-04-24 with total page 969 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiac problems in athletic individuals are rare, but when they occur can be devastating. This book provides a definitive review of current practice and thinking surrounding the often difficult and life-changing practice of sports cardiology. Topics which remain a challenge for practitioners, athletes and families are investigated, including cardiovascular screening, exercise participation prescription, and prevention strategies for sudden cardiac arrest. Also given are guidelines for diagnosis, management and prevention of specific cardiac illnesses.This second edition includes new information on a number of key issues surrounding modern sports and cardiology, including the athlete at altitude, heat stress in athletes, exercise aspects of swimming and diving and ergogenics in the cardiac care of athletes. Additionally, further details are given on new research related to sports and exercise for individuals with implantable cardioverter defibrillators, advanced echocardiography in athletes and non-compaction cardiomyopathy.Building on the first edition, Exercise and Sports Cardiology (2nd Edition) provides cardiologists, physicians, coaches, trainers and medical students and researchers with a comprehensive go-to reference for modern day concerns in the expanding field of sports cardiology research and treatment.
Download or read book The ESC Textbook of Sports Cardiology written by Antonio Pelliccia and published by Oxford University Press. This book was released on 2019-03-14 with total page 477 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sports and exercise have been intensely advocated as protective lifestyle measures which prevent or reduce the risk of severe health issues, including cardiovascular disease. More extreme forms of sports (for instance at high altitudes) have been identified as an important way of promoting cardiovascular adaptation, but have also been associated with adverse effects and even major cardiovascular events in predisposed individuals. Participating in more commonplace sports and exercise, such as football, may also increase a person's risk of cardiac events. This publication is timely in the light of a burgeoning number of clinical papers in the field. The ESC Textbook of Sports Cardiology provides an overview of the detection and treatment of cardiovascular disease in elite athletes and young sports professionals in training, as well as prevention. It will be useful for clinical cardiologists, sports physicians, and general physicians alike. Split into 11 key areas in sports cardiology, ranging from sudden cardiac death in athletes to the most common cardiovascular abnormalities seen in athletes, and to the effects of substance abuse and doping, the text is an invaluable resource covering all aspects of sports cardiology. Access to the digital version of the textbook is included with purchase of the printed version. Highly illustrated with embedded multimedia features, together with cross-referenced links to related content and primary research data in major journals in the field, the digital version provides users with a dynamic and forward-thinking resource. The ESC Textbook of Sports Cardiology is the second textbook from the European Association of Preventive Cardiology (EAPC) and aligns with ESC clinical practice guidelines and EAPC recommendations and position papers.
Download or read book Sudden Cardiac Death in the Young and Athletes written by Gaetano Thiene and published by Springer. This book was released on 2018-04-25 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text atlas focuses on the pathology and molecular genetics of sudden cardiac death in the young and in athletes, presenting the state of the art in the field as the basis for development and implementation of more effective prevention strategies, including, ultimately, molecular therapy that will cure the underlying biological defect. A wealth of high-resolution color images, accompanied by clear supporting text, are presented to document the anatomic pathology of the cardiac diseases most frequently responsible for sudden cardiac death in this population, including coronary artery diseases, cardiomyopathies, myocarditis, valve diseases, conduction system abnormalities, congenital heart diseases, and ion channel diseases. The role of the molecular autopsy in overcoming the limitations of morphological investigations and offering new insights and avenues for prevention is explained. The approach is, however, interdisciplinary, with close attention also to epidemiologic and clinical aspects. The authors draw throughout on their experience gained over 30 years in the course of a prospective study carried out in the Veneto Region, North East Italy. This text atlas will be of great value not only for cardiologists but also for geneticists, sports physicians, and residents in cardiology and pathology.
Download or read book Clinical and Molecular Aspects of Cardiomyopathies On the road from gene to therapy An Issue of Heart Failure Clinics E Book written by Giuseppe Limongelli and published by Elsevier Health Sciences. This book was released on 2018-04-02 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Heart Failure Clinics--edited by Drs. Giuseppe Limongelli, Sharlene Day, and Perry Elliott--will cover Clinical and Molecular Aspects of Cardiomyopathies: On the Road from Gene to Therapy. Topics include, but are not limited to, Epidemiology and Clinical aspects of Genetic Cardiomyopathies, Existing and New therapies, Gene editing and gene-based therapeutics, Controversies surrounding exercise in genetic cardiomyopathies, Genetic infiltrative cardiomyopathies, LV Noncompaction, Clinical presentation and natural history of hypertrophic cardiomyopathy in Rasopathies, and Moelcular basis and new treatments of cardiac diseases in Rasopathies.
Download or read book Sports Cardiology An Issue of Clinics in Sports Medicine written by Peter Dean and published by Elsevier. This book was released on 2022-07-28 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this issue of Clinics in Sports Medicine, guest editor Dr. Peter Dean brings his considerable expertise to the topic of Sports Cardiology. Top experts in the field cover key topics such as the importance of surrounding the athlete with a "team;" pre-participation evaluation of the athlete; risk and causes of sudden death in athletes; non-cardiac diseases that mimic cardiac symptoms in young athletes; incorporating new heart rate monitors, wearables, and watches into sports cardiology practice; and more. Contains 12 relevant, practice-oriented topics including differentiating between pathologic heart disease and an "athletic heart;" exercise stress testing in the athlete; myocarditis/COVID-19 and the athlete; sports participation and physical activity in patients with hypertrophic cardiomyopathy; sports participation and physical activity in patients with inherited arrhythmias and atrial fibrillation; and more. Provides in-depth clinical reviews on sports cardiology, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
Download or read book Genomic Medicine written by Dhavendra Kumar and published by Oxford Monographs on Medical G. This book was released on 2014-10-15 with total page 853 pages. Available in PDF, EPUB and Kindle. Book excerpt: Preceded by Genomics and clinical medicine / edited by Dhavendra Kumar. [First edition]. 2008.
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1994 with total page 1516 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Current Challenges in Cardiovascular Molecular Diagnostics written by Matteo Vatta and published by Frontiers Media SA. This book was released on 2017-09-12 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of cardiovascular genetics has tremendously benefited from the recent application of massive parallel sequencing technology also referred to as next generation sequencing (NGS). However, along with the discovery of additional genes associated with human cardiac diseases, the analysis of large dataset of genetic information uncovered a much more complex and variegated landscape, which often departs from the comfort zone of the monogenic Mendelian diseases image that clinical molecular geneticists have been well acquainted with for many decades. It is now clear that, in addition to highly penetrant genetic variants, which in isolation are able to recapitulate the full clinical presentation when expressed in animal models, we are now aware that a small but significant fraction of subjects presenting with cardiac muscle diseases such as cardiomyopathies or primary arrhythmias such as long QT syndrome (LQTS), may harbor at least two deleterious variants in the same gene (compound heterozygous) or in different gene (double heterozygous). Although the clinical presentation in subjects with more than one deleterious variant appears to be more severe and with an earlier disease onset, it somehow changes the viewpoint of clinical molecular geneticists whose aim is to identify all possible genetic contributors to a human condition. In this light, the employment in clinical diagnostics of the NGS technology, allowing the simultaneous interrogation of a DNA target spanning from large panel of genes up to the entire genome, will definitely aid at uncovering all such contributors, which will have to be tested functionally to confirm their role in human cardiac conditions. The uncovering of all clinically relevant deleterious changes associated with a cardiovascular disease would probably increase our understanding of the clinical variability commonly occurring among affected family relatives, and potentially provide with unexpected therapeutic targets for the treatment of symptoms related to the presence of “accessory” deleterious genetic variants other than the key molecular culprit. The objective of this Research Topic is to explore the current challenges presenting to the cardiovascular genetics providers, such as clinical geneticists, genetic counselors, clinical molecular geneticists and molecular pathologists involved in the diagnosis, counseling, testing and interpretation of genetic tests results for the comprehensive management of patients affected by cardiovascular genetic disorders.
