Download or read book Cholinergic Function and Dysfunction written by and published by Elsevier. This book was released on 1993-09-09 with total page 461 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cholinergic Function and Dysfunction

Download or read book Cholinergic Function and Dysfunction written by A. Claudio Cuello and published by . This book was released on 1993 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Central Cholinergic Mechanisms and Adaptive Dysfunctions written by Man Singh and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although serious interest in studying the role of central cho linergic processes in psychopathology is just beginning to emerge, experimental literature on the part played by cholinergic mechanisms in brain behavior. reiations is quite extensive. During the past thirty years, cholinergic research has contributed significantly to the characterization and differentiation of adaptive mechanisms in volved in input selection, perception, cortical, autonomic and behav ioral activation, learning, memory, and inhibitory control of behav ioral outputs. To say that dysfunction of one or more of these mech anisms may be at the root of neuropsychiatric illnesses such as schiz ophrenia would be stating the obvious. This book examines the part cholinergic processes might play in dysfunctions of the adaptive processes involved in higher brain func tions and their significance for the pathogenesis, classification, etiology, and treatment of psychopathological conditions. In a series of wide ranging reviews of the available information, the subject is discussed from a variety of perspectives, using data derived from both experimental and clinical research. The purpose is not so much to determine whether cholinergic excess or deficiency is causal in this or that neuropsychiatric syndrome, but rather to try to understand the disease mechanisms in terms of adaptive processes in which cholinergic systems seem to play an important part.

Download or read book Cholinergic Mechanisms and Psychopharmacology written by D. Jenden and published by Springer Science & Business Media. This book was released on 2013-03-13 with total page 867 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume represents a collection of papers which were contributed by participants at a Symposium for Cholinergic Mechanisms and Psycho pharmacology, held in La Jolla, California on March 28-30, 1977. The were chosen to emphasize areas in which there has been substantial topics progress in the past 2-3 years and fall into seven major groups dealingwith: cholinergiC receptors; chemistry, histochemistry and enzymology; cyclic nucleotides and cholinergiC mechanisms; storage, compartmentation and release of acetylcholine; regulatory mechanisms in acetylcholine metab olism; modulation of acetylcholine metabolism; and behavioral and clin ical manifestations of cholinergiC function and dysfunction. Each group contains one or more reviews and a number of shorter contributions de scribing current work. This symposium was the third in a series of which the first two were held in Skokloster, Sweden in 1970 and Boldern, Switzerland in 1974. The Proceedings of the meetings indicate a rapid development of knowledge of cholinergiC mechanisms which for many years lagged behind that of other neurotransmitters and neuroregulators. The inclusion of a large section in the present volume dealing with clinical manifestations of cholinergiC dysfunction reflects one of the most important trends in current research on cholinergiC mechanisms, namely the close inter-relationship and mutual support of basic science and clinical investigation. I hope that this volume will be of value to all those whose work relates to cholinergiC function, at both basic and clinicalleve18, and will continue to stimulate the vigorous exchange of ideas which was such a prominent feature of the Symposium.

Download or read book Animal Models of Cognitive Impairment written by Edward D. Levin and published by CRC Press. This book was released on 2006-06-22 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: The costs associated with a drug's clinical trials are so significant that it has become necessary to validate both its safety and efficacy in animal models prior to the continued study of the drug in humans. Featuring contributions from distinguished researchers in the field of cognitive therapy research, Animal Models of Cognitive Impairmen

Download or read book Methods of Behavior Analysis in Neuroscience written by Jerry J. Buccafusco and published by CRC Press. This book was released on 2000-08-29 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: Using the most well-studied behavioral analyses of animal subjects to promote a better understanding of the effects of disease and the effects of new therapeutic treatments on human cognition, Methods of Behavior Analysis in Neuroscience provides a reference manual for molecular and cellular research scientists in both academia and the pharmaceutic

Download or read book Neural Plasticity and Memory written by Federico Bermudez-Rattoni and published by CRC Press. This book was released on 2007-04-17 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive, multidisciplinary review, Neural Plasticity and Memory: From Genes to Brain Imaging provides an in-depth, up-to-date analysis of the study of the neurobiology of memory. Leading specialists share their scientific experience in the field, covering a wide range of topics where molecular, genetic, behavioral, and brain imaging techniq

Download or read book Behavioral Pharmacology of the Cholinergic System written by Mohammed Shoaib and published by Springer Nature. This book was released on 2020-08-29 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: The molecular genetics of the cholinergic system including both muscarinic and nicotinic acetylcholine receptors, cholinesterases, acetylcholine synthesis and release have provided significant insights into potential targeting for pharmacological intervention. Cholinergic drugs are being used or evaluated for the treatment of diseases. Thus, this volume aims to broaden our understanding of the current state of cholinergic mechanisms to enable implementation of novel approaches for the development of more effective treatments.

Download or read book Nutrition and Traumatic Brain Injury written by Institute of Medicine and published by National Academies Press. This book was released on 2011-07-01 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: Traumatic brain injury (TBI) accounts for up to one-third of combat-related injuries in Iraq and Afghanistan, according to some estimates. TBI is also a major problem among civilians, especially those who engage in certain sports. At the request of the Department of Defense, the IOM examined the potential role of nutrition in the treatment of and resilience against TBI.

Download or read book Cholinergic Mechanisms From Molecular Biology to Clinical Significance written by J. Klein and published by Elsevier. This book was released on 1996-12-18 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume offers a comprehensive update and overview of the field of cholinergic transmission as presented by some thirty distinguished investigators who were recruited for their task from Germany, Great Britain, Canada, USA, Sweden, Israel, France and Italy. Exciting new discoveries, described in this volume, are due to recent methodological breakthroughs. These discoveries throw new light on many areas of cholinergic mechanisms.

Download or read book Neuronal Networks in Brain Function CNS Disorders and Therapeutics written by Carl Faingold and published by Academic Press. This book was released on 2013-12-26 with total page 537 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuronal Networks in Brain Function, CNS Disorders, and Therapeutics, edited by two leaders in the field, offers a current and complete review of what we know about neural networks. How the brain accomplishes many of its more complex tasks can only be understood via study of neuronal network control and network interactions. Large networks can undergo major functional changes, resulting in substantially different brain function and affecting everything from learning to the potential for epilepsy. With chapters authored by experts in each topic, this book advances the understanding of: How the brain carries out important tasks via networks How these networks interact in normal brain function Major mechanisms that control network function The interaction of the normal networks to produce more complex behaviors How brain disorders can result from abnormal interactions How therapy of disorders can be advanced through this network approach This book will benefit neuroscience researchers and graduate students with an interest in networks, as well as clinicians in neuroscience, pharmacology, and psychiatry dealing with neurobiological disorders. Utilizes perspectives and tools from various neuroscience subdisciplines (cellular, systems, physiologic), making the volume broadly relevant Chapters explore normal network function and control mechanisms, with an eye to improving therapies for brain disorders Reflects predominant disciplinary shift from an anatomical to a functional perspective of the brain Edited work with chapters authored by leaders in the field around the globe – the broadest, most expert coverage available

Download or read book Food Components to Enhance Performance written by Institute of Medicine and published by National Academies Press. This book was released on 1994-02-01 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: The physiological or psychological stresses that employees bring to their workplace affect not only their own performance but that of their co-workers and others. These stresses are often compounded by those of the job itself. Medical personnel, firefighters, police, and military personnel in combat settingsâ€"among othersâ€"experience highly unpredictable timing and types of stressors. This book reviews and comments on the performance-enhancing potential of specific food components. It reflects the views of military and non-military scientists from such fields as neuroscience, nutrition, physiology, various medical specialties, and performance psychology on the most up-to-date research available on physical and mental performance enhancement in stressful conditions. Although placed within the context of military tasks, the volume will have wide-reaching implications for individuals in any job setting.

Download or read book Neurotransmitters and Cortical Function written by Massimo Avoli and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 610 pages. Available in PDF, EPUB and Kindle. Book excerpt: Herbert Henri Jasper is a scientist whose research activities have initiated and encompassed many of the major themes of neuroscience. He has pioneered in single unit recording, chronic neuronal studies, neurochemistry, electroencephalography, and many other disciplines. His students now hold important positions in universities and hospitals around the world. From July 21 to 23, 1986, a symposium entitled Neurotransmitters and Cortical Function: From Molecules to Mind was held in Montreal to honor Professor Jasper and to continue his pioneering efforts. The following chapters originated in that meeting. They summarize the current v vi PREFACE status of our knowledge in some of the fields influenced by Professor Jasper. They share a focus on neurotransmitters in cortical function, where we presume higher mental events originate. Professor Jasper has made contributions to the understanding of three different classes of neuro transmitters: GABA, acetylcholine, and catecholamines. It is an interest in trying to link neu rochemical events to some aspects of complex brain function and behavior that has characterized his work, and it is this philosophy that led to the present symposium to honor him. We dedicate this volume to Professor Jasper and the integrative approach that he has fostered. The Editors Montreal Contents 1. H. H. Jasper, Neuroscientist of Our Century .......................... .

Download or read book Colonic Motility written by Sushil K. Sarna and published by Biota Publishing. This book was released on 2010-11-01 with total page 159 pages. Available in PDF, EPUB and Kindle. Book excerpt: Three distinct types of contractions perform colonic motility functions. Rhythmic phasic contractions (RPCs) cause slow net distal propulsion with extensive mixing/turning over. Infrequently occurring giant migrating contractions (GMCs) produce mass movements. Tonic contractions aid RPCs in their motor function. The spatiotemporal patterns of these contractions differ markedly. The amplitude and distance of propagation of a GMC are several-fold larger than those of an RPC. The enteric neurons and smooth muscle cells are the core regulators of all three types of contractions. The regulation of contractions by these mechanisms is modifiable by extrinsic factors: CNS, autonomic neurons, hormones, inflammatory mediators, and stress mediators. Only the GMCs produce descending inhibition, which accommodates the large bolus being propelled without increasing muscle tone. The strong compression of the colon wall generates afferent signals that are below nociceptive threshold in healthy subjects. However, these signals become nociceptive; if the amplitudes of GMCs increase, afferent nerves become hypersensitive, or descending inhibition is impaired. The GMCs also provide the force for rapid propulsion of feces and descending inhibition to relax the internal anal sphincter during defecation. The dysregulation of GMCs is a major factor in colonic motility disorders: irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), and diverticular disease (DD). Frequent mass movements by GMCs cause diarrhea in diarrhea predominant IBS, IBD, and DD, while a decrease in the frequency of GMCs causes constipation. The GMCs generate the afferent signals for intermittent short-lived episodes of abdominal cramping in these disorders. Epigenetic dysregulation due to adverse events in early life is one of the major factors in generating the symptoms of IBS in adulthood.

Download or read book Synthesis of Best Seller Drugs written by Ruben Vardanyan and published by Academic Press. This book was released on 2016-01-07 with total page 868 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthesis of Best-Seller Drugs is a key reference guide for all those involved with the design, development, and use of the best-selling drugs. Designed for ease of use, this book provides detailed information on the most popular drugs, using a practical layout arranged according to drug type. Each chapter reviews the main drugs in each of nearly 40 key therapeutic areas, also examining their classification, novel structural features, models of action, and synthesis. Of high interest to all those who work in the captivating areas of biologically active compounds and medicinal drug synthesis, in particular medicinal chemists, biochemists, and pharmacologists, the book aims to support current research efforts, while also encouraging future developments in this important field. Describes methods of synthesis, bioactivity and related drugs in key therapeutic areas Reviews the main drugs in each of nearly 40 key therapeutic areas, also examining their classification, novel structural features, models of action, and more Presents a practical layout designed for use as a quick reference tool by those working in drug design, development and implementation

Download or read book Exploring the Vertebrate Central Cholinergic Nervous System written by Alexander G. Karczmar and published by Springer Science & Business Media. This book was released on 2007-04-05 with total page 698 pages. Available in PDF, EPUB and Kindle. Book excerpt: Even if the “weapons of mass destruction” (WMD) and, among them, stocks of organoph- phorus (OP) agents (also referred to as war gases and nerve gases) were not found in Iraq following the US-Iraq war, the relative ease with which these substances can be made from harmless precursors and the low cost of their manufacture will continue to fascinate pow- hungry, ruthless dictators, as well as multinational and international terrorists, particularly as the close relationship between the OP agents and useful insecticides makes it easy to disguise the importation and purchase of small amounts of the precursors. Indeed, the use by Saddam Hussein of a nerve gas against the Kurds and his possible employment of the OP agents during his war with Iran, and the Sarin attack in the Tokyo underground by an extremist religious set magnetized the world with respect to the OP drugs. As these drugs exert their toxicity via their cholinergic action on the nervous, particularly central nervous, system, it is no wonder that the research in the cholinergic ? eld attracts, and merits, our intense attention. These considerations underlie the signi? cance of this book, as Alex Karczmar devotes an entire chapter of Exploring the Vertebrate Central Cholinergic Nervous System to anticholinest- ases (antiChEs), and as he is an acknowledged expert in the ? eld of cholinergic toxicity as well as a consultant to the Surgeon General of the U. S. Army.

Download or read book Psychiatry of Parkinson s Disease written by K.P. Ebmeier and published by Karger Medical and Scientific Publishers. This book was released on 2012-01-06 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: Psychiatric symptoms are common in the neurological and geriatric care of patients with Parkinson’s disease. This book assembles short reviews from experts in the field to chart the various psychiatric syndromes known in Parkinson’s disease, their presentation, etiology and management. Presented are special topics on epidemiology of psychiatric symptoms, affective disorders and apathy, early cognitive impairment through to dementia, visuoperceptual dysfunction, psychotic disorders, sleep disturbances, impulse disorders and sexual problems. Further, rarely discussed issues, such as the relationship between somatoform disorders and parkinsonism are reviewed. This publication is essential reading for old age psychiatrists, gerontologists and neurologists who work with patients suffering from Parkinson’s disease. In addition, health practitioners who deal with senior patients, as well as scientists who need a quick update on the progress in this important clinical field will find this volume a helpful reference.