Download or read book Chemotherapeutic and Chemopreventive Roles of Sphingolipids in Human Breast Cancer written by Hong Yang and published by . This book was released on 1999 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Exploring the Roles of Sphingolipid Metabolites on Breast Cancer written by and published by . This book was released on 2013 with total page 38 pages. Available in PDF, EPUB and Kindle. Book excerpt: Breast cancer is the most common cancer in women worldwide despite recent progress in breast cancer diagnosis and therapy. Thus, it remains crucial to explore novel approaches for its management. Sphingolipids have emerged as important regulators of cancer cell fate: ceramide has been shown to be pro-apoptotic, while sphingosine-1 phosphate (S1P) induces cell growth and survival. This research explores the roles of sphingolipid metabolites by evaluating five Drosophila melanogaster mutants with altered endogenous levels of ceramide, S1P, sphingosine and sphingadiene. Isolating, purifying and measuring lipid extracts from Drosophila allows the assessment of how different levels of sphingolipids can affect the growth of breast cancer cells by measuring their cytotoxicity, ability to generate ROS, and their effect on cell proliferation. The results indicate that the Sply, SK-1 and SK-2 lipid extracts were cytotoxic to breast cancer cells and stimulated ROS production in vitro. These results confirm the importance of investigating sphingolipid metabolites for chemotherapeutic development.

Download or read book Chemopreventive and Chemotherapeutic Mechanisms of Sphingolipid Metabolites in Human Colon Cancer Cells and Breast Stem Normal and Tumorigenic Cells written by Eun Hyun Ahn and published by . This book was released on 2002 with total page 470 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Cellular Lipid in Health and Disease written by James Mukasa Ntambi and published by Elsevier. This book was released on 2023-08-21 with total page 558 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cellular Lipid in Health and Disease presents a comprehensive and systematic coverage of the various roles lipids play in human biology. This book is organized in four parts covering the foundational concepts of lipid biology all the way to the therapeutic opportunities they present. The first part is dedicated to the basic concepts of cellular lipid, the roles it plays in the cell, structure and physiology, regulation mechanisms, storage, and utilization. The second part is focused on lipid metabolism, covering the organelles involved in lipid trafficking, metabolism in aging, cholesterol homeostasis, lipid droplets (LDs), and lipid oxidation. Part three is dedicated to the roles lipids play in specific disease states including renal, metabolic, cardiovascular, and fatty liver diseases. Other conditions include cancer, neurodegenerative diseases, and the intricate relationship between cellular lipids and autophagy. The final part covers therapeutic opportunities, including drug carrier systems, modeling lipid metabolism, and prevention therapeutics. Cellular Lipid in Health and Disease is a complete reference targeted at graduate students and early career researchers in cell biology, biochemistry, and pharmacology. Research physicians can also benefit from the foundational content and links to pathologies and therapeutic opportunities. Offers a complete and systematic coverage of lipid biology Provides foundational content and establishes the needed connections to translational aspects of the research in this area Includes chapters on the therapeutic opportunities presented by lipids

Download or read book Experimental Biology and Medicine written by and published by . This book was released on 2006 with total page 582 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Nutrition and Cancer Prevention written by Atif B. Awad and published by CRC Press. This book was released on 2005-09-19 with total page 637 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epidemiological studies have estimated that approximately 35 percent of cancers are potentially avoidable by nutritional modification. These modifications include strategies such as caloric restriction and limitation of specific macro-nutrient groups. However, recent research indicates that what you eat may well be just as important as what you s

Download or read book Natural Products for Cancer Prevention and Therapy written by Anupam Bishayee and published by MDPI. This book was released on 2018-11-07 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "Natural Products for Cancer Prevention and Therapy" that was published in Nutrients

Download or read book Nutrition in the Prevention and Treatment of Disease written by Ann M. Coulston and published by Academic Press. This book was released on 2012-12-17 with total page 920 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nutrition in the Prevention and Treatment of Disease, Third Edition is a comprehensive clinical nutrition textbook that integrates food issues with nutrition to provide a unique perspective to disease prevention/control. A proven classroom resource for understanding how nutrition can be used to improve health status, this book focuses on the clinical applications and disease prevention of nutrition, clearly linking the contributions of basic science to applied nutrition research and, in turn, to research-based patient care guidelines. The diversity of material makes this text useful for nutritional scientists and also for upper division nutrition course work. This new edition contains chapters that have been completed updated and features 26 new authors or co-authors. Topics include: Surgery for Severe Obesity; Snacking and Energy Balance in Humans; Phytochemicals in the Prevention and Treatment of Obesity and Its Related Cancers; Bioavailability and Metabolism of Bioactive Compounds from Foods; and Dietary Bioactive Compounds for Health. There are also discussions on bioactive components present in edible plants of particular interest for the prevention of disease; management of patients who have undergone surgical treatment for obesity; and greatly expanded coverage of biomarkers used to monitor nutrition interventions. Updated appendices include the latest dietary reference intakes. This book is aimed at upper division undergraduates and graduate students in nutrition and dietetics; professional nutritionists; dieticians; epidemiologists; general practitioners; nurse practitioners; and family medicine physicians. Selected for inclusion in Doody's Core Titles 2013, an essential collection development tool for health sciences libraries Integration of food issues with nutrition provides a unique perspective to disease prevention/control Material in the book is up-to-date with current research Individual sections of the book can be used for mini-courses or in-depth study Diversity of material makes this text useful for nutritional scientists and also for upper division nutrition course work

Download or read book Index Medicus written by and published by . This book was released on 2003 with total page 2268 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.

Download or read book Ceramide Signaling written by Anthony H. Futerman and published by Springer. This book was released on 2012-11-06 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ceramide Generation 127 Ceramide Targets 129 Ceramide Function 129 Therapeutic Implications 130 Concluding Remarks 130 14. Ceramide Glycosylation and Chemotherapy Resistance 133 Myles C. Cabot 15. Ceramide in Serum Lipoproteins: Function and Regulation of Metabolism 141 Mariana N. Nikolova-Karakashian Abstract . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 141 Int roduction 141 Ceramide is a Component ofSerum Lipoproteins 142 Secretion of Ceramide in the Form ofVLOL by the Liver 142 Generation of Ceramide in LOL Particles 143 Biological Consequences of Elevation of Ceramide Concentrations in LDL 145 Conclusions and Future Directions 147 16. T herapeutic Implications of Ceramide-Regulated Signaling Cascades 149 Mark Kester, fongK Yun, Tom Stover andLakshman Sandirasegarane Abstract 149 The Bench-Ceramides and Signaling Cascades 149 The Bedside-Ceramides and Cardiovascular Disease 150 The Bedside-Ceramides and Cancer 153 The Bedside-Other Potential Applications for Ceramide-Based Therapeutics 155 Conclusions-Back to the Bench 155 Index 161 EDITOR ====================;-t Anthony H. Futerman, PhD Department of Biological Chemistry Weizmann Institute of Science Rehovot, Israel email: tony. futerman@Weizmann. ac. iI Chapter 11 I===========CONTRIBUTORS==========~ JeremyC. Allegood Myles C. Cabot Schoolof Biology John Wayne Cancer Institute Petit Institute for Bioengineering SantaMonica, California, U. S. A. and Biosciences email: cabot@jwci. org GeorgiaInstitute of Technology Chapter 14 Atlanta, Georgia, U. S. A. Chapter 1 Charles E. Chalfant Department of Biochemistry Lindsay Andras and Molecular Biology Schoolof Biology Medical University of South Carolina Petit Institute for Bioengineering Charleston, South Carolina, U. S. A. and Biosciences email: chalfant@musc. edu Georgia Institute of Technology Chapter 6 Atlanta, Georgia, U. S. A.

Download or read book Drug Targets in Cellular Processes of Cancer From Nonclinical to Preclinical Models written by Hardeep Singh Tuli and published by Springer Nature. This book was released on 2020-09-30 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores potential cellular drug targets for cancer therapy. The first couple of chapters describe conventional treatment (radiotherapy, chemotherapy, and immunotherapy) & detection (biosensors) strategies for cancer. In contrast, the subsequent chapters address the role of cyclin-dependent kinases and cell cycle regulatory proteins in the growth of cancer cells and their potential as target for cancer treatment. The book then discusses the regulation of various pro-apoptotic and anti-apoptotic proteins via chemotherapeutic drugs. In addition, it examines the molecular mechanisms that are critical for mediating autophagic cell death in cancer cells. It subsequently reviews the role of reactive oxygen (ROS) species during carcinogenesis and during chemotherapy, and the potential of anti-inflammatory routes for the development of new therapeutic modulators. Lastly, it describes therapeutic strategies that target the tumor microenvironment and various angiogenic pathways for the treatment of cancer and to develop personalized medicine. Given its scope, the book is valuable resource for oncologists, cancer researchers, clinicians, and pharmaceutical industry personnel.

Download or read book Bioactive Molecules in Food written by Jean-Michel Mérillon and published by Springer Nature. This book was released on 2019-01-25 with total page 2353 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference work provides comprehensive information about the bioactive molecules presented in our daily food and their effect on the physical and mental state of our body. Although the concept of functional food is new, the consumption of selected food to attain a specific effect existed already in ancient civilizations, namely of China and India. Consumers are now more attentive to food quality, safety and health benefits, and the food industry is led to develop processed- and packaged-food, particularly in terms of calories, quality, nutritional value and bioactive molecules. This book covers the entire range of bioactive molecules presented in daily food, such as carbohydrates, proteins, lipids, isoflavonoids, carotenoids, vitamin C, polyphenols, bioactive molecules presented in wine, beer and cider. Concepts like French paradox, Mediterranean diet, healthy diet of eating fruits and vegetables, vegan and vegetarian diet, functional foods are described with suitable case studies. Readers will also discover a very timely compilation of methods for bioactive molecules analysis. Written by highly renowned scientists of the field, this reference work appeals to a wide readership, from graduate students, scholars, researchers in the field of botany, agriculture, pharmacy, biotechnology and food industry to those involved in manufacturing, processing and marketing of value-added food products.

Download or read book Omega 3 Fatty Acids written by Mahabaleshwar V. Hegde and published by Humana Press. This book was released on 2016-09-15 with total page 611 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume argues for the importance of essential nutrients in our diet. Over the last two decades there has been an explosion of research on the relationship of Omega-3 fatty acids and the importance of antioxidants to human health. Expert authors discuss the importance of a diet rich in Omega-3 Fatty acids for successful human growth and development and for the prevention of disease. Chapters highlight their contribution to the prevention and amelioration of a wide range of conditions such as heart disease, diabetes, arthritis, cancer, obesity, mental health and bone health. An indispensable text designed for nutritionists, dietitians, clinicians and health related professionals, Omega-3 Fatty Acids: Keys to Nutritional Health presents a comprehensive assessment of the current knowledge about the nutritional effects of Omega-3 fatty acids and their delivery in foods.

Download or read book Metabolism in Cancer written by Thorsten Cramer and published by Springer. This book was released on 2016-08-24 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook presents concise chapters written by internationally respected experts on various important aspects of cancer-associated metabolism, offering a comprehensive overview of the central features of this exciting research field. The discovery that tumor cells display characteristic alterations of metabolic pathways has significantly changed our understanding of cancer: while the first description of tumor-specific changes in cellular energetics was published more than 90 years ago, the causal significance of this observation for the pathogenesis of cancer was only discovered in the post-genome era. The first 10 years of the twenty-first century were characterized by rapid advances in our grasp of the functional role of cancer-specific metabolism as well as the underlying molecular pathways. Various unanticipated interrelations between metabolic alterations and cancer-driving pathways were identified and currently await translation into diagnostic and therapeutic applications. Yet the speed, quantity, and complexity of these new discoveries make it difficult for researchers to keep up to date with the latest developments, an issue this book helps to remedy.

Download or read book Bioactive Natural Products for the Management of Cancer from Bench to Bedside written by Anil K. Sharma and published by Springer. This book was released on 2019-07-17 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book illustrates the importance of the Natural Biometabolites, which offer a rich reservoir of candidate compounds for drug discovery in the battle against cancer. Recent research and development efforts concerning anti-cancer drugs derived from natural products have led to the identification of numerous candidate molecules that inhibit cancer cell proliferation and metastasis using a variety of mechanisms. Given its scope, the book offers a valuable resource for cancer biologists and general oncologists alike, while also benefitting research professionals in Science, Nursing, Medicine, Biochemistry, Genetics and Bioscience who wish to understand the fundamentals of prognosis and prediction in tumorigenesis. Moreover, the book provides an essential platform for understanding drug resistance mechanisms and combatting the growing menace of multidrug resistance.

Download or read book Oxidative Stress and Chronic Degenerative Diseases written by Jose Antonio Morales-Gonzalez and published by BoD – Books on Demand. This book was released on 2013-05-22 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work responds to the need to find, in a sole document, the affect of oxidative stress at different levels, as well as treatment with antioxidants to revert and diminish the damage. Oxidative Stress and Chronic Degenerative Diseases - a Role for Antioxidants is written for health professionals by researchers at diverse educative institutions (Mexico, Brazil, USA, Spain, Australia, and Slovenia). I would like to underscore that of the 19 chapters, 14 are by Mexican researchers, which demonstrates the commitment of Mexican institutions to academic life and to the prevention and treatment of chronic degenerative diseases.

Download or read book Autophagy Cancer Other Pathologies Inflammation Immunity Infection and Aging written by M. A. Hayat and published by Academic Press. This book was released on 2016-12-28 with total page 431 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging is an eleven volume series that discusses in detail all aspects of autophagy machinery in the context of health, cancer, and other pathologies. Autophagy maintains homeostasis during starvation or stress conditions by balancing the synthesis of cellular components and their deregulation by autophagy. This series discusses the characterization of autophagosome-enriched vaccines and its efficacy in cancer immunotherapy. Autophagy serves to maintain healthy cells, tissues, and organs, but also promotes cancer survival and growth of established tumors. Impaired or deregulated autophagy can also contribute to disease pathogenesis. Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward-thinking, these books offer a valuable guide to cellular processes while also inciting researchers to explore their potentially important connections. Presents the most advanced information regarding the role of the autophagic system in life and death Examines whether autophagy acts fundamentally as a cell survivor or cell death pathway or both Introduces new, more effective therapeutic strategies in the development of targeted drugs and programmed cell death, providing information that will aid in preventing detrimental inflammation Features recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities, including atherosclerosis and CNS tumors, and their development and treatment Includes chapters authored by leaders in the field around the globe—the broadest, most expert coverage available