Download or read book Chemically Induced Aneuploidy written by Peter Arni and published by . This book was released on 1998 with total page 121 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Chemically Induced Aneuploidy written by R. D. P. Bourner and published by . This book was released on 1998 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Chemically Induced Aneuploidy written by and published by . This book was released on 1986 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Chemically Induced Aneuploidy written by Associazione genetica italiana. Comitato Nazionale per la Ricerca e lo Sviluppo dell' Energia Nucleare e delle Energie Alternative and published by . This book was released on 1986 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Detection of Chemically Induced Aneuploidy in Male and Female Meiosis written by Fengyun Sun and published by . This book was released on 2004 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Detection of Chemically Induced Aneuploidy in Rat Cells Using Fluorescence in Situ Hybridization written by Joyce Marina de Stoppelaar and published by . This book was released on 2000 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Aneuploidy written by Vicki Dellarco and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 557 pages. Available in PDF, EPUB and Kindle. Book excerpt: The "Symposium on Aneuploidy: Etiology and Mechanisms" was held at the Carnegie Institution of Washington Auditorium from March 25-29. 1985. This Symposium developed as a consequence of the concern of the Environmen tal Protection Agency with the support of the National Institute of Envi ronmental Health Sciences about human exposure to environmental agents that cause aneuploidy. The program was chosen to explore what is currently known about the underlying causes, the origins, and the extent of the prob lem of human aneuploidy, and whether exposure to environmental agents is assodated with an increased incidence of aneuploidy in humans. Basic research findings in the area of mitosis and meiosis were presented and related to possible mechanisms of how aneuploidy may be produced spontane ously and chemically. A survey of data regarding the chemical induction of aneuploidy in experimental organisms was presented. Outstanding scientists from different fields were invited to cover a broad perspective of aneu ploidy from the molecular aspects to the human situation. We hope that the publication of the proceedings will share the enthu siasm of the meeting and its scientific content. The topic of aneuploidy has received little attention and it is the purpose of this Volume to establish a scientific basis for assessing health risks posed by environ mental exposures to aneuploidy-inducing chemicals. Vicki L. DeJlarco Peter E. Voytek Alexander Hollaender vii ACKNOWLEDGEMENT The Editors of the proceedings of the "Symposium on Aneuploidy" wish to acknowledge the support of Dr. Elizabeth L.

Download or read book Chemically Induced Aneuploidy Tests and Mechanisms written by and published by . This book was released on 1987* with total page 87 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Molecular Cytogenetic Analysis of Chemically Induced Aneuploidy in Germinal and Somatic Cells of Mice written by Sabry Attia and published by . This book was released on 2004 with total page 125 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Aneuploidy written by and published by . This book was released on 1987 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Chromosomal Imbalance Theory of Cancer written by David Rasnick and published by CRC Press. This book was released on 2016-04-19 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Exploring the chromosomal imbalance (aneuploidy) theory of cancer, this volume describes how cancer is initiated and why progression takes years to decades. It clarifies why cancer cells often become drug resistant, provides objective, quantitative measures for detecting cancer and monitoring its progression, and suggests non-toxic strategies of ca

Download or read book Mechanisms and Chemical Induction of Aneuploidy in Rodent Germ Cells written by and published by . This book was released on 2004 with total page 25 pages. Available in PDF, EPUB and Kindle. Book excerpt: The objective of this review is to suggest that the advances being made in our understanding of the molecular events surrounding chromosome segregation in non-mammalian and somatic cell models be considered when designing experiments for studying aneuploidy in mammalian germ cells. Accurate chromosome segregation requires the temporal control and unique interactions among a vast array of proteins and cellular organelles. Abnormal function and temporal disarray among these, and others to be inidentified, biochemical reactions and cellular organelles have the potential for predisposing cells to aneuploidy. Although numerous studies have demonstrated that certain chemicals (mainly those that alter microtubule function) can induce aneuploidy in mammalian germ cells, it seems relevant to point out that such data can be influenced by gender, meiotic stage, and time of cell-fixation post-treatment. Additionally, a consensus has not been reached regarding which of several germ cell aneuploidy assays most accurately reflects the human condition. More recent studies have shown that certain kinase, phosphatase, proteasome, and topoisomerase inhibitors can also induce aneuploidy in rodent germ cells. We suggest that molecular approaches be prudently incorporated into mammalian germ cell aneuploidy research in order to eventually understand the causes and mechanisms of human aneuploidy. Such an enormous undertaking would benefit from collaboration among scientists representing several disciplines.

Download or read book Molecular Cytogenetic Analysis of Chemically Induced Aneuploidy in Germinal and Somatic Cells of Mice written by and published by . This book was released on 2007 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Aneuploidy is a frequent cause of mental retardation, congenital malformations and pregnancy wastage in human beings. In addition, it is also frequently observed in various stages of carcinogenesis in man. A series of three related but separated studies were conducted to assess the aneugenic effects induced in mouse sperm and bone marrow following etoposide (VP-16) and merbarone (MER) administrations. First, the possibility of a cell cycle delay caused by the test chemicals was assessed using the meiotic delay assay in order to optimise the test protocol and to avoid missing an effect by inappropriate timing of the sperm samples. Second, the sperm-FISH assay with DNA-probes specific for mouse chromosomes X, Y and 8 was used to determine the frequency of hyperhaploidy and diploidy in mouse sperm induced during meiotic divisions of spermatocytes. Lastly, the conventional bone marrow micronuclei (MN) assay was applied and the origin of the MN was determined with FISH using the minor satellite DNA probe. By using the BrdU-incorporation assay it could be shown that topoisomerase (topo) II poison VP-16 induced a meiotic delay of 24 h while the catalytic topo II inhibitor MER did not prolong the meiotic divisions. By using the sperm-FISH analysis, it could be shown that the topo II-inhibitor VP-16 and MER induce aneuploidy during meiosis that results in disomic sperm and caused meiotic arrest that results in diploid sperm. By using FISH analysis with the minor mouse-satellite DNA-probe for erythrocyte MN it could be shown that VP-16 and MER are aneugens as well as clastogens. These data explain why cancer patients treated with drug regimens that include topo II inhibitors such as VP-16 or MER are at risk for siring chromosomally abnormal off-spring and, may develop secondary tumours.

Download or read book Measure of the Induction of Aneuploidy by Chemicals written by James M. Parry and published by . This book was released on 2000-11-23 with total page 76 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemicals capable of inducing aneuploidy are of concern in chemical testing because of the role of numerical chromosome changes in human congenital abnormalities and cancer induction and progression. A primary aim of the project recorded in this report was to develop and validate suitable in vitro protocols for the detection and assessment of potential chemical aneugens, including chemcials that may be presents in the workplace,

Download or read book The Origin of Malignant Tumors written by Theodor Boveri and published by . This book was released on 1929 with total page 119 pages. Available in PDF, EPUB and Kindle. Book excerpt: The translation helped bring her husband's chromosome theory of cancer to the attention of a wider audience and rediscover his work.

Download or read book Human Reproductive and Prenatal Genetics written by Peter C.K. Leung and published by Elsevier. This book was released on 2023-03-22 with total page 930 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human Reproductive and Prenatal Genetics, Second Edition provides application-driven coverage of key topics in human reproductive and prenatal genetics, including genetic control underlying the development of the reproductive tracts and gametogenesis, the genetics of fertilization and implantation, the genetic basis of female and male infertility, as well as genetic and epigenetic aspects of assisted reproduction. Also examined are the genetics and epigenetics of the placenta in normal and abnormal pregnancy, preimplantation genetic diagnosis and screening, and cutting-edge advances in noninvasive prenatal screening, prenatal genetic counseling, and bioethical and medicolegal aspects of relevance in the lab and clinic. This new edition has been fully revised to address new and evolving technologies in human reproductive genetics, with new chapters added on chromatin landscapes and sex determination, genetic alterations of placental development and preeclampsia, metabolism and inflammation in PCOS, pre-implantational genetic testing, maternal genetic disorders, bioethics, and future applications. Features chapter contributions from leading international scientists and clinicians Provides in-depth coverage of key topics in human reproductive and prenatal genetics, including genetic controls, fertilization, placental development, embryo implantation, in vitro culture of the human embryo for the study of post-implantation development, and more Identifies how researchers and clinicians can implement the latest genetic, epigenetic, and –omics-based approaches Includes all new chapters on evolving technologies and recent genetic discoveries of relevance to reproductive medicine

Download or read book Holland Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates