Download or read book Chemical Models of the Active Sites of Metalloenzymes Containing Nickel and Iron written by Matthew Charles Smith and published by . This book was released on 2002 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Chemical Models of the Active Site Cores of Some Nickel Containing Enzymes written by Samantha Elaine Duff and published by . This book was released on 2005 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Encyclopedia of Geobiology written by Joachim Reitner and published by Springer. This book was released on 2011-03-10 with total page 927 pages. Available in PDF, EPUB and Kindle. Book excerpt: The interplay between Geology and Biology has shaped the Earth from the early Precambrian, 4 billion years ago. Moving beyond the borders of the classical core disciplines, Geobiology strives to identify chains of cause-and-effect and synergisms between the geo- and the biospheres that have been driving the evolution of life in modern and ancient environments. Combining modern methods, geobiological information can be extracted not only from visible remains of organisms, but also from organic molecules, rock fabrics, minerals, isotopes and other tracers. An understanding of these processes and their signatures reveals enormous applied potentials with respect to issues of environment protection, public health, energy and resource management. The Encyclopedia of Geobiology has been designed to act as a key reference for students, researchers, teachers, and the informed public and to provide basic, but comprehensible knowledge on this rapidly expanding discipline that sits at the interface between modern geo- and biosciences.
Download or read book Modeling the Active Sites of Metalloenzymes with Thiolate Coordination written by Curtis Eugene Moore and published by . This book was released on 2007 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nitrile Hydratase (NHase) is a bacterial enzyme which catalyzes the hydrolysis of organic nitriles to their corresponding amides. The active site of NHase contains Fe (III) or Co(III) ions in an unusual coordination sphere containing 2 amide N atoms and three S donors. The research described herein is an attempt to model this active site using two different model systems: one that generates metal-coordinated imines, and one that generates metal-coordinated amides. Using 2,20́9-dithiodibenzaldehyde and derivatives of 2,20́9-dithiodisalicylic acid as reactants, several new and interesting metal coordinated imine and metal coordinated amide complexes have been synthesized. The synthesis and crystallization of several new organic and ligand species is discussed as well. The synthesis of a Co complex that resembles the active site of NHase is reported herein, along with several other new organometallic species. Also, two projects using computational chemistry are reported: one modeling trispyrazolylborate (Tp) complexes of iron and copper, and one modeling iron, manganese, and copper complexes of pentadentate imine/phenolate ligands. Complexes of Tp ligands with relatively bulky substituents in the 3-position are subject to isomerization through a borotropic shift. Computational chemistry has shed light on the energetics behind the borotropic shift. Calculations on the CO stretching frequency of several different TpCu(I)CO complexes have been carried out in an effort to match experimental data and generate predictive values for several other species not yet synthesized. This stretching frequency can generally be directly related to the electron withdrawing/donating character of the Tp ligand attached to the metal center. Pentdentate imine/phenolate ligands can coordinate to transition metals in a number of isomers. Computational chemistry has been used to shed light on the structural preferences of the iron, manganese, and copper species. These calculations were able to match the experimental data for crystallographically characterized species, and the metal complexes were shown to have specific structural preferences depending on the identity of the metal used.
Download or read book Metal Containing Enzymes written by and published by Academic Press. This book was released on 2014-11-24 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: Published continuously since 1944, the Advances in Protein Chemistry and Structural Biology series is the essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins. Each thematically organized volume is guest edited by leading experts in a broad range of protein-related topics. Describes advances in metal-containing enzymes Chapters are written by authorities in their field Targeted to a wide audience of researchers, specialists, and students The information provided in the volume is well supported by a number of high quality illustrations, figures, and tables
Download or read book Peptide Protein and Enzyme Design written by and published by Academic Press. This book was released on 2016-08-27 with total page 686 pages. Available in PDF, EPUB and Kindle. Book excerpt: De Novo Enzyme Design, the newest volume in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume includes the design of metal binding maquettes, insertion of non-natural cofactors, Cu metallopeptides, non-covalent interactions in peptide assemblies, peptide binding and bundling, heteronuclear metalloenzymes, florinated peptides, De Novo imaging agents, and protein-protein interaction. Continues the legacy of this premier serial with quality chapters on de novo enzyme design Represents the newest volume in the Methods in Enzymology series, providing premier, quality chapters authored by leaders in the field Ideal reference for those interested in the study of enzyme design that looks at both structure and mechanism
Download or read book Metal Transporters written by Jose M. Arguello and published by Academic Press. This book was released on 2012-10-25 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of Current Topics in Membranes focuses on metal transmembrane transporters and pumps, a recently discovered family of membrane proteins with many important roles in the physiology of living organisms. The book summarizes the most recent advances in the field of metal ion transport and provides a broad overview of the major classes of transporters involved in homeostasis of heavy metals. Various families of the transporters and metal specificities are discussed with the focus on the structural and mechanistic aspects of their function and regulation. The reader will access information obtained through a variety of approaches ranging from X-ray crystallography to cell biology and bioinformatics, which have been applied to transporters identified in diverse biological systems, such as pathogenic bacteria, plants, humans and others. Field is cutting-edge and a lot of the information is new to research community Wide breadth of topic coverage Contributors of high renown and expertise
Download or read book Advances in Heterocyclic Chemistry written by Alan R. Katritzky and published by Academic Press. This book was released on 2011-02-17 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: Established in 1960, Advances in Heterocyclic Chemistry is the definitive serial in the area—one of great importance to organic chemists, polymer chemists, and many biological scientists. Written by established authorities in the field, the comprehensive reviews combine descriptive chemistry and mechanistic insight and yield an understanding of how the chemistry drives the properties. Provides up-to-date material on a fast-growing and highly topical subject area Contains the latest research covering a wide variety of heterocyclic topics Written by leading authorities and designed as a handbook for students and industry and academic researchers
Download or read book Research Awards Index written by and published by . This book was released on 1985 with total page 1588 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Concepts and Models in Bioinorganic Chemistry written by Heinz-Bernhard Kraatz and published by Wiley-VCH. This book was released on 2006-07-21 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: Destined to set the standard, this book meets the need for a didactic textbook focusing on the role of model systems in bioinorganic chemistry. The first part features concepts in bioinorganic chemistry such as electron transfer, medicinal inorganic chemistry, bioorganometallics and metal DNA complexes, while the second part presents inorganic model chemistry on metallo-enzymes, organized by metal ion. Experts in the pertinent fields provide a didactically well-organized background on relevant biological systems, as well as on their structural, functional and spectroscopic properties. All chapters are similarly structured, each one beginning with a timeline featuring the most important historical facts on the subject, followed by a table of the most significant enzymes. The authors also summarize key developments and open questions within the respective model systems. This book is aimed at senior undergraduate and graduate students in chemistry, biochemistry, life science and related fields.
Download or read book Computational Studies of Metalloenzymes written by Magne Torbjörnsson and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Enzymes are involved in most reactions in nature. They are important both for the understanding of biological life and for reactions of industrial interest, e.g. in the production of artificial fertilizers, the production of biomass or biofuels. Enzymes with one or several metal ions are called metalloenzymes. In this thesis we study three different metalloenzymes, nitrogenase, lytic polysaccharide monooxygenase (LPMO) and particulate methane monooxygenase (pMMO) with computer simulations. We use mainly combined quantum mechanical and molecular mechanical (QM/MM) calculations with the density functional theory (DFT) method. Nitrogenase is the only enzyme that can break the triple bond in nitrogen molecules, making nitrogen available for plant metabolism. Previous studies have shown that different DFT methods give widely different results for the relative energies of different structures of putative intermediates in the reaction mechanism of nitrogenase. Therefore, we have tried to calibrate DFT calculations in two different ways. First, we use experimental data of structures and reactions related to nitrogenase to see what DFT functionals give the most accurate results. Our results indicate that BLYP, B97D and MN15 give the best results. Second, we have developed a small and simple model system of the active site of nitrogenase, [Fe(SH)4H]−. This model still shows a large variation in DFT estimate of the energy difference between structures protonated on Fe or on S, 25-163 kJ/mol. We then use a series of advanced and accurate QM methods, including coupled-cluster, selected configuration-interaction and multicon gurational perturbation theory methods to calibrate the DFT methods. With this model, M06 and B3LYP give the most accurate results. The second studied enzyme is LPMO, which is a copper dependent enzyme used for the degradation of polysaccharides, such as cellulose and chitin. The mechanism of this enzyme is quite well known but it has an unusual methyl modi cation of one of the ligands. Our calculations suggest that this group may protect the enzyme from self-oxidation. The third studied enzyme is pMMO. This enzyme can hydroxylate methane. This enzyme is hard to study experimentally and the nature and location of the active site is still controversial. We have studied the reactivity of three putative active sites, involving mononuclear copper sites, and have shown that they can support similar reactions. The CuC site gives the most favourable energetics.
Download or read book Hydrogen as a Fuel written by Richard Cammack and published by CRC Press. This book was released on 2001-11-15 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: There continues to be widespread interest in the applications of hydrogen as a clean fuel and its potential for local electricity production and use in transport. Recent years have seen a variety of breakthroughs in our understanding of the nature, structure, and biosynthesis of hydrogenases. This book is a timely description of these developments,
Download or read book Iron containing Enzymes written by Sam P. De Visser and published by Royal Society of Chemistry. This book was released on 2011 with total page 463 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mononuclear iron containing enzymes are important intermediates in bioprocesses and have potential in the industrial biosynthesis of specific products. This book features topical review chapters by leaders in this field and its various sub-disciplines.
Download or read book Nickel and Its Surprising Impact in Nature written by Astrid Sigel and published by John Wiley & Sons. This book was released on 2007-03-13 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: Helmut Sigel, Astrid Sigel and Roland K.O. Sigel, in close cooperation with John Wiley & Sons, launch a new Series “Metal Ions in Life Sciences”. The philosophy of the Series is based on the one successfully applied to a previous series published by another publisher, but the move from “biological systems” to “life sciences” will open the aims and scope and allow for the publication of books touching on the interface between chemistry, biology, pharmacology, biochemistry and medicine. Volume 2 focuses on the vibrant research area concerning nickel as well as its complexes and their role in Nature. With more than 2,800 references and over 130 illustrations, it is an essential resource for scientists working in the wide range from inorganic biochemistry all the way through to medicine. In 17 stimulating chapters, written by 47 internationally recognized experts, Nickel and Its Surprising Impact in Nature highlights critically the biogeochemistry of nickel, its role in the environment, in plants and cyanobacteria, as well as for the gastric pathogen Helicobacter pylori, for gene expression and carcinogenensis. In addition, it covers the complex-forming properties of nickel with amino acids, peptides, phosphates, nucleotides, and nucleic acids. The volume also provides sophisticated insights in the recent progress made in understanding the role of nickel in enzymes such as ureases, hydrogenases, superoxide dismutases, acireductone dioxygenases, acetyl-coenzyme A synthases, carbon monoxide dehydrogenases, methyl-coenzyme M reductases...and it reveals the chaperones of nickel metabolism.
Download or read book Biorefinery From Biomass to Chemicals and Fuels written by Michele Aresta and published by Walter de Gruyter GmbH & Co KG. This book was released on 2021-12-20 with total page 669 pages. Available in PDF, EPUB and Kindle. Book excerpt: This updated edition presents topical knowledge and technologies for the thermal, chemo- and enzymatic-catalytic conversion of biomass into chemicals, materials and fuels. International experts from academia and industry cover the complete value chain from raw materials into final products. A new focus discusses feedstock, processes and products in potential concepts of future biorefining.
Download or read book Bioinorganic Chemistry of Nickel written by Michael J. Maroney and published by MDPI. This book was released on 2020-06-16 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: The chemistry of nickel in biological systems has been intensely investigated since the discovery of the essential role played by this transition metal in the enzyme urease, ca. 1975. Since then, several nickel-dependent enzymes have been discovered and characterized at the molecular level using structural, spectroscopic, and kinetic methods, and insight into reaction mechanisms has been elaborated using synthetic and computational models. The dual role of nickel as both an essential nutrient and as a toxin has prompted efforts to understand the molecular mechanisms of nickel toxicology and to uncover the means by which cells select nickel from among a pool of different and more readily available metal ions and thus regulate the intracellular chemistry of nickel. This latter effort highlights the importance of proteins involved in the extra- and intra-cellular sensing of nickel, the roles of nickel-selective proteins for import and export, and nickel-responsive transcription factors, all of which are important for regulating nickel homeostasis. In this Special Issue, the contributing authors have covered recent advances in many of these aspects of nickel biochemistry, including toxicology, bacterial pathogenesis, carcinogenesis, computational and synthetic models, nickel trafficking proteins, and enzymology.
Download or read book Artificial Metalloenzymes and MetalloDNAzymes in Catalysis written by Montserrat Diéguez and published by John Wiley & Sons. This book was released on 2018-02-21 with total page 431 pages. Available in PDF, EPUB and Kindle. Book excerpt: An important reference for researchers in the field of metal-enzyme hybrid catalysis Artificial Metalloenzymes and MetalloDNAzymes in Catalysis offers a comprehensive review of the most current strategies, developed over recent decades, for the design, synthesis, and optimization of these hybrid catalysts as well as material about their application. The contributors—noted experts in the field—present information on the preparation, characterization, and optimization of artificial metalloenzymes in a timely and authoritative manner. The authors present a thorough examination of this interesting new platform for catalysis that combines the excellent selective recognition/binding properties of enzymes with transition metal catalysts. The text includes information on the various applications of metal-enzyme hybrid catalysts for novel reactions, offers insights into the latest advances in the field, and contains an informative perspective on the future: Explores the development of artificial metalloenzymes, the modern and strongly evolving research field on the verge of industrial application Contains a comprehensive reference to the research area of metal-enzyme hybrid catalysis that has experienced tremendous growth in recent years Includes contributions from leading researchers in the field Shows how this new catalysis combines the selective recognition/binding properties of enzymes with transition metal catalysts Written for catalytic chemists, bioinorganic chemists, biochemists, and organic chemists, Artificial Metalloenzymes and MetalloDNAzymes in Catalysis offers a unique reference to the fundamentals, concepts, applications, and the most recent developments for more efficient and sustainable synthesis.
