Download or read book Chemical Models of Manganese Metalloenzymes written by Eduardo Libby and published by . This book was released on 1990 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Inorganic Model Complexes of Manganese Metalloenzymes written by John Stanley Bashkin and published by . This book was released on 1988 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Advances in the Development of Artificial Metalloenzymes written by Tatjana N. Parac-Vogt and published by Frontiers Media SA. This book was released on 2019-11-05 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reactions catalyzed by metalloenzymes have great potential for applications in the biotechnology and pharmaceutical industries. While only a few of these enzymes have yet been used in such applications, in the last few decades numerous efficient, selective, environmentally friendly and economical synthetic analogues have been described, including supramolecular, polymeric, nanoparticulate and lowmolecular- weight organometallic complexes, and metal organic frameworks. In this Research Topic, we present a collection of original research and review articles that show significant recent advances made in the rational design of such artificial metalloenzymes.
Download or read book Chemical Models of the Active Sites of Metalloenzymes Containing Nickel and Iron written by Matthew Charles Smith and published by . This book was released on 2002 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Manganese Redox Enzymes written by Vincent L. Pecoraro and published by Wiley-VCH. This book was released on 1992 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Modeling the Active Sites of Metalloenzymes with Thiolate Coordination written by Curtis Eugene Moore and published by . This book was released on 2007 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nitrile Hydratase (NHase) is a bacterial enzyme which catalyzes the hydrolysis of organic nitriles to their corresponding amides. The active site of NHase contains Fe (III) or Co(III) ions in an unusual coordination sphere containing 2 amide N atoms and three S donors. The research described herein is an attempt to model this active site using two different model systems: one that generates metal-coordinated imines, and one that generates metal-coordinated amides. Using 2,20́9-dithiodibenzaldehyde and derivatives of 2,20́9-dithiodisalicylic acid as reactants, several new and interesting metal coordinated imine and metal coordinated amide complexes have been synthesized. The synthesis and crystallization of several new organic and ligand species is discussed as well. The synthesis of a Co complex that resembles the active site of NHase is reported herein, along with several other new organometallic species. Also, two projects using computational chemistry are reported: one modeling trispyrazolylborate (Tp) complexes of iron and copper, and one modeling iron, manganese, and copper complexes of pentadentate imine/phenolate ligands. Complexes of Tp ligands with relatively bulky substituents in the 3-position are subject to isomerization through a borotropic shift. Computational chemistry has shed light on the energetics behind the borotropic shift. Calculations on the CO stretching frequency of several different TpCu(I)CO complexes have been carried out in an effort to match experimental data and generate predictive values for several other species not yet synthesized. This stretching frequency can generally be directly related to the electron withdrawing/donating character of the Tp ligand attached to the metal center. Pentdentate imine/phenolate ligands can coordinate to transition metals in a number of isomers. Computational chemistry has been used to shed light on the structural preferences of the iron, manganese, and copper species. These calculations were able to match the experimental data for crystallographically characterized species, and the metal complexes were shown to have specific structural preferences depending on the identity of the metal used.
Download or read book Manganese in Health and Disease written by Lucio G Costa and published by Royal Society of Chemistry. This book was released on 2014-11-27 with total page 655 pages. Available in PDF, EPUB and Kindle. Book excerpt: Manganese in the diet is nutritionally essential for normal physiologic functioning. However, excessive exposure to manganese has been associated with developmental, neurodegenerative and other disorders. The book comprehensively covers the toxicology of manganese. Leading investigators provide perspectives from toxicology, neuroscience, nutrition, molecular biology and risk assessment disciplines and chapters cover the toxicokinetics, toxicodynamic interactions and health effects of manganese, as well as its potential role in neurodegenerative diseases. A large section devoted to health effects presents the latest research that associates manganese exposure to potential human diseases. Any scientists, health professional or regulator involved with metal exposure and toxicology should find this volume essential reading. Students and researchers in neurotoxicology will also find this book a useful reference.
Download or read book Sustaining Life on Planet Earth Metalloenzymes Mastering Dioxygen and Other Chewy Gases written by Peter M. H Kroneck and published by Springer. This book was released on 2015-02-23 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: MILS-15 provides an up-to-date review of the metalloenzymes involved in the activation, production, and conversion of molecular oxygen as well as the functionalization of the chemically inert gases methane and ammonia. Found either in aerobes (humans, animals, plants, microorganisms) or in anaerobes (so-called “impossible bacteria”) these enzymes employ preferentially iron and copper at their active sites, in order to conserve energy by redox-driven proton pumps, to convert methane to methanol, or ammonia to hydroxylamine or other compounds. When it comes to the light-driven production of molecular oxygen, the tetranuclear manganese cluster of photosystem II must be regarded as the key player. However, dioxygen can also be produced in the dark, by heme iron-dependent dismutation of oxyanions. Metalloenzymes Mastering Dioxygen and Other Chewy Gases is a vibrant research area based mainly on structural and microbial biology, inorganic biological chemistry, and environmental biochemistry. All this is covered in an authoritative manner in 7 stimulating chapters, written by 21 internationally recognized experts, and supported by nearly 1100 references, informative tables, and over 140 illustrations (many in color). MILS-15 provides excellent information for teaching; it is also closely related to MILS-14, The Metal-Driven Biogeochemistry of Gaseous Compounds in the Environment. Peter M. H. Kroneck is a bioinorganic chemist who is exploring the role of transition metals in biology, with a focus on functional and structural aspects of microbial iron, copper, and molybdenum enzymes and their impact on the biogeochemical cyles of nitrogen and sulfur. Martha E. Sosa Torres is an inorganic chemist, with special interests in magnetic properties of newly synthesized transition metal complexes and their reactivity towards molecular oxygen, applying kinetic, electrochemical, and spectroscopic techniques.
Download or read book Chemical Models of Metalloenzymes Models of B12 dependent Methylmalonyl CoA Mutase and Methyltransferases Zn dependent Methyltransferases and Class II Aldolases written by Tamis Darbre and published by . This book was released on 2003 with total page 207 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Metals in Biology written by Graeme Hanson and published by Springer. This book was released on 2010-03-11 with total page 419 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metal ions in biology is an ever expanding area in science and medicine involving metal ions in proteins and enzymes, their biosynthesis, catalysis, electron transfer, metal ion trafficking, gene regulation and disease. While X-ray crystallography has provided snapshots of the geometric structures of the active site redox cofactors in these proteins, the application of high resolution EPR spectroscopy in conjunction with quantum chemistry calculations has enabled, in many cases, a detailed understanding of a metalloenzymes mechanism through investigations of the geometric and electronic structure of the resting, enzyme-substrate intermediates and product complexes. This volume, Part II of a two-volume set demonstrates the application of high resolution EPR spectroscopy in determining the geometric and electronic structure of active site metal ion centers in iron sulfur cluster containing metalloproteins, mononuclear molybdenum metalloenzymes, manganese-containing enzymes and novel metalloproteins.
Download or read book Manganese in Metabolism and Enzyme Function written by Vern L. Schramm and published by Elsevier. This book was released on 2012-12-02 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: Manganese in Metabolism and Enzyme Function provides an understanding of the various biological roles of the trace levels of manganese found in mammalian systems. This text discusses the nutritional aspects of manganese in mammals. This book is organized into three sections encompassing 19 chapters. Section I discusses the effects of manganese deficiency, including abnormal pancreatic action and reduced pancreatic manganese in humans and laboratory animals. This text considers the criteria for adding manganese to infant formulas that are commercially available. Section II explores the effects of Mn(II) in protein kinases, protein phosphatases, and other enzymes. The reader is introduced to the electron paramagnetic resonance spectroscopic probes of manganese function. Other chapters discuss the extrinsic tag technique used to study the bioavailability of trace elements, such as iron and zinc. Finally, Section III examines the biophysical, biochemical, and physiological properties and uses of manganese. Nutritionists, toxicologists, scientists, and researchers will find this book extremely useful.
Download or read book Encyclopedia of Geobiology written by Joachim Reitner and published by Springer. This book was released on 2011-03-10 with total page 927 pages. Available in PDF, EPUB and Kindle. Book excerpt: The interplay between Geology and Biology has shaped the Earth from the early Precambrian, 4 billion years ago. Moving beyond the borders of the classical core disciplines, Geobiology strives to identify chains of cause-and-effect and synergisms between the geo- and the biospheres that have been driving the evolution of life in modern and ancient environments. Combining modern methods, geobiological information can be extracted not only from visible remains of organisms, but also from organic molecules, rock fabrics, minerals, isotopes and other tracers. An understanding of these processes and their signatures reveals enormous applied potentials with respect to issues of environment protection, public health, energy and resource management. The Encyclopedia of Geobiology has been designed to act as a key reference for students, researchers, teachers, and the informed public and to provide basic, but comprehensible knowledge on this rapidly expanding discipline that sits at the interface between modern geo- and biosciences.
Download or read book The Chemistry of Manganese Technetium and Rhenium written by R. D. W. Kemmitt and published by Elsevier. This book was released on 2016-01-26 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Chemistry of Manganese, Technetium and Rhenium is a three-chapter book that discusses the composition, structure, properties, and change of manganese, technetium, and rhenium. The first chapter in this particular book is the 37th chapter of the volume of a series, which focuses on manganese. The history, occurrence, metallurgy, uses, and chemistry of manganese are specifically discussed in this chapter. The compounds of manganese are also presented. This chapter is followed by a chapter on the chemistry of technetium, including its discovery, isolation, and compounds. The last chapter is devoted to rhenium, discussing its discovery, isolation, compounds, and physical and chemical properties. This book will be invaluable to chemistry students and practitioners, especially those interested in the elements featured in this release.
Download or read book The Coordination Chemistry of Metalloenzymes written by I. Bertini and published by Springer Science & Business Media. This book was released on 1983-01-31 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: Assembling a program in bioinorganic chemistry that is scientifi cally relevant, well defined, and self-consistent is not an easy task. In this attempt we decided to consider zinc enzymes, copper oxidases, cytochromes and cytochrome oxidase. The choice is in part due to the great attention that the current specialized literature devotes to these topics, which are now debated among chemists, biochemists, biophysicists, etc .. We believe that hydration reactions, hydrolytic and oxidative processes have much in common from the point of view of the reaction mechanisms, the comprehension of which represents a frontier of science. For these reasons these topics have been the subject of the NATO-ASI held at San Miniato, Pisa, Italy, from May 28 to June 8, 1982. We hope we can transfer here the main conclusions of what (we believe) was a very stimulating scientific meeting. We would like to thank the local saving bank, Cassa di Risparmio di San Miniato, for helping in many ways. The financial contribution from the European Research Office of the US Army, and from the Bruker Spectrospin s.r.l., Italy, is also acknowledged. The National Science Foundation of the United States has provided a travel grant to one of the participants from the U.S.A. We are grateful to the NATO Scientific Affairs Division which provided a grant to finance this Institute.
Download or read book Protein Engineering written by Huimin Zhao and published by John Wiley & Sons. This book was released on 2021-08-23 with total page 41 pages. Available in PDF, EPUB and Kindle. Book excerpt: A one-stop reference that reviews protein design strategies to applications in industrial and medical biotechnology Protein Engineering: Tools and Applications is a comprehensive resource that offers a systematic and comprehensive review of the most recent advances in the field, and contains detailed information on the methodologies and strategies behind these approaches. The authors—noted experts on the topic—explore the distinctive advantages and disadvantages of the presented methodologies and strategies in a targeted and focused manner that allows for the adaptation and implementation of the strategies for new applications. The book contains information on the directed evolution, rational design, and semi-rational design of proteins and offers a review of the most recent applications in industrial and medical biotechnology. This important book: Covers technologies and methodologies used in protein engineering Includes the strategies behind the approaches, designed to help with the adaptation and implementation of these strategies for new applications Offers a comprehensive and thorough treatment of protein engineering from primary strategies to applications in industrial and medical biotechnology Presents cutting edge advances in the continuously evolving field of protein engineering Written for students and professionals of bioengineering, biotechnology, biochemistry, Protein Engineering: Tools and Applications offers an essential resource to the design strategies in protein engineering and reviews recent applications.
Download or read book Multiscale Modeling of Metalloenzymes Design and Evolution written by Michael Nechay and published by . This book was released on 2017 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: With just a simple alphabet of natural amino acids and common metals, enzymes perform a spectacular number of reactions necessary for life on earth with enviable ease - with neither the extreme conditions nor chemical waste seen from many industrial reactors in human-developed catalysis. Principally, protein structure and related function is not well understood beyond being decisive for its unique selectivity and efficiency. A reliable treatment of larger protein movements/sampling coupled with precise quantum mechanical treatment of metals and bonds breaking/forming (multiscale) is still an open problem in Computational Chemistry. Metalloenzymes can be particularly challenging to model so we present some of the latest in multiscale modeling techniques. We have developed methods sensitive enough to study "selection" of similar metals in enzymes such as HDAC8, where previous literature failed to conclude which metal is active during in vivo catalysis, while fast enough to study larger protein movements including fold stability. Eminently, multiscale modeling opens the discussion of engineering enzymes to cater to modern day needs in catalysis. Society has not only developed needs in catalysis outside the scope of natural evolution (e.g., drug synthesis, energy conversion) but also has access to more of the periodic table than nature has had a chance to explore. Thus, combining the efficacy of natural enzymes with modern catalytic processes has enormous potential. We have studied iridium, a rare metal with thermodynamic advantages over other metals in promoting catalysis of hydroamination and transfer hydrogenation. In the context of an enzyme we predict catalytic rates near and even exceeding existing organometallic catalysts with further design for specificity available. We are in collaboration with an experimental group in designing a protein fold which both directly accommodates and uses iridium in catalysis. We hope these foundations will support metalloenzyme design efforts towards novel chemical transformations performed as efficiently and environmentally soundly as nature has shown us is possible.
Download or read book The Chemistry of Manganese written by R. D. W. Kemmitt and published by Pergamon. This book was released on 1975 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt:
