Download or read book Characterizing Atrial Fibrillation Substrate Via Molecular and Electrical Fingerprint written by and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Atrial fibrillation (AF) is a complex cardiac arrhythmia characterized by irregular rhythm and rapid heart beats. Although fibrosis has been traditionally considered a key factor in AF development, the current research challenges this notion. The findings suggest that lone fibrosis is not the sole culprit in AF trigger and persistence, indicating the involvement of additional and parallel pathophysiological mechanisms. Proteostasis, the maintenance of protein homeostasis, plays a significant role in AF pathogenesis. The present study sheds light to the importance of HSPs as chaperones that maintain proteostasis in atrial cardiomyocyte, and consequently its proper function. It was shown that levels of HSPs, including HSP70, cvHSP, HSP60, and HSP27, can serve as potential indicators of AF stage, recurrence after therapy, and post-operative AF onset. Assessing electrical remodeling through high-resolution epicardial mapping is a promising approach for identifying features of electropathology, and ultimately bio-electrical markers in AF. This methodology provides valuable insights into the correlation between molecular findings and electrophysiological features. By characterizing the molecular mechanisms underlying electrical alterations, clinicians acquire a deeper understanding of AF and tailor treatment strategies accordingly. Furthermore, cytoskeletal proteins, such as desmin, lamin A/C, titin, seem to have an important role driving AF. Genetic variants in these proteins can lead to contractile and electrophysiological atrial abnormalities in cardiomyocytes, associated with AF. In summary, these articles collectively contribute to our understanding of AF by exploring AF substrate under molecular and electrical perspectives.
Download or read book A Multiscale In Silico Study to Characterize the Atrial Electrical Activity of Patients With Atrial Fibrillation A Translational Study to Guide Ablation Therapy written by Sánchez Arciniegas, Jorge Patricio and published by KIT Scientific Publishing. This book was released on 2022-05-30 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt: The atrial substrate undergoes electrical and structural remodeling during atrial fibrillation. Detailed multiscale models were used to study the effect of structural remodeling induced at the cellular and tissue levels. Simulated electrograms were used to train a machine-learning algorithm to characterize the substrate. Also, wave propagation direction was tracked from unannotated electrograms. In conclusion, in silico experiments provide insight into electrograms' information of the substrate.
Download or read book Characterizing Atrial Fibrillation Substrate by Electrogram and Restitution Analysis written by Mark Nothstein and published by . This book was released on 2021 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Electrical and Structural Remodelling in Atrial Fibrillation Phenotypes for Personalized Therapy written by Vijay S. Chauhan and published by Frontiers Media SA. This book was released on 2021-07-27 with total page 127 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Fabry Disease written by Deborah Elstein and published by Springer Science & Business Media. This book was released on 2010-08-02 with total page 525 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fabry disease is an X-linked inborn error of metabolism wherein deficiency of a lysosomal enzyme results in systemic deposition of glycosphingolipids. Storage deposition, and hence pathological disease, occurs preferentially in renal glomerular and tubular epithelial cells, myocardial cells, heart valve fibrocytes, neurons of dorsal root ganglia, and in endothelial smooth muscle cells of blood vessels. Thus, Fabry disease is a multi-system disorder, albeit with considerable phenotypic heterogeneity in onset and in severity; however, it is progressive, exhibits extensive morbidity, and is life-threatening. Within the past two decades, there has been a radical change in the natural course Fabry disease by virtue of the availability of specific enzyme replacement therapy. Moreover, there has been a concerted effort to better understand the underlying pathology and equally to identify patients prior to the onset of irreversible end-organ damage. It is to be hoped that the future for patients with Fabry disease can be viewed with greater, albeit guarded, optimism. This state-of-the-art textbook attempts to bridge the span of pre-clinical studies, clinical finding, and management options in a readable but comprehensive manner for the medical practitioner as well as the interested non-medical reader.
Download or read book Molecular Genetics of Cardiac Electrophysiology written by C. Berul and published by Springer Science & Business Media. This book was released on 2000-04-30 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: The molecular basis for atrial fibrillation continues to be largely unknown, and therapy remains unchanged, aimed at controlling the heart rate and preventing systemic emboli with anticoagulation. Familial atrial fibrillation is more common than previously suspected. While atrial fibrillation is commonly associated with acquired heart disease, a significant proportion of individuals have early onset without other forms of heart disease, referred to as "lone" atrial fibrillators. It is also well recognized that atrial fibrillation occurs on a reversible or functional basis, without associated structural heart disease, such as with hyperthyroidism or of atrial fibrillation following surgery. It remains to be determined what percentage in these individuals is familial or due to a genetic predisposition. Mapping the locus for familial atrial fibrillation is the first step towards the identification of the gene. Isolation of the gene and subsequent identification of the responsible molecular genetic defect should provide a point of entry into the mechanism responsible for the familial form and the common acquired forms of the disease and eventually provide more effective therapy. We know that the ionic currents responsible for the action potential of the atrium is due to multiple channel proteins as is electrical conduction throughout the atria. Analogous to the ongoing genetic studies in patients with familial long QT syndrome, it is highly likely that defects in each of these channel proteins will be manifested in familial atrial fibrillation.
Download or read book Arrhythmias in Adult Congenital Heart Disease written by Balaji Seshadri and published by Elsevier Health Sciences. This book was released on 2018-11-08 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Get a quick, expert overview of the many key facets of adult congenital heart disease (ACHD) with this concise, practical resource by Drs. Seshadri Balaji, Ravi Mandapati, and Gary Webb. This easy-to-read reference presents a case-based approach to this fascinating and complex field. Presents cases provided by ACHD specialists of patients with arrhythmia issues, which are evaluated by an international panel of arrhythmia experts. Provides commentary and practical guidance on management of complex cases by today’s leaders in the field. Consolidates today’s available information and experience in this emerging area into one convenient resource.
Download or read book Acquired Long QT Syndrome written by A. John Camm and published by John Wiley & Sons. This book was released on 2008-04-15 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years there has been considerable interest in the diagnosis and understanding of ventricular repolarisation, particularly the QT interval prolongation and abnormal T and T/U wave morphology associated with torsades de pointes. Advances in ion channel cloning have greatly improved our understanding of the role of ionic channels in mediating cardiac repolarisation. Unfortunately, it is increasingly recognised that a number of drugs, both those associated with altering repolarisation, and others for non-cardiac conditions can increase the propensity for polymorphic ventricular tachycardia, syncope and even ventricular fibrillation and sudden death. In this volume, arrhythmia specialists from St. George’s Hospital Medical School, London discuss the mechanisms behind QT prolongation and torsades de pointes. They focus particularly on the risk of individual cardiac and non-cardiac drugs in provoking long QT syndrome, providing a comprehensive review which will be useful for all electrophysiologists treating polymorphic ventricular tachycardias, and will expose important regulatory issues for pharmaceutical authorities and for the wider medical community.
Download or read book Recent Advances in Multidisciplinary Applied Physics written by Antonio Mendez-Vilas and published by Elsevier. This book was released on 2005-09-28 with total page 999 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 1st International Meeting on Applied Physics (APHYS-2003) succeeded in creating a new international forum for applied physics in Europe, with specific interest in the application of techniques, training, and culture of physics to research areas usually associated with other scientific and engineering disciplines.This book contains a selection of peer-reviewed papers presented at APHYS-2003, held in Badajoz (Spain), from 15th to 18th October 2003, which included the following Plenary Lectures:* Nanobiotechnology - Interactions of Cells with Nanofeatured Surfaces and with Nanoparticles* Radiation Protection of Nuclear Workers - Ethical Issues* Chaotic Data Encryption for Optical Communications
Download or read book Registries for Evaluating Patient Outcomes written by Agency for Healthcare Research and Quality/AHRQ and published by Government Printing Office. This book was released on 2014-04-01 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: This User’s Guide is intended to support the design, implementation, analysis, interpretation, and quality evaluation of registries created to increase understanding of patient outcomes. For the purposes of this guide, a patient registry is an organized system that uses observational study methods to collect uniform data (clinical and other) to evaluate specified outcomes for a population defined by a particular disease, condition, or exposure, and that serves one or more predetermined scientific, clinical, or policy purposes. A registry database is a file (or files) derived from the registry. Although registries can serve many purposes, this guide focuses on registries created for one or more of the following purposes: to describe the natural history of disease, to determine clinical effectiveness or cost-effectiveness of health care products and services, to measure or monitor safety and harm, and/or to measure quality of care. Registries are classified according to how their populations are defined. For example, product registries include patients who have been exposed to biopharmaceutical products or medical devices. Health services registries consist of patients who have had a common procedure, clinical encounter, or hospitalization. Disease or condition registries are defined by patients having the same diagnosis, such as cystic fibrosis or heart failure. The User’s Guide was created by researchers affiliated with AHRQ’s Effective Health Care Program, particularly those who participated in AHRQ’s DEcIDE (Developing Evidence to Inform Decisions About Effectiveness) program. Chapters were subject to multiple internal and external independent reviews.
Download or read book Free Fatty Acid Receptors written by Graeme Milligan and published by Springer. This book was released on 2017-02-08 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights the important role free fatty acids (FFA) play as potential drug targets. While FFA have long been considered byproducts of cell metabolism, they are now recognized as ligands that regulate cell and tissue function via G-protein-coupled receptors. At least three receptors have been identified for which FFA appear to be the endogenous ligands.
Download or read book Chou s Electrocardiography in Clinical Practice E Book written by Borys Surawicz and published by Elsevier Health Sciences. This book was released on 2008-04-22 with total page 752 pages. Available in PDF, EPUB and Kindle. Book excerpt: Widely considered the optimal electrocardiography reference for practicing physicians, and consistently rated as the best choice on the subject for board preparation, this is an ideal source for mastering the fundamental principles and clinical applications of ECG. The 6th edition captures all of the latest knowledge in the field, including expanded and updated discussions of pediatric rhythm problems, pacemakers, stress testing, implantable cardiodefibrillator devices, and much more. It's the perfect book to turn to for clear and clinically relevant guidance on all of today’s ECG applications. Comprehensively and expertly describes how to capture and interpret all normal and abnormal ECG findings in adults and children. Features the expertise of internationally recognized authorities on electrocardiography, for advanced assistance in mastering the subtle but critical nuances of this complex diagnostic modality. Features new chapters on pediatric electrocardiography that explore rhythm problems associated with pediatric obesity, heart failure, and athletic activity. Presents a new chapter on recording and interpreting heart rhythms in patients with pacemakers. Includes new material on interpreting ECG findings associated with implantable cardioverter-defibrillators. Provides fully updated coverage on the increased importance of ECGs in stress testing.
Download or read book Oxford Textbook of Advanced Heart Failure and Cardiac Transplantation written by Michael J. Domanski and published by Oxford University Press. This book was released on 2016 with total page 457 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Oxford Textbook of Advanced Heart Failure and Cardiac Transplantation is the authoritative text on advanced heart failure and a key resource for clinicians caring for heart failure patients. It comes with an online version which allows you to find content quickly and easily, with intuitive search options and cross-linking, and access to downloadable content.
Download or read book Non coding RNAs in Cardiovascular Diseases written by Junjie Xiao and published by Springer. This book was released on 2021-04-28 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the latest research on non-coding RNAs in cardiovascular disease, a major cause of death worldwide. Non-coding RNAs play a significant role in development, proliferation, differentiation and apoptosis. Since altered non-coding RNA expression is often associated with various diseases, their potential use in diagnostics, prognostics and therapeutics is an important current area of study. The book consists of six parts: 1) An overview of non-coding RNAs and cardiovascular system, 2) Bioinformatics and interactions, 3) Non-coding RNA regulation in cardiovascular system, 4) Non-coding RNAs and cardiovascular diseases, 5) Potential biomarkers and therapeutic implications, 6) Future prospects. It is particularly useful for researchers and students in the field of non-coding RNA and cardiovascular biology, as well as for cardiologists, pharmacologists and physiologists.
Download or read book Agrindex written by and published by . This book was released on 1993 with total page 938 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Endothelial Cell Culture written by Roy Bicknell and published by Cambridge University Press. This book was released on 1996-09-28 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of the Handbooks in Practical Animal Cell Biology is to provide practical workbooks for those involved in primary cell culture. Each volume addresses a different cell lineage, and contains an introductory section followed by individual chapters on the culture of specific differentiated cell types. The authors of each chapter are leading researchers in their fields and use their first-hand experience to present reliable techniques in a clear and thorough manner. Endothelial Cell Culture contains chapters on endothelial cells derived from 1) lung, 2) bone marrow, 3) brain, 4) mammary glands, 5) skin, 6) adipose tissue, 7) female reproductive system, and 8) synovium.
Download or read book Principles of Nutrigenetics and Nutrigenomics written by Raffaele De Caterina and published by Academic Press. This book was released on 2019-09-22 with total page 586 pages. Available in PDF, EPUB and Kindle. Book excerpt: Principles of Nutrigenetics and Nutrigenomics: Fundamentals for Individualized Nutrition is the most comprehensive foundational text on the complex topics of nutrigenetics and nutrigenomics. Edited by three leaders in the field with contributions from the most well-cited researchers conducting groundbreaking research in the field, the book covers how the genetic makeup influences the response to foods and nutrients and how nutrients affect gene expression. Principles of Nutrigenetics and Nutrigenomics: Fundamentals for Individualized Nutrition is broken into four parts providing a valuable overview of genetics, nutrigenetics, and nutrigenomics, and a conclusion that helps to translate research into practice. With an overview of the background, evidence, challenges, and opportunities in the field, readers will come away with a strong understanding of how this new science is the frontier of medical nutrition. Principles of Nutrigenetics and Nutrigenomics: Fundamentals for Individualized Nutrition is a valuable reference for students and researchers studying nutrition, genetics, medicine, and related fields. Uniquely foundational, comprehensive, and systematic approach with full evidence-based coverage of established and emerging topics in nutrigenetics and nutrigenomics Includes a valuable guide to ethics for genetic testing for nutritional advice Chapters include definitions, methods, summaries, figures, and tables to help students, researchers, and faculty grasp key concepts Companion website includes slide decks, images, questions, and other teaching and learning aids designed to facilitate communication and comprehension of the content presented in the book
