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Book Characterization of the Role of Herpes Simplex Virus Protein VP16 in Viral Gene Expression Through Interactions with the Virion Host Shutoff Protein  VHS  and HCF 1  microform

Download or read book Characterization of the Role of Herpes Simplex Virus Protein VP16 in Viral Gene Expression Through Interactions with the Virion Host Shutoff Protein VHS and HCF 1 microform written by Jozo Knez and published by Library and Archives Canada = Bibliothèque et Archives Canada. This book was released on 2003 with total page 207 pages. Available in PDF, EPUB and Kindle. Book excerpt: Herpes Simplex Virus 1 (HSV1) VP16 transcriptionally activates viral immediate-early (IE) genes, through the formation of a multi-protein structure termed the VP16-induced complex (VIC). VIC is comprised of cellular transcription factors Oct-1 and HCF-1. In addition, VP16 is a pre-formed, structural protein that has a critical role in virion assembly. At least one aspect of its role at late times post-infection includes the downregulation of the virion host shutoff protein (vhs); which functions to indiscriminately degrade mRNA.

Book Herpes Simplex Virus 1 DNA Packaging

Download or read book Herpes Simplex Virus 1 DNA Packaging written by Ying Fan and published by . This book was released on 1997 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Characterization of Expression of the Herpes Simplex Virus Type 1 ICP22 and Us1 5 Proteins

Download or read book Characterization of Expression of the Herpes Simplex Virus Type 1 ICP22 and Us1 5 Proteins written by John Jason Bowman and published by . This book was released on 2008 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: Using this system and newly generated C-terminal specific ICP22 Abs, we show that Us1.5 expression is independent of full length ICP22. In addition, we demonstrate that the reported Us1.5 start sites, M147 and M171 are incorrect and that Us1.5 initiates translation at M90 of the ICP22 ORF. Mutation of M90 to alanine resulted in loss of Us1.5 expression but had no effect on expression of the full length protein. We introduced the M90A mutation into the viral genome and, as observed in transfected cells, Us1.5 expression was greatly reduced in M90A-infected cells. Although Us1.5 expression was greatly reduced, the M90A mutant replicated efficiently in restrictive Rab-9 cells and levels of the late gene gC accumulated to WT levels. Collectively, this dissertation describes multiple systems to transiently express ICP22. Using this system we mapped the true start site of the Us1.5 protein and raised questions to the origin of Us1.5 protein expression.

Book Genetic Characterization of a Delayed Host Shutoff Temperature Sensitive Mutant of Herpes Simplex Virus Type I

Download or read book Genetic Characterization of a Delayed Host Shutoff Temperature Sensitive Mutant of Herpes Simplex Virus Type I written by Edward Francis.* Arko and published by . This book was released on 1989 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Characterization of a Novel Plasmid based Herpes Simplex Virus Vector System

Download or read book Characterization of a Novel Plasmid based Herpes Simplex Virus Vector System written by Robert Troy Ramos and published by . This book was released on 1990 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Further Characterization of the UL37 Protein of Herpes Simplex Virus Type 1 and Its Interaction with ICP8  the Major DNA binding Protein of Herpes Simplex Virus

Download or read book Further Characterization of the UL37 Protein of Herpes Simplex Virus Type 1 and Its Interaction with ICP8 the Major DNA binding Protein of Herpes Simplex Virus written by Allen G. Albright and published by . This book was released on 1994 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book A Structural and Functional Analysis of Herpes Simplex Virus Type 1 Glycoprotein L  an Essential Component of the Viral Fusogenic Complex

Download or read book A Structural and Functional Analysis of Herpes Simplex Virus Type 1 Glycoprotein L an Essential Component of the Viral Fusogenic Complex written by Michael J. Novotny and published by . This book was released on 1996 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Isolation and Characterization of Herpes Simplex Virus 1 Primary Enveloped Virions

Download or read book Isolation and Characterization of Herpes Simplex Virus 1 Primary Enveloped Virions written by Maryn E. Padula and published by . This book was released on 2009 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Characterization of the Herpes Simplex Virus Type 1 Tegument Protein VP22

Download or read book Characterization of the Herpes Simplex Virus Type 1 Tegument Protein VP22 written by Gerasimos Mouzakitis and published by . This book was released on 1998 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: