Download or read book Characterization of Genetic Alterations in Ovarian Cancer written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ovarian cancer is a highly lethal malignancy specific to women, We have set up the infrastructure at Mayo for an Ovarian Cancer Research Program utilizing the rich resources of clinical material and linking work from molecular geneticists with that of dedicated clinicians. What we are proposing to do is to combine several powerful strategies to clone many of the genes involved in ovarian cancer development.
Download or read book Characterization of Genetic Alterations in Ovarian Cancer Associated with Chemotherapy Response written by Lovisa Österberg and published by . This book was released on 2009 with total page 43 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Diagnosis and Management of Ovarian Disorders written by Albert Altchek and published by Elsevier. This book was released on 2003-09-04 with total page 595 pages. Available in PDF, EPUB and Kindle. Book excerpt: This updated second edition of Diagnosis and Management of Ovarian Disorders provides thorough, yet succinct insight into the ever-changing realm of ovarian disorders. It presents a novel multidisciplinary approach to the subject as described by clinicians, surgeons, pathologists, basic scientists and related medical researchers. Topics covered include reproductive technology, early diagnosis of ovarian cancer, and management of menopause among others. The breadth of information provided by this book will appeal to clinicians and researchers involved in the study and treatment of ovarian disorders. KEY FEATURES* Includes updated information on early diagnosis of ovarian cancer* Reviews new diagnostic techniques for ovarian disorders* Discusses latest information on reproductive technology* Presents translational treatment linking laboratory research with clinical medicine
Download or read book Ovarian Cancers written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2016-04-25 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt: In an era of promising advances in cancer research, there are considerable and even alarming gaps in the fundamental knowledge and understanding of ovarian cancer. Researchers now know that ovarian cancer is not a single disease-several distinct subtypes exist with different origins, risk factors, genetic mutations, biological behaviors, and prognoses. However, persistent questions have impeded progress toward improving the prevention, early detection, treatment, and management of ovarian cancers. Failure to significantly improve morbidity and mortality during the past several decades is likely due to several factors, including the lack of research being performed by specific disease subtype, lack of definitive knowledge of the cell of origin and disease progression, and incomplete understanding of genetic and non-genetic risk factors. Ovarian Cancers examines the state of the science in ovarian cancer research, identifies key gaps in the evidence base and the challenges to addressing those gaps, considers opportunities for advancing ovarian cancer research, and examines avenues for translation and dissemination of new findings and communication of new information to patients and others. This study makes recommendations for public- and private-sector efforts that could facilitate progress in reducing the incidence of morbidity and mortality from ovarian cancers.
Download or read book Identification and Characterization of Candidate Tumor Suppressor Genes Potentially Involved in the Etiology of Ovarian Cancer written by David Charles Schultz and published by . This book was released on 1997 with total page 696 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last century it has become widely accepted that cancer is a genetic disease. Initiation and progression of cancer results from the accumulation of mutations in at least three classes of cellular genes. In this aspect the genetics of ovarian cancer have remained poorly understood with respect to other diseases. During tumorigenesis, many of the documented changes in cellular DNA involve inactivation of tumor suppressor genes. In this aspect, molecular analyses of ovarian cancer specimens indicate that several tumor suppressor genes may be involved in the etiology of this disease. Loss of heterozygosity for polymorphic markers on a chromosome arm is often indicative of the inactivation of a tumor suppressor on that chromosome based on Knudson's "two-hit" hypothesis. Allelic loss studies in a large series of ovarian tumors identified several candidate tumor suppressor loci on chromosome 9. Mutational analysis of CDKN2A/p16 on 9p21 in ovarian tumors revealed a minor role for the inactivation of this gene in ovarian cancer. Overall, these studies suggest the potential involvement of a gene or genes on chromosome 9q in the progression of this disease.
Download or read book Ovarian Cancer Biomarkers written by Khalid El Bairi and published by Springer Nature. This book was released on 2021-10-09 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book comprehensively summarizes the biology, etiology, and pathology of ovarian cancer and explores the role of deep molecular and cellular profiling in the advancement of precision medicine. The initial chapter discusses our current understanding of the origin, development, progression and tumorigenesis of ovarian cancer. In turn, the book highlights the development of resistance, disease occurrence, and poor prognosis that are the hallmarks of ovarian cancer. The book then reviews the role of deep molecular and cellular profiling to overcome challenges that are associated with the treatment of ovarian cancer. It explores the use of genome-wide association analysis to identify genetic variants for the evaluation of ovarian carcinoma risk and prognostic prediction. Lastly, it highlights various diagnostic and prognostic ovarian cancer biomarkers for the development of molecular-targeted therapy.
Download or read book Universit ts und Stadtbibliothek K ln written by and published by . This book was released on 1968 with total page 10 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Genomic Alterations in Residual High grade Serous Ovarian Cancer After Neoadjuvant Chemotherapy and Their Impact on Survival written by David Octeau and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "Background: The prognosis of patients afflicted with high-grade serous ovarian cancer remains poor and a deeper molecular understanding of the disease is required to improve treatment strategies. Tumor biomarkers, such as mutations in BRCA1 and BRCA2, and aberrant expression profiles, have been linked to improved response in patients with high-grade serous ovarian cancers (HGSC) undergoing primary debulking surgery (PDS). Recently, the use of chemotherapy prior to surgery, neoadjuvant chemotherapy (NACT), has become more widely used. While large-scale genomic studies have detailed the molecular landscape of tumors from patients that underwent primary debulking surgery (PDS) and correlated the identified subgroups to survival, none have done the same for the group of patients with residual tumor after NACT. Residual HGSC after NACT may represent a subset of disease enriched for molecular features of resistance.Objective: Describe the underlying genomics of NACT-treated HGSC and correlate them to patient progression- free survival (PFS) and overall survival (OS).Methods: Tumor samples were collected from patients with stage III or IV HGSC before and following neoadjuvant chemotherapy (NACT cohort, n = 57 and PDS cohort, n = 30). Tumor content was validated by histologic examination. Gene expression analysis was performed using a tailored NanoString-based assay, while next generation sequencing was performed on the MiSeq platform. Semi-supervised clustering, gene set analyses, and the appropriate survival models were used to assess the associations between genetic alterations and survival.Results: Semi-supervised, internally validated consensus clustering of gene expression data revealed two patient clusters with prognostic relevance. The association with overall survival remained significant after controlling for clinical variables (OS: p=0.0003). Pathway based analysis of the differentially expressed genes between the Good and the Bad outcome groups revealed high cell cycle and DNA repair gene expression, and actionable targets in the Bad outcome group. Mutational analysis revealed relatively low TP53 mutation frequency in both NACT-treated group, but TP53 mutation status was not associated with survival.Conclusions: A partial genomic profiling of the intratumoral molecular characteristics observed after NACT in high grade serous ovarian cancers revealed molecular subtypes with prognostic significance." --
Download or read book Ovarian Cancer written by Omer Devaja and published by BoD – Books on Demand. This book was released on 2018-10-24 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ovarian cancer management is a rapidly changing field with new treatment agents available as a result of a greater understanding of the pathogenesis of this disease. In addition, both surgical and chemotherapeutic treatment strategies are evolving to maximise response in this disease. This book brings together leading specialists from around the world to discuss and outline a variety of new concepts in ovarian cancer, ranging from molecular biology and genetics through screening to both surgical and chemotherapeutic management.
Download or read book Cancer Genomics for the Clinician written by Ramaswamy Govindan, MD and published by Springer Publishing Company. This book was released on 2019-01-28 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer Genomics for the Clinician is a practical guide to cancer genomics and its application to cancer diagnosis and care. The book begins with a brief overview of the various types of genetic alterations that are encountered in cancer, followed by accessible and applicable information on next generation sequencing technology and bioinformatics; tumor heterogeneity; whole genome, exome, and transcriptome sequencing; epigenomics; and data analysis and interpretation. Each chapter provides essential explanations of concepts, terminology, and methods. Also included are tips for interpreting and analyzing molecular data, as well as a discussion of molecular predictors for targeted therapies covering hematologic malignancies and solid tumors. The final chapter explains the use of FDA-approved genomic-based targeted therapies for breast cancer, lung cancer, sarcomas, gastrointestinal cancers, urologic cancers, head and neck cancer, thyroid cancer, and many more. Assembled in an accessible format specifically designed for the non-expert, this book provides the clinical oncologist, early career practitioner, and trainee with an essential understanding of the molecular and genetic basis of cancer and the clinical aspects that have led to advancements in diagnosis and treatment. With this resource, physicians and trainees will increase their breadth of knowledge and be better equipped to educate patients and families who want to know more about their genetic predispositions to cancer and the targeted therapies that could be considered and prescribed. Key Features: Describes how cancer genomics and next generation sequencing informs cancer screening, risk factors, therapeutic options, and clinical management across cancer types Explains what mutations are, what tests are needed, and how to interpret the results Provides information on FDA-approved targeted therapies that are being used in the clinic Covers different sequencing platforms and technologies and how they perform in research settings Includes access to the fully searchable eBook
Download or read book Functional Characterization of a Novel Pro Apoptotic Transcription Regulatory Protein in Ovarian Cancer written by and published by . This book was released on 2006 with total page 66 pages. Available in PDF, EPUB and Kindle. Book excerpt: In an effort to identify genetic changes involved in ovarian cancer (OvCa) development, we performed differential display-PCR, cDNA microarray and suppression subtraction hybridization analyses (SHH) to identify early genetic alterations associated with OvCa. These studies resulted in identification of several genes differentially expressed in OvCa, including a novel gene encoding a transcription elongation-like protein with the ability to induce apoptosis and suppress cancer cell growth. We named the protein ProApoptotic Protein on chromosome X (PAPX). Pro-apoptotic protein on X (PAPX) is a novel nuclear protein with sequence homology to transcription elongation factor like 1 (TCEAL1) [1]. PAPX expression is down-regulated in majority of ovarian cancer cell lines and primary tumors [2]. Re-expression of PAPX induces cell death and attenuates cell growth. We therefore proposed to study the functional role of PAPX as a candidate tumor suppressor in ovarian cancer. We proposed to (1) determine effect of PAPX on tumor and cell growth in vivo and in vitro; (2) analyze genes regulated by PAPX by transcriptional profiling using microarray chips; and (3) identify proteins that interact with PAPX and elucidate the function of PAPX related to tumor suppression.
Download or read book The Isolation and Characterization of Genes Down regulated in a Rat Model System of Ovarian Cancer written by David Roberts and published by . This book was released on 2001 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: The LOT1 gene is composed of 6 exons and spans more than 65 kb. This gene was previously determined to be down regulated in a rat model system of ovarian cancer and in a high percentage of human ovarian cancer cell lines. Unlike traditional tumor suppressor genes, which follow Knudson's two-hit hypothesis, the LOT1 open reading frame (ORF) was determined to be devoid of any inactivating mutations. Since the 5' regulatory region of a gene may also regulate a gene's expression, we sought to clone and functionally characterize the LOT1 cis-acting region. A region upstream of the LOT1 5' end was cloned and was demonstrated to have transcriptional activity in luciferase reporter assays using human ovarian cancer cell line A2780.
Download or read book Mammography and Beyond written by National Research Council and published by National Academies Press. This book was released on 2001-07-23 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: Each year more than 180,000 new cases of breast cancer are diagnosed in women in the U.S. If cancer is detected when small and local, treatment options are less dangerous, intrusive, and costly-and more likely to lead to a cure. Yet those simple facts belie the complexity of developing and disseminating acceptable techniques for breast cancer diagnosis. Even the most exciting new technologies remain clouded with uncertainty. Mammography and Beyond provides a comprehensive and up-to-date perspective on the state of breast cancer screening and diagnosis and recommends steps for developing the most reliable breast cancer detection methods possible. This book reviews the dramatic expansion of breast cancer awareness and screening, examining the capabilities and limitations of current and emerging technologies for breast cancer detection and their effectiveness at actually reducing deaths. The committee discusses issues including national policy toward breast cancer detection, roles of public and private agencies, problems in determining the success of a technique, availability of detection methods to specific populations of women, women's experience during the detection process, cost-benefit analyses, and more. Examining current practices and specifying research and other needs, Mammography and Beyond will be an indispensable resource to policy makers, public health officials, medical practitioners, researchers, women's health advocates, and concerned women and their families.
Download or read book Holland Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Download or read book Accomplishments Collaborative Projects and Future Initiatives in Breast Cancer Genetic Predisposition written by Paolo Peterlongo and published by Frontiers Media SA. This book was released on 2019-10-16 with total page 141 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this eBook, we described the accomplishments, collaborative projects and future initiatives in the field of breast cancer genetic predisposition. More specifically, the articles included focused on aspects such as mutation screening in unexplored populations, identification and characterization of novel predisposing genes and mutations, and population screening.
Download or read book Epigenetic Characterization of Ovarian Cancer written by and published by . This book was released on 2008 with total page 105 pages. Available in PDF, EPUB and Kindle. Book excerpt: The overall objective of this research was to identify genes that are aberrantly methylated in epithelial ovarian cancer. Our approach was to treat or mock treat primary normal or tumor cultured cells with drugs that inhibit DNA methyltransferase activity and then perform microarray analysis to identify genes that are likely to exhibit methylation-mediated silencing. We also employed similar analysis of 43 ovarian cell lines. Two major criteria identified genes likely to be methylated: maximum fold-change in expression following drug treatment, and a high standard deviation in expression among untreated cells. These criteria were validated using a gene set known to exhibit methylation in other cancers and led to prediction of a total of 360 methylated genes in ovarian cancer, among which 32 were validated. Genes involved in TGF-beta pathway activity were overrepresented among the candidates, and their methylation status was confirmed. Pathway activity was found to increase when DNA methyltransferase activity is inhibited, indicating coordinate epigenetic suppression of this pathway in ovarian cancer.
Download or read book Recueil factice d articles de presse concernant Jane Arnoux written by and published by . This book was released on 2005 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt:
