Download or read book Characterisation of a Forkhead Transcription Factor written by Martyn Bullock and published by . This book was released on 2007 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Evolutionary Analysis and Functional Characterization of the Forkhead Transcription Factor FoxG1 written by Nicholas Bredenkamp and published by . This book was released on 2006 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cloning and Characterization of FREACs Human Forkhead Transcription Factors written by Marika Hellqvist Greberg and published by . This book was released on 1997 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Characterization of the Immunomodulation by the Forkhead Transcription Factor FOXO3 written by Jelka Hartwig and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cloning and Characterization of a Forkhead Transcription Factor Gene FoxOla From Thirteen Lined Ground Squirrel written by and published by . This book was released on 2004 with total page 8 pages. Available in PDF, EPUB and Kindle. Book excerpt: This research analyzes the regulation of ischemic tolerance in hibernating thirteen-lined ground squirrels (Spermophilus tridecemlineatus). Hibernation is studied because it represents a unique state of reversible suspended animation associated with tolerance to an otherwise lethal reduction of core body temperature and metabolism. An integral aspect of hibernation is the profound decrease of cerebral perfusion without neurological damage. As such, hibernation serves as a model for studying natural tolerance to brain ischemia. Identification of regulatory mechanisms that control hibernation in ground squirrels may guide efforts to develop improved treatments for stroke and brain trauma. It was previously shown that phosphorylation of Akt (protein kinase B), an insulin-like growth factor-regulated serine/threonine kinase, was significantly reduced as was its kinase activity in hibernating thirteen-lined ground squirrels. Here we studied the forkhead (FH) in rhabdomyosarcoma (FKHR) transcription factor, which is controlled by Akt signaling and is involved in regulating cell cycle progression and cell death. A cDNA derived from brains of S. tridecemlineatus, encoding a specific FKHR transcription factor, FoxO1a, was cloned and sequenced, and the amino acid sequence of the protein was deduced. FoxO1a is composed of 653 amino acids and has a predicted molecular mass of 69.4 kilodaltons (kDa). Here, for the first time, we report the contrary expression of phosphorylation of two members in the insulin-like growth factor signaling pathway during hibernation (i.e., phosphorylated FKHR was significantly up-regulated as phosphorylation of its upstream kinase, Akt, was significantly down-regulated). Further study is required to identify the possible connection between FoxO1a and Akt activity and the possible role of such interactions in hibernation.
Download or read book Real Time RT PCR Analysis of the Effect of the Forkhead Transcription Factor FoxL2 on the Steroidogenic Acute Regulatory Gene StAR written by Kimberly Kershea Gray and published by . This book was released on 2007 with total page 106 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Forkhead Transcription Factors written by Kenneth Maiese and published by Springer Science & Business Media. This book was released on 2010-07-29 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: Forkhead Transcription Factors: Vital Elements in Biology and Medicine provides a unique platform for the presentation of novel work and new insights into the vital role that forkhead transcription factors play in multiple systems throughout the body. Leading international authorities provide their knowledge and insights to offer a novel perspective for translational medicine that highlights the role of forkhead genes and proteins that may have the greatest impact for the development of new strategies for a broad array of disorders. Equally important, Forkhead Transcription Factors: Vital Elements in Biology and Medicine clearly sets a precedent for the necessity to understand the diverse and complex nature of forkhead proteins since this family of transcription factors can limit as well as foster disease progression depending upon the cellular environment. The presentation and discussion of innovative studies and especially those that examine previously unexplored pathways that may influence clinical survival and longevity offer an exciting approach to address the potential of forkhead transcription factors for new therapeutic avenues in multiple disciplines.
Download or read book Identification and Characterization of the Forkhead Box Family of Transcriptional Regulators in Parasitic Schistosomes written by Melissa M. Varrecchia and published by . This book was released on 2017 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: Schistosomiasis is a disease of global scale with more than 240 million people infected and more than 700 million people at risk of infection. Historically, treatment of this disease has been with one primary drug, praziquantel. Due to this, concern for resistance developing in the parasitic worms that cause this disease has risen. The three species of blood flukes responsible for the majority of the schistosomiasis disease burden are Schistosoma mansoni (S. mansoni), S. japonicum, and S. haematobium. These trematodes have a complex life cycle in which they undergo distinct morphological changes during the transitions from free-swimming to invertebrate and vertebrate host stages. The molecular factors and mechanisms which regulate their development during these metamorphoses are widely unknown. A better understanding of the basic biology of these worms and the factors which drive their development will be critical in the process of identifying new treatment targets or developing preventative measures. Forkhead Box (Fox) proteins, are a family of transcription factors that play key roles in a variety of biological processes including development, metabolism, stress tolerance, and lifespan and have been identified in a number of organisms. The major goal of this thesis is to identify and characterize the complement of forkhead box genes found in the S. mansoni genome. Here, we have identified 15 Fox genes, two with multiple isoforms, which were classified into 11 classes (SmFoxA, SmFoxC, SmFoxD, SmFoxF, SmFoxG, SmFoxJ, SmFoxK, SmFoxL, SmFoxN, SmFoxO, and SmFoxP) using bioinformatics and a phylogenetic comparison to mouse, fly, nematode, and yeast forkhead proteins. Additionally, the expression pattern during the sporocyst, cercarial, 4h schistosomula, and adult stages was determined for each gene using absolute quantitative PCR. To test functionality, SmFox-GAL4 DBD fusion proteins were tested in a modified yeast one-hybrid to determine their ability to activate transcription of the reporter genes HIS3 and MEL1. We determined 12 schistosome Fox proteins are transcriptional activators, though the level of activation varied between proteins and between isoforms of the same protein. This project lays a foundation for the study of schistosome Fox transcription factors and their potential roles in schistosome development.
Download or read book Forkhead FOXO Transcription Factors in Development and Disease written by and published by Academic Press. This book was released on 2018-02-07 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: Forkhead FOXO Transcription Factors in Development and Disease, Volume 127, the latest release in the Current Topics in Developmental Biology series, provides a comprehensive set of reviews on transcription factors FOXO and their various functions in health and disease. Each chapter is contributed by a leading expert in the field, with specific sections covering Exceptional Longevity: Insights from Hydra to Humans, FOXO in neural cells and diseases of the nervous system, maintaining the equilibrium for better or for worse, and The Role of FoxOs in Bone Health and Disease, amongst other topics. This compilation provides a unique, up-to-date view of this enigmatic, highly evolutionary conserved family of transcription factors with a diverse array of functions in aging and longevity, cancer, and metabolism. Provides the authority and expertise of leading contributors Includes sections on the regulation of FOXO factors and stem cells Presents a unique view of this highly evolutionary family of transcription factors
Download or read book Signaling Mechanisms Regulating T Cell Diversity and Function written by Jonathan Soboloff and published by CRC Press. This book was released on 2017-03-27 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: T cells play a vital role mediating adaptive immunity, a specific acquired resistance to an infectious agent produced by the introduction of an antigen. There are a variety of T cell types with different functions. They are called T cells, because they are derived from the thymus gland. This volume discusses how T cells are regulated through the operation of signaling mechanisms. Topics covered include positive and negative selection, early events in T cell receptor engagement, and various T cell subsets.
Download or read book Holland Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Download or read book Genetics of Human Infertility written by P.H. Vogt and published by Karger Medical and Scientific Publishers. This book was released on 2017-09-12 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt: Infertility affects more than one in ten couples worldwide and is related to highly heterogeneous pathologies sometimes only discernible in the germ line. Its complex etiology often, but not always, includes genetic factors besides anatomical defects, immunological interference, and environmental aspects. Nearly 30% of infertility cases are probably caused only by genetic defects. Thereby experimental animal knockout models convincingly show that infertility can be caused by single or multiple gene defects. Translating those basic research findings into clinical studies is challenging, leaving genetic causes for the vast majority of infertility patients unexplained. Nevertheless, a large number of candidate genes have been revealed by sophisticated molecular methods. This book provides a comprehensive overview on the subject of infertility written by the leading authorities in this field. It covers topics including basic biological, cytological, and molecular studies, as well as common and uncommon syndromes. It is a must-read for human geneticists, endocrinologists, epidemiologists, zoologists, and counsellors in human genetics, infertility, and assisted reproduction.
Download or read book A Handbook of Transcription Factors written by Timothy R. Hughes and published by Springer Science & Business Media. This book was released on 2011-05-10 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transcription factors are the molecules that the cell uses to interpret the genome: they possess sequence-specific DNA-binding activity, and either directly or indirectly influence the transcription of genes. In aggregate, transcription factors control gene expression and genome organization, and play a pivotal role in many aspects of physiology and evolution. This book provides a reference for major aspects of transcription factor function, encompassing a general catalogue of known transcription factor classes, origins and evolution of specific transcription factor types, methods for studying transcription factor binding sites in vitro, in vivo, and in silico, and mechanisms of interaction with chromatin and RNA polymerase.
Download or read book Fluorescence Correlation Spectroscopy written by R. Rigler and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 503 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first book-length treatment of both the theoretical background to fluorescence correlation spectroscopy (FCS) and a variety of applications in various fields of science. The high spatial and temporal resolution of FCS has made it a powerful tool for the analysis of molecular interactions and kinetics, transport properties due to thermal motion, and flow. It contains an essential contribution from Nobel Prize winner M. Eigen, who is credited with inventing FCS.
Download or read book Gonadotropins From Bench Side to Bedside written by Rajendra T. Kumar and published by Academic Press. This book was released on 2016-09-30 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gonadotropins: From Bench Side to Bedside, the latest volume in the Progress in Molecular Biology and Translational Science series, focuses on all aspects of gonadotropins, from research to treatment. Contains contributions from leading authorities on the topic Publishes cutting-edge reviews in molecular biology Informs and updates on all the latest developments available regarding the research of gonadotropins
Download or read book Winged Helix Transcription Factors Advances in Research and Application 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-26 with total page 26 pages. Available in PDF, EPUB and Kindle. Book excerpt: Winged-Helix Transcription Factors—Advances in Research and Application: 2012 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Winged-Helix Transcription Factors in a compact format. The editors have built Winged-Helix Transcription Factors—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Winged-Helix Transcription Factors in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Winged-Helix Transcription Factors—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Download or read book The Retardation of Aging and Disease by Dietary Restriction written by Richard Weindruch and published by Charles C Thomas Pub Limited. This book was released on 1988-01-01 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt:
