Download or read book Characterisation and Peparation sic of Fluorescent Magetic sic Silica Nanoparticles for Drug Delivery written by Niancen Peng and published by . This book was released on 2010 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt: Magnetic silica nanoparticles with the core-shell structure were prepared by Stober method. There has been dramatic interest in the use of these particles for drug delivery in the recent years, however, little is known about their stability in aqueous environments. The aim of the current project is to examine their fate in water, to optimize their surface properties and finally to label them with a fluorescent dye for tracking purposes. Magnetic particles served as the core, and the silica shell was prepared from tetraethyl orthosilicate (TEOS). Changing the amount and the surface properties of the core, and varying the concentration of the shell or the solvent (ethanol) were conducted to prepare different types of magnetic silica nanoparticles. Different methods were used to characterize the nanoparticles, with the aim of finding the best conditions to prepare stable, uniform and narrow small sized nanoparticles. These measurements included: dynamic light scattering (DLS) for measuring the particles size, average count rate and to perform dissolution studies, differential scanning calorimetry (DSC) for thermal analysis of the dissolution process, UV/Vis Spectroscopy to study the turbidity, transmission electron microscopy (TEM), and measurement for zeta potential and pH. -- The first parameter studied was the magnetic core (Fe304). Coating these particles with citric acid seemed to improve the silica coating. This was attributed to the complexation between the TEOS and the citric acid, which resulted in uniform coating with silica. Another factor studied was the concentration of the precursor (TEOS). The results showed that the particle size increased with increasing the amount of TEOS. The latter was also accompanied by better stability (against dissolution) in water.

Download or read book Silica coated Magnetic Nanoparticles written by Mariela A. Agotegaray and published by Springer. This book was released on 2017-01-04 with total page 93 pages. Available in PDF, EPUB and Kindle. Book excerpt: This brief offers a comprehensive discussion of magnetic targeted drug delivery of silica-coated nanodevices. Focusing on the latest trend in pharmaceutical applications of these nanodevices, a multidisciplinary overview is displayed, from synthesis and design to pharmacokenetics, biodistribution and toxicology. Chapters include design of silica-coated magnetic nanodevices; techniques for drug loading with features applicable to biological systems; synthesis, characterization and the assessment of biomedical issues with both in vitro and in vivo experiments. Applications in the treatment of different localized diseases are also addressed in order to present the potential use of these nanosystems as global, commercially available therapeutics.

Download or read book Magnetic Nanoparticles written by K. S. Joshy and published by Springer Nature. This book was released on 2021-05-17 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt: ​This volume covers current research in the usage of magnetic nanoparticles for drug delivery. It discusses synthesis methods, stabilizers used for surface coating on MNPs, and potential target ligands which can be used to ferry payloads to the targeted disease region. It also highlights the factors affecting delivery efficiency and toxicity, as well as the different routes of administration. The content also focus on the use of these carriers for gene therapy and to target brain tumors. This volume will be of interest to researchers working on drug discovery and delivery platforms.

Download or read book Silica Nanoparticles written by Juan Vivero-Escoto and published by . This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book, the authors present topical research in the study of the preparation, properties and use of silica nanoparticles. Topics discussed include the reactivity of inorganic radicals and excited triplet states in colloidal silica suspensions; multifunctional mesoporous silica nanoparticles for controlled drug delivery, multimodal imaging and simultaneous imaging and drug delivery; monodisperse luminescent silica nanoparticles and their application to DNA microarray technology.

Download or read book Synthesis of Fluorescent Silica Nanoparticles Studying Their Cellular Interactions and Their Application for Drug Delivery written by Shakiba Shahabi and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Mesoporous Silica Nanoparticles written by Sachin Namdeo Kothawade and published by . This book was released on 2024-11-20 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mesoporous silica comprehensively covers the importance and applications of mesoporous silica nanoparticles in the field of nanoscience and nanotechnology. The book delves into the synthesis and characterization of mesoporous silica nanoparticles, discussing various synthesis methods and characterization techniques employed in their production. It explores the properties and structure of mesoporous silica nanoparticles, including their porosity, surface area, structural features, and tunability. It discusses mechanical, thermal, and optical properties. The applications of mesoporous silica nanoparticles in drug delivery are covered in detail, focusing on controlled release systems, targeted drug delivery, and theranostic applications.The catalytic applications of mesoporous silica nanoparticles are examined, including the use of these nanoparticles as supported catalysts in catalytic reactions, with discussions on reaction mechanisms. The book also explores the sensing and biosensing applications of mesoporous silica nanoparticles, including optical and electrochemical sensing, bioanalytical applications, and detection of biomolecules and environmental pollutants. Surface functionalization techniques for mesoporous silica nanoparticles are discussed, highlighting the importance of tailoring their properties for specific applications. Biocompatibility and toxicity considerations are addressed, providing insights into the assessment of biocompatibility, toxicity evaluation, mitigation strategies, and regulatory considerations. The future directions and emerging trends in mesoporous silica nanoparticle research are explored, along with interdisciplinary approaches, challenges, and opportunities in the field. The book concludes by summarizing the key findings and discussing the overall significance of mesoporous silica nanoparticles in nanoscience and nanotechnology. The references section provides a comprehensive list of sources used throughout the book for further exploration. The book serves as an essential resource for researchers, professionals, and students interested in understanding the synthesis, characterization, properties, and diverse applications of mesoporous silica nanoparticles in the realm of nanoscience and nanotechnology.

Download or read book Nano and Microscale Drug Delivery Systems written by Alexandru Mihai Grumezescu and published by William Andrew. This book was released on 2017-03-27 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nano- and Microscale Drug Delivery Systems: Design and Fabrication presents the developments that have taken place in recent years in the field of micro- and nanoscale drug delivery systems. Particular attention is assigned to the fabrication and design of drug delivery systems in order to i) reduce the side effects of therapeutic agents, ii) increase their pharmacological effect, and iii) improve aqueous solubility and chemical stability of different therapeutic agents. This book is designed to offer a cogent, concise overview of current scholarship in this important area of research through its focus on the characterization and fabrication of a variety of nanomaterials for drug delivery applications. It is an invaluable reference source for both biomaterials scientists and biomedical engineers who want to learn more about how nanomaterials are engineered and used in the design of drug delivery nanosystems. Shows how micro- and nanomaterials can be engineered to create more effective drug delivery systems Summarizes current nanotechnology research in the field of drug delivery systems Explores the pros and cons of using particular nanomaterials as therapeutic agents Serves as a valuable reference for both biomaterials scientists and biomedical engineers who want to learn more about how nanomaterials are engineered and used in the design of drug delivery nanosystems

Download or read book Multifunctional Core shell Silica Particles written by Hooisweng Ow and published by . This book was released on 2005 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Design and Synthesis of Multifunctional Mesoporous Silica Nanoparticles for Drug Delivery and Bioimaging Applications written by Wei Chen and published by . This book was released on 2019 with total page 263 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multifunctional mesoporous silica nanoparticles (MSNs) have aroused much attention during the past decades for drug delivery and bioimaging applications because of their intrinsic properties including extremely high surface area, large pore volume, tunable pore diameter, easy surface modification, and high biocompatibility. Even though MSNs have these preeminent properties, rendering this unique nanostructure a promising nanocarrier for biomedical applications, several hurdles still challenge the fields of drug delivery and bioimaging when using MSNs as the nanocarries: (i) high loading and high release amounts of water-insoluble drugs delivered to the site of diseases; (ii) precise control of the dosage of drugs delivered to the site of diseases using non-invasive external stimuli; and (iii) construction of MSNs-based shortwave infrared optical imaging contrast agents as an innovative tool for bioimaging and cancer diagnostics. Therefore, this dissertation primarily focuses on the development of innovative strategies that solve these unmet needs and that advance the research in the field of biomedical applications using MSNs as the nanocarriers. In this dissertation, first of all, we review the research work, which mainly focuses on the design and synthesis of multifunctional MSNs and nanomachines for biomedical applications in Accounts of Chemical Research. A wide variety of nanomachines responsive to the different stimuli (pH, redox, enzyme, heat, light, and/or magnetic field) are discussed in this Account. Additionally, we develop a facile strategy for MSNs delivery and release of the water-insoluble drug clofazimine (CFZ), which is used to treat multidrug-resistant tuberculosis. The strategy employs a companion molecule as a chaperone to improve both the loading of CFZ into the pores of MSNs and its subsequent release, thus enabling both high loading and high release of this water-insoluble drug by MSNs. In vitro treatment of macrophages infected with Mycobacterium tuberculosis with the optimized CFZ-loaded MSNs killed the bacteria in the cells in a dose-dependent manner. These studies demonstrate a highly efficient method for loading nanoparticles with water-insoluble drug molecules and the efficacy of the nanoparticles in delivering drugs into eukaryotic cells in aqueous media. Additionally, we used a noninvasive alternating magnetic field (AMF) to stimulate and control the dosage of drug release from MSNs. Noninvasive stimuli-responsive drug delivery using AMF in conjunction with superparamagnetic nanoparticles also offers the potential for the spatial and temporal control of drug release. In vitro studies showed that the death of pancreatic cancer cells treated by drug-loaded nanoparticles was controlled by different lengths of AMF exposure time due to different amounts of drug released from the carriers. Finally, to develop a new shortwave infrared (SWIR) optical imaging contrast agent which has a higher tissue penetration depth, we demonstrate that J-aggregates of near infrared (NIR) fluorophore IR-140 can be prepared inside hollow mesoporous silica nanoparticles (HMSNs) to result in nanomaterials that absorb and emit SWIR light. The use of J-aggregates stabilized in HMSNs as SWIR imaging agents has the potential to overcome the stability, toxicity, and brightness challenges of contrast agents for this compelling region of the electromagnetic spectrum. Collectively, in this dissertation, we explore and develop innovative strategies to load and deliver high amounts of water-insoluble drugs; control the dosage of anticancer drugs released from MSNs triggered by an AMF; and establish a new SWIR optical imaging contrast agent based on the superior carriers - MSNs.

Download or read book Gas phase Synthesis of Silica Nanoparticles Reaction Kinetics Synthesis and Characterization written by Ali Abdali and published by . This book was released on 2014-04-25 with total page 122 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Synthesis Characterization and Optical Properties of Colloidal Organic Dye containing Fluorescent Core shell Silica Nanoparticles written by Erik Herz and published by . This book was released on 2009 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since fluorescence was first observed in a solution containing quinine sulfate in 1845, methods employing fluorescent materials have abounded. Today, fluorescent probes are widely used in many fields, including biological imaging and security. For all applications brightness, stability, size control and compatibility are key parameters for probe design. Recent research to address these parameters has been focused on synthesizing nanoparticle materials. A class of those materials, core-shell silica nanoparticles, covalently encapsulating organic dyes within the core, have been found to be particularly effective in meeting the need for brighter, more stable probes, while also providing size and compatibility control. This dissertation will describe how I have built on previous research by focusing on the synthesis, characterization and optical properties of core-shell silica nanoparticles that span the full spectral range, from ultraviolet to near-infrared emission. Through scattering corrected comparisons of coumarin dye-containing nanoparticles and dye in aqueous solution, relative quantum yield enhancements of an order of magnitude were measured. Similar brightness enhancements were observed when large Stokes-shift dyes were incorporated into the particles. By creating a graded series of Stokes-shifted particles, single-excitation functionality was added to the fluorescent core-shell silica nanoparticle platform, to allow for spectral multiplexing. Since both light scattering and autofluorescence backgrounds in biological samples tend to be stronger at shorter wavelengths, new probe design has swiftly moved toward near-infrared (NIR) excitation and emission. To this end, NIR fluorescent silica nanoparticles with emissions up to 800nm were synthesized and dye structure-optical property correlations were investigated. Using a self-built fluorescence correlation spectroscopy (FCS) instrument, cyanine dye containing particles of the NIR series were investigated in further depth. The FCS allows for measurement of the size, brightness and concentration of the particles in solution and, with small modifications to the beam-path also provides information on the fluorescence stability of the particles in solution, which is of particular importance in NIR probes. Photostability in aqueous solution was investigated for the NIR dye Cy5 and compared to the dye incorporated into particles, leading to findings that will impact future probe designs.

Download or read book Monodisperse Mesoporous Silica Nanoparticles written by Leilei Luo and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Synthesis Characterization and Structure Control of Ordered Mesoporous Silica Nanoparticles written by Teeraporn Suteewong and published by . This book was released on 2011 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ordered mesoporous silica materials are characterized by uniform and tunable pore size, high surface area and large pore volume. In particular, nano-sized ordered mesoporous silica particles have drawn interest from several fields, including biorelated areas, because silica is benign, possesses chemical stability and can be integrated with other materials. Structural aspects, such as pore connectivity, geometry and pore size are known to govern materials performance. Extensive efforts have been devoted to synthesize mesoporous silica particles with different structures, functionalities and sizes. In contrast, only a small number of studies so far have concentrated on the formation mechanism of these particles. This is hence the focus of the present dissertation. The first part reports on the synthesis and characterization of ordered mesoporous silica nanoparticles with and without embedded magnetic nanoparticles. The formation mechanism of silica nanocomposites is investigated by capturing particle formation at different time points during the synthesis. A combination of transmission electron microscopy (TEM) and small angle x-ray scattering (SAXS) is used to characterize the structure evolution of resulting materials. Incorporating organic moieties into the silica matrix provides additional functionalities to ordered mesoporous silica nanoparticles. However, it often leads to disordered pore structure or pore blockage. The second part demonstrates the preparation of aminated and ordered mesoporous silica nanoparticles using a cocondensation method. Increasing the amount of aminosilane in the synthesis feed causes a structural transition of organically modified particles from hexagonal to cubic. Pore size of ordered mesoporous silica and aminated ordered mesoporous silica nanoparticles can be tailored by the addition of a swelling agent during the synthesis. The structural transformation from hexagonal to cubic is also observed in the latter case, albeit at different amino silane concentrations. The final part reports on the internalization of nanoparticles into cells. Fluorescent aminated mesoporous silica nanoparticles are first prepared and then coated with poly(ethylene glycol) to improve particle stability and lower protein adsorption. Dye-labeled aminated mesoporous silica nanoparticles are spontaneously internalized by cells.

Download or read book Preparation and characterization of drug containing microspheres and nanoparticles for controlled drug delivery written by Huagang Chen and published by . This book was released on 1992 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Synthesis and Characterization of Silicon Nanoparticles for Bioimaging and Dynamic Nuclear Polarization Magnetic Resonance Imaging written by Tonya Marie Atkins and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Silicon (nanoparticles) NPs are currently used for a wide range of applications. These applications include photovoltaics, biological sensors, thermoelectrics, electronics, hyperpolarized MRI agents and biological applications. Their application depends on size, which correlates with their physical properties. In chapter 2, a microwave-assisted synthesis was performed and the reaction of the Zintl salt, Na4Si4, or Mn-doped Na4Si4, Na4Si4(Mn), with ammonium bromide, NH4Br, produces small dispersible nanoparticles along with larger particles that precipitate. Allylamine and 1-amino-10-undecene were reacted with the hydrogen-terminated Si NPs to provide water solubility and stability. A one pot, single reaction process and a one pot, two-step reaction process were investigated. Details of the microwave-assisted process are provided with the optimal synthesis being the two-step reaction procedure with a total time of 15 minutes. In chapter 3, a microwave-assisted reaction has been developed to produce hydrogen-terminated Si NPs. The Si NPs were coated for water solubility via two procedures: hydrosilylation producing 3-aminopropenyl-terminated and a modified St©œber process producing silica-encapsulated Si quantum dots. Femtosecond transient absorption spectroscopy was used to temporally resolve the photo-excited carrier dynamics between the nanoparticle and ligand. In chapter 4, a solution phase redox reaction of the Zintl salt, Na4Si4, and NH4Br produced Si NPs and a modified Stober process was used to grow a silica shell on the Si NP surface. "Cold" zirconium was encapsulated into the silica shell for potential applications involving positron emission tomography (PET). In chapter 5, the synthesis of water soluble poly(allylamine) encapsulated Mn-doped Si NPs used as a multimodal probe for biologically related applications has been developed and will be discussed.In chapter 6, the synthesis of dynamic nuclear polarization (DNP) of Si NPs for use as hyperpolarized magnetic resonance imaging (MRI) agents was developed. The nanoparticles are synthesized through a metathesis reaction between sodium silicide (Na4Si4), and silicon tetrachloride and surface functionalized with a variety of passivating ligands.

Download or read book Preparation of Silica Nanoparticles for Biomedical Applications written by Giorgia Giovannini and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Advanced Ceramic Coatings for Energy Applications written by Ram Gupta and published by Elsevier. This book was released on 2024-02-16 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: Smart ceramic coatings containing multifunctional components are now finding application in transportation and automotive industries, in electronics, and energy, sectors, in aerospace and defense, and in industrial goods and healthcare. Their wide application and stability in harsh environments are only possible due to the stability of the inorganic components that are used in ceramic coatings. Ceramic coatings are typically silicon nitride, chromia, hafnia, alumina, alumina-magnesia, silica, silicon carbide, titania, and zirconia-based compositions. The increased demand for these materials and their application in energy, transportation, and the automotive industry, are considered, to be the main drivers. Advanced Ceramic Coatings for Energy Applications covers recent developments in conducting electrodes, photovoltaics, solar cells, battery applications, fuel cells, electrocatalysts, photocatalysts and supercapacitors. The book is one of four volumes that together provide a comprehensive resource in the field of Advanced Ceramic Coatings, also including titles covering: fundamentals, manufacturing, and classification; biomedical applications; and emerging applications. The books will be extremely useful for academic and industrial researchers and practicing engineers who need to find reliable and up-to-date information about recent progresses and new developments in the field of advanced ceramic coatings. It will also be of value to early career scientists providing background knowledge to the field. Includes comprehensive coverage of advanced ceramic coatings for energy applications Features the latest progress and recent technological developments Includes comparisons to other coatings types (e.g., polymers, metals, and enamel) to demonstrate potential, limitations, and differences Contains extensive case studies and worked examples