Download or read book Challenging the Limits of the Human Life Span written by Wulf Droge and published by . This book was released on 2010-07 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interventions that delay aging are expected to improve health. In the current US National Institute on Aging's Interventions Testing Program (ITP) the immunosuppressive drug rapamycin was found to increase the maximum life span in mice. These mice started receiving this treatment at an age corresponding to 60 years in humans. Rapamycin targets the same mechanism which was critically involved in the life span extension previously seen in certain mutants of worms flies and mice. The maximum life span was increased in some of these mutants by more than 250 percent, suggesting 1) that the maximum life span is limited by a common mechanism of death, and 2) that humans may possibly gain a few more decades beyond 120 years by interfering in this mechanism. As rapamycin has important adverse effects, this books looks into the underlying mechanisms and describes several natural interventions likely to decrease the rate of aging without using pharmacological drugs

Download or read book Challenging the Limits of the Human Life Span written by Wulf Dröge and published by iUniverse. This book was released on 2010-07-21 with total page 189 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interventions that delay aging are expected to improve health. In the current US National Institute on Agings Interventions Testing Program (ITP) the immunosuppressive drug rapamycin was found to increase the maximum life span in mice. These mice started receiving this treatment at an age corresponding to 60 years in humans. Rapamycin targets the same mechanism which was critically involved in the life span extension previously seen in certain mutants of worms flies and mice. The maximum life span was increased in some of these mutants by more than 250 percent, suggesting 1) that the maximum life span is limited by a common mechanism of death, and 2) that humans may possibly gain a few more decades beyond 120 years by interfering in this mechanism. As rapamycin has important adverse effects, this books looks into the underlying mechanisms and describes several natural interventions likely to decrease the rate of aging without using pharmacological drugs

Download or read book Coping with Methuselah written by Henry Aaron and published by Rowman & Littlefield. This book was released on 2004-01-20 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many medical authorities predict that average life expectancy could well exceed 100 years by mid century and rise even higher soon thereafter. This astonishing prospect, brought on by the revolution in molecular biology and information technology, confronts policymakers and public health officials with a host of new questions. How will increased longevity affect local and global demographic trends, government taxation and spending, health care, the workplace, Social Security, Medicare, and Medicaid? What ethical and quality-of-life issues are raised by these new breakthroughs? In Coping with Methuselah, a group of practicing scientists and public policy experts come together to address the problems, challenges, and opportunities posed by a longer life span. This book will generate discussion in political, social, and medical circles and help prepare us for the extraordinary possibilities that the future may hold.

Download or read book The 100 Year Life written by Lynda Gratton and published by Bloomsbury Publishing. This book was released on 2020-05-28 with total page 299 pages. Available in PDF, EPUB and Kindle. Book excerpt: What will your 100-year life look like? A new edition of the international bestseller, featuring a new preface 'Brilliant, timely, original, well written and utterly terrifying' Niall Ferguson Does the thought of working for 60 or 70 years fill you with dread? Or can you see the potential for a more stimulating future as a result of having so much extra time? Many of us have been raised on the traditional notion of a three-stage approach to our working lives: education, followed by work and then retirement. But this well-established pathway is already beginning to collapse – life expectancy is rising, final-salary pensions are vanishing, and increasing numbers of people are juggling multiple careers. Whether you are 18, 45 or 60, you will need to do things very differently from previous generations and learn to structure your life in completely new ways. The 100-Year Life is here to help. Drawing on the unique pairing of their experience in psychology and economics, Lynda Gratton and Andrew J. Scott offer a broad-ranging analysis as well as a raft of solutions, showing how to rethink your finances, your education, your career and your relationships and create a fulfilling 100-year life. · How can you fashion a career and life path that defines you and your values and creates a shifting balance between work and leisure? · What are the most effective ways of boosting your physical and mental health over a longer and more dynamic lifespan? · How can you make the most of your intangible assets – such as family and friends – as you build a productive, longer life? · In a multiple-stage life how can you learn to make the transitions that will be so crucial and experiment with new ways of living, working and learning? Shortlisted for the FT/McKinsey Business Book of the Year Award and featuring a new preface, The 100-Year Life is a wake-up call that describes what to expect and considers the choices and options that you will face. It is also fundamentally a call to action for individuals, politicians, firms and governments and offers the clearest demonstration that a 100-year life can be a wonderful and inspiring one.

Download or read book The Health Gap written by Michael Marmot and published by Bloomsbury Publishing. This book was released on 2015-09-10 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: 'Punchily written ... He leaves the reader with a sense of the gross injustice of a world where health outcomes are so unevenly distributed' Times Literary Supplement 'Splendid and necessary' Henry Marsh, author of Do No Harm, New Statesman There are dramatic differences in health between countries and within countries. But this is not a simple matter of rich and poor. A poor man in Glasgow is rich compared to the average Indian, but the Glaswegian's life expectancy is 8 years shorter. The Indian is dying of infectious disease linked to his poverty; the Glaswegian of violent death, suicide, heart disease linked to a rich country's version of disadvantage. In all countries, people at relative social disadvantage suffer health disadvantage, dramatically so. Within countries, the higher the social status of individuals the better is their health. These health inequalities defy usual explanations. Conventional approaches to improving health have emphasised access to technical solutions – improved medical care, sanitation, and control of disease vectors; or behaviours – smoking, drinking – obesity, linked to diabetes, heart disease and cancer. These approaches only go so far. Creating the conditions for people to lead flourishing lives, and thus empowering individuals and communities, is key to reduction of health inequalities. In addition to the scale of material success, your position in the social hierarchy also directly affects your health, the higher you are on the social scale, the longer you will live and the better your health will be. As people change rank, so their health risk changes. What makes these health inequalities unjust is that evidence from round the world shows we know what to do to make them smaller. This new evidence is compelling. It has the potential to change radically the way we think about health, and indeed society.

Download or read book Exceptional Longevity written by Bernard Jeune and published by . This book was released on 1995 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: States that the number of genuine long-livers is exploding and a substantial proportion of new-borns in developed countries may survive to celebrate their 100th birthday. This book examines the storied realms of exceptional longevity.

Download or read book Extra Life written by Steven Johnson and published by Penguin. This book was released on 2021-05-11 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: “Offers a useful reminder of the role of modern science in fundamentally transforming all of our lives.” —President Barack Obama (on Twitter) “An important book.” —Steven Pinker, The New York Times Book Review The surprising and important story of how humans gained what amounts to an extra life, from the bestselling author of How We Got to Now and Where Good Ideas Come From In 1920, at the end of the last major pandemic, global life expectancy was just over forty years. Today, in many parts of the world, human beings can expect to live more than eighty years. As a species we have doubled our life expectancy in just one century. There are few measures of human progress more astonishing than this increased longevity. Extra Life is Steven Johnson’s attempt to understand where that progress came from, telling the epic story of one of humanity’s greatest achievements. How many of those extra years came from vaccines, or the decrease in famines, or seatbelts? What are the forces that now keep us alive longer? Behind each breakthrough lies an inspiring story of cooperative innovation, of brilliant thinkers bolstered by strong systems of public support and collaborative networks, and of dedicated activists fighting for meaningful reform. But for all its focus on positive change, this book is also a reminder that meaningful gaps in life expectancy still exist, and that new threats loom on the horizon, as the COVID-19 pandemic has made clear. How do we avoid decreases in life expectancy as our public health systems face unprecedented challenges? What current technologies or interventions that could reduce the impact of future crises are we somehow ignoring? A study in how meaningful change happens in society, Extra Life celebrates the enduring power of common goals and public resources, and the heroes of public health and medicine too often ignored in popular accounts of our history. This is the sweeping story of a revolution with immense public and personal consequences: the doubling of the human life span.

Download or read book Advances in Geroscience written by Felipe Sierra and published by Springer. This book was released on 2015-11-10 with total page 637 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the first comprehensive overview of a new scientific discipline termed Geroscience. Geroscience examines the molecular and cellular mechanisms that might explain why aging is the main risk factor for most chronic diseases affecting the elderly population. Over the past few decades, researchers have made impressive progress in understanding the genetics, biology and physiology of aging. This book presents vital research that can help readers to better understand how aging is a critical malleable risk factor in most chronic diseases, which, in turn, could lead to interventions that can help increase a healthy lifespan, or ‘healthspan.’ The book begins with an analysis of the Geroscience hypothesis, as well as the epidemiological underpinnings that define aging as a candidate main risk factor for most chronic diseases. Next, each chapter focuses on one particular disease, or group of diseases, with an emphasis on how basic molecular and cellular biology might explain why aging is a major risk factor for it. Coverage in the book includes: cancer, cardiovascular disease, dementias, stroke, Parkinson's and Alzheimer’s diseases, osteoporosis, arthritis, diabetes asthma, emphysema, kidney disease, vision impairment, and AIDS/HIV. It finishes with a chapter on pain in the elderly and an overview of future steps needed to bring the newly acquired knowledge into the clinic and the public at large.

Download or read book Between Zeus and the Salmon written by Caleb E. Finch and published by . This book was released on 1997-10-29 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Demographers and public health specialists have been surprised by the rapid increases in life expectancy, especially at the oldest ages, that have occurred since the early 1960s. Some scientists are calling into question the idea of a fixed upper limit for the human life span. There is new evidence about the genetic bases for both humans and other species. There are also new theories and models of the role of mutations accumulating over the life span and the possible evolutionary advantages of survival after the reproductive years. This volume deals with such diverse topics as the role of the elderly in other species and among human societies past and present, the contribution of evolutionary theory to our understanding of human longevity and intergenerational transfers, mathematical models for survival, and the potential for collecting genetic material in household surveys. It will be particularly valuable for promoting communication between the social and life sciences.

Download or read book Aging written by Stuart Jay Olshansky and published by . This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Aging affects us all and is characterized not only by increasing frailty but by increased susceptibility to conditions such as Alzheimer's, cardiovascular disease, and cancer. We are gaining an increasing understanding of the molecular mechanisms underlying aging, however, and uncovering clues to how life may be prolonged. This book examines the biological basis of aging and research into strategies that may extend lifespan"--

Download or read book Communities in Action written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-04-27 with total page 583 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the United States, some populations suffer from far greater disparities in health than others. Those disparities are caused not only by fundamental differences in health status across segments of the population, but also because of inequities in factors that impact health status, so-called determinants of health. Only part of an individual's health status depends on his or her behavior and choice; community-wide problems like poverty, unemployment, poor education, inadequate housing, poor public transportation, interpersonal violence, and decaying neighborhoods also contribute to health inequities, as well as the historic and ongoing interplay of structures, policies, and norms that shape lives. When these factors are not optimal in a community, it does not mean they are intractable: such inequities can be mitigated by social policies that can shape health in powerful ways. Communities in Action: Pathways to Health Equity seeks to delineate the causes of and the solutions to health inequities in the United States. This report focuses on what communities can do to promote health equity, what actions are needed by the many and varied stakeholders that are part of communities or support them, as well as the root causes and structural barriers that need to be overcome.

Download or read book The Limits to Growth written by Donella H. Meadows and published by Universe Pub. This book was released on 1972 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Examines the factors which limit human economic and population growth and outlines the steps necessary for achieving a balance between population and production. Bibliogs

Download or read book When I m 64 written by National Research Council and published by National Academies Press. This book was released on 2006-02-13 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: By 2030 there will be about 70 million people in the United States who are older than 64. Approximately 26 percent of these will be racial and ethnic minorities. Overall, the older population will be more diverse and better educated than their earlier cohorts. The range of late-life outcomes is very dramatic with old age being a significantly different experience for financially secure and well-educated people than for poor and uneducated people. The early mission of behavioral science research focused on identifying problems of older adults, such as isolation, caregiving, and dementia. Today, the field of gerontology is more interdisciplinary. When I'm 64 examines how individual and social behavior play a role in understanding diverse outcomes in old age. It also explores the implications of an aging workforce on the economy. The book recommends that the National Institute on Aging focus its research support in social, personality, and life-span psychology in four areas: motivation and behavioral change; socioemotional influences on decision-making; the influence of social engagement on cognition; and the effects of stereotypes on self and others. When I'm 64 is a useful resource for policymakers, researchers and medical professionals.

Download or read book Space Time and the Limits of Human Understanding written by Shyam Wuppuluri and published by Springer. This book was released on 2016-12-01 with total page 524 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this compendium of essays, some of the world’s leading thinkers discuss their conceptions of space and time, as viewed through the lens of their own discipline. With an epilogue on the limits of human understanding, this volume hosts contributions from six or more diverse fields. It presumes only rudimentary background knowledge on the part of the reader. Time and again, through the prism of intellect, humans have tried to diffract reality into various distinct, yet seamless, atomic, yet holistic, independent, yet interrelated disciplines and have attempted to study it contextually. Philosophers debate the paradoxes, or engage in meditations, dialogues and reflections on the content and nature of space and time. Physicists, too, have been trying to mold space and time to fit their notions concerning micro- and macro-worlds. Mathematicians focus on the abstract aspects of space, time and measurement. While cognitive scientists ponder over the perceptual and experiential facets of our consciousness of space and time, computer scientists theoretically and practically try to optimize the space-time complexities in storing and retrieving data/information. The list is never-ending. Linguists, logicians, artists, evolutionary biologists, geographers etc., all are trying to weave a web of understanding around the same duo. However, our endeavour into a world of such endless imagination is restrained by intellectual dilemmas such as: Can humans comprehend everything? Are there any limits? Can finite thought fathom infinity? We have sought far and wide among the best minds to furnish articles that provide an overview of the above topics. We hope that, through this journey, a symphony of patterns and tapestry of intuitions will emerge, providing the reader with insights into the questions: What is Space? What is Time? Chapter [15] of this book is available open access under a CC BY 4.0 license.

Download or read book Kids Beyond Limits written by Anat Baniel and published by Penguin. This book was released on 2012-03-27 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discover the revolutionary way to harness the brain's capacity to heal itself Supported by the latest brain research, The Anat Baniel Method uses simple, gentle movements and focus to help any child, who has been diagnosed with autism, Asperger's Syndrome, ADHD, Cerebral Palsy or other developmental disorders. In this supportive and hands-on book, Anat Baniel guides parents through the nine essentials of the method, each one designed to harness the brain's capacity to heal itself -- with remarkable and sometimes immediate results. By shifting the focus to connecting rather than "fixing," this powerful yet simple method helps both children and parents to de- stress, focus, and grow. Most of all, the it helps all children maximize their potential, no matter what their diagnosis.

Download or read book Setting Limits written by Daniel Callahan and published by Georgetown University Press. This book was released on 1995-03-01 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: A provocative call to rethink America's values in health care.

Download or read book What Money Can t Buy written by Michael J. Sandel and published by Farrar, Straus and Giroux. This book was released on 2012-04-24 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Should we pay children to read books or to get good grades? Should we allow corporations to pay for the right to pollute the atmosphere? Is it ethical to pay people to test risky new drugs or to donate their organs? What about hiring mercenaries to fight our wars? Auctioning admission to elite universities? Selling citizenship to immigrants willing to pay? In What Money Can't Buy, Michael J. Sandel takes on one of the biggest ethical questions of our time: Is there something wrong with a world in which everything is for sale? If so, how can we prevent market values from reaching into spheres of life where they don't belong? What are the moral limits of markets? In recent decades, market values have crowded out nonmarket norms in almost every aspect of life—medicine, education, government, law, art, sports, even family life and personal relations. Without quite realizing it, Sandel argues, we have drifted from having a market economy to being a market society. Is this where we want to be?In his New York Times bestseller Justice, Sandel showed himself to be a master at illuminating, with clarity and verve, the hard moral questions we confront in our everyday lives. Now, in What Money Can't Buy, he provokes an essential discussion that we, in our market-driven age, need to have: What is the proper role of markets in a democratic society—and how can we protect the moral and civic goods that markets don't honor and that money can't buy?