Download or read book cGMP Generators Effectors and Therapeutic Implications written by Harald H. H. W. Schmidt and published by Springer Science & Business Media. This book was released on 2008-12-17 with total page 581 pages. Available in PDF, EPUB and Kindle. Book excerpt: After the discovery of endogenous NO formation in the late '80s and the 1998 Nobel Prize in Physiology or Medicine, many researchers and physicians again became interested in the NO/sGC interaction and cGMP-dependent signaling. This book is an enthusiastic celebration of cyclic guanosine monophosphate (cGMP) and amply illustrates the importance of this field of science to patients and the way in which the field has evolved. It is exclusively devoted to this exciting and important signaling molecule, addressing all recent advances in understanding guanylate cyclase regulation, NO/sGC interactions, cGMP effector mechanisms and their pathophysiological and pharmacological implications. Particular attention will also be given to clinical applications of the novel cGMP-elevating drugs which are on the horizon, thus spanning the continuum from basic science to clinic.
Download or read book cGMP Generators Effectors and Therapeutic Implications written by Harald H. H. W. Schmidt and published by Springer. This book was released on 2009-08-29 with total page 583 pages. Available in PDF, EPUB and Kindle. Book excerpt: After the discovery of endogenous NO formation in the late '80s and the 1998 Nobel Prize in Physiology or Medicine, many researchers and physicians again became interested in the NO/sGC interaction and cGMP-dependent signaling. This book is an enthusiastic celebration of cyclic guanosine monophosphate (cGMP) and amply illustrates the importance of this field of science to patients and the way in which the field has evolved. It is exclusively devoted to this exciting and important signaling molecule, addressing all recent advances in understanding guanylate cyclase regulation, NO/sGC interactions, cGMP effector mechanisms and their pathophysiological and pharmacological implications. Particular attention will also be given to clinical applications of the novel cGMP-elevating drugs which are on the horizon, thus spanning the continuum from basic science to clinic.
Download or read book Signaling in the Heart written by José Marín-García and published by Springer Science & Business Media. This book was released on 2011-06-21 with total page 511 pages. Available in PDF, EPUB and Kindle. Book excerpt: Signal transduction pathways are at the core of most biological processes and are critical regulators of heart physiology and pathophysiology. The heart is both a transmitter and dynamic receptor of a variety of intracellular and extracellular stimuli, playing a critical role of an integrator of diverse signaling mechanisms. Alterations in signaling pathways are contributing factors in the development and progression of a broad spectrum of diseases, ranging from dysrhythmias and atherosclerosis to hypertension and the metabolic syndrome. Targeting specific components of these signaling pathways has been shown to be effective in preclinical studies with significant therapeutic impact. This book brings together current knowledge in cardiovascular cell signal transduction mechanisms, advances in novel therapeutic approaches to improve cardiac function, and discussion of future directions. Presented from a post-genomic perspective, this exciting book introduces important new ideas in cardiovascular systems biology. It is an invaluable reference for cardiology researchers and practitioners.
Download or read book Reactive Oxygen Species written by Harald H. H. W. Schmidt and published by Springer Nature. This book was released on 2021-02-23 with total page 425 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reactive oxygen species (ROS) have been implicated in almost every human disease phenotype, without much, if any, therapeutic consequence foremost exemplified by the failure of the so-called anti-oxidants. This book is a game changer for the field and many clinical areas such as cardiology and neurology. The term ‘oxidative stress’ is abandoned and replaced with a systems medicine and network pharmacology-based mechanistic approach to disease. The ROS-related drugs discussed here target either ROS- forming or ROS -modifying enzymes for which there is strong clinical evidence. In addition, ROS targets are included as they jointly participate in causal mechanisms of disease. This approach is transforming the ROS field and represents a breakthrough in redox medicine indicating a path to patient benefit. In the coming years more targets and drugs may be discovered, but the approach will remain the same and this book will thus become, and for many years remain, the leading reference for ROSopathies and their treatment by network pharmacology. Chapter "Soluble Guanylate Cyclase Stimulators and Activators" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Download or read book Non canonical Cyclic Nucleotides written by Roland Seifert and published by Springer. This book was released on 2017-04-28 with total page 379 pages. Available in PDF, EPUB and Kindle. Book excerpt: The cyclic purine nucleotides 3’,5’-cAMP and 3’,5’-cGMP are well-established second messengers. cGMP has recently been covered in a volume of the Handbook of Experimental Pharmacology (volume 191). In addition to 3’,5’-cAMP and 3’,5’-cGMP, so-called non-canonical cyclic nucleotides exist. These comprise the cyclic pyrimidine nucleotides 3’,5’-cCMP and 3’,5’-cUMP, the purine nucleotide 3’,5’-cIMP, the 2’,3’-nucleoside monophosphates and cyclic dinucleotides. In this volume of the Handbook of Pharmacology, word-leading experts in the field summarize our current knowledge on these non-canonical cyclic nucleotides, discuss open questions, future research directions and the pharmacotherapeutic implications. Special emphasis will be given to the emerging roles of 3’,5’-cCMP and 3’,5’-cUMP as second messengers with regard to generators, effectors, biological functions, inactivation and bacterial toxins. The role of 3’,5’-cIMP as potential second messenger will also be critically discussed. Furthermore, we will consider transport of cyclic nucleotides and their potential role as first messengers. The role of the cyclic dinucleotide cGAMP in the immune system will covered, too. Lastly, the book will present important methodological aspects ranging from mass-spectrometric methods for cyclic nucleotide detection to the synthesis of nucleotide analogs as experimental tools and holistic methods for analysis of cyclic nucleotide effects.
Download or read book Cyclic Nucleotide Signaling and the Cardiovascular System written by Thomas Brand and published by MDPI. This book was released on 2018-07-10 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "Cyclic Nucleotide Signaling and the Cardiovascular System" that was published in JCDD
Download or read book Hemodynamics written by Aise Seda Artis and published by BoD – Books on Demand. This book was released on 2012-04-25 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hemodynamics is study of the mechanical and physiologic properties controlling blood pressure and flow through the body. The factors influencing hemodynamics are complex and extensive. In addition to systemic hemodynamic alterations, microvascular alterations are frequently observed in critically ill patients. The book "Hemodynamics: New Diagnostic and Therapeuric Approaches" is formed to present the up-to-date research under the scope of hemodynamics by scientists from different backgrounds.
Download or read book Pharmacotherapy of Pulmonary Hypertension written by Marc Humbert and published by Springer Science & Business Media. This book was released on 2013-10-04 with total page 569 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume focuses on current evidence-based pharmacological treatments of various forms of pulmonary hypertension and provides a comprehensive review of the latest developments in this area. The first part of the book covers the definition, classification, pathophysiology, pathology, biomarkers and animal models of the disease, thus laying the conceptual basis for what follows. The middle section provides an overview of the established therapies, such as calcium channel blockers, prostanoids, endothelin receptor antagonists, phosphodiesterase-5 inhibitors and inhaled nitric oxide. The last section explores novel pathways and emerging therapeutic approaches including soluble guanylate cyclase stimulators, Rho-kinase inhibitors, inhibitors of serotonin receptors and transporters, peptide growth factors, vasoactive peptides, modulators of redox equilibrium and cyclic nucleotide homeostasis, as well as immunosuppressive and anti-proliferative agents. Particular attention is given to the clinical applications of these experimental therapies, that are on the horizon. The book thus spans the continuum from basic science to clinical applications.
Download or read book Muscle Cell and Tissue written by Kunihiro Sakuma and published by BoD – Books on Demand. This book was released on 2021-07-07 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: The loss of skeletal muscle mass and strength substantially impairs physical performance and quality of life. This book details some approaches to the treatment of muscle wasting. It also reviews novel applications against pulmonary arterial hypertension such as cell reprogramming and the use of anticancer drugs that induce programmed cell death. Vascular smooth muscle cells (VSMCs) are the most prevalent cell types in blood vessels and serve critical regulatory roles. This publication also introduces mathematical models concerning the molecular mechanism and targets of cyclic guanosine 3′,5′-monophosphate (cGMP) in the contraction of VSMCs. This book will be of interest to professionals in clinical practice, medical and health care students, and researchers working in muscle-related fields of science.
Download or read book Adipose Tissue written by Leszek Szablewski and published by BoD – Books on Demand. This book was released on 2018-05-30 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adipose tissue is a specialized connective tissue which, depending on type, plays different and significant roles in the human body: protects against environmental factors, stores lipids and triacylglycerol, synthesizes fatty acids and is involved in the process of thermogenesis. It is also a major secretory organ and highly active metabolic tissue. It secretes, for example, cholesterol, retinol, steroid hormones, prostaglandins and proteins known as "adipokines". Some of these molecules may be associated with pathologies such as obesity and insulin resistance. In humans, there are two main sites of adipose tissue accumulation: visceral and subcutaneous. Obesity is a worldwide health problem. This book also discusses a series of up-to-date topics about this pathology.
Download or read book Microdomains in the Cardiovascular System written by Viacheslav Nikolaev and published by Springer. This book was released on 2017-09-19 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book comprehensively presents new findings in cardiovascular research related to signaling microdomains in health and disease. Important second messengers such as cAMP, cGMP, calcium and their role in microdomain signaling are discussed. The book offers and explains methodical approaches and technical ways how to successfully analyze microdomain signaling, also in the context of disease. It further provides scientific perspectives and strategies that are based on the concept of signaling within microdomains and that can revolutionize pharmacology and eventually lead to the effective treatment of cardiovascular diseases in future.This book is written for scientists in cardiovascular research, pharmacology, molecular and cellular biology as well as medical doctors in cardiology, angiology and nephrology.
Download or read book Reviews of Physiology Biochemistry and Pharmacology Vol 174 written by Bernd Nilius and published by Springer. This book was released on 2018-05-10 with total page 159 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leading researchers are specially invited to provide a complete understanding of a key topic within the multidisciplinary fields of physiology, biochemistry and pharmacology. In a form immediately useful to scientists, this periodical aims to filter, highlight and review the latest developments in these rapidly advancing fields.
Download or read book Receptor Endocytosis and Signalling in Health and Disease Part A written by and published by Elsevier. This book was released on 2023-01-09 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: Receptor Endocytosis and Signalling in Health and Disease, Volume 194 in the Progress in Molecular Biology and Translational Science, highlights new advances in the field. Chapters in this release include An overview on receptor endocytosis and signaling, Signaling molecules: Importance in health and disease conditions, Emerging tools for studying of receptor endocytosis and signaling, Endocytosis of EGFR: Signalling in cancer, Endocytosis of AT1 and AT2 receptors: Signalling in the kidney, Regulation of transferrin receptor trafficking by optineurin and its disease-associated mutants, Endocytosis of Insulin receptor: Signalling in the regulation of glucose homeostasis, Endocytosis of VEGFR: Role in the regulation of angiogenesis, and more. Other sections in this new release include Lymphocyte and monocyte/macrophage receptors mediating immune recognition of tumors, Lymphocyte and monocyte/macrophage receptors triggering immune suppression of tumor immunity, Prion receptors and prion internalization and intra- and inter-cellular transport, Multifunctional role of the ubiquitin proteasome pathway in phagocytosis, Adrenoceptors and SCD1 in adipocytes/adipose tissues: the expression and variation in health and obesity, Frizzled receptors and SFRP5 in lipid metabolism: current findings and potential applications. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the Progress in Molecular Biology and Translational Science series - Includes the latest information on Receptor Endocytosis and Signaling in Health and Disease
Download or read book Topics in Anti Cancer Research Volume 9 written by Atta-ur-Rahman and published by Bentham Science Publishers. This book was released on 2020-12-21 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: Topics in Anti-Cancer Research covers new developments in the field of cancer diagnosis and drug therapy. Novel drugs as anticancer agents include natural and synthetic phenazirines and other anti-cancer compounds. The series also covers information on the current understanding of the pathology and molecular biology of specific neoplasms. The diversity of research topics published in this book series give broad and valuable perspectives for cancer researchers, clinicians, cancer professionals aiming to develop novel anti-cancer targets and patents for the treatment of various cancers. The topics covered in this volume are: - Recent Patents on Exosome-Derived Therapeutic Agents - Serrated Lesions of the Colon and Rectum: An Overview of Pathology and Emphasis on a New Classification - Introducing the 188W/188Re and 144Ce/144Pr Plaques for Eye Cancers Brachytherapy - ShcA Family of Adaptor Proteins: Dual Role in Cell Growth - Hormones Management as Anticancer Treatment and Protection: Functions and Mechanism of Action
Download or read book Approach to Lower Limb Oedema written by Satyendra K. Tiwary and published by Springer Nature. This book was released on 2022-01-28 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book covers all aspects of lower limb oedema including aetiology, pathophysiology, clinical approach, investigations, differential diagnosis and management. It presents all the medical and surgical aspects of lower limb oedema in a well-illustrated manner for better understanding. It covers the lower limb oedema of different origins separately to highlight the different spectrums in their presentation and management. Separate chapters include special conditions like pregnancy, trauma and vascular malformations. The book augments the learning and knowledge for lower limb oedema management by illustrating all aspects of it. It suggests proceeding with every possible aetiology with a better understanding of pathophysiology and adequate designated investigations. It also includes clinical guidelines that help to solve the diagnostic dilemma in lower limb oedema management with infused points to reach a consensus in each and every possible cause. The book includes recent scientific literature and accepted guidelines adopted from the publications during the last ten years to provide latest knowledge in the field. The approaches discussed in the book with specific importance to clinical workup and meticulous investigation protocols will help the surgeons, physicians, primary care workers as well as surgical resident trainees to reach the correct diagnosis and proper management.
Download or read book Pharmacology of Neurotransmitter Release written by Thomas C. Südhof and published by Springer Science & Business Media. This book was released on 2007-12-07 with total page 582 pages. Available in PDF, EPUB and Kindle. Book excerpt: It has been known for half a century that neurotransmitters are released in preformed quanta, that the quanta represent transmitter-storing vesicles, and that release occurs by exocytosis. The focus of this book is twofold. In the first part, the molecular events of exocytosis are analysed. In the second part of the book, the presynaptic receptors for endogenous chemical signals are presented that make neurotransmitter release a highly regulated process.
Download or read book Neurodegenerative Diseases written by Celia Dominguez and published by Springer Science & Business Media. This book was released on 2010-11-18 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Role of Histone Deacetylases in Neurodegenerative Diseases and Small-Molecule Inhibitors as a Potential Therapeutic Approach.- Phosphodiesterase Inhibition to Target the Synaptic Dysfunction in Alzheimer’s Disease.- Glutamate and Neurodegenerative Disease.- Modulation of the Kynurenine Pathway for the Potential Treatment of Neurodegenerative Diseases.- Spinal Muscular Atrophy: Current Therapeutic Strategies
