Download or read book Central Neurotransmitter Turnover written by C. J. Pycock and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: The concept of chemical transmission in the central nervous system has taken some time to be generally accepted, but an increasing number of compounds are now being recognized as hav ing a transmitter role in the brain. The acetylcholine system was the first to be discovered in the periphery and its charac teristic features of storage of transmitter in vesicles in the nerve terminal, its electrically-evoked release and rapid extra neuronal breakdown were considered to be necessary criteria for any neurotransmitter candidate. The subsequent elucidation of the noradrenergic system made it apparent that rapid enzymatic breakdown was not essential for a released transmitter, and the possibility of high-affinity re-uptake processes became establ ished as an alternative means of terminating the synaptic actions of a transmitter. With the eventual acceptance of the amino acids as excitat ory or inhibitory transmitters, the requirement for a transmit ter to be present in a low concentration overall (although locally concentrated in specific terminals) also had to be discarded. This necessitated the additional concept of specif ic metabolic pools with different functions being located in different cells or within different regions of the same cell. Some localization of glutamate and aspartate remote from excit able membranes is clearly essential since their overall brain concentrations would be sufficient to maximally depolarize the majority of neurones in the brain. The concept of separate metabolic pools has been supported by stUdies on turnover rate (see Chapter 5).
Download or read book Central Neurotransmitter Turnover written by Christopher J. Pycock and published by University Park Press. This book was released on 1981-01-01 with total page 197 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Choline and Acetylcholine Handbook of Chemical Assay Methods written by Israel Hanin and published by . This book was released on 1974 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Neural Plasticity and Memory written by Federico Bermudez-Rattoni and published by CRC Press. This book was released on 2007-04-17 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive, multidisciplinary review, Neural Plasticity and Memory: From Genes to Brain Imaging provides an in-depth, up-to-date analysis of the study of the neurobiology of memory. Leading specialists share their scientific experience in the field, covering a wide range of topics where molecular, genetic, behavioral, and brain imaging techniq
Download or read book Food Components to Enhance Performance written by Institute of Medicine and published by National Academies Press. This book was released on 1994-02-01 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: The physiological or psychological stresses that employees bring to their workplace affect not only their own performance but that of their co-workers and others. These stresses are often compounded by those of the job itself. Medical personnel, firefighters, police, and military personnel in combat settingsâ€"among othersâ€"experience highly unpredictable timing and types of stressors. This book reviews and comments on the performance-enhancing potential of specific food components. It reflects the views of military and non-military scientists from such fields as neuroscience, nutrition, physiology, various medical specialties, and performance psychology on the most up-to-date research available on physical and mental performance enhancement in stressful conditions. Although placed within the context of military tasks, the volume will have wide-reaching implications for individuals in any job setting.
Download or read book Neurotransmitters And Anterior Pituitary Function written by Giuseppe Nistico and published by Elsevier. This book was released on 2012-12-02 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurotransmitters and Anterior Pituitary Function discusses research findings on neurotransmitter-neurohormone interactions in the control of the anterior pituitary. This book contains five chapters that specifically tackle the most salient constituents of the neural-endocrine communication system in mammals. This book deals first with the biochemistry, physiology, and pharmacology of proved or putative neurotransmitters, as well as some of the techniques used for determining their synthesis or turnover in the central nervous system (CNS) of experimental animals or in man. These topics are followed by a discussion on the principal functions of the most well-known neurotransmitter containing neurons based on sophisticated techniques for neurotransmitter measurements. A chapter highlights both traditional and a vast series of developed drugs that affect both neurotransmitter and neuroendocrine function. Discussions then shift to the experimental evidence on pituitary function control by the brain through releasing and inhibiting hormones secreted by hypothalamic neuroendocrine cells; the chemical isolation, identification, and synthesis of hypothalamic neurohormones; and concepts of their mechanism of action at the level of the pituitary cells. This text further explores the role of specific brain neurotransmitters in controlling pituitary hormone secretions in both experimental animals and in man and the possible CNS site(s) where neurotransmitters and neurohormones interact for the control of anterior pituitary secretion. The concluding chapter describes the actual or potential application of neuropharmacologic approaches to the diagnosis of and therapy for specific disorders of neuroendocrine function. Clinical neuroendocrinologists and researchers and students in neuroendocrinology, neurobiology, neuropharmacology, neurophysiology, and psychiatry will find this book invaluable.
Download or read book Biochemistry of Characterised Neurons written by Neville N. Osborne and published by Elsevier. This book was released on 2013-10-22 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biochemistry of Characterised Neurons provides a report on the progress made in the analysis of the biology of specific neurons in the central nervous system. This book emphasizes the biochemical, morphological, and functional aspects of characterized neurons, including ways and sophisticated techniques of isolating them. This publication is divided into 11 chapters. The first chapter evaluates the relevance of working with single neurons. Chapters 2 to 6 discuss specific, characterized, invertebrate neurons containing one of the putative neurotransmitter substances. Chapter 7 deals with the biochemistry of a unique vertebrate (Torpedo) cholinergic system that enables pure cholinergic neuronal cell bodies and endings to be analyzed separately. The sensitive radiochemical procedures used to analyze transmitter substances and transmitter enzymes, and how they can be adapted to map the distribution of transmitters in individual neurons of Aplysia, are discussed in Chapter 8. Chapter 9 describes methods for the analysis of specific cells in the retina, while Chapters 10 and 11 focus on the analysis of proteins within defined neurons. This text is beneficial to biochemists and students interested in analyzing neurons.
Download or read book Pyretics and Antipyretics written by A. S. Milton and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 706 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fever has always been recognised as the major sign of infectious disease as well as being associated with other illnesses. The suggestion of publishing a volume dedicated exclusively to the subject of fever in the Handbook of Experimental Pharmacology series was one that greatly appealed to me, and I felt very honoured when I was invited to edit it. The first ideas about this volume were conceived in the latter part of 1977 and by the middle of 1978 the first authors had been approached. As is usual with such publications, by the time the first manuscripts were beginning to arrive in the late spring of 1979 there were still a few chapters for which authors had not yet been found. Finally by the end of 1981 the volume was complete. Because of the span of time over which the chapters were written, some refer to more recent work than others; however, I do not feel that this detracts from the overall contribution of all the chapters.
Download or read book Tourette Syndrome written by Davide Martino and published by Oxford University Press. This book was released on 2022 with total page 577 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tourette syndrome (TS) has become increasingly recognised within society and has gained scientific interest worldwide. Knowledge of its clinical presentation, mechanisms of disease, and available treatment approaches has increased remarkably over the last two decades. Likewise, the way clinicians, teachers, social care workers, and families face the problems manifested by patients with TS is rapidly evolving. Tourette Syndrome, edited by Davide Martino and James F. Leckman, offers a unique opportunity to capture this knowledge advance through a comprehensive and up-to-date overview. Tourette Syndrome covers all the main aspects related to TS, analyzing its complex clinical presentation, the novel viewpoints of causes and mechanisms, state-of-the-art assessment techniques, and the diversity of treatment options. Multidisciplinarity is the main asset of this volume, which represents a source of consultation for a wide audience of professionals, integrated with video tutorials related to particularly complex areas of patient management. Medical and PhD students, as well as post-doctoral scientists, will be able to use the volume as a valuable learning source.
Download or read book Obsessive Compulsive Disorder written by Christopher Pittenger and published by Oxford University Press. This book was released on 2017 with total page 777 pages. Available in PDF, EPUB and Kindle. Book excerpt: Obsessive-compulsive disorder (OCD) affects one person in 40 and can cause great suffering. This volume provides the first comprehensive summary of our understanding of this enigmatic condition, summarizing current work ranging from genetics and neurobiology through cognitive psychology, treatment, personal experiences, and societal implications
Download or read book Schizophrenia and Psychotic Spectrum Disorders written by S. Charles Schulz and published by Oxford University Press. This book was released on 2016-04-01 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: Schizophrenia and Psychotic Spectrum Disorders aims to engage young caregivers in psychiatry, psychology, nursing and social work so that they will be able to become well informed about this significant--and at times confusing--illness. Because schizophrenia is considered to be one of the most complicated and severe psychiatric disorders, this book has the goal of summarizing key issues of the illness, such as its presentation, frequency and age of onset, and diagnostic characteristics. It also contains informative chapters about the pathophysiology of schizophrenia, ranging from brain development issues, genetics, and likely abnormalities in neurotransmitters. This book will give young professionals and those joining the field an excellent and accessible background to treatment. In this area, Schizophrenia and Psychotic Spectrum Disorders provides a comprehensive approach to diagnosis, treatment initiation, strategies for non-response, approaches of therapy, and importantly, ways to provide family therapy and support.
Download or read book Introduction to Neuropsychopharmacology written by Leslie Iversen and published by Oxford University Press. This book was released on 2009 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt: The text ranges from drugs that affect the mood and behavior to hypnotics, narcotics, anticonvulsants, and analgesics, as well as a variety of drugs that affect the autonomic nervous system and psychoactive drugs used for non-medical reasons - nicotine, alcohol, opiates, psychostimulants and cannabis."--BOOK JACKET.
Download or read book Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on with total page 1550 pages. Available in PDF, EPUB and Kindle. Book excerpt: First multi-year cumulation covers six years: 1965-70.
Download or read book Chemical Biology of Neurodegeneration written by Pedro Merino and published by John Wiley & Sons. This book was released on 2019-08-07 with total page 446 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bridges the gap between the chemistry of small molecule neuromodulators and the complex pattern of neurodegenerative disorders Written by an experienced neurochemist, this book focuses on the main actors involved in neurodegenerative disorders at a molecular level, and places special emphasis on structural aspects and modes of action. Drawing on recent data on enzyme structure, mode of action, and inhibitor design, it describes?from a biochemical point of view?the six most important neurotransmitter systems and their constituent enzymes and receptors. Misfolding and aggregation of proteins within the brain is also covered. In addition, the book surveys a wide range of proven and prospective therapeutic agents that modulate key processes in the brain, from their chemical synthesis to their mode of action in model systems as well as in the patient. Chemical Biology of Neurodegeneration: A Molecular Approach is presented in two parts. The first introduces the neurotransmitter systems and provides a general explanation of the synapse and a description of the main structures involved in neurotransmission that can be considered therapeutic targets for disorders of the central nervous system. The second part presents molecular and chemical aspects directly involved or affected in neurodegeneration, including the metabolism of neurotransmitters, enzymes processing neurotransmitters, protein misfolding, and therapeutic agents. -Uses an interdisciplinary approach to bridge the gap between the basic biochemical events in a nerve cell and their neurological effects on the brain -Places emphasis on the chemistry of small molecule modulators that are potential lead molecules for new drugs -Covers six key neurotransmitter systems and their enzymes and receptors?dopaminergic, noradrenergic, serotonergic, cholinergic, GABAergic, and glutamatergic Chemical Biology of Neurodegeneration: A Molecular Approach is a key resource for medicinal chemists, neurobiologists, neurochemists, biochemists, molecular biologists, and neurophysiologists.
Download or read book Transmitter Molecules in the Brain written by and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 85 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second volume of Basic and Clinical Aspects of Neuroscience is devoted to the various transmitter systems of the brain (classical and neuropeptides). In Part I the basic aspects are given, including a critical appraisal of the methods used yesterday and today to describe such neurotransmitter systems. Part II concentrates on the functioning in the body of these transmitter systems under physiologic and pathologic conditions. It goes on to show how neuroendocrine investigations may give insights into the functioning of neurotransmitter sys tems at least in the hypothalamus, to end with a chapter which assesses very critically the errors and deficiencies of the concepts and techniques used in the attempt to understand the functioning of the brain and the mind. The editors have been fortunate to have the eight chapters written by a team of investigators working under the direction of Professor G. Fink in the MRC Brain Metabolic Unit at Edinburgh University. We are grateful to him and his colleagues for their work in writing these chapters and for the fine result they achieved. I am grateful for the editorial work done by Professor E. E. Muller (Milan) and Professor M. O. Thorner (Charlottesville), which made this volume possible. Basle, May 1987 E. Fluckiger Managing Editor Table of Contents Part I: Biochemistry of Transmitter Molecules Introduction: Role of Chemical Neurotransmission in Brain Function G.FINK References 4 Classical Transmitters and Neuromodulators 1. K. MCQUEEN Process of Synaptic Transmission. 7 Classification of Synaptic Messengers 7 Dale's Principle ...... .
Download or read book In VIVO Perfusion and Release of Neroactive substances written by Alejandro Bayon and published by Elsevier. This book was released on 2012-12-02 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Vivo Perfusion and Release of Neuroactive Substances: Methods and Strategies examines the perfusion and release methods and strategies used to study in vivo neurochemistry in relation to electrophysiological and behavioral events. More specifically, it reviews methodological alternatives and experimental strategies for investigating the in vivo perfusion and release of brain substances in the central nervous system. It also assesses the potential and limitations of in vivo perfusion methods, including high-pressure liquid chromatography and highly sensitive as well as specific immunoassays and receptor assays, as a means to discover novel neurochemicals recovered from perfusates. Organized into two sections comprised of 17 chapters, this book begins with an overview of methodological alternatives and experimental strategies that are deemed critical for the outcome of research on the perfusion and release of neuroactive substances in the CNS. It then discusses the personal experiences of the scientists in studying the in vivo neurochemistry and its correlation with other neural events. The chapters that follow focus on the chemical, bioelectrical, and behavioral aspects of brain function; interdisciplinary techniques for approaching problems of neuronal connectivity, neuroendocrinology, motor behavior, neuropathology, etc.; technical issues associated with push-pull perfusion in unanesthetized and unrestrained experimental animals; hippocampal involvement in the effects of ethyl alcohol; and the use of the push-pull perfusion technique in neuroendocrinology. This book will be of interest to specialists and neuroscientists as well as students working in the fields of neuroscience, neurochemistry, and neuroendocrinology.
Download or read book Neurotransmitters and Drugs written by Zygmunt L. Kruk and published by Springer. This book was released on 2014-11-14 with total page 211 pages. Available in PDF, EPUB and Kindle. Book excerpt:
