Download or read book Cellular and Molecular Regulation of Hemoglobin Switching written by George Stamatoyannopoulos and published by Grune & Stratton, Incorporated. This book was released on 1979 with total page 828 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cellular and Molecular Regulation of Hemoglobin Switching written by George Stamatoyannopoulos and published by . This book was released on 1979 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Hemoglobin Switching written by George Stamatoyannopoulos and published by . This book was released on 1989 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Regulation of Hemoglobin Switching written by George Stamatoyannopoulos and published by . This book was released on 1991 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of the Seventh Conference on [title] held in Airlie, Virginia, September 1990, and sponsored by the National Institute of Diabetes, Digestive and Kidney Diseases and the National Heart, Lung, and Blood Institute. Contributors address hemoglobin switching in transgenic animals, the locus control region of the globin gene domain, other Cis sequences, transcriptional control of switching, and of erythropoiesis, manipulation of hemoglobin switching in vivo, molecular and cellular biology of hematopoiesis, and gene transfer. (c) by Book News, Inc., Portland, OR.
Download or read book Hemoglobin switching proceedings of the Sixth Conference on Hemoglobin Switching held in Airlie Virginia September 24 27 1988 B Cellular and molecular mechanisms written by Conference on Hemoglobin Switching and published by . This book was released on 1989 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Hemoglobin Switching written by Conference on Hemoglobin Switching and published by . This book was released on 1989-01-01 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Disorders of Hemoglobin written by Martin H. Steinberg and published by Cambridge University Press. This book was released on 2009-08-17 with total page 883 pages. Available in PDF, EPUB and Kindle. Book excerpt: Completely revised new edition of the definitive reference on disorders of hemoglobin.
Download or read book Hemoglobin Switching written by George Stamatoyannopoulos and published by . This book was released on 1989 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Regulators of Hemoglobin Switching in Zebrafish and Human Models written by Jared Jason Ganis and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Hemoglobin switching is a developmental process involving the dynamic transcriptional regulation of multiple globin genes. This molecular process involves multiple layer of complexity, and elucidating new mechanisms in this process will result in a more complete understanding of general gene regulation and will likely have direct clinical implications for hemoglobinopathies, such as sickle cell anemia. In this dissertation, I develop and characterize a new model for hemoglobin switching, the zebrafish. I defined and fully annotated the two zebrafish globin loci, termed major and minor loci. Both loci contain [alpha]- and [beta]- genes oriented in a head-to-head fashion. Characterization of the globin expression pattern precisely defined the timing of normal switching and demonstrated that zebrafish, like humans, have two globin switches. The locus control region for the major locus was identified and in conjunction with a proximal promoter was able to generate robust, erythroid-specific expression in a transgenic line.
Download or read book Hemoglobin Switching written by George Stamatoyannopoulos and published by John Wiley & Sons. This book was released on 1989-09-01 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Molecular Basis of Blood Diseases written by George Stamatoyannopoulos and published by Saunders. This book was released on 2001 with total page 1080 pages. Available in PDF, EPUB and Kindle. Book excerpt: The superb Third Edition of this popular text covers all the recent groundbreaking developments which have taken place in this field. Comprehensively revised, it presents all the latest findings on the molecular bases of blood cell functions and disease mechanisms and the impact of these discoveries on the state of medicine. This edition includes new chapters such as signaling and antigen presentation by B-lymphocytes, molecular oncogenesis and more!
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1977 with total page 804 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Regulation of Haemoglobin Synthesis written by J. Neuwirt and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: Haemoglobin is one of the most important molecules in the animal kingdom. Its function is to carry oxygen to tissues. In lower invertebrates the blood pigment is present in the haemolymph and is not bound in cells. Later in the course of phylo genesis haemoglobin remains associated with cells which produce it and in this form it reaches the peripheral circulation. In higher organisms the haemoglobin production is thus determined by two main factors: haemoglobin synthesis in erythroid cells and the formation of these erythroid cells which depends on cell proliferation in haematopoietic organs. Human haemoglobin is made up of two chains which combine from four different polypeptide chains formed in varying ratios in different periods of the life cycle. During the life span of humans the following haemoglobins are formed: embryonic haemoglobins Gower 1 and 2, foetal haemoglobin F and two adult haemoglobins A and A . E-and IX-chains are part of the embryonic haemoglobins Gower 1 (E4) and 2 Gower 2 (1X2E2). These haemoglobins predominate in embryos during the second month of pregnancy and at the end of the first trimester they are completely re placed by foetal haemoglobin F (~Y2). Adult haemoglobin A consists of two IX and two ~-chains and is the main component of red cells in adults. A relatively small component of red cells accounting for less than 2 % of the total haemo globin, is haemoglobin A2 (1X0).
Download or read book The Molecular Switch written by Rob Phillips and published by Princeton University Press. This book was released on 2020-09 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: A signature feature of living organisms is their ability to carry out purposeful actions by taking stock of the world around them. To that end, cells have an arsenal of signaling molecules linked together in signaling pathways, which switch between inactive and active conformations. The Molecular Switch articulates a biophysical perspective on signaling, showing how allostery—a powerful explanation of how molecules function across all biological domains—can be reformulated using equilibrium statistical mechanics, applied to diverse biological systems exhibiting switching behaviors, and successfully unify seemingly unrelated phenomena. Rob Phillips weaves together allostery and statistical mechanics via a series of biological vignettes, each of which showcases an important biological question and accompanying physical analysis. Beginning with the study of ligand-gated ion channels and their role in problems ranging from muscle action to vision, Phillips then undertakes increasingly sophisticated case studies, from bacterial chemotaxis and quorum sensing to hemoglobin and its role in mammalian physiology. He looks at G-protein coupled receptors as well as the role of allosteric molecules in gene regulation. Phillips concludes by surveying problems in biological fidelity and offering a speculative chapter on the relationship between allostery and biological Maxwell demons. Appropriate for graduate students and researchers in biophysics, physics, engineering, biology, and neuroscience, The Molecular Switch presents a unified, quantitative model for describing biological signaling phenomena.
Download or read book Renaissance Of Sickle Cell Disease Research In The Genome Era written by Betty Pace and published by World Scientific. This book was released on 2007-01-24 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Human Genome Project has spawned a Renaissance of research faced with the daunting expectation of personalized medicine for individuals with sickle cell disease in the Genome Era. This book offers a comprehensive and timeless account of emerging concepts in clinical and basic science research, and community concerns of health disparity to educate professionals, students and the general public about meeting this challenging expectation. Contributions from physicians, research scientists, scientific administrators and community workers make Renaissance of Sickle Cell Disease Research in the Genome Era unique among the catalogue of books on this genetic disorder.Part 1 offers detailed review of the National Heart Lung and Blood Institute's leadership role in funding sickle cell research, as well as developing progressive research initiatives and the predicted impact of the Human Genome Project. Part 2 gives an account of several clinical research perspectives based on the Cooperative Study of Sickle Cell Disease. These include recommendations for newborn screening, pain management, stroke, transfusion therapy and pediatric and adult healthcare. Part 3 offers novel insights into basic science research progress and the impact of the Human Genome Project on the direction of hemoglobinopathy research, including hemoglobin switching, bone marrow transplantation and gene therapy. Part 4 engages the reader in a culture-based discussion of the stigma attached to sickle cell disease in the African American community and the apprehensions about genetic research in this community. It concludes with a global perspective on sickle cell disease from African, European and American experiences. For readers seeking a definitive account of sickle cell disease appropriate for students, researchers and community workers, this collaborative effort is an ideal textbook./a
Download or read book The Obstetric Hematology Manual written by Sue Pavord and published by Cambridge University Press. This book was released on 2018-02-08 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understand the rapidly growing complexities of obstetric hematology and high-risk pregnancy management, with experts in the field. Now in its second edition, this comprehensive and essential guide focuses on providing the best support for patients and clinical staff, to prevent serious complications in pregnancy and the post-partum period for both mother and baby. Wide-ranging and detailed, the guide offers discussions on basic principles of best care, through to tackling lesser-known hematological conditions, such as cytopenias and hemoglobinopathies. Updated with color illustrations, cutting-edge research, accurate blood film reproductions, and practical case studies, the revised edition places invaluable advice into everyday context. This unique resource is essential reading for trainees and practitioners in obstetrics, anesthesia, and hematology, as well as midwives, nurses, and laboratory staff. Clarifying difficult procedures for disease prevention, the guide ensures safety when the stakes are high. Reflecting current evidence-based guidelines, the updated volume is key to improving pregnancy outcomes worldwide.
