Download or read book Cellular and Molecular Control of Neuronal Migration written by Laurent Nguyen and published by Springer Science & Business Media. This book was released on 2013-11-18 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cellular and Molecular Control of Neuronal Migration provides an up-to-date collection of reviews on the molecular and cellular principles of neuronal migration in the mammalian brain. Over the last decades a rich catalogue of signaling molecules controlling neuronal migration has been compiled, and within this book an international panel of experts provides up-to-date discussions of the state of knowledge how these distinct signaling pathways regulate various aspects of neuronal migration. This book introduces the reader to the latest discoveries and concepts of neuronal migration enabled through the application of most sophisticated methods and cutting edge experimental approaches. Cellular and Molecular Control of Neuronal Migration also provides an update on the underlying cellular and molecular basis of neurodevelopmental migration disorders in human patients for all interested neuroscientists and clinicians.

Download or read book Cellular and Molecular Guidance of Neuronal Migration written by Yan Zhu and published by . This book was released on 2003 with total page 570 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Cellular Migration and Formation of Neuronal Connections written by and published by Academic Press. This book was released on 2013-05-06 with total page 1081 pages. Available in PDF, EPUB and Kindle. Book excerpt: The genetic, molecular, and cellular mechanisms of neural development are essential for understanding evolution and disorders of neural systems. Recent advances in genetic, molecular, and cell biological methods have generated a massive increase in new information, but there is a paucity of comprehensive and up-to-date syntheses, references, and historical perspectives on this important subject. The Comprehensive Developmental Neuroscience series is designed to fill this gap, offering the most thorough coverage of this field on the market today and addressing all aspects of how the nervous system and its components develop. Particular attention is paid to the effects of abnormal development and on new psychiatric/neurological treatments being developed based on our increased understanding of developmental mechanisms. Each volume in the series consists of review style articles that average 15-20pp and feature numerous illustrations and full references. Volume 2 offers 56 high level articles devoted mainly to Formation of Axons and Dendrites, Migration, Synaptogenesis, Developmental Sequences in the Maturation of Intrinsic and Synapse Driven Patterns. - Series offers 144 articles for 2904 full color pages addressing ways in which the nervous system and its components develop - Features leading experts in various subfields as Section Editors and article Authors - All articles peer reviewed by Section Editors to ensure accuracy, thoroughness, and scholarship - Volume 2 sections include coverage of mechanisms which regulate: the formation of axons and dendrites, cell migration, synapse formation and maintenance during development, and neural activity, from cell-intrinsic maturation to early correlated patterns of activity

Download or read book Cellular Migration and Formation of Axons and Dendrites written by Bin Chen and published by Academic Press. This book was released on 2020-05-29 with total page 630 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cellular Migration and Formation of Neuronal Connections, Second Edition, the latest release in the Comprehensive Developmental Neuroscience series, presents the latest information on the genetic, molecular and cellular mechanisms of neural development. This book provides a much-needed update that underscores the latest research in this rapidly evolving field, with new section editors discussing the technological advances that are enabling the pursuit of new research on brain development. This volume focuses on the formation of axons and dendrites and cellular migration. - Features leading experts in various subfields as section editors and article authors - Presents articles that have been peer reviewed to ensure accuracy, thoroughness and scholarship - Includes coverage of mechanisms which regulate the formation of axons and dendrites and cellular migration - Covers neural activity, from cell-intrinsic maturation, to early correlated patterns of activity

Download or read book The Extracellular Environment in Controlling Neuronal Migration During Neocortical Development written by Yuki Hirota and published by Frontiers Media SA. This book was released on 2021-06-30 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Role of Endocytosis in Neuronal Migration written by Jennifer Cynthia Shieh and published by Stanford University. This book was released on 2010 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: Disruptions in neuronal migration have been implicated in a variety of human mental disorders, including epilepsy, autism, and schizophrenia. Despite the critical role of migration during nervous system development, the basic physical and cytoskeletal mechanisms of coordinated neuronal movement have not yet been fully characterized. A migrating neuron moves with morphologically distinct steps: a single leading process extends ahead of a stationary cell soma, followed by the formation of a cytoplasmic dilation ahead of the nucleus, subsequent movement of the nucleus into the dilation, and retraction of the cell rear. The temporal and spatial regulation of adhesion is important for the proper progression of these steps. I investigated the role of endocytosis in regulating adhesion during neuronal migration. Using genetic and pharmacological methods to disrupt endocytosis either in vitro or in vivo leads to altered neuronal migration. Introducing dominant negative clathrin or dynamin into the developing cortex delays radial migration in vivo. Pharmacologically inhibiting clathrin or dynamin reduces the velocity of anterior subventricular zone (SVZa) neurons migrating in a three-dimensional matrix in vitro. Components of clathrin endocytic machinery are localized to the dilation region of a migrating neuron at points of matrix attachment. The absence of adhesion molecules at the cell rear led us to the hypothesis that endocytosis weakens adhesions in the dilation to allow the cell rear to move forward during migration. In support of this hypothesis, exposing SVZa explants to pharmacological inhibitors of either clathrin or dynamin prevents migration out of explants, and neurons that have migrated out have altered morphology and adhesion molecule distribution. Neurons exposed to a dynamin inhibitor tend to have "tails" of membrane at the rear, and these tails contain adhesion molecules. The presence of adhesion molecules at the rear of migrating neurons exposed to a dynamin inhibitor supports the idea that endocytosis plays a role in regulating adhesion disassembly. Endocytosis likely plays a critical role in general neuronal migration regardless of the specific neuronal subtype, migration mode, or substrate.

Download or read book Comprehensive Developmental Neuroscience Cellular Migration and Formation of Neuronal Connections written by F. Beaubien and published by Elsevier Inc. Chapters. This book was released on 2013-05-06 with total page 60 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Comprehensive Developmental Neuroscience Cellular Migration and Formation of Neuronal Connections written by F. Bielle and published by Elsevier Inc. Chapters. This book was released on 2013-05-06 with total page 66 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Comprehensive Developmental Neuroscience Cellular Migration and Formation of Neuronal Connections written by A. Griveau and published by Elsevier Inc. Chapters. This book was released on 2013-05-06 with total page 68 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Comprehensive Developmental Neuroscience Cellular Migration and Formation of Neuronal Connections written by A. Stanco and published by Elsevier Inc. Chapters. This book was released on 2013-05-06 with total page 40 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Molecular and Cellular Approaches to Neural Development written by W. Maxwell Cowan and published by Oxford University Press, USA. This book was released on 1997 with total page 575 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text provides a broad but authoritative view of the cellular and molecular aspects of developmental neurobiology written by leaders in the field.

Download or read book Comprehensive Developmental Neuroscience Cellular Migration and Formation of Neuronal Connections written by J. Falk and published by Elsevier Inc. Chapters. This book was released on 2013-05-06 with total page 60 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book In vivo Cell Biology of Cerebral Cortical Development and Its Related Neurological Disorders Cellular Insights into Neurogenesis and Neuronal Migration written by Takeshi Kawauchi and published by Frontiers Media SA. This book was released on 2016-09-21 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: The brain consists of a complex but precisely organized neural network, which provides the structural basis of higher order functions. Such a complex structure originates from a simple pseudostratified neuroepithelium. During the developing mammalian cerebral cortex, a cohort of neural progenitors, located near the ventricle, differentiates into neurons and exhibits multi-step modes of migration toward the pial surface. Tight regulation of neurogenesis and neuronal migration is essential for the determination of the neuron number in adult brains and the proper positioning of excitatory and inhibitory neurons in a specific layer, respectively. In addition, defects in neurogenesis and neuronal migration can cause several neurological disorders, such as microcephaly, periventricular heterotopia and lissencephaly. Recent advances in genetic approaches to study the developing cerebral cortex, as well as the use of a number of novel techniques, particularly in vivo electroporation and time-lapse analyses using explant slice cultures, have significantly increased our understanding of cortical development. These novel techniques have allowed for cell biological analyses of cerebral cortical development in vivo or ex vivo, showing that many cellular events, including endocytosis, cell adhesion, microtubule and actin cytoskeletal regulation, neurotransmitter release, stress response, the consequence of cellular crowding (physical force), dynamics of transcription factors, midbody release and polarity transition are required for neurogenesis and/or neuronal migration. The aim of this research topic is to highlight molecular and cellular mechanisms underlying cerebral cortical development and its related neurological disorders from the cell biological point of views, such as cell division, cell-cycle regulation, cytoskeletal organization, cell adhesion and membrane trafficking. The topic has been organized into three chapters: 1) neurogenesis and cell fate determination, 2) neuronal migration and 3) cortical development-related neurological disorders. We hope that the results and discussions contributed by all authors in this research topic will be broadly useful for further advances in basic research, as well as improvements in the etiology and care of patients suffering from neurological and psychiatric disorders.

Download or read book Neuronal Migrations in Caenorhabditis Elegans written by Tobey Ming-Hui Tam and published by . This book was released on 2001 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Mechanisms of Neuronal Migration during Corticogenesis written by Chiaki Ohtaka-Maruyama and published by Frontiers Media SA. This book was released on 2016-07-15 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: The cerebral cortex plays central roles in many higher-order functions such as cognition, language, consciousness, and the control of voluntary behavior. These processes are performed by the densely interconnected networks of excitatory pyramidal neurons and inhibitory interneurons, and the balanced development of these two types of neuron is quite important. During cortical development, pyramidal neurons and interneurons show quite different migratory behaviors: radial migration and tangential migration, respectively. Pyramidal neurons are generated in the ventricular zone of the dorsal telencephalon, and migrate radially along radial glial fibers toward the pial surface, forming a six-layered cortical structure in an “ inside-out” manner. On the other hand, cortical interneurons are generated in the medial and caudal ganglionic eminence in the ventral telencephalon, and follow long tangential migratory paths into the cortex. Defects in these migration processes result in abnormalities in the cortical layer structure and neuronal networks, which may cause various neurological and psychiatric conditions such as epilepsy and schizophrenia. Accordingly, besides basic scientific interest, elucidation of the mechanism of neuronal migration is essential for understanding the pathogenesis of these diseases. This Research Topic includes a series of articles ranging from the basic mechanism of neocortical development to the malformation and evolution of the neocortex. We do hope that the present ebook will further stimulate the interest in the fascinating investigations of neuronal migration and corticogenesis.

Download or read book Comprehensive Developmental Neuroscience Cellular Migration and Formation of Neuronal Connections written by T.L. Dickendesher and published by Elsevier Inc. Chapters. This book was released on 2013-05-06 with total page 69 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Guidance Cues in the Developing Brain written by Ivica Kostovic and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many complex molecular interactions are involved in the development of the mammalian brain. Molecules serving as guidance cues for migratory cells, growing axons and for recognition of postsynaptic targets are a major topic for research because they are directly involved in the formation of neuronal circuits, thus creating the foundation for subsequent functional refinement through interactions with the environment. In addition, most guidance cue molecules are also involved in plasticity, damage repair and regeneration in the adult brain. This volume reviews current knowledge on major classes of molecules involved in: guidance of growing axons; tau proteins involved in the establishment of axonal polarity, outgrowth and contact recognition; gangliosides and lectins involved in neuronal migration, neurite outgrowth and contact recognition; and myelin molecules that inhibit nerve regeneration.