Download or read book Cellular and Molecular Biology of Intermediate Filaments written by R.D. Goldman and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 483 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research activity on intermediate filaments (IF) has increased dramatically over the past decade. For the most part, this surge of interest is due to their identification as ubiquitous constituents of the cytoskeleton and karyoskeleton (nuclear matrix) of eukaryotic cells and the fact that we know very little regarding their functions. In sharp contrast to the other major cytoskeletal systems, microfilaments and microtubules, IF exhibit a high degree of heterogeneity with regard to their protein subunit composition. Indeed, one can only marvel at the number of different IF polypeptides, their associated proteins (IFAP) and, consequently, the number of genes involved in encoding the multiple constituents of the various IF networks found in different cell types. The chapters in this book demonstrate how various experimental approaches involv ing cellular, molecular, biochemical, and immunological methods have been utilized to generate information regarding the structure and function of IF. To this end, we have gathered together chapters from experts in the major fields of IF research. In each chapter, the authors have combined reviews of the available scientific literature with their own ideas on current and future directions for IF research. The chapters have been divided into five major sections which are concerned with the subcellular organization of IF, the molecular structure of IF, the differential expression of IF genes, descriptions of associ ated proteins involved in the intracellular organization of IF, and finally an analysis of the changes seen in IF in pathological conditions.
Download or read book Intermediate Filament Proteins written by and published by Academic Press. This book was released on 2016-01-18 with total page 857 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intermediate Filament Proteins, the latest volume in the Methods in Enzymology series covers all the intermediate filaments in vertebrates and invertebrates, providing a unique understanding of the multiple different tissue-specific intermediate filaments. This volume also covers the latest methods that are currently being used to study intermediate filament protein function and dynamics. It will be an important companion for any experimentalist interesting in studying this protein family in their cell or organism model system. Focuses on intermediate filaments, including the latest information Provides an up-to-date understanding of the field Contains contributions from the major scientists working and publishing in the field
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Intermediate Filament Cytoskeleton written by M. Bishr Omary and published by Gulf Professional Publishing. This book was released on 2004-12-02 with total page 966 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intermediate filaments are a large family of proteins that are the cytoskeletal elements involved in a number of skin, liver, neuromuscular, cardiac, eye and hair diseases. Intermediate filament genes are regulated in a tissue-and cell type-specific manner and their polymerized protein products protects the cells and tissue they are part of against a variety of mechanical and nonmechanical stresses. This book provides a comprehensive resource of methodology essentials, describing a variety of essential tools and assays for studying intermediate filaments. The book provides user-friendly advice and protocols covering all aspects of intermediate filaments including protein isolation and structure, protein and gene regulation, relationship to disease and apoptosis, and associated proteins. Both mammalian and non-mammalian systems and animal models are covered, making this book a must-have for any investigator wishing to study IF genes or their protein products. * Covers intermediate filaments from crystallography, protein chemistry, cell and molecular biology, microrheology, gene regulation, to animal models and human disease * Practical and user-friendly with detailed "how-to-protocols and "tricks of the trade" * Includes detailed tables of useful reagents, vendors and web links
Download or read book Intermediate Filaments written by Jesus Paramio and published by Springer Science & Business Media. This book was released on 2007-06-07 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intermediate Filaments focuses on desmin and other intermediate filaments in disease and health. This new volume will serve as a resource for graduate students and researchers in the field.
Download or read book Intermediate Filament Associated Proteins written by and published by Academic Press. This book was released on 2016-01-14 with total page 628 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intermediate Filament Associated Proteins, the latest volume in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in intermediate filament associated proteins and contains sections on such topics as lamin-associated proteins, intermediate filament-associated proteins and plakin, and other cytoskeletal cross-linkers. Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers research methods in intermediate filament associated proteins and contains sections on such topics as lamin-associated proteins, intermediate filament-associated proteins and plakin, and other cytoskeletal cross-linkers
Download or read book Intermediate Filaments written by P. Traub and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research on cytoskeletal elements of eukaryotic cells has been expand ing explosively during the past 5 to 10 years. Due largely to the employment of electron and immunofluorescent microscopy, significant results have been obtained which have provided interesting new insights into the dynamics of nucleated cells at the structural, physiological, as well as developmental levels. While a substantial amount of knowledge has accumulated on the function of microfilaments and microtubules, the roles of the third major class of cytoskeletal structures in vertebrate cells, the intermediate filaments, have largely resisted clarification. The investigation of cultured cells and of tissues from various developmental stages has furnished a host of information on the inter-and intracellular distribution of the different types of intermediate filaments and led to the contention that they have a structural and organizing function in the cytoplasm of vertebrate cells. However, the results of recent experimen that vertebrate cells can function perfectly in the tation have shown complete absence of cytoplasmically extended intermediate filament meshworks. It is legitimate to suppose, therefore, that their function in vertebrate cells is much more subtle and complex than generally presumed. Our interest in the structure and function of intermediate filament proteins was initiated approximately 7 years ago while working on the regulation of macromolecular synthesis in picornavirus-infected mam malian cells. In attempts to demonstrate virus-induced changes in the nuclear protein components of the host cells, the nonionic detergent extraction method was used to purify nuclei.
Download or read book Cell and Molecular Biology of the Cytoskeleton written by J.W. Shay and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Cytoskeleton written by Thomas Dean Pollard and published by . This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The cytoskeleton is the intracellular filament system that controls the morphology of a cell, allows it to move, and provides trafficking routes for intracellular transport. It comprises three major filament systems-actin, microtubules, and intermediate filaments-along with a host of adaptors, regulators, molecular motors, and additional structural proteins. This textbook presents a comprehensive and up-to-date view of the cytoskeleton, cataloguing its many different components and explaining how they are functionally integrated in different cellular processes. It starts by laying out the basic molecular hardware, before describing in detail how these components are assembled in cells and linked to neighboring cells and the extracellular matrix to maintain tissue architecture. It then surveys the roles of the cytoskeleton in processes such as intracellular transport, cell motility, signal transduction, and cell division. The book is thus essential reading for students learning about intracellular structure. It also represents a vital reference for all cell and developmental biologists working in this field.
Download or read book Intermediate Filaments written by Harald Herrmann and published by Springer Science & Business Media. This book was released on 1998-09-30 with total page 660 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprises 20 contributions on intermediate filament (IF) proteins, providing a comprehensive overview of the essentials of IF research and very recent developments, including many previously unpublished concepts and results. Representative topics include intermediate filament organization during oogenesis and early development in the clawed frog, lessons from keratin transgenic and knockout mice, cytokeratins as markers of differentiation in the diagnosis of epithelial tumors, vimentin and lipid metabolism, and nuclear lamin- binding proteins. Annotation copyrighted by Book News, Inc., Portland, OR
Download or read book Intermediate Filaments written by Normand Marceau and published by Biota Publishing. This book was released on 2014-06-01 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intermediate filaments (IFs), in concert with microfilaments (MFs) and microtubules (MTs), form the cytoskeleton, and each of these fibrillar networks exhibits rather unique structural and functional characteristics. Intermediate filaments were discovered in eukaryotic cells in the late 1960s, and their name comes from the fact that their diameter is intermediate between MFs and MTs. In contrast to the latter, IFs constitute a network that extends from the nuclear envelope throughout the cytoplasm, and in many cases, interact with cell surface domains involved in cell-cell and cell- matrix interactions. Several key features of their expression, assembly, structure and dynamics are highlighted in this eBook. For instance, IF proteins are encoded by several genes, which are classified into six types reflecting the tissues (cells) of origin. Moreover, IF proteins contain a conserved central α-helical (rod) domain flanked by N-terminal (head) and C-terminal (tail) globular domains that enables assembly of fibrous IFs exhibiting a tripartite structure. Although the rod domain is responsible for the formation of the coiled-coil framework and yields the main driving force during the IF protein assembly, the head and tail domains contribute to most of the structural heterogeneity of IF organization and undergo several types of post-translational modifications. Furthermore, the development of gene targeting methods to genetically knockout the expression of the IF genes in mice has uncovered the mechanical versus non-mechanical features of the IF networks, namely, their involvement in cell response to diverse forms of stress, growth stimulation, migration, or death insults. Finally, there is accumulating evidence revealing that the tissue and cell-type expression of IF genes reflects itself in the presence of causal or predisposition mutations responsible for numerous human tissue-specific diseases, known as IF-pathies. Table of Contents: List of Abbreviations / Introduction / IFs as a Multigene Family of Filamentous Proteins / Nuclear Lamina / IF Functional Interplay with Cell Surface Domains and Organelles / IFs and Cell Specialization / IF Relevance to Human Diseases / Conclusion / References / Author Biographies
Download or read book Cells Molecules and Mechanisms written by Eric Wong and published by Axolotl Academic Publishing. This book was released on 2009 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Yet another cell and molecular biology book? At the very least, you would think that if I was going to write a textbook, I should write one in an area that really needs one instead of a subject that already has multiple excellent and definitive books. So, why write this book, then? First, it's a course that I have enjoyed teaching for many years, so I am very familiar with what a student really needs to take away from this class within the time constraints of a semester. Second, because it is a course that many students take, there is a greater opportunity to make an impact on more students' pocketbooks than if I were to start off writing a book for a highly specialized upper- level course. And finally, it was fun to research and write, and can be revised easily for inclusion as part of our next textbook, High School Biology."--Open Textbook Library.
Download or read book Intermediate Filament Structure written by David A. D. Parry and published by R G Landes Company. This book was released on 1995 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covers the structure and role of intermediate filament (IF) proteins in a variety of cell types. The text examines the expression of IF proteins, the hierarchical assembly of those proteins into molecules, oligomers, protofilaments, protofilbrils and intact IF.
Download or read book Cell Movements written by Dennis Bray and published by Garland Science. This book was released on 2001 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book vividly describes how complex and integrated movements can arise from the properties and behaviors of biological molecules. It provides a uniquely integrated account in which the latest findings from biophysics and molecular biology are put into the context of living cells. This second edition is updated throughout with recent advances in the field and has a completely revised and redrawn art program. The text is suitable for advanced undergraduates, graduate students, and for professionals wishing for an overview of this field.
Download or read book The Cytoskeleton in Health and Disease written by Heide Schatten and published by Springer. This book was released on 2015-08-21 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume addresses the structural and functional roles of the cytoskeleton and its dysfunctions which often lead to disease. It provides thorough discussion of microtubules, microfilaments, intermediate filaments, and cytoskeletal functions and dysfunctions in different organ systems. Comprehensive yet concise. The Cytoskeleton In Health And Disease presents cutting-edge discoveries balanced with background information and highlights the new aspects of the research and its impact on the design of new strategies or the identification of new targets for therapeutic intervention. There is a significant need for a book on this topic, as interest in the cytoskeleton continues to grow as causes and cures for cytoskeletal diseases are further explored in biomedical research. This book is essential reading for scientists, students, and teachers interested in expanding their knowledge related to the cytoskeleton. New researchers entering the field will find classic and well as contemporary information not easily found in the current literature or internet resources.
Download or read book The Cytoskeleton written by Manfred Schliwa and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: The term cytoskeleton has become firmly established in today's scientific vocabulary. Indeed, it is difficult to believe that only ten years ago, it was virtually non-existent. Since then, the modern field of research on the structural organization of the cytoplasm has turned into one of the most productive and rapidly expanding research areas in Cell Biology today. Considerable progress has been made towards the identification of the various structural components of the cytoskeleton and their interactions with one another and with membranes. The first attempts to understand, in molecular terms, complex cellular processes such as shape changes, locomotion, division, and organelle movements have been made. And it is now apparent that the cytoskeleton has impact on other biological processes such as the control of gene expression, protein synthesis, cell cycle regulation, and development. This monograph outlines the basic properties of the major components of the polymeric filament networks and their interactions and associations. Wherever possible, emphasis is placed on more recent references. Any attempt to cover a research field this complex in an introductory mono graph is, by necessity, fragmentary, and oversights or omissions are inevitable. I wish to apologize in advance to all those colleagues who feel that their work is not adequately represented.
Download or read book Cell Biology by the Numbers written by Ron Milo and published by Garland Science. This book was released on 2015-12-07 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Top 25 CHOICE 2016 Title, and recipient of the CHOICE Outstanding Academic Title (OAT) Award. How much energy is released in ATP hydrolysis? How many mRNAs are in a cell? How genetically similar are two random people? What is faster, transcription or translation?Cell Biology by the Numbers explores these questions and dozens of others provid
