Download or read book Cell Therapy for Perinatal Brain Injury written by Haruo Shintaku and published by Springer. This book was released on 2018-03-01 with total page 155 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a wealth of insights, advances and new perspectives on cell therapy for different types of neonatal ischemic disease, such as Hypoxic-Ischemic Encephalopathy (HIE), Periventricular Leukomalacia (PVL) and neonatal infarction. These diseases pose serious challenges for neonatologists and neurologists, because the severe sequelae lead to decreasing QOL for patients and their families. Accordingly, new treatments for neonatal ischemic diseases are needed all over the world. The book develops new effective therapies combined with hypothermia therapy, an established treatment for HIE. After reviewing past approaches, it presents cutting-edge topics in cell therapy, one of the most promising candidates for treating neonatal ischemic disease. Cell Therapy for Neonatal Ischemic Disease will offer readers a better understanding of the current state of the art in this field from bench to bedside, and inspire researchers and physicians to further explore this evolving therapy.
Download or read book Experimental and Clinical Approaches in the Pursuit of Novel Therapeutic Strategies for Perinatal Brain Injury and its Neurological Sequelae written by Changlian Zhu and published by Frontiers Media SA. This book was released on 2021-12-06 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cell Therapy for Brain Injury written by David C. Hess and published by Springer. This book was released on 2015-05-15 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell Therapy for Brain Injury is a thorough examination of using state-of-the-art cell therapy in the treatment of strokes and other traumatic brain injuries. This invaluable book covers this niche topic in depth from basic stem cell biology and principles of cell therapy through proposed mechanisms of action of cell therapy in stroke, pre-clinical data in stroke models, ongoing clinical trials, imaging and tracking of cells with MRI, neural stem cells in stroke and the "big pharma" perspective of cell therapy. Each chapter is written by well-known leaders in each field, thus providing a wealth of expertise. The breadth of this book makes it essential reading for neuroscientists, stem cell biologists, researchers or clinical trialists at pharmaceutical or biotechnology companies. It also serves as a thorough introduction for graduate students or post-doctoral fellows who hope to work in these fields.
Download or read book Perinatal Stem Cells written by Anthony Atala and published by Academic Press. This book was released on 2018-06-14 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: Perinatal Stem Cells provides researchers and clinicians with a comprehensive description of the current clinical and pre-clinical applications of stem cells derived from perinatal sources, such as amniotic fluid, placenta and placental membranes, the umbilical cord and Wharton’s jelly. It's compiled by leading experts in the field, offering readers detailed insights into sources of perinatal stem cells and their potential for disease treatment. Therapeutic applications of perinatal stem cells include the treatment of in utero and pregnancy related diseases, cardiac disease, liver disease, pulmonary disease, inflammatory diseases, for hematopoietic regeneration, and for neural protection after stroke or traumatic brain injury. In addition, the rapid advance in clinical translation and commercialization of perinatal stem cell therapies is highlighted in a section on Clinical and Industry Perspective which provides insight into the new opportunities and challenges involved in this novel and exciting industry. Explores current clinical and pre-clinical application of stem cells derived from perinatal sources Offers detailed insight into sources of perinatal stem cells and their potential for disease treatment Discusses progress in the manufacturing, banking and clinical translation of perinatal stem cells Edited by a world-renowned team to present a complete story of the development and promise of perinatal stem cells
Download or read book Fetal and Neonatal Brain Injury written by David K. Stevenson and published by Cambridge University Press. This book was released on 2009-06-18 with total page 1638 pages. Available in PDF, EPUB and Kindle. Book excerpt: Improvements in the detection of fetal and neonatal brain injuries, advances in our understanding of the pathophysiology, cellular and molecular bases of encephalopathy, and new treatment options have all combined to produce significant changes in the management of neonatal brain disorders in the past few years. This new edition of Fetal and Neonatal Brain Injury brings the reader fully up to date with all advances in clinical management and outcome assessment. New material includes pregnancy-induced hypertension, HELLP syndrome and chronic hypertension, complications of multiple gestation, neurogenic disorders of the brain, neonatal stroke and much more. An expanded, highly illustrated chapter on structural and functional imaging of the fetal and neonatal brain is also included. An outstanding international team of highly experienced neonatologists and maternal-fetal medicine clinicians have produced a practical, authoritative clinical text that gives clear management advice to all clinicians involved in the treatment of these patients.
Download or read book Umbilical Cord Blood Cells for Perinatal Brain Injury The Right Cells at the Right Time written by Courtney A. McDonald and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Cerebral palsy (CP) is the most common cause of physical disability in children. CP currently has no cure and there are only few interventions to prevent the development of disability. There are four principal complications of pregnancy or birth that can damage the developing brain and lead to CP: preterm birth, fetal growth restriction, infection during pregnancy and severe hypoxia-ischemia at birth. Umbilical cord blood (UCB) cells are a very promising therapy for the treatment of CP. While UCB therapy for juveniles with CP is currently being assessed in clinical trials, very little is known about their mechanisms of action or which cells found in umbilical cord blood protect against and/or repair brain injury. In this chapter, we first explore the complications that can lead to perinatal brain injury. We then discuss the different cell types found in UCB and the specific properties that make each of them individually attractive therapeutic candidates for treatment of perinatal brain injury. While UCB holds much promise as a therapy for CP, it is imperative that more research is conducted to understand how the different cell types found in UCB can protect against brain injury in order to design more effective and targeted therapies.
Download or read book Perinatal brain damage written by Luca Ramenghi and published by John Libbey Eurotext. This book was released on 2008-01-01 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is based on a highly successful conference dedicated to “Perinatal brain damage:from pathogenesis to neuroprotection ”. Neonatologists, paediatricians, paediatric neurologists, obstetricians, basic researchers involved in neurosciences, as well as rehabilitation professionals, will be interested by this ensuing publication. The volume covers pathogenic aspects of brain lesions occurring in the fetal and neonatal period, and addresses the issues of diagnostic workup and treatment.The most authoritative basic researchers, clinicians, and specialists in the field of neuroimaging, provide chapters on recent clinical advances. A subject of particular importance is the neurological vulnerability of the preterm infant, which also touches on ethical aspects of the care of high-risk preterm babies and those born from multiple pregnancies. A particularly original session focuses on cerebral white matter and the many issues related to this crucial part of the developing brain. Experts also deal with cerebral visual impairment, motor development, cognitive function, and the mechanisms underlying the neuronal plasticity of the infant’s brain. Concepts of neuroprotection are also outlined, based on pharmacological agents tested on experimental animals and the best drugs used to treat neonatal convulsions.
Download or read book Fetal and Neonatal Brain Injury written by David K. Stevenson and published by Cambridge University Press. This book was released on 2003-02-06 with total page 932 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in its third edition, this is a comprehensive survey of fetal and neonatal brain injury arising from hypoxia, ischemia or other causes. The volume spans a broad range of areas from epidemiology and pathogenesis, through to clinical manifestations and obstetric care, and then on to diagnosis, long-term outcomes, and medico-legal aspects. An important theme running throughout is to highlight scientific and clinical advances that have a role to play in minimising risk, improving clinical care and outcomes.
Download or read book Perinatal Stem Cells written by Kyle Cetrulo and published by John Wiley & Sons. This book was released on 2013-02-04 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: Perinatal Stem Cells, 2nd Edition builds on the first edition to provide an updated tutorial on perinatal stem cells, including stem cells harvested from the amniotic fluid, placenta, maternal blood supply, umbilical cord and Wharton's Jelly. As in the first edition, coverage includes the underlying biology of each of the sources of pregnancy related stem cells, cell culture, and potential therapeutic uses, as well as insights on the impact of these stem cells from obstetricians and gynecologists, cardiologists, hematologists, tissue engineers, and cord blood bankers. Normally discarded as medical waste, perinatal stem cells offer a powerful therapeutic tool box alternative to the controversial embryonic stem cells. Since publication of the first edition, a burgeoning commerical industry has developed around various sources of perinatal cells, and the second edition now includes an overview of this growing industry. With contributions from some of the top academic stem cell laboratories in the United States as well as new chapters from international stem cell scientists, Perinatal Stem Cells presents an update on the cutting-edge research in the field while maintaining its signature clinical focus.
Download or read book Neonatal Brain Injury and the Search for New Therapies written by Daniel Alonso-Alconada and published by Frontiers Media SA. This book was released on 2022-07-04 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Fetal and Neonatal Brain Injury written by David K. Stevenson and published by Cambridge University Press. This book was released on 2017-12-21 with total page 855 pages. Available in PDF, EPUB and Kindle. Book excerpt: Authoritative, practical clinical text giving clear management advice on diagnosis, treatment and outcomes of all fetal and neonatal brain injuries.
Download or read book Preventing Developmental Brain Injury From Animal Models to Clinical Trials written by Masahiro Tsuji and published by Frontiers Media SA. This book was released on 2019-10-23 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Human Amniotic Epithelial Cell Therapy for Neuroprotection and Neuro repair After Perinatal Asphyxial Brain Injury written by Lotte Gertrudis Theodora Van den Heuij and published by . This book was released on 2017 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: The primary purpose of this thesis was to investigate the effects of human amniotic epithelial cells (hAECs) on preterm and term brain injury after hypoxic-ischaemic (HI) insults. I also examined the long-term effects of asphyxia on the neural development, and the pre-HI conditioning of inflammation on the preterm fetal responses to asphyxia. A secondary aim was to assess the effect of hAECs on the recovery of fetal EEG, cardiovascular and cerebrovascular activity, biochemistry and cytokines after HI insults. In chapter 3, I tested the hypothesis that acute-on-chronic exposure to LPS would exacerbate white matter injury after subsequent asphyxia in preterm fetal sheep. Contrary to this hypothesis, the combination of acute-on-chronic LPS with subsequent asphyxia reduced neuroinflammation and white matter injury. In chapters 4 and 5, I examined the effect of hAECs given i.c.v. at 2 and 24 hours post- asphyxia in preterm fetal sheep, with outcomes studied at 7 days. HAEC treatment in both groups significantly reduced neuronal injury in selected subcortical regions, and improved CNPase positive cells in selected regions. These changes were associated with a significant reduction in microglia and astrocytes in both groups, and reduced plasma pro-inflammatory and increased anti-inflammatory cytokines and modulated seizure activity in the 2 hour, but not the 24 hour study. In chapter 6, I investigated the 21 day recovery of preterm fetal sheep after asphyxia, and observed that inflammation does not resolve. HAEC treatment via intranasal administration at 1, 3 and 10 days after asphyxia significantly reduced neuronal injury, white matter hypomyelination, neural inflammation, and improved EEG maturation. In chapter 7, I examined the effects of hAECs given intravenously on injury after cerebral ischaemia with a 7 day follow-up. HAECs did not improve neuronal or glia cell loss, or reduce inflammation. Treatment was associated with an earlier onset of seizures. My data demonstrate, for the first time, that hAECs are neuroprotective after an HI insult in preterm, but not term fetal sheep. Treatment efficacy is in part due to immunomodulation. We did not observe an effect on cardiovascular or cerebrovascular variables suggesting the treatment is safe.
Download or read book Progenitor Cell Therapy for Neurological Injury written by Charles S. Cox, Jr. and published by Springer Science & Business Media. This book was released on 2010-11-25 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: There are currently no reparative therapies for severe neurological injury, including brain injury, spinal cord injury and stroke. Actually, most treatments are designed simply to limit secondary damage. However, pre-clinical data supports the idea that exogenous stem and progenitor cells have the potential to promote a reparative response to severe neurological injuries. Progenitor Cell Therapy for Neurological Injury is a compilation of seminal essays that explore many unique aspects of neurological injury, focusing on the critical translational issues of cell delivery. Specifically, it discusses routes of administration, types of progenitor cells (alone and/or in combinations), timing of delivery and adjuncts to promote cell engraftment, survival and effectiveness. In addition, many chapters address measuring the effects of transplanted cells and cell tracking. The paradigms of how cell-based therapeutics affect neurological injury is changing rapidly. The developments in this field may ultimately offer realistic hope for improvement in patients with severe injuries. This book is a vital key toward unlocking those future treatments.
Download or read book Neural Plasticity and Cognitive Development written by Joan Stiles and published by Oxford University Press. This book was released on 2012-05-24 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: The advent of modern neurobiological methods over the last three decades has provided overwhelming evidence that it is the interaction of genetic factors and the experience of the individual that guides and supports brain development. Brains do not develop normally in the absence of critical genetic signaling, and they do not develop normally in the absence of essential environmental input. The key to understanding the origins and emergence of both the brain and behavior lies in understanding how inherited and environmental factors are engaged in the dynamic and interactive processes that define and direct development of the neurobehavioral system. Neural Plasticity and Cognitive Development focuses on children who suffered focal brain insult (typically stroke) in the pre- or perinatal period which provides a model for exploring the dynamic nature of early brain and cognitive development. In most, though not all, of the cases considered, the injuries affect substantial portions of one cerebral hemisphere, resulting in patterns of neural damage that would compromise cognitive ability in adults. However, longitudinal behavioral studies of this population of children have revealed only mild cognitive deficits, and preliminary data from functional brain imaging studies suggest that alternative patterns of functional organization emerge in the wake of early injury. Neural Plasticity and Cognitive Development posits that the capacity for adaptation is not the result of early insult. Rather, it reflects normal developmental processes which are both dynamic and adaptive operating against a backdrop of serious perturbation of the neural substrate.
Download or read book Muse Cells written by Mari Dezawa and published by Springer. This book was released on 2018-11-27 with total page 315 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the first comprehensive account of multilineage-differentiating stress-enduring (Muse) cells, a pluripotent and non-tumorigenic subpopulation of mesenchymal stem cells (MSCs) that have the ability to detect damage signals, migrate to damaged sites, and spontaneously differentiate into cells compatible with the affected tissue, thereby enabling repair of all tissue types. The coverage encompasses everything from the basic properties of Muse cells to their tissue repair effects and potential clinical applications—for example, in acute myocardial infarction, stroke, skin injuries and ulcers, renal failure, and liver disease. An important technical chapter provides a practical and precise protocol for the isolation of Muse cells, which will enable readers to use Muse cells in their own research. In offering fascinating insights into the strategic organization of the body’s reparative function and explaining how full utilization of Muse cells may significantly enhance the effectiveness of MSC treatment, the book will be of high value for Ph.D. students, postdocs, basic researchers, clinical doctors, and industrial developers.
Download or read book Perinatal Tissue Derived Stem Cells written by Babak Arjmand and published by Springer. This book was released on 2016-12-01 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers several aspects of perinatal tissue-derived stem cells, from theoretical concepts to clinical applications. Topics include functions and different sources, immunomodulatory properties, translational point of view, GMP facility design and manufacturing for clinical translation, therapeutic potentials, and finally ethical considerations. The text provides a brief review of each type of perinatal stem cells and then focuses on their multi- or pluripotent properties, regenerative capacity, and future therapeutic potential in regenerative medicine. Additionally, the book discusses GMP compliance in stem cell facilities and the manufacture of stem cells for clinical translation. The chapters are authored by world-renowned experts in the perinatal stem cell field. Perinatal Tissue-Derived Stem Cells: Alternative Sources of Fetal Stem Cells, part of Springer’s Stem Cell Biology and Regenerative Medicine series, is essential reading for basic and clinical scientists, clinicians, and pharmaceutical experts working or conducting research in the fields of stem cell biology, molecular aspects of stem cell research, tissue engineering, regenerative medicine, and cellular therapy.
