Download or read book Cell Polarity and Cancer written by Andrew D. Chalmers and published by . This book was released on 2012 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt: The majority of cells exhibit some form of polarization by having an asymmetric distribution of macromolecules within them. Epithelial cells, for example, have distinct apical and basolateral plasma membrane domains which are separated by specialized cell - cell junctions. This asymmetry is essential for cellular function
Download or read book Cell Polarity 2 written by Klaus Ebnet and published by Springer. This book was released on 2015-02-24 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work provides a state-of-the art overview on the most relevant aspects of cell polarity. Volume 2 discusses the physiological and pathophysiological relevance of cell polarity. It especially focuses on pathophysiological conditions in which one or several aspects of cell polarity are impaired, and in which a loss of cell polarity possibly contributes to disease (e.g. epithelial-to-mesenchymal transition in cancer, role of polarity proteins in cancer). Both volumes are intended for professors, group leaders and researchers in cell biology as well as for medical professionals working in anatomy, cell biology, physiology, pathology and tumor biology.
Download or read book Cell Polarity in Development and Disease written by Douglas W Houston and published by Academic Press. This book was released on 2017-11-14 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell Polarity in Development and Disease offers insights into the basic molecular mechanisms of common diseases that arise as a result of a loss of ordered organization and intrinsic polarity. Included are diseases affecting highly polarized epithelial tissues in the lung and kidney, as well as loss and gain of cell polarity in the onset and progression of cancer. This book provides a basic resource for understanding the biology of polarity, offering a starting point for those thinking of targeting cell polarity for translational medical research. Provides basic science understanding of cell polarity disease and development Covers diseases affecting polarized epithelial tissues in the lung and kidney, also covering the progression of cancer Includes historical context of cell polarity research for potential future breakthroughs
Download or read book Cell Polarity 1 written by Klaus Ebnet and published by Springer. This book was released on 2015-03-04 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work provides a state-of-the art overview on the most relevant aspects of cell polarity. Volume 1 addresses cell polarity and cell migration (front-rear polarity), cell polarity and barrier formation (apico-basal polarity) and neuronal polarity. It particularly focuses on cell polarity at the molecular level and the underlying molecular mechanisms. It also elaborates the common principles and mechanisms that regulate cellular polarization in different cell types and contexts. Both volumes are intended for professors, group leaders and researchers in cell biology as well as medical professionals in the fields of anatomy, cell biology, physiology, pathology and tumor biology.
Download or read book Cell Polarity in Development and Disease written by and published by Elsevier. This book was released on 2023-04-28 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell Polarity in Development and Disease, Volume 154 in the Methods in Cell Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Cell polarity in the protist-to-animal transition, Polarized actin networks in development: Case studies from Drosophila, Protein clustering and cell polarization, Polarity in the Drosophila female germline, Context Matters: Mechanisms governing epithelial polarization in C. elegans, Epithelial polarity in the fly: Principles and diversity, Polarizing epithelial expulsion and expulsion driven by mispolarization, The Role of Apical-Basal Polarization in the Mammalian First Cell Fate Decision, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Methods in Cell Biology series Updated release includes the latest information on Cell Polarity in Development and Disease
Download or read book The Role of PKC in Cell Polarity Mitosis and Cancer written by Rebecca Louise Gresham and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Comparative Oncology written by Alecsandru Ioan Baba and published by . This book was released on 2007 with total page 787 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Characterization of Apical basal Polarity as a Tumor Suppressive Mechanism written by Rachel Catterall and published by . This book was released on 2021 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "The majority of human cancers originate in epithelial tissue. Normal epithelial tissue is highly organized and maintains apical-basal polarity to establish different signaling compartments at the cellular membrane and polarity within the cell, including in the cortex and distribution of organelles. This organization is often lost in cancers, leading to disrupted control of cell processes including proliferation, apoptosis, adhesion, and motility. In this project, I first sought to understand polarity status of invasive carcinomas, using breast cancer as a model. To investigate the cell polarity statuses of invasive breast cancers, we performed multiplex imaging of polarity markers on tissue samples from patients with a spectrum of grades, stages, and molecular subtypes. Apical-basal cell polarity was lost in 100% of cells in all cases studied, indicating that loss of epithelial polarity is a universal feature of invasive breast cancer. I then analyzed genomic events from the TCGA dataset for an 18-gene set of core polarity genes. Our data indicate that apical and basal polarity proteins are more often amplified than deleted and that genomic events likely contribute to pervasive disruption of epithelial polarity observed in invasive breast cancer. Having established a disrupted apical domain as a feature of breast carcinoma, we next explored apical-basal polarity as a tumor suppressive mechanism. To do this, we induced apical-basal polarization in human adenocarcinoma CaCo-2 cells expressing oncogenic KRASG12V by overexpressing CD13, a protein involved in early apical membrane specialization. CD13 expression was sufficient to re-establish apical-basal polarity and revert KRASG12V-expressing spheroids from a solid, malignant phenotype to a single layer of cells surrounding a hollow lumen. We demonstrate that following induction of polarization, the lumen is cleared through JNK-mediated apoptosis. RNA-seq data indicates that re-polarization induced by CD13 overexpression alters a subset of pathways regulated by KRASG12V, including apoptosis-related genes. These findings reveal unexpected epithelial plasticity maintained in malignant cells. Overall, this thesis provides data supporting apical-basal polarity is a tumor suppressive feature of epithelial cells that must be suppressed during tumorigenesis"--
Download or read book The Impact of Food Bioactives on Health written by Kitty Verhoeckx and published by Springer. This book was released on 2015-04-29 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: “Infogest” (Improving Health Properties of Food by Sharing our Knowledge on the Digestive Process) is an EU COST action/network in the domain of Food and Agriculture that will last for 4 years from April 4, 2011. Infogest aims at building an open international network of institutes undertaking multidisciplinary basic research on food digestion gathering scientists from different origins (food scientists, gut physiologists, nutritionists...). The network gathers 70 partners from academia, corresponding to a total of 29 countries. The three main scientific goals are: Identify the beneficial food components released in the gut during digestion; Support the effect of beneficial food components on human health; Promote harmonization of currently used digestion models Infogest meetings highlighted the need for a publication that would provide researchers with an insight into the advantages and disadvantages associated with the use of respective in vitro and ex vivo assays to evaluate the effects of foods and food bioactives on health. Such assays are particularly important in situations where a large number of foods/bioactives need to be screened rapidly and in a cost effective manner in order to ultimately identify lead foods/bioactives that can be the subject of in vivo assays. The book is an asset to researchers wishing to study the health benefits of their foods and food bioactives of interest and highlights which in vitro/ex vivo assays are of greatest relevance to their goals, what sort of outputs/data can be generated and, as noted above, highlight the strengths and weaknesses of the various assays. It is also an important resource for undergraduate students in the ‘food and health’ arena.
Download or read book The Drosophila Model in Cancer written by Wu-Min Deng and published by Springer Nature. This book was released on 2019-09-13 with total page 251 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides a series of review articles that capture the advances in using the fruit fly, Drosophila melanogaster, model system to address a wide range of cancer-related topics. Articles in this book provide case studies that shed light on the intricate cellular and molecular mechanisms underlying tumor formation and progression. Readers will discover the beauty of the fly model’s genetic simplicity and the vast arsenal of powerful genetic tools enabling its efficient and adaptable use. This model organism has provided a unique opportunity to address questions regarding cancer initiation and development that would be extremely challenging in other model systems. This book provides a useful resource for a researcher who wishes to learn about and apply the Drosophila model to tackle fundamental questions in cancer biology, and to find new ways to fight against this devastating disease.
Download or read book Holland Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Download or read book The Epithelial to Mesenchymal Transition EMT in Cancer written by Joëlle Roche and published by MDPI. This book was released on 2018-04-09 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "The Epithelial-to-Mesenchymal Transition (EMT) in Cancer" that was published in Cancers
Download or read book The Possible Role of Cell Polarity for Cancer Disease U2013 the Implication of Cancer Regression by Human Body Axes Interaction written by Pang Chu (Chung) and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduction / Background: The human body anatomical axes (HBAAs) interaction shows an anti-inflammatory effect (Ou MC decrescendo phenomenon, OuDP, Am J Emerg Med. 2012) which indicates a normalization of dysfunctional cells and has shown to induce tumor regression (TJOG, 2017; Cancer arch, 2019).Methodology: OuDP treatment is performed by putting the contralateral hand over the lesion along human body anatomical axis of left-right, dorsoventral or vertical axis by the patient.Results: Ten patients with cancer diseases including gynecological cancers as uterine leiomyosarcoma (1/10), endometrial cancer (2/10), ovarian cancer (1/10) and breast cancer (1/10) showed initial cancer suppression or regression. However, long term follow up showed tumor regrowth in endometrial cancer (2/10) and the ovarian cancer.Conclusion: The signaling system of embryonic axes has shown to impart polarization of individual cells in Drosophila. Normal cell polarity is essential for normal cell function. The effect of OuDP is rapid, which indicates a direct mending effect on cell function (ICST, 2015). Normalizing the tumor cells and microenvironment function may make tumor cells conform to the regulations with apoptosis, metastasis suppression, preventing uninhibited proliferation, minimizing angiogenesis and supervision by host immunological systems. Long term follow up of advanced cancer diseases treated with OuDP showed tumor regrowth after initial regression, which may be due to poor accessibility, insufficient therapeutic efficacy or escape phenomenon. However, OuDP may be availed for an active prevention for cancer.
Download or read book The Role of PKC iota in Cell Polarity Mitosis and Cancer written by Rebecca Louise Gresham and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cell Polarity written by J.R. Bartles and published by Elsevier. This book was released on 1998-08-25 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: Few cells conform to the stereotype of the spherical blob hastily scribbled on chalkboards and, regrettably, sometimes even displayed prominently in textbooks. Instead, real cells display a remarkable degree of structural and functional asymmetry. In modern cell biological parlance, this asymmetry has come to be lumped under the general heading of "cell polarity". Cell polarity is by no means restricted to the cells of tissues and organs, but can also be displayed by cells that lead a more solitary existence. The amazing extent to which cell morphology is correlated with function has long been a source of inspiration for biologists. Today the fascination continues unabated in the field of cell polarity, where it is fueled by an ever-deepening appreciation for the ways that fundamental cellular processes, such as membrane trafficking and cytoskeleton assembly, contribute to the establishment and maintenance of cell polarity. In the ensuing chapters, a collection of experts will summarize and interpret the findings obtained from basic research on cell polarity in a diverse array of experimental systems.
Download or read book Cell Motility and Cancer written by José I López and published by Mdpi AG. This book was released on 2021-10-29 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Special Issue is conceived as a forum for basic, translational, and clinical research related to cell directional motility mechanisms and tumor cell migration. Under such a generic umbrella, basic researchers in biology, systems biology, and other quantitative sciences, as well as in physiology and pharmacology, will have the opportunity to join clinical specialties in medical oncology, biochemistry, immunology, and pathology. Such unique convergence of disciplines will enrich the panorama of a central characteristic of malignant tumors' cell motility.
Download or read book The Role of PKCi in Cell Polarity Mitosis and Cancer written by Rebecca Louise Gresham and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
