Download or read book Cell and Tissue Reaction Engineering written by Regine Eibl and published by Springer Science & Business Media. This book was released on 2008-09-30 with total page 367 pages. Available in PDF, EPUB and Kindle. Book excerpt: The completion of the Human Genome Project and the rapid progress in cell bi- ogy and biochemical engineering, are major forces driving the steady increase of approved biotech products, especially biopharmaceuticals, in the market. Today mammalian cell products (“products from cells”), primarily monoclonals, cytokines, recombinant glycoproteins, and, increasingly, vaccines, dominate the biopharmaceutical industry. Moreover, a small number of products consisting of in vitro cultivated cells (“cells as product”) for regenerative medicine have also been introduced in the market. Their efficient production requires comprehensive knowledge of biological as well as biochemical mammalian cell culture fundamentals (e.g., cell characteristics and metabolism, cell line establishment, culture medium optimization) and related engineering principles (e.g., bioreactor design, process scale-up and optimization). In addition, new developments focusing on cell line development, animal-free c- ture media, disposables and the implications of changing processes (multi-purpo- facilities) have to be taken into account. While a number of excellent books treating the basic methods and applications of mammalian cell culture technology have been published, only little attention has been afforded to their engineering aspects. The aim of this book is to make a contribution to closing this gap; it particularly focuses on the interactions between biological and biochemical and engineering principles in processes derived from cell cultures. It is not intended to give a c- prehensive overview of the literature. This has been done extensively elsewhere.

Download or read book Cell and Tissue Reaction Engineering written by Regine Eibl and published by Springer. This book was released on 2009-08-29 with total page 363 pages. Available in PDF, EPUB and Kindle. Book excerpt: The completion of the Human Genome Project and the rapid progress in cell bi- ogy and biochemical engineering, are major forces driving the steady increase of approved biotech products, especially biopharmaceuticals, in the market. Today mammalian cell products (“products from cells”), primarily monoclonals, cytokines, recombinant glycoproteins, and, increasingly, vaccines, dominate the biopharmaceutical industry. Moreover, a small number of products consisting of in vitro cultivated cells (“cells as product”) for regenerative medicine have also been introduced in the market. Their efficient production requires comprehensive knowledge of biological as well as biochemical mammalian cell culture fundamentals (e.g., cell characteristics and metabolism, cell line establishment, culture medium optimization) and related engineering principles (e.g., bioreactor design, process scale-up and optimization). In addition, new developments focusing on cell line development, animal-free c- ture media, disposables and the implications of changing processes (multi-purpo- facilities) have to be taken into account. While a number of excellent books treating the basic methods and applications of mammalian cell culture technology have been published, only little attention has been afforded to their engineering aspects. The aim of this book is to make a contribution to closing this gap; it particularly focuses on the interactions between biological and biochemical and engineering principles in processes derived from cell cultures. It is not intended to give a c- prehensive overview of the literature. This has been done extensively elsewhere.

Download or read book Standardisation in Cell and Tissue Engineering written by V Salih and published by Elsevier. This book was released on 2013-07-31 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: The increased use of biodegradable synthetic or natural scaffolds combined with cells and/or biological molecules, in order to create functional replacement tissue in a damaged tissue site, has led to the need for the development of ‘best practice’ methods in the area of tissue engineering to help ensure the creation of safe, high quality products. Standardisation in cell and tissue engineering introduces concepts and current practice in the field of cell and tissue engineering to a wide audience and aims to provide awareness of the importance of standardisation in this area while suggesting directions for further investigation. Part one provides an overview of methods for cell and tissue engineering and includes chapters on the fundamentals of cell and matrix biology for tissue engineering, 3D collagen biomatrix development, and control and vascularisation of tissue-engineered constructs. Part two begins with a chapter exploring the methods and protocols of standardisation in cell and tissue engineering before moving on to highlight issues of quality control in cell and tissue engineering, standardised chemical analysis and testing of biomaterials and principles of good laboratory practice (GLP) for in vitro cell culture applications. Standardisation in cell and tissue engineering is a standard reference for leading research groups, government agencies, regulatory bodies, and researchers and technicians at all levels across the whole range of disciplines using cell culture within the pharmaceutical, biotechnology and biomedical industries. Introduces concepts and current practice in the field of cell and tissue engineering Highlights the importance of standardisation in cell and tissue engineering and suggests directions for further investigation Explores methods and protocols of standardisation in cell and tissue engineering and issues of quality control in cell and tissue engineering

Download or read book Tissue Engineering II written by Kyongbum Lee and published by Springer. This book was released on 2006-10-19 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is our pleasure to present this special volume on tissue engineering in the series Advances in Biochemical Engineering and Biotechnology. Thisvolume re?ects the emergence of tissue engineering as a core discipline of modern biomedical engineering, and recognizes the growing synergies between the technological developments in biotechnology and biomedicine. Along this vein, the focusof thisvolume istoprovide abiotechnology driven perspective on cell engineering fundamentals while highlighting their signi?cance in p- ducing functional tissues. Our aim is to present an overview of the state of the art of a selection of these technologies, punctuated with current applications in the research and development of cell-based therapies for human disease. To prepare this volume, we have solicited contributions from leaders and experts in their respective ?elds, ranging from biomaterials and bioreactors to gene delivery and metabolic engineering. Particular emphasis was placed on including reviews that discuss various aspects of the biochemical p- cesses underlying cell function, such as signaling, growth, differentiation, and communication. The reviews of research topics cover two main areas: cel- lar and non-cellular components and assembly; evaluation and optimization of tissue function; and integrated reactor or implant system development for research and clinical applications. Many of the reviews illustrate how bioche- cal engineering methods are used to produce and characterize novel materials (e. g. genetically engineered natural polymers, synthetic scaffolds with ce- type speci?c attachment sites or inductive factors), whose unique properties enable increased levels of control over tissue development and architecture.

Download or read book Bioreactors for Tissue Engineering written by Julian Chaudhuri and published by Springer Science & Business Media. This book was released on 2006-01-16 with total page 373 pages. Available in PDF, EPUB and Kindle. Book excerpt: For the first time in a single volume, the design, characterisation and operation of the bioreactor system in which the tissue is grown is detailed. Bioreactors for Tissue Engineering presents an overall picture of the current state of knowledge in the engineering of bioreactors for several tissue types (bone, cartilage, vascular), addresses the issue of mechanical conditioning of the tissue, and describes the use of techniques such as MRI for monitoring tissue growth. This unique volume is dedicated to the fundamentals and application of bioreactor technology to tissue engineering products. Not only will it appeal to graduate students and experienced researchers in tissue engineering and regenerative medicine, but also to tissue engineers and culture technologists, academic and industrial chemical engineers, biochemical engineers and cell biologists who wish to understand the criteria used to design and develop novel systems for tissue growth in vitro.

Download or read book Reaction Engineering written by H. Binder and published by Springer. This book was released on 2013-11-20 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: With contributions by numerous experts

Download or read book Transport Phenomena in Biomedical Engineering written by Robert A. Peattie and published by CRC Press. This book was released on 2012-11-20 with total page 205 pages. Available in PDF, EPUB and Kindle. Book excerpt: Design, analysis and simulation of tissue constructs is an integral part of the ever-evolving field of biomedical engineering. The study of reaction kinetics, particularly when coupled with complex physical phenomena such as the transport of heat, mass and momentum, is required to determine or predict performance of biologically-based systems whether for research or clinical implementation. Transport Phenomena in Biomedical Engineering: Principles and Practices explores the concepts of transport phenomena alongside chemical reaction kinetics and thermodynamics to introduce the field of reaction engineering as it applies to physiologic systems in health and disease. It emphasizes the role played by these fundamental physical processes. The book first examines elementary concepts such as control volume selection and flow systems. It provides a comprehensive treatment with an overview of major research topics related to transport phenomena pertaining to biomedical engineering. Although each chapter is self-contained, they all bring forth and reinforce similar concepts through applications and discussions. With contributions from world-class experts, the book unmasks the fundamental phenomenological events in engineering devices and explores how to use them to meet the objectives of specific applications. It includes coverage of applications to drug delivery and cell- and tissue-based therapies.

Download or read book Molecular Cellular and Tissue Engineering written by Joseph D. Bronzino and published by CRC Press. This book was released on 2018-10-08 with total page 1891 pages. Available in PDF, EPUB and Kindle. Book excerpt: Known as the bible of biomedical engineering, The Biomedical Engineering Handbook, Fourth Edition, sets the standard against which all other references of this nature are measured. As such, it has served as a major resource for both skilled professionals and novices to biomedical engineering. Molecular, Cellular, and Tissue Engineering, the fourth volume of the handbook, presents material from respected scientists with diverse backgrounds in molecular biology, transport phenomena, physiological modeling, tissue engineering, stem cells, drug delivery systems, artificial organs, and personalized medicine. More than three dozen specific topics are examined, including DNA vaccines, biomimetic systems, cardiovascular dynamics, biomaterial scaffolds, cell mechanobiology, synthetic biomaterials, pluripotent stem cells, hematopoietic stem cells, mesenchymal stem cells, nanobiomaterials for tissue engineering, biomedical imaging of engineered tissues, gene therapy, noninvasive targeted protein and peptide drug delivery, cardiac valve prostheses, blood substitutes, artificial skin, molecular diagnostics in personalized medicine, and bioethics.

Download or read book Bioengineering in Cell and Tissue Research written by Gerhard M. Artmann and published by Springer Science & Business Media. This book was released on 2008-04-09 with total page 688 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cutting edge research in cell and tissue research abounds in this review of the latest technological developments in the area. The chapters are written by excellent scientists on advanced, frontier technology and address scientific questions that require considerable engineering brainpower. The aim is to provide students and scientists working in academia and industry new information on bioengineering in cell and tissue research to enhance their understanding and innovation.

Download or read book Methods of Tissue Engineering written by Anthony Atala and published by Gulf Professional Publishing. This book was released on 2001-10-12 with total page 580 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference book combines the tools, experimental protocols, detailed descriptions and know-how for the successful engineering of tissues and organs in one volume.

Download or read book Tissue Engineering II written by Kyongbum Lee and published by Springer. This book was released on 2006-11-14 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is our pleasure to present this special volume on tissue engineering in the series Advances in Biochemical Engineering and Biotechnology. Thisvolume re?ects the emergence of tissue engineering as a core discipline of modern biomedical engineering, and recognizes the growing synergies between the technological developments in biotechnology and biomedicine. Along this vein, the focusof thisvolume istoprovide abiotechnology driven perspective on cell engineering fundamentals while highlighting their signi?cance in p- ducing functional tissues. Our aim is to present an overview of the state of the art of a selection of these technologies, punctuated with current applications in the research and development of cell-based therapies for human disease. To prepare this volume, we have solicited contributions from leaders and experts in their respective ?elds, ranging from biomaterials and bioreactors to gene delivery and metabolic engineering. Particular emphasis was placed on including reviews that discuss various aspects of the biochemical p- cesses underlying cell function, such as signaling, growth, differentiation, and communication. The reviews of research topics cover two main areas: cel- lar and non-cellular components and assembly; evaluation and optimization of tissue function; and integrated reactor or implant system development for research and clinical applications. Many of the reviews illustrate how bioche- cal engineering methods are used to produce and characterize novel materials (e. g. genetically engineered natural polymers, synthetic scaffolds with ce- type speci?c attachment sites or inductive factors), whose unique properties enable increased levels of control over tissue development and architecture.

Download or read book Introduction to Chemical Engineering Kinetics and Reactor Design written by Charles G. Hill and published by John Wiley & Sons. This book was released on 2014-04-24 with total page 580 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Second Edition features new problems that engage readers in contemporary reactor design Highly praised by instructors, students, and chemical engineers, Introduction to Chemical Engineering Kinetics & Reactor Design has been extensively revised and updated in this Second Edition. The text continues to offer a solid background in chemical reaction kinetics as well as in material and energy balances, preparing readers with the foundation necessary for success in the design of chemical reactors. Moreover, it reflects not only the basic engineering science, but also the mathematical tools used by today’s engineers to solve problems associated with the design of chemical reactors. Introduction to Chemical Engineering Kinetics & Reactor Design enables readers to progressively build their knowledge and skills by applying the laws of conservation of mass and energy to increasingly more difficult challenges in reactor design. The first one-third of the text emphasizes general principles of chemical reaction kinetics, setting the stage for the subsequent treatment of reactors intended to carry out homogeneous reactions, heterogeneous catalytic reactions, and biochemical transformations. Topics include: Thermodynamics of chemical reactions Determination of reaction rate expressions Elements of heterogeneous catalysis Basic concepts in reactor design and ideal reactor models Temperature and energy effects in chemical reactors Basic and applied aspects of biochemical transformations and bioreactors About 70% of the problems in this Second Edition are new. These problems, frequently based on articles culled from the research literature, help readers develop a solid understanding of the material. Many of these new problems also offer readers opportunities to use current software applications such as Mathcad and MATLAB®. By enabling readers to progressively build and apply their knowledge, the Second Edition of Introduction to Chemical Engineering Kinetics & Reactor Design remains a premier text for students in chemical engineering and a valuable resource for practicing engineers.

Download or read book Nanoreactor Engineering for Life Sciences and Medicine written by Agnes Ostafin and published by Artech House. This book was released on 2008 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: This trail-blazing volume covers nanoreactor essentials, including a review of synthetic procedures and materials used to develop various nanoreactor configurations. It explores nanoreactor theory and design, highlighting the fundamental differences between molecular events in macroscale and nanoscale reactors.

Download or read book Tissue Engineering I written by Kyongbum Lee and published by Springer. This book was released on 2017-04-30 with total page 243 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers trends in modern biotechnology. All aspects of this interdisciplinary technology, where knowledge, methods and expertise are required from Chemistry, Biochemistry, Microbiology, Genetics, Chemical Engineering and Computer Science, are treated. More information as well as the electronic version available at springeronline.com

Download or read book Tissue Engineering written by Narine Sarvazyan and published by Springer Nature. This book was released on 2020-04-02 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tissue engineering and regenerative medicine is a new, interdisciplinary branch of science that combines knowledge from numerous scientific fields including biology, biochemistry, physics, chemistry, applied engineering, and medicine. It aims to restore damaged parts of the human body by rebuilding them in vitro using individual building blocks of biological tissues such as cells and the extracellular matrix that surrounds them. The authors hope to spark students’ interest in this exciting new field of science as well as give them a basic knowledge of its terminology. This book is based on a hands-on practical course in tissue engineering conducted by the Fulbright US Scholar recipient, Dr. Narine Sarvazyan (George Washington University, Washington USA). It provides an overview of the core topics of the tissue engineering field, including stem cell differentiation, the role of extracellular matrix and attachment proteins, scaffolds, and culturing of engineered tissues. Each chapter is accompanied by hands-on demonstrations and self-check questions. The text is easily readable for students of all backgrounds and the described protocols can be conducted using common lab equipment. This textbook is also useful for developing undergraduate and graduate courses that teach basic methods and approaches in this promising and rapidly developing field.

Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Bioprocess Engineering written by Shijie Liu and published by Newnes. This book was released on 2012-11-21 with total page 1001 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioprocess Engineering involves the design and development of equipment and processes for the manufacturing of products such as food, feed, pharmaceuticals, nutraceuticals, chemicals, and polymers and paper from biological materials. It also deals with studying various biotechnological processes. "Bioprocess Kinetics and Systems Engineering" first of its kind contains systematic and comprehensive content on bioprocess kinetics, bioprocess systems, sustainability and reaction engineering. Dr. Shijie Liu reviews the relevant fundamentals of chemical kinetics-including batch and continuous reactors, biochemistry, microbiology, molecular biology, reaction engineering, and bioprocess systems engineering- introducing key principles that enable bioprocess engineers to engage in the analysis, optimization, design and consistent control over biological and chemical transformations. The quantitative treatment of bioprocesses is the central theme of this book, while more advanced techniques and applications are covered with some depth. Many theoretical derivations and simplifications are used to demonstrate how empirical kinetic models are applicable to complicated bioprocess systems. Contains extensive illustrative drawings which make the understanding of the subject easy Contains worked examples of the various process parameters, their significance and their specific practical use Provides the theory of bioprocess kinetics from simple concepts to complex metabolic pathways Incorporates sustainability concepts into the various bioprocesses