Download or read book Cellular Aging and Cell Death written by Nikki J. Holbrook and published by John Wiley & Sons. This book was released on 1995-12-20 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cellular AGING AND CELL DEATH Edited by Nikki J. Holbrook, George R. Martin, and Richard A.Lockshin Cellular Aging and Cell Death provides a thorough understanding ofthe mechanisms responsible for cellular aging, covering the recentresearch on programmed cell death and senescence, and describingtheir role in the control of cell proliferation and the agingprocess. This one-of-a-kind book is the first to combine the twohottest research areas of cell biology into one comprehensivetext. Leading experts contribute to give readers an authoritativeoverview of the distinct fields of cellular aging and programmedcell death, as well as to demonstrate how both fields are criticalto understanding the aging process. They address the large andgrowing interest in apoptosis, especially with regard to themolecular signals that induce and regulate programmed cell death,and the role of apoptosis in a variety of age-associated diseasesand disabilities. Throughout the book, a strong emphasis is placedon the interrelationship of the molecular, cellular, andphysiological aspects of senescence. Individual chapters discuss such topics as the role and regulationof apoptosis in development, the potential impact of cell death onsuch postmitotic tissues as nerve and muscle, and suggest thatprogrammed cell death plays an important role in both pathologicaland nonpathological aspects of aging, including neurodegenerativediseases. One important chapter focuses on the most recent research involvingthe study of telomeres, whose reduction in length with age and celldivision may underlie cellular senescence. The subject of neuronalcell death is also put into the perspective of aging. Cellular Aging and Cell Death bridges the rapidly growing fields ofcellular aging and programmed cell death. This thorough, yetconcise book will be of particular interest to graduate studentsand researchers within the fields of cell and developmentalbiology, neurobiology, immunology, and physiology. Physicians andmedical students involved in the fields of gerontology andpathology will also find this an informative reference.

Download or read book Cell Ageing and Cell Death written by Ioan Davies and published by . This book was released on 1984 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: The phenomenon of cell aging and cell death are of considerable importance in many areas of biology. This joint symposium between the Society for Experimental Biology and the British Society for Research in Ageing considers the topic from an interdisciplinary point of view. The contents range from the initiation of cell senescence and the factors controlling the life span of cells, to the competing theories implicating programmed or accidental sequences of events in the process of cell deterioration. The fundamental nature of the subject will generate interest in the book across a wide range of biological and medical disciplines.

Download or read book Cellular and Molecular Aspects of Ageing written by Valquiria Bueno and published by Springer Nature. This book was released on with total page 159 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Handbook of Oxidants and Antioxidants in Exercise written by C. Sen and published by Elsevier. This book was released on 2000-02-16 with total page 1219 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interest in the science of exercise dates back to the time of ancient Greece. Today exercise is viewed not only as a leisurely activity but also as an effective preventive and therapeutic tool in medicine. Further biomedical studies in exercise physiology and biochemistry reports that strenuous physical exercise might cause oxidative lipid damage in various tissues. The generation of reactive oxygen species is elevated to a level that overwhelms the tissue antioxidant defense systems resulting in oxidative stress.The Handbook of Oxidants and Antioxidants in Exercise examines the different aspects of exercise-induced oxidative stress, its management, and how reactive oxygen may affect the functional capacity of various vital organs and tissues. It includes key related issues such as analytical methods, environmental factors, nutrition, aging, organ function and several pathophysiological processes.This timely publication will be of relevance to those in biomedical science and was designed to be readily understood by the general scientific audience.

Download or read book New Research on Cell Aging and Death written by Roman Strakos̆ and published by . This book was released on 2018 with total page 181 pages. Available in PDF, EPUB and Kindle. Book excerpt: New Research on Cell Aging and Death reviews previous literature to describe the main behavioral and biochemical characteristics of the SAMP8 mouse model, discussing its main advantages as well as potential weaknesses to model age-related diseases. The subsequent chapter discusses the effect of the mechanism of cell death of neutrophil granulocytes on the realization of the inflammatory process. Neutrophil granulocytes play a central role in the innate nonspecific defense response of the human organism. In addition, neutrophils infiltrate secondary lymphoid organs where they regulate the development of adaptive immunity. Later, the authors suggest that in C. albicans, apoptotic mechanisms are valuable as major strategies with several characteristics such as phosphatidylserine exposure, DNA fragmentation, and activation of metacaspase. Studying antifungal agents with varying mechanisms of action can be effective in appropriately treating potentially fatal candidiasis. In one study, the authors evaluated the effects of natural and chemical compounds on promoter activities of several human DNA repair-associated genes in HeLa S3 cells. . The results indicated that naturally occurring compounds, for example, trans-resveratrol, upregulate TP53 promoter activity. Sustaining an appropriate level of genes encoding DNA repair factors is thought to be necessary for cell survival by preventing the accumulation of DNA mismatches and epigenetic alterations. The concluding review focuses on the effects of aging on adult neurogenesis, a process of producing new neurons from neural stem cells and neural progenitor cells in the neocortex, comparing the dentate gyrus and subventricular zone.

Download or read book Cellular Ageing and Replicative Senescence written by Suresh I.S. Rattan and published by Springer. This book was released on 2016-05-09 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the origins and subsequent history of research results in which attempts have been made to clarify issues related to cellular ageing, senescence, and age-related pathologies including cancer. Cellular Ageing and Replicative Senescence revisits more than fifty-five years of research based on the discovery that cultured normal cells are mortal and the interpretation that this phenomenon is associated with the origins of ageing. The mortality of normal cells and the immortality of cancer cells were also reported to have in vivo counterparts. Thus began the field of cytogerontology. Cellular Ageing and Replicative Senescence is organized into five sections: history and origins; serial passaging and progressive ageing; cell cycle arrest and senescence; system modulation; and recapitulation and future expectations. These issues are discussed by leading thinkers and researchers in biogerontology and cytogerontology. This collection of articles provides state-of-the-art information, and will encourage students, teachers, health care professionals and others interested in the biology of ageing to explore the fascinating and challenging question of why and how our cells age, and what can and cannot be done about it.

Download or read book Times Cells and Aging written by Bernard Strihler and published by Academic Press. This book was released on 1977-01-28 with total page 510 pages. Available in PDF, EPUB and Kindle. Book excerpt: Time, Cells, and Aging, 2nd Edition presents the mechanics of cell function and the relevant implications of the molecular-genetic view to the aging phenomena. This book explores the biology of the aging process. Comprised of 11 chapters, this edition starts with an overview of the causes and mechanisms underlying the gradual deterioration of structure and function characteristics of aging. This text then examines the two aspects of the behavior of man, including the reasoned conscious behavior and the greater dependence on reaction patterns predicted on the successful responses of the past. Other chapters explore the relationship between aging and mortality rate in animals, which is a result of an organism's deceasing ability to function optimally in carrying out his vital functions. The final chapter deals with the implementation of a research plan relevant to understanding the primary mechanisms of the aging process. This book is a valuable resource for gerontologists, biologists, and molecular biologists.

Download or read book Studies of Aging written by Hal Sternberg and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: This laboratory manual provides the researcher with a specific group of techniques, emphasising throughout hands-on information. A variety of protocols using molecular, cellular and physiological techniques are presented in detail and appropriate animal models have been selected for the study of ageing and ageing-related diseases. Non-invasive in vivo techniques are described for the study of Alzheimers dementia and cardiovascular diseases, while techniques for detection of oxidative processes are presented to explore the role of free radicals in causing cell damage and mutations as well as techniques to study apoptosis for its role in cell ageing. XXXXXXXXX Neuer Text This lab manual provides hands-on protocols using molecular, cellular, and physiological techniques and the appropriate animal models for the study of aging and aging-related diseases. Non-invasive in vivo techniques are described for the study of Alzheimers dementia and cardiovascular diseases. Techniques for detection of oxidative processes are presented to explore the role of free radicals in causing cell damage, as well as techniques to study apoptosis for its role in cell aging. A Springer Lab Manual

Download or read book The Biology of Death written by André Klarsfeld and published by Cornell University Press. This book was released on 2004 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: Why do we die? Do all living creatures share this fate? Is the body's slow degradation with the passage of time unavoidable, or can the secrets of longevity be unlocked? Over the past two decades, scientists studying the workings of genes and cells have uncovered some of the clues necessary to solve these mysteries. In this fascinating and accessible book, two neurobiologists share the often-surprising findings from that research, including the possibility that aging and natural death may not be forever a certainty for most living beings. André Klarsfeld and Frédéric Revah discuss in detail the latest scientific findings and views on death and longevity. They challenge many popular assumptions, such as the idea that the death of individual organisms serves to rejuvenate species or that death and sexual reproduction are necessarily linked. Finally, they describe current experimental approaches to postpone natural death in lower organisms as well as in mammals. Are all organisms that survive until late in life condemned to a "natural" death, as a consequence of aging, even if they live in a well-protected, supportive environment? The variability of the adult life span--from a few hours for some insects to more than a millennium for the sequoia and thirteen times that for certain wild berry bushes--challenges the notion that death is unavoidable. Evolutionary theory helps explain why and how some species have achieved biological mechanisms that seemingly allow them to resist time. Death cannot be understood without looking into cells--the essential building blocks of life. Intriguingly, at the level of cells, death is not always an accident; it is often programmed as an indispensable aspect of life, which benefits the organism as a whole.

Download or read book New Research on Cell Aging written by Reginald B. Garvey and published by Nova Publishers. This book was released on 2007 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents research on cell growth and the ageing process. Emphasis is given to implications for cancer therapy, abnormal mitosis and aberrant nuclear morphology, neoplastic transformations, negative charges on various malignant cell types.

Download or read book Plant Cell Death Processes written by Larry D. Nooden and published by Elsevier. This book was released on 2003-12-09 with total page 419 pages. Available in PDF, EPUB and Kindle. Book excerpt: Programmed cell death is a common pattern of growth and development in both animals and plants. However, programmed cell death and related processes are not as generally recognized as central to plant growth. This is changing fast and is becoming more of a focus of intensive research. This edited work will bring under one cover recent reviews of programmed cell death, apoptosis and senescence.Summaries of the myriad aspects of cell death in plantsDiscussion of the broadest implications of these disparite resultsA unification of fields where there has been no cross talkEnables easy entry into diverse but related lines of research

Download or read book Cell Aging Molecular Mechanisms and Implications for Disease written by Christian Behl and published by Springer Science & Business Media. This book was released on 2013-12-18 with total page 113 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aging represents a physiological and per se non-pathological and multifactorial process involving a set of key genes and mechanisms being triggered by different endogenous and exogenous factors. Since aging is a major risk factor in connection with a variety of human disorders, it is increasingly becoming a central topic in biochemical and medical research. The plethora of theories on aging – some of which have been discussed for decades – are neither isolated nor contradictory but instead can be connected in a network of pathways and processes at the cellular and molecular levels. This book summarizes the most prominent and important approaches, focusing on telomeres, DNA damage and oxidative stress as well as on the possible role of nutrition, the interplay between genes and environment (epigenetics) and intracellular protein homeostasis and introduces some genes that have actually extended life spans in animal models. Linking these different determinants of aging with disease, this volume aims to reveal their multiple interdependencies. We see that there is no single “perfect” theory of aging and that instead it is possible to define what the authors call the molecular aging matrix of the cell. A better knowledge of its key mechanisms and the mutual connections between its components will lead to a better understanding of age-associated disorders such as Alzheimer’s disease.

Download or read book Aging and Human Longevity written by M.-F. Schulz-Aellen and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: The proportion of elderly people continues to increase in the western world-nearly a quarter of the population will be over 65 years by the year 2050. Since aging is accompanied by an increase in diseases and by a deterioration in well-being, finding solutions to these social, medical and psychological problems is necessarily a major goal for society. Scientists and medical practitioners are therefore faced with the urgent task of increasing basic knowledge of the biological processes that cause aging. More resources must be put into this research in order to achieve better understanding of the cellular mechanisms that underlie the differences in life span between species and to answer the difficult questions of why some individuals age more quickly than others, and why some develop liver problems, some have heart problems, and others brain problems. The results of such a wide program of research will provide important information about the causes of many life-threatening and/ or debilitating diseases of old age; it will help find ways to prevent some of the ailments that result from aging, and it may well lead to discoveries enabling the prolongation of human life.

Download or read book Cellular Senescence and Aging written by and published by Elsevier. This book was released on 2024-01-30 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cellular Senescence and Aging, Volume 181 in the Methods in Cell Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on topics such as assessing polyglutamine tract aggregation in the nematode Caenorhabditis elegans, Generation of glial cell-derived neurotrophic factor (gdnf) morphants in zebrafish larvae by cerebroventricular microinjection of vivo morpholino, Methods for detection of mitochondrial reactive oxygen species in senescent cells, Assessment of cell cycle progression and mitotic slippage by videomicroscopy, The original colorimetric method to detect cellular senescence, and more.Additional sections cover Assessing microbiota composition in the context of aging, Assessing chronological aging in Saccharomyces cerevisiae, Image processing and supervised machine learning for retinal microglia characterization in senescence, Measuring telomerase activity using TRAP assays, High throughput assessment of cellular senescence, Detection of radiation-induced senescence by the Debacq-Chainiaux protocol: Improvements and upgrade in the detection of positive events, Dynamic and scalable assessment of the senescence-associated secretory phenotype (SASP), Flow cytometry-assisted quantification of cell cycle arrest in cancer cells treated with CDK4/6 inhibitors, and more. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the Methods in Cell Biology series - Updated release includes the latest information on Cellular Senescence and Aging

Download or read book A Means to an End written by William R. Clark and published by Oxford University Press. This book was released on 2002-02-28 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: Why do we age? Is aging inevitable? Will advances in medical knowledge allow us to extend the human lifespan beyond its present limits? Because growing old has long been the one irreducible reality of human existence, these intriguing questions arise more often in the context of science fiction than science fact. But recent discoveries in the fields of cell biology and molecular genetics are seriously challenging the assumption that human lifespans are beyond our control. With such discoveries in mind, noted cell biologist William R. Clark clearly and skillfully describes how senescence begins at the level of individual cells and how cellular replication may be bound up with aging of the entire organism. He explores the evolutionary origin and function of aging, the cellular connections between aging and cancer, the parallels between cellular senescence and Alzheimer's disease, and the insights gained through studying human genetic disorders--such as Werner's syndrome--that mimic the symptoms of aging. Clark also explains how reduction in caloric intake may actually help increase lifespan, and how the destructive effects of oxidative elements in the body may be limited by the consumption of antioxidants found in fruits and vegetables. In a final chapter, Clark considers the social and economic aspects of living longer, the implications of gene therapy on senescence, and what we might learn about aging from experiments in cloning. This is a highly readable, provocative account of some of the most far-reaching and controversial questions we are likely to ask in the next century.

Download or read book The Clock of Ages written by John J. Medina and published by Cambridge University Press. This book was released on 1997-08-13 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Anyone who has watched a wrinkle slowly gouge their face like a strip mine, or has been disturbed by a loss of memory, has uncomfortably confronted the human ageing process. The inexorable march of time on our bodies begs an important question: why do we have to grow old? Written in everyday language, The Clock of Ages takes us on a tour of the ageing human body - all from a research scientist's point of view. From the deliberate creation of organisms that live three times their natural span to the isolation of human genes that may allow us to do the same, The Clock of Ages also examines the latest discoveries in geriatric genetics. Sprinkled throughout the pages are descriptions of the aging of many historical figures, such as Florence Nightingale, Jane Austen, Bonaparte and Casanova. These stories underscore the common bond that unites us all: they aged, even as we do. The Clock of Ages tells you why.

Download or read book The Role of DNA Damage and Repair in Cell Aging written by B.A. Gilchrest and published by Elsevier. This book was released on 2001-03-09 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aging occurs at the level of individual cells, a complex interplay between intrinsic "programming" and exogenous "wear and tear", with genetically-determined cellular capacity to repair environmentally-induced DNA damage playing a central role in the rate of aging and its specific manifestations. In 12 chapters, "The Role of DNA Damage and Repair in Cell Aging" provides an intellectual framework for aging of mitotic and post-mitotic cells, describes a variety of model systems for further studies, and reviews current concepts of DNA responses and their relationship to the phenomenon of aging. As part of a series entitled "Advances in Cell Aging and Gerontology," this volume also summarizes seminal recent discoveries such as the molecular basis for Werner syndrome (a mutant DNA helicase), the complementary roles of telomere shortening and telomerase activity in cell senescence versus immortalization, the role of apoptosis in the homeostasis of aging tissue, and the existence of an inducible SOS-like response in mammalian cells that minimizes DNA damage from repeatedly encountered injurious environmental agents. Insights into the relationship between cellular aging and age-associated diseases, particularly malignancies, are also provided in several chapters. This book is an excellent single source of information for anyone interested in DNA repair, mechanisms of aging, or certainly their intersection. Students will gain a general appreciation of these fields, but even the most senior investigators will benefit from the detailed coverage of rapidly advancing areas.