Download or read book Cell Adhesion and Communication Mediated by the CEA Family written by Clifford P Stanners and published by CRC Press. This book was released on 2003-09-02 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: Considers the recent explosion of knowledge about the carcinoembryonic antigen (CEA) family, which resulted from the molecular cloning of family member genes in 1986. Results indicating CEA family members upregulated in cancer could have an instrumental role in malignant transformation and metastasis, while those that are downregulated could have tumor suppressive functions are considered. Reviews, recent results, hypotheses, and clinical applications regarding a gene family that, from its widespread changes in expression in tumors at many sites, should be regarded as a "major player" in human cancer are also discussed. The normal functions such as epithelial and hematopoietic adhesion and signalling molecules are explored, and the possibly unique role of this family in evolution is introduced. This volume will be of interest to researchers in the fields of intercellular adhesion, evolution, and molecular recognition, as well as clinicians interested in the recent knowledge regarding a tumor marker commonly utilised in the clinic, and companies wishing to exploit this cancer-related family for novel commercial applications in the biomedical sphere.
Download or read book Cell Adhesion written by Jürgen Behrens and published by Springer Science & Business Media. This book was released on 2010-05-10 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an overview of the main topics of current cell adhesion research including structural analyses of cell adhesion molecules and studies to their functional role in vitro and in vivo. The present volume focuses on the four major families of cell-adhesion receptors, i.e. the cadherins, the integrins, the Ig-superfamily and the selectin-based adhesion system which are discussed in detail by numerous experts in the field.
Download or read book Tumor Models in Cancer Research written by Beverly A. Teicher and published by Springer Science & Business Media. This book was released on 2001-11-07 with total page 745 pages. Available in PDF, EPUB and Kindle. Book excerpt: Beverly A. Teicher and a panel of leading experts comprehensively describe for the first time in many years the state-of-the-art in animal tumor model research. The wide array of models detailed form the basis for the selection of compounds and treatments that go into clinical testing of patients, and include syngeneic models, human tumor xenograft models, orthotopic models, metastatic models, transgenic models, and gene knockout models. Synthesizing many years experience with all the major in vivo models currently available for the study of malignant disease, Tumor Models in Cancer Research provides preclinical and clinical cancer researchers alike with a comprehensive guide to the selection of these models, their effective use, and the optimal interpretation of their results.
Download or read book Intracellular Pathogens in Membrane Interactions and Vacuole Biogenesis written by Jean-Pierre Gorvel and published by Springer Science & Business Media. This book was released on 2004-01-31 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides information on the molecular interactions between host cell organelles and pathogens, which have developed strategies to survive within infected cells. Chapters are grouped into five sections: I. Endocytosis and phagocytosis. Collectively, the chapters of this section review basic knowledge regarding intracellular organelles are involved in membrane interactions with pathogen-containing vacuoles. II. Professional and non-professional phagocytes. Here the authors describe the major differences between the two host cell types, which can be infected by microorganisms. III. Maturation pathways of bacteria-containing vacuoles. Molecular interactions between vacuoles and intracellular organelles leading to the search of the Holy Grail, the replication niche, are described. IV. Host response. Host cells are able to react against intruders and eventually mount host responses. In these chapters the various types of host response mechanisms against intracellular intruders are reviewed. V. Co-evolution. In these final chapters, the question is addressed of whether knowledge of bacteria-host cell interactions will be acquired fast enough to find the necessary tools for controlling microorganism development.
Download or read book Cell Adhesion and Migration in Skin Disease written by Jonathan Barker and published by CRC Press. This book was released on 2003-09-02 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt: The past few years have seen considerable advances in our understanding of the molecular basis underlying cutaneous cell adhesion mechanisms. Co-authored by a number of leading experts in the field ^Cell Adhesion and Migration in Skin Disease provides a comprehensive overview of the critical role played by cell adhesion in determining the structure and function of both healthy and diseased human skin. The book is divided into three main sections, with each one addressing a principal function of adhesion molecules. The first part focuses on the epidermis, which as the skin's outermost layer, acts as the human body's primary barrier of defence. Roles played by cytoskeletal intermediate filaments and junctional complexes in cutaneous cell adhesion are emphasised with descriptions of blistering skin diseases that can arise if these molecules malfunction. The second part describes the macromolecular interactions responsible for the anchorage of cells to the underlying extracellular basement membrane. The experimental approaches detailed in the text not only reveal how the molecular components of the dermal-epidermal junction have been elucidated, but also highlight how mutations in the genes which encode these molecules are responsible for many heritable skin diseases. Leukocytes continually infiltrate the skin and patrol it for potentially harmful pathogens. Control of leukocyte adhesion to resident cells within the skin and to the extracellular matrix plays a key role in controlling these processes. These mechanisms constitute the primary focus of the final section. The pivotal role of leukocytes is examined in conjunction with the chronic inflammatory diseases which arise when components of the skin's finely tuned defence strategy go awry and the potential for these anomalies to be pinpointed as important immunotherapeutic targets for skin diseases.
Download or read book Biomarkers in Medicine written by Pınar Atukeren and published by Bentham Science Publishers. This book was released on 2022-09-01 with total page 739 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomarkers in Medicine is a comprehensive guide to understanding the current and future status of biomarkers. The book features 27 chapters focusing on disease biomarkers for diseases such as cancer, neurodegenerative diseases, cardiac diseases, metabolic conditions and much more. This book supplies readers with the unique insight of experts in multiple specialties in medicine and life sciences who have extensive experience in diagnostics and clinical laboratories. The book includes case studies and practical examples from different classes of biomarkers on different platforms, including new data for biomarkers in different therapeutic indications. In addition to presenting biomarker information, each chapter covers the relevant pathology and also emphasizes on preclinical and clinical manifestation of the disease process. Clinicians managing patients or clinical trials, clinical researchers, clinical laboratories, diagnostic companies, regulatory agencies, medical school graduate students, academic students, and the general public involved in healthcare delivery will all benefit from information presented in this book.
Download or read book Ig Superfamily Molecules in the Nervous System written by Peter Sonderegger and published by CRC Press. This book was released on 2003-09-02 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: A vast number of neural cell surface glycoproteins belonging to the immunoglobulin superfamily have been isolated over the past two decades. In functional studies, many of them have been shown to confer adhesive properties to cells and to play an important role in developmental processes such as cell migration and axon outgrowth. Recent observations implicate Ig superfamily adhesion molecules in the regulation of activity-dependent synaptic plasticity, in regeneration after neural trauma, as well as in the pathogenesis of malformations in the developing nervous systems. This book summarizes the molecular features and some of the cellular functions of this important class of cell surface molecules. It includes detailed information on the molecular structure of the immunoglobulin fold, the common domain of these proteins, the molecular interactions between various neural Ig superfamily members and their role in signal transduction, as well as the role of Ig superfamily adhesion molecules in axon guidance during both vertebrate and invertebrate neurogenesis. Recent observations on a role for these molecules in activity-dependent synaptic plasticity and in the regeneration of injured axons in the peripheral and central nervous system are described. A discussion on the connection between Ig superfamily adhesion molecules and medical genetics is also provided.
Download or read book Cancer Research written by and published by . This book was released on 2005-10 with total page 1076 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Encyclopedia of Cancer written by Manfred Schwab and published by Springer Science & Business Media. This book was released on 2008-09-23 with total page 3307 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive encyclopedic reference provides rapid access to focused information on topics of cancer research for clinicians, research scientists and advanced students. Given the overwhelming success of the first edition, which appeared in 2001, and fast development in the different fields of cancer research, it has been decided to publish a second fully revised and expanded edition. With an A-Z format of over 7,000 entries, more than 1,000 contributing authors provide a complete reference to cancer. The merging of different basic and clinical scientific disciplines towards the common goal of fighting cancer makes such a comprehensive reference source all the more timely.
Download or read book Journal of Cell Science written by and published by . This book was released on 2004 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2000 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular Biology Biochemistry and Biophysics written by and published by . This book was released on 2000 with total page 1588 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Therapeutic Nuclear Medicine written by Richard P. Baum and published by Springer. This book was released on 2014-08-16 with total page 922 pages. Available in PDF, EPUB and Kindle. Book excerpt: The recent revolution in molecular biology offers exciting new opportunities for targeted radionuclide therapy. This up-to-date, comprehensive book, written by world-renowned experts, discusses the basic principles of radionuclide therapy, explores in detail the available treatments, explains the regulatory requirements, and examines likely future developments. The full range of clinical applications is considered, including thyroid cancer, hematological malignancies, brain tumors, liver cancer, bone and joint disease, and neuroendocrine tumors. The combination of theoretical background and practical information will provide the reader with all the knowledge required to administer radionuclide therapy safely and effectively in the individual patient. Careful attention is also paid to the role of the therapeutic nuclear physician in coordinating a diverse multidisciplinary team, which is central to the safe provision of treatment.
Download or read book Wiley Encyclopedia of Molecular Medicine Volume 1 written by Wiley and published by Wiley-Interscience. This book was released on 2001-11-01 with total page 794 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Research Report written by and published by . This book was released on 1997 with total page 556 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cytometric Analysis of Cell Phenotype and Function written by Desmond A. McCarthy and published by Cambridge University Press. This book was released on 2001-11 with total page 518 pages. Available in PDF, EPUB and Kindle. Book excerpt: Flow cytometry and laser scanning cytometry are increasingly used in clinical and research settings due to improvements in instrument design and computing power and the increased availability of fluorescent agents. This book provides a comprehensive introduction to the theory and clinical applications of these techniques in the assessment of cell phenotype and function. With an emphasis on clinical relevance, the book presents the principles and potential of cytometry in the analysis of phenomena including cell-mediated cytotoxicity, metabolic burst, phagocytosis, cell-cell aggregation, receptor shedding, and apoptosis. The volume guides the reader through data interpretation, quality control procedures, pitfalls, and problems.
Download or read book Liver Metastasis Biology and Clinical Management written by Pnina Brodt and published by Springer Science & Business Media. This book was released on 2011-03-01 with total page 447 pages. Available in PDF, EPUB and Kindle. Book excerpt: Liver metastases are a frequent and often fatal occurrence in cancer patients, particularly those with malignancies of the gastrointestinal (GI) tract. While recent improvements in surgical techniques and a more aggressive approach to resection of liver metastases have improved long term survival for some patients, most patients with hepatic metastases still succumb to their disease. To improve these dismal statistics, a better understanding of the biology of liver metastasis, particularly the early stages that can be targeted for prevention, is essential. Once cancer cells enter the liver, several different scenarios may occur. The cancer cells may be immediately destroyed by local defence mechanisms, they may enter a state of dormancy as solitary cells and never produce a metastasis, initiate a short-lived process of proliferation that is aborted before a metastasis is established or actively proliferate to form macrometastases. The chapters in Part I of this book provide insight into the cellular/molecular mechanisms that determine which of these scenarios prevails. Written by experts researchers in the filed of metastasis, these chapters provide state-of-the art reviews on the cellular and molecular processes that impact the early stages of the metastatic process. The unique microenvironment of the liver, its various anatomical, cellular and molecular features and the impact they have on metastasis are highlighted. In addition, the role of inflammation (pre-existing and tumor-induced), host innate and adaptive immune responses, cytokines, chemokines, growth factors and the unique molecular signatures of metastatic tumor cells are reviewed with an underscoring of the translational implications of the current state of knowledge. Against this background, the chapters in Part II of the book provide critical reviews on major aspects of the clinical management of hepatic metastases. These include imaging strategies, surgical and chemotherapeutic treatment approaches and the use of targeted biological therapeutics such as anti-angiogenic drugs as treatment modalities. By combining information on biological and clinical aspects of liver metastasis, this volume will serve as an excellent resource for scientists, clinicians, clinician/ scientists and trainees in the domains of oncology, surgical oncology, hepatobiliary physiology and radiology.
