Download or read book Catalytic Enantioselective Dearomatization and Studies Towards the Total Synthesis of morphine written by Robert David Matthew Pace and published by . This book was released on 2009 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book A Catalytic Enantioselective Dearomatization Strategy and Studies Towards the Total Synthesis of Daldinone C written by Ngoc Tri Vo and published by . This book was released on 2009 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Synthetic Studies Towards a Total Synthesis of Morphine written by Mark David Charles and published by . This book was released on 2003 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Enantioselective Chemical Synthesis written by Elias J. Corey and published by Elsevier. This book was released on 2013-10-23 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by world-renowned and best-selling experts, Nobel Laureate E. J. Corey and Laszlo Kurti, Enantioselective Chemical Synthesis offers an authoritative and comprehensive overview of the field’s progress; the processes and tools for key formations; future development for complex, stereocontrolled (enantiomeric or diastereoisomeric) molecules; and valuable examples of multi-step syntheses. Utilizing a color-coded scheme to illustrate chemical transformations, Enantioselective Chemical Synthesis provides clear explanation and guidance through vital asymmetrical syntheses and insight into the next steps for the field. Researchers, professionals, and academics will benefit from this valuable, thorough, and unique resource. In Part I, the authors present clearly, comprehensively and concisely the most useful enantioselective processes available to synthetic chemists. Part II provides an extensive discussion of the most logical ways to apply these new enantioselective methods to the planning of syntheses of stereochemically complex molecules. This hitherto neglected area is essential for the advancement of enantioselective synthesis to a more rational and powerful level. Part III describes in detail many reaction sequences which have been used successfully for the construction of a wide variety of complex target molecules Clearly explains stereochemical synthesis in theory and practice Provides a handy tool box for scientists wishing to understand and apply chiral chemical synthesis Describes almost 50 real life examples of asymmetric synthesis in practice and examines how the chiral centers were introduced at key synthetic stages
Download or read book Synthetic Studies Towards a Total Synthesis of Morphine written by and published by . This book was released on 2003 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Organocatalytic Michael Cycloisomerization written by Ronald Thomas Smith and published by . This book was released on 2006 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt: The organocatalytic Michael cycloisomerization has been utilized in both methodological and synthetic chemistry by our research group. This paper investigates the extension of this methodology to other electron deficient alkenes, i.e. nitroalkenes, and their utility in the total synthesis of the classical organic target morphine. The problems and successes encountered en route to the synthetic target as well as the chemistry involved is discussed in detail herein.
Download or read book I Novel Catalytic Enantioselective Diels Alder Reactions Total Synthesis of Eunicenone A written by Thomas Wai-Ho Lee and published by . This book was released on 2001 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Studies Towards the Enantioselective Total Synthesis of Manzamine A written by Theodore Mark Kamenecka and published by . This book was released on 1996 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Synthetic Studies Toward a Total Synthesis of Morphine written by Mark David Charles and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Part I A Scalable Synthesis of rasfonin Enabled by a Convergent Enantioselective alpha hydroxymethylation Strategy written by Justin Michael Niziol and published by . This book was released on 2020 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Part I. A scalable synthesis of (-)-rasfonin enabled by a convergent enantioselective [alpha]-hydroxymethylation strategy. A scalable total synthesis of (-)-rasfonin, a potent antitumor agent, has been achieved. The synthetic strategy features a highly convergent approach based on a single protocol construction of both molecular hemispheres via catalytic enantioselective a-hydroxymethylation of simple aliphatic aldehydes. The described route has been successful in near-gram quantities of the natural product and serves as the first synthetic strategy to provide sufficient material for broad biological testing. With a keen focus on efficiency, atom economy, cost, and overall yield, the synthetic route described herein is certainly the shortest and most effective way currently described to synthesize significant quantities of (-)-rasfonin. Part II. Studies towards the total synthesis of FK-506. The synthesis of advanced intermediates towards the total synthesis of FK-506 is described herein. FK-506 has been an interesting synthetic target for some time, as it is not only structurally complex, but also a highly potent immunosuppressant. The purpose of the synthesis is to provide FK-506 in its natural form, as well as provide the option for late-stage functionalization in order to manipulate its level of toxicity. Our synthesis towards FK-506 is highly convergent, relying on the synthesis and combination of 4 subunits. Using a modified Julia olefination reaction, the major subunits of FK-506 have been successfully coupled to provide highly advanced structures. The following work also shows the improvement in yield, scalability, and simplicity of numerous reactions in the multiple routes towards the target molecule."--Pages ix-x.
Download or read book Enantioselective Organocatalytic Ammonium Enolate Mediated Transformations and Studies Towards the Total Synthesis of galanthamine written by C. C. C. Johansson and published by . This book was released on 2006 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Studies Toward the Enantioselective Synthesis of an Epidithiapiperazinedione Ring and Pummerer Reaction Chemistry written by and published by . This book was released on 2005 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Studies Toward the Enantioselective Total Synthesis of Manzamine A written by Matthew David Kowalski and published by . This book was released on 2008 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Towards the Enantioselective Synthesis of Lycoricidine Alkaloids written by Ruowei Mo and published by . This book was released on 1998 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Two efficient, regio- and stereo controlled synthetic approaches to the synthesis of racemic analogs of pancratistatin have been accomplished and they serve as the model systems for the total synthesis of optically active 7-deoxy-pancratistatin. In the Diels-Alder approach, an efficient [4+2] cycloaddition of 3,4-methylenedioxyco- nitrostyrene with Danishefsky's diene to selectively form an exo-nitro adduct has been developed as the key step in the construction of the C-ring of the target molecule. In the Michael addition approach, the key step was a conjugate addition of an organic zinc-cuprate to the 3,4-methylenedioxy-(B-nitrostyrene, followed by a diastereocontroUed closure to form the cyclohexane C-ring of the target molecule via an intramolecular nitro-aldol cyclization on a neutral alumina surface. A chair-like transition state for such a cyclization has been established and such a chelation controlled transition state can be useful in the prediction of diastereoselectivity in other related 6-exo-trig nitroaldol reactions. Cyclization of the above products fi^om both approaches by using a Bischler-Napieralski type reaction afforded two lycoricidine derivatives 38 and 50 in good yields. The initial results from the above modeling studies as well as the analysis of the synthetic strategy were directed to a chiral pool approach to the total synthesis of optically active 7-deoxy-pancratistatin. Selective monsilylation and iodination of Ltartaric acid provided a chiral precursor for the proposed key Michael transformation. The outlook for the total synthesis of 7-deoxy-pancratistatin by this approach is very promising.A concise synthesis of novel designed, optically pure, Cz-symmetrical disulfonylamide chiral ligands starting from L-tartaric acid has also been achieved. This sequence employs the metallation of indole followed by Sfj2 replacement of a dimesylate as the key step. The activity for this Cz-symmetric chiral disulfonamide ligand in the catalytic enantioselective reaction has been confirmed by nucleophilic addition to benzaldehyde in the disulfonamide-Ti (0-i-Pr)4-diethylzinc system with a 48% yield and a 33% e.e. value. Such a ligand tethered with a suitable metal complex should be also applicable towards the total synthesis of 7-deoxy-pancratistatin.
Download or read book Studies Toward the Enantioselective Total Synthesis of Quadrigemine H written by Leonard Sung and published by . This book was released on 2008 with total page 38 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthetic efforts toward the [3+1] quadrigemine alkaloids are described in this dissertation. Chapter 1 reviews the quadrigemine alkaloids from a historical perspective and discusses methods for the construction of their highly congested vicinal and diaryl all-carbon quaternary stereocenters. The application of these methods is featured in the presentation of the enantioselective syntheses of hodgkinsine and quadrigemine C.
Download or read book Studies Toward an Enantioselective Total Synthesis of Aleurodiscal written by Todd M. Heidelbaugh and published by . This book was released on 1996 with total page 694 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Iodine Catalysis in Organic Synthesis written by Kazuaki Ishihara and published by John Wiley & Sons. This book was released on 2022-05-16 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: Iodine Catalysis in Organic Synthesis The first book of its kind to highlight iodine as a sustainable alternative to conventional transition metal catalysis Iodine Catalysis in Organic Synthesis provides detailed coverage of recent advances in iodine chemistry and catalysis, focusing on the utilization of various iodine-containing compounds as oxidative catalysts. Featuring contributions by an international panel of leading research chemists, this authoritative volume explores the development of environmentally benign organic reactions and summarizes catalytic transformations of molecular iodine and iodine compounds such as hypervalent organoiodine and inorganic iodine salts. Readers are first introduced to the history of iodine chemistry, the conceptual background of homogeneous catalysis, and the benefits of iodine catalysis in comparison with transition metals. Next, chapters organized by reaction type examine enantioselective transformations, catalytic reactions involving iodine, catalyst states, oxidation in iodine and iodine catalyses, and catalytic reactions based on halogen bonding. Practical case studies and real-world examples of different applications in organic synthesis and industry are incorporated throughout the text. An invaluable guide for synthetic chemists in both academic and industrial laboratories, Iodine Catalysis in Organic Synthesis: Provides a thorough overview of typical iodine-catalyzed reactions, catalyst systems, structures, and reactivity Explores promising industrial applications of iodine-based reagents for organic synthesis Highlights the advantages iodine catalysis has over classical metal-catalyzed reactions Discusses sustainable and eco-friendly methods in hypervalent iodine chemistry Edited by two world authorities on the catalytic applications of organoiodine compounds, Iodine Catalysis in Organic Synthesis is required reading for catalytic, organic, and organometallic chemists, medicinal and pharmaceutical chemists, industrial chemists, and academic researchers and advanced students in relevant fields.
