Download or read book Catalytic Asymmetric Synthesis Enabled by VANOL VAPOL Borox Catalysts written by Hong Ren and published by . This book was released on 2013 with total page 253 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Catalytic Asymmetric Synthesis written by Iwao Ojima and published by John Wiley & Sons. This book was released on 2004-08-27 with total page 879 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the reviews of the First Edition . . . "An excellent text . . . will no doubt provide the benchmark for comparative works for many years."-Journal of the American Chemical Society "A resounding success . . . the definitive current summaries on their respective subjects."-Synthesis Since this important work was first published in 1993, the field of catalytic asymmetric synthesis has grown explosively, spawning effective new methods for obtaining enantiomerically pure compounds on a large scale and stimulating new applications in diverse fields-from medicine to materials science. Catalytic Asymmetric Synthesis, Second Edition addresses these rapid changes through new or substantially revised contributions from highly recognized world leaders in the field. It presents detailed accounts of the most important catalytic asymmetric reactions known today, discusses recent advances, and retains from the previous edition essential and intriguing information on the initial development of certain processes. An excellent working resource for academic researchers and industrial chemists alike, the Second Edition features: * Contributions from Noyori, Sharpless, Kagan, Trost, Overman, Shibasaki, Doyle, Okamoto, Bolm, Carreira, and many other internationally renowned authorities * New chapters on asymmetric carbometallations, asymmetric amplification and autocatalysis, and asymmetric polymerization * Extended coverage of asymmetric carbene reactions, including asymmetric intramolecular carbene insertion to C-H bonds as well as asymmetric dihydroxylation and aminohydroxylation * Extended coverage of asymmetric carbon-carbon bond-forming reactions and applications * An appendix listing all chiral ligands in the book
Download or read book Catalytic Methods in Asymmetric Synthesis written by Michelangelo Gruttadauria and published by John Wiley & Sons. This book was released on 2011-09-27 with total page 720 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers advances in the methods of catalytic asymmetric synthesis and their applications. Coverage moves from new materials and technologies to homogeneous metal-free catalysts and homogeneous metal catalysts. The applications of several methodologies for the synthesis of biologically active molecules are discussed. Part I addresses recent advances in new materials and technologies such as supported catalysts, supports, self-supported catalysts, chiral ionic liquids, supercritical fluids, flow reactors and microwaves related to asymmetric catalysis. Part II covers advances and milestones in organocatalytic, enzymatic and metal-based mediated asymmetric synthesis, including applications for the synthesis of biologically active molecules. Written by leading international experts, this book consists of 16 chapters with 2000 References and illustrations of 560 schemes and figures.
Download or read book Asymmetric Synthesis with Vapol Derivatives and Novel Chiral Thiourea Organocatalysts written by Konstantinos Rampalakos and published by . This book was released on 2008 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book New Trends in Asymmetric Catalysis written by Giorgio Della Sala and published by MDPI. This book was released on 2021-08-30 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt: The synthesis of enantiopure organic compounds is a key issue for several applications in pharmacology, food chemistry, agricultural chemistry, perfumery, materials science and other industrial sectors. Nowadays, asymmetric catalysis is undoubtedly the most important tool to achieve this goal. This technology, in fact, enables the production of large amounts of enantiomerically enriched compounds, employing relatively small quantities of chiral enantiopure catalysts, which is exactly what is accomplished by enzymes in nature. Since the pioneering works of Noyori, Knowles and Sharpless, which later earned them the Nobel Prize in Chemistry, asymmetric catalysis has experienced a rapid and relentless development in the last fifty years. The tremendous expansion of enantioselective transformations, the design of novel and more efficient organometallic and organic catalysts, the development of sophisticated bioreactors and cell factories, are just some of the elements responsible for such growth. However, new challenges of asymmetric catalysis are devoted to enhancing the process’s sustainability, by the introduction of recyclable and low-cost catalysts, and the use of renewable starting materials and energy source. This book provides an overview of some of these development directions and comprises a collection of review papers and a research article authored by renowned researchers actively involved in this field. The topics covered by the review papers are photoredox-catalyzed reactions of imines, asymmetric catalytic electrosynthesis, cooperative catalysis of chiral N-heterocyclic carbenes and Lewis acid, and asymmetric ring-opening reactions of epoxides catalyzed by metal–salen complexes. The research article presents a proline-catalyzed aldol reaction in water–methanol solvent mixture.
Download or read book Application of Chameleon Catalyst and VAPOL VANOL Imidodiphosphorimidate Catalysts in Asymmetric Catalysis written by Aliakbar Mohammadlou and published by . This book was released on 2020 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: In chapter 1 the discovery of chameleon catalysts was discussed. The chameleon catalyst was defined as an agent that can catalyze different reactions with different mechanisms. We have found that a chiral biaryl borate ester with two VANOL ligands and one boron complex is an extremely active catalyst for the epoxidation of aldehydes and the aziridination of imines. Mechanistic investigation revealed that this catalyst can catalyze epoxidation aziridination reactions with a different mechanism. We have shown that the aforementioned catalyst acts as a Lewis acid in the epoxidation of aldehydes and Bronsted acid in the aziridination of imines. X-ray structural analysis, Hammett study, and 11B-NMR study support our hypothesis.In chapter two the discovery and utility of the aluminum VAPOL catalyst and aluminum VANOL catalyst were explored. We have found that a chiral biaryl aluminum with two VAPOL ligands and one aluminum complex is an extremely active catalyst for the epoxidation of aldehydes with diazo acetamide. The excellent performance of aluminum VAPOL catalyst has also shown in the total synthesis of (−)-tedanalactam which was accomplished in only 5 steps with excellent enantioinduction in 37% overall yield. The aluminum catalyst also performed well in the aziridination reaction transforming the imine into the aziridine with good yield and excellent ee. We believe the aluminum catalyst also acts as a chameleon; however, more experiments are required to show the chameleon behavior of these complexes.In chapter three, inspired by Benjamin List's imidodiphosphorimidate catalysts, VANOL imidodiphosphorimidate (VIP) and VAPOL imidodiphosphorimidate (VAPIP) catalysts were synthesized. X-ray structural analysis aided us to perform crystal engineering on VIP derivatives and design a highly efficient VIP catalyst for the asymmetric halonium-ion induced spiroketalization. VIP catalysts were also explored in the asymmetric intramolecular Schmidt reaction; however, no asymmetric induction was observed after exploring the reaction with a library of these catalysts.
Download or read book Asymmetric Catalysis from a Chinese Perspective written by Shengming Ma and published by Springer Science & Business Media. This book was released on 2011-07-06 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: Qi-Lin Zhou and Jian-Hua Xie: Chiral Spiro Catalysts.- Fuk Loi Lam, Fuk Yee Kwong and Albert S. C. Chan: Chiral Phosphorus Ligands with Interesting Properties and Practical Applications.- Jiang Pan, Hui-Lei Yu, Jian-He Xu, Guo-Qiang Lin: Advances in Biocatalysis: Enzymatic Reactions and Their Applications.- Mei-Xiang Wang: Enantioselective Biotransformations of Nitriles.- Man Kin Wong, Yiu Chung Yip and Dan Yang: Asymmetric Epoxidation Catalyzed by Chiral Ketones.- W. J. Liu, N. Li and L. Z. Gong: Asymmetric Organocatalysis.- Qing-Hua Fan and Kuiling Ding: Enantioselective Catalysis with Structurally Tunable Immobilized Catalysts.- Chang-Hua Ding, Xue-Long Hou: Transition Metal-Catalyzed Asymmetric Allylation.- Jian Zhou and Yong Tang: Enantioselective Reactions with Trisoxazolines.- Xiang-Ping Hu, Duo-Sheng Wang, Chang-Bin Yu, Yong-Gui Zhou, and Zhuo Zheng: Adventure in Asymmetric Hydrogenation: Synthesis of Chiral Phosphorus Ligands and Asymmetric Hydrogenation of Heteroaromtics.
Download or read book Catalytic Asymmetric Aziridination written by Yu Zhang and published by . This book was released on 2006 with total page 538 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book VAPOL Chemistry written by Siu Man Yeung and published by . This book was released on 1997 with total page 566 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Handbook of Reagents for Organic Synthesis written by Tomislav Rovis and published by John Wiley & Sons. This book was released on 2016-10-20 with total page 816 pages. Available in PDF, EPUB and Kindle. Book excerpt: Spurred by the desire to make chemistry a sustainable and "greener" technology, the field of organocatalysis has grown to become one of the most important areas in synthetic organic chemistry. Organic catalysts can often replace potentially toxic metal catalysts and allow reactions to proceed under mild reaction conditions, thereby saving energy costs and rendering chemical processes inherently safer. More importantly perhaps, organocatalysis offers a complementary reactivity in many instances leading to increased versatility.This Handbook describes 126 key reagents for organocatalytic reactions and will be especially useful for professionals in the area of sustainable chemistry, medicinal research, as well as synthetic organic chemists working in academia and the pharmaceutical industry. All the information compiled in this volume is also available in electronic format on Wiley Online Library. The 126 reagents represented here are but a small fraction of the ca. 5,000 reagents available in the electronic Encyclopedia of Reagents for Organic Synthesis (e-EROS). e-EROS offers various search interfaces to locate reagents of interest, including chemical structure, substructure and reactions search modes. e-EROS is updated regularly with new and updated entries.
Download or read book Special Issue on Catalytic Asymmetric Synthesis written by and published by . This book was released on 2000 with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Applications of Chiral Aluminum and Boron Catalysts in Asymmetric Synthesis written by Li Zheng and published by . This book was released on 2020 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: A potent chiral aluminum catalyst has been developed for asymmetric MPV reduction of ketones with broad substrate scope and excellent yields and enantiomeric inductions. The catalyst consists an aluminum core, a VANOL-derived chiral ligand and an isopropoxy group. Different ligands have been screened and reaction parameters have been optimized. A variety of aromatic (both electron-poor and electron-rich) and aliphatic ketones were converted to chiral alcohols in good yields with high enantioselectivities (26 examples, 70-98% yield and 82-99% ee). This method operates under mild conditions (-10 °C) and low catalyst loading (1-10 mol%). Furthermore, this process is catalyzed by the earth-abundant main group element aluminum and employs inexpensive and environmentally benign 2-propanol as hydride source. This catalyst has also been employed in resolution of racemic alcohols. The kinetic resolution of alcohols by Oppenauer oxidation has been achieved with moderate results. The formal dynamic kinetic resolution via Oppenauer oxidation/ MPV reduction sequence has also been examined and discussed, which avoided acylation and the use of enzymes.A highly efficient asymmetric heteroatom Diels-Alder reaction between diene and aldehydes for the construction of 6-membered heterocycles catalyzed by chiral boron catalysts has been developed. A BINOL-derived propeller borate is found to be effective catalyzing the reaction of aromatic aldehydes. A VANOL-derived meso-borate is found to be able to catalyze the reaction of both aromatic and aliphatic aldehydes with high asymmetric inductions. Excellent yields and enantioselectivities have been achieved after optimization. Furthermore, the skeleton of 6-carbon saccharides is synthesized in the reaction of 2-hydoxyacetaldehyde with different protecting groups, which can be derivatized into many saccharide analogs. The mechanism of this reaction is proposed to be concerted based on experiments involving different methods for the reaction quench. A reversal of direction of the asymmetric induction by switching boron to aluminum has been observed. Computational studies show that catalysts derived from boron and aluminum have different geometries at the Lewis acid center.
Download or read book Enantioselective Synthesis Enantiomeric Separations and Chiral Recognition written by Maria Elizabeth Tiritan and published by MDPI. This book was released on 2020-11-13 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book includes both fundamental studies and applications in a multidisciplinary research field involving a high diversity of chiral compounds, including commercial substances with industrial applications, pharmaceuticals, and new chiral compounds with promising biological activities.
Download or read book Catalytic Asymmetric Aza Diels Alder Reaction written by Cory Allan Newman and published by . This book was released on 2007 with total page 778 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Synthesis of Aziridines and Oxaziridines from Imines written by Navjeet Kaur and published by Elsevier. This book was released on 2024-01-13 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: The smallest possible saturated azaheterocycle, aziridine, is well-known to organic chemists for its tremendous potential in pharmaceutical chemistry and organic synthesis. The general biological importance of aziridines is proven by the fact that they found several uses as subunits in pharmacologically active compounds such as antitumor agents, enzyme inhibitors, and antibiotics. Although aziridines are highly reactive, this framework occurs in many synthetic compounds and the natural products of biological interest also contain aziridine skeleton in their structures. The synthetic community is captivated with prospects of selective synthesis and conversions of aziridines. Several important advances in this area have been witnessed in recent years and discovering efficient novel methods for the synthesis of aziridines has been very active field of research. Its powerful synthetic utility has been described by an overpowering amount of documentation on the approaches for the formation of aziridine. Synthesis of Aziridines and Oxaziridines from Imines describes the new and old methods for the synthesis of aziridines from imines and covers an important and rapidly growing branch of heterocyclic chemistry. Readers will have access to different methods and information allowing them to evaluate which method is most suitable for particular cases. Focuses on the biological importance of different heterocycles Describes traditional and innovative methods for the synthesis of aziridines from imines Includes comparison amongst different methods, reagents, reaction conditions in tabulated forms, advantages, disadvantages, and critical analysis of different methodologies with respect to their comparison with green technique
Download or read book New Directions in Catalytic Asymmetric Synthesis written by Richard D. Adams and published by . This book was released on 2000 with total page 133 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Industrial Catalytic Processes for Fine and Specialty Chemicals written by Sunil S Joshi and published by Elsevier. This book was released on 2016-04-12 with total page 784 pages. Available in PDF, EPUB and Kindle. Book excerpt: Industrial Catalytic Processes for Fine and Specialty Chemicals provides a comprehensive methodology and state-of-the art toolbox for industrial catalysis. The book begins by introducing the reader to the interesting, challenging, and important field of catalysis and catalytic processes. The fundamentals of catalysis and catalytic processes are fully covered before delving into the important industrial applications of catalysis and catalytic processes, with an emphasis on green and sustainable technologies. Several case studies illustrate new and sustainable ways of designing catalysts and catalytic processes. The intended audience of the book includes researchers in academia and industry, as well as chemical engineers, process development chemists, and technologists working in chemical industries and industrial research laboratories. Discusses the fundamentals of catalytic processes, catalyst preparation and characterization, and reaction engineering Outlines the homogeneous catalytic processes as they apply to specialty chemicals Introduces industrial catalysis and catalytic processes for fine chemicals Includes a number of case studies to demonstrate the various processes and methods for designing green catalysts
