Download or read book Cartilage Properties After Allogeneic Transplantation of Cryopreserved Osteochondral Plugs and Cartilage bone Paste grafts written by and published by . This book was released on 2005 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt: Articular cartilage has a limited capacity to heal due to the avascular nature of the tissue. A lesion that traverses the full thickness of cartilage and penetrates the subchondral bone plate will have access to subchondral blood flow. Blood-borne inflammatory mediators trigger a repair response that culminates in fibrocartilage repair tissue that may fill the lesion site. Unfortunately, fibrocartilage cannot withstand the physiologic load-bearing required of articular cartilage and begins to degenerate within a year. The aim of this research was to determine if transplantation of allogenic tissues could result in repair tissue that was more similar to native articular cartilage than to fibrocartilage. The first study, performed in 5 sheep, compared the transplantation of cryopreserved osteochondral allografts to fresh autografts (a clinically established technique) at one year after transplantation. The second study, performed in 40 rabbits, evaluated repair tissue properties 6 months after allogeneic cartilage and bone paste-graft implantation. In both studies, repair tissue was evaluated by the following techniques: macroscopic and histologic appearance, cartilage firmness, and chondrocyte viability. Viability was quantified through digital analysis of confocal microscopy images. In addition, sulfate-uptake analysis, an indicator of cartilage metabolism, was performed in the cryopreserved osteochondral allograft study. At one year, cryopreserved osteochondral allografts performed better when transplanted into load-bearing sites compared to those in non-load-bearing areas. Load bearing grafts demonstrated macroscopic appearance, cartilage firmness, cell metabolism and viability similar to fresh osteochondral autografts and adjacent articular cartilage. Paste-graft tissue, evaluated at six months, was significantly inferior to intact articular cartilage, but superior to fibrocartilage repair tissue. Paste-graft properties were not affected by load-bearing site, the ratio of cartilage to bone within the paste-graft mixture, or by the use of fibrin sealant as an adhesive. While osteochondral allograft provided functional restoration of the articular surface, both repair techniques resulted in repair tissue that was inferior to native articular cartilage. However, both techniques demonstrated improvements in the quality of repair tissue compared to previous studies.
Download or read book Cartilage Restoration written by Jack Farr and published by Springer Science & Business Media. This book was released on 2013-08-15 with total page 251 pages. Available in PDF, EPUB and Kindle. Book excerpt: Attempting to bridge the gap between the science and art of cartilage restoration, Cartilage Restoration: Practical Clinical Applications combines an overview of clinical research and methodologies with clinical cases to help guide the orthopedic treatment and care of patients presenting with cartilage issues. With chapters written by internationally-renowned orthopedic surgeons, topics include an overview of current surgical options, debridement and marrow stimulation, autograft plug transfer, allografts, cell therapy, and meniscal issues. Cartilage Restoration is a valuable resource for orthopedic surgeons, residents, and fellows.
Download or read book Dissertation Abstracts International written by and published by . This book was released on 2005 with total page 768 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Postgraduate Orthopaedics written by Paul A. Banaszkiewicz and published by Cambridge University Press. This book was released on 2012-08-16 with total page 301 pages. Available in PDF, EPUB and Kindle. Book excerpt: The must-have book for candidates preparing for the oral component of the FRCS (Tr and Orth).
Download or read book Return to Sport after ACL Reconstruction and Other Knee Operations written by Frank R. Noyes and published by Springer Nature. This book was released on 2019-11-05 with total page 709 pages. Available in PDF, EPUB and Kindle. Book excerpt: The wealth of information provided in this unique text will enable orthopedic surgeons, medical practitioners, physical therapists, and trainers to ensure that athletes who suffer anterior cruciate ligament (ACL) injuries, or who require major knee operations for other reasons, have the best possible chance of safely resuming sporting activity at their desired level without subsequent problems. Divided into seven thematic sections, the coverage is wide-ranging and encompasses common barriers to return to sport, return to sport decision-based models, and the complete spectrum of optimal treatment for ACL injuries, including preoperative and postoperative rehabilitation. Advanced training concepts are explained in detail, with description of sports-specific programs for soccer, basketball, and tennis. Readers will find detailed guidance on objective testing for muscle strength, neuromuscular function, neurocognitive function, and cardiovascular fitness, as well as validated assessments to identify and manage psychological issues. In addition, return to sport considerations after meniscus surgery, patellofemoral realignment, articular cartilage procedures, and knee arthroplasty are discussed. Generously illustrated and heavily referenced, Return to Sport after ACL Reconstruction and Other Knee Operations is a comprehensive resource for all medical professionals and support staff working with athletes and active patients looking to get back in the game with confidence.
Download or read book Bone Transplantation written by Max Aebi and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 561 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the result of an international symposium on bone transplantation, the first of its kind, held in Berne, Switzerland, on May 14-16, 1987. This symposium brought together some of the most outstanding experts - from all over the world, principally from North America and Europe -in the clinical bone transplantation and in basic research. It was an unique opportunity to summarize in a few days the state of the art in this field and to bring clinicians who carry out some research related to their work together with basic scientists. The clinician can on the one hand profit from the basis researcher's knowledge and on the other stimulate the researcher to share the orthopedic surgeon's interest in osteo articular allografts. The book, like the symposium, contains two types of contributions: 1. Papers from invited experts who have often dedicated a significant part of their professional life to the subject of bone transplantation. Knowledge which would otherwise be scattered among original papers from many different sources, some of it less firmly established and therefore less well known, is thus collected together in one volume, so that the reader does not have to weed out a mass ofless important material. These chapters may for a certain time act as a textbook on bone transplantation, but inevitably will eventually be superseded by new findings. 2. Descriptions of current research in all the main subjects covered in the state of-the-art papers.
Download or read book Advanced Healthcare Materials written by Ashutosh Tiwari and published by John Wiley & Sons. This book was released on 2014-05-09 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: Offers a comprehensive and interdisciplinary view of cutting-edge research on advanced materials for healthcare technology and applications Advanced healthcare materials are attracting strong interest in fundamental as well as applied medical science and technology. This book summarizes the current state of knowledge in the field of advanced materials for functional therapeutics, point-of-care diagnostics, translational materials, and up-and-coming bioengineering devices. Advanced Healthcare Materials highlights the key features that enable the design of stimuli-responsive smart nanoparticles, novel biomaterials, and nano/micro devices for either diagnosis or therapy, or both, called theranostics. It also presents the latest advancements in healthcare materials and medical technology. The senior researchers from global knowledge centers have written topics including: State-of-the-art of biomaterials for human health Micro- and nanoparticles and their application in biosensors The role of immunoassays Stimuli-responsive smart nanoparticles Diagnosis and treatment of cancer Advanced materials for biomedical application and drug delivery Nanoparticles for diagnosis and/or treatment of Alzheimers disease Hierarchical modelling of elastic behavior of human dental tissue Biodegradable porous hydrogels Hydrogels in tissue engineering, drug delivery, and wound care Modified natural zeolites Supramolecular hydrogels based on cyclodextrin poly(pseudo)rotaxane Polyhydroxyalkanoate-based biomaterials Biomimetic molecularly imprinted polymers
Download or read book The Anterior Cruciate Ligament written by Douglas W. Jackson and published by Lippincott Williams & Wilkins. This book was released on 1993 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Illustrative Book of Cartilage Repair written by Deepak Rajkumar Goyal and published by Springer Nature. This book was released on 2020-10-26 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book employs a wealth of high-quality illustrations to provide the reader with a detailed understanding of the anatomy and the histology of the cartilage, the etiology and the classification of the cartilage lesions, and the numerous techniques employed for cartilage repair. Detailed attention is devoted to healthy cartilage, to each stage in the degenerative process, and to the response of the cartilage to the treatment. Imaging of the damaged and the repaired cartilage, as well as the information on the biomechanics are provided in great detail. The chapters on the techniques cover a wide range of approaches: marrow stimulation techniques, osteochondral cylinder transfer techniques, first, second and third generation autologous chondrocyte implantation techniques, allografts, cell-based therapies, orthobiologic approaches, and the role of 3D printing. The chapters closes with a consideration of the success of rehabilitation devices and the long-term results of cartilage repair.The book will be invaluable for all general orthopaedic and arthroscopic surgeons seeking a deeper knowledge of cartilage science and will help to dispel the confusion that still surrounds the reparative treatment. The authors are recognized experts in the fields of cartilage histology, assessment, classification, and repair.
Download or read book Bone graft substitutes written by Cato T. Laurencin and published by ASTM International. This book was released on 2003 with total page 323 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Nanotechnology Characterization Tools for Tissue Engineering and Medical Therapy written by Challa S.S.R. Kumar and published by Springer Nature. This book was released on 2019-11-22 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ninth volume of a 40 volume series on nanoscience and nanotechnology, edited by the renowned scientist Challa S.S.R. Kumar. This handbook gives a comprehensive overview about Nanotechnology Characterization Tools for Tissue Engineering and Medical Therapy. Modern applications and state-of-the-art techniques are covered and make this volume an essential reading for research scientists in academia and industry.
Download or read book Bone Regeneration and Repair written by Jay R. Lieberman and published by Springer Science & Business Media. This book was released on 2007-10-27 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: This collection of articles by leading orthopedic and craniofacial surgeons and researchers comprehensively reviews the biology of bone formation and repair, the basic science of autologous bone graft, allograft, bone substitutes, and growth factors, and explore their clinical application in patients with bone repair problems.
Download or read book Bioinspired Biomaterials written by Heung Jae Chun and published by Springer Nature. This book was released on 2020-06-29 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the first of two volumes that together offer a comprehensive account of cutting-edge advances in the development of biomaterials for use within tissue engineering and regenerative medicine. Topics addressed in this volume, which is devoted to bioinspired biomaterials, range from novel biomaterials for regenerative medicine through to emerging enabling technologies with applications in, for example, drug delivery, maternal–fetal medicine, peripheral nerve repair and regeneration, and brain tumor therapy. New bioinspired hydrogels receive detailed attention in the book, and a further focus is the use of bioinspired biomaterials in the regulation of stem cell fate. Here the coverage includes the role of scaffolds in cartilage regeneration, the bioapplication of inorganic nanomaterials in tissue engineering, and guidance of cell migration to improve tissue regeneration. The authors are recognized experts in the interdisciplinary field of regenerative medicine and the book will be of value for all with an interest in regenerative medicine based on biomaterials.
Download or read book Bone Management in Dental Implantology written by Andi Setiawan Budihardja and published by Springer. This book was released on 2019-06-24 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes all methods of bone management currently employed within the field of dental implantology, with the aim of equipping oral surgeons and other practitioners with a sound practical understanding of bone augmentation. The different possibilities for augmentation of the jaw in the vertical and horizontal dimensions are explained, and detailed information provided on the latest techniques of augmentation, including guided bone regeneration, mandibular bone grafting, 3D technique, extraoral bone augmentation, and microvascular bone transplantation. Readers will find clear guidance on diagnosis and treatment planning and helpful discussion of the basic principles of bone augmentation. Individual chapters also address the role of lasers, complications and risks, and emerging trends. The extensive case documentation, with numerous color illustrations and photos, highlights what is possible today in the field of bone regeneration. This book is a “must read” for all implantologists, oral maxillofacial surgeons, periodontists, and dentists with an interest in oral surgery.
Download or read book Osteoarthritis written by Mohit Kapoor and published by Springer. This book was released on 2015-07-20 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive book grants readers exclusive insight into current advancements in the field of osteoarthritis (OA). Contributions from leading scientists and clinicians provide a detailed introduction into current understanding of the pathogenesis of OA, different joint structures affected by this debilitating disease (hip, knee, elbow, shoulder, foot, ankle, hand, wrist, and spine), current knowledge and practice in imaging, joint conservative strategies, OA biomarkers as well as currently available treatments, their safety profile and future therapeutic targets. This book further discusses the potential of regenerative therapies and recent advances in OA Personalized Medicine, and how collection of OA patient’s phenotypic, genetic and proteomic data is able to direct treatment strategies through Bio-Informatics.
Download or read book Fundamentals of Cell Immobilisation Biotechnology written by Viktor Nedovic and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 542 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell Immobilisation Biotechnology Biotechnology is divided into two volumes. The first volume is dedicated to fundamental aspects of cell immobilisation while the second volume deals with the diverse applications of this technology. The first volume, Fundamentals of Cell Immobilisation Biotechnology, comprises 26 chapters arranged into four parts: Materials for cell immobilisation/encapsulation, Methods and technologies for cell immobilisation/encapsulation, Carrier characterisation and bioreactor design, and Physiology of immobilised cells: techniques and mathematical modelling.
Download or read book Regenerative Strategies for the Treatment of Knee Joint Disabilities written by Joaquim Miguel Oliveira and published by Springer. This book was released on 2016-09-26 with total page 406 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents regenerative strategies for the treatment of knee joint disabilities. The book is composed of four main sections totaling 19 chapters which review the current knowledge on the clinical management and preclinical regenerative strategies. It examines the role of different natural-based biomaterials as scaffolds and implants for addressing different tissue lesions in the knee joint. Section one provides an updated and comprehensive discussion on articular cartilage tissue regeneration. Section two focuses on the important contributions for bone and osteochondral tissue engineering. Section three overview the recent advances on meniscus repair/regeneration strategies. Finally, section four further discusses the current strategies for treatment of ligament lesions. Each chapter is prepared by world know expert on their fields, so we do firmly believe that the proposed book will be a reference in the area of biomaterials for regenerative medicine.
