Download or read book Cardiovascular Toxicity of Cocaine written by Pushpa Thadani and published by Department of Health and Human Services. This book was released on 1991 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cardiovascular Toxicity of Cocaine written by and published by . This book was released on 1993-05 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cardiovascular Toxicity of Cocaine written by and published by . This book was released on 1991 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cardiovascular Toxicity of Cocaine written by Pushpa Thadani and published by . This book was released on 1991 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cocaine Cardiac Toxicity Revisited written by Parthasarathi Pramanik and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Cocaine is a potent stimulant which affects cardiovascular system severely. The mechanism of cardiac toxicity depends on multiple factors. Cocaine increases sympathetic stimulation and causes excess catecholamine secretion. Besides, its indirect sympathomimetic effect also directly exerts cardiotoxic effect by different cellular, molecular, and ionic mechanisms, resulting in acute or chronic cardiovascular impairment. Cardiac arrhythmia and acute myocardial ischemia or infarction is the most common cause of cocaine-induced sudden cardiac death. Chronic cocaine abuse can develop sustained hypertension or myocarditis or cardiomyopathy leading to depressed left ventricular function. Therapy for cocaine induced cardiac toxicity generally includes use of benzodiazepine agents, nitric oxide mediated vasodilators, alpha blockers and even calcium channel blockers. Beta blockers are relatively contraindicated in acute settings of cocaine cardiovascular toxicity. Hypersensitivity reaction to cocaine is often manifested by infiltration of eosinophilic or mononuclear cells without myocardial cell damage. Vascular dissection, endocarditis, and tricuspid valvular abnormalities are some less frequent manifestations in cocaine-induced cardiac toxicity.
Download or read book Cardiovascular Disease and Acute Cocaine Toxicity Death written by Elizabeth Heier Hopewell and published by . This book was released on 1998 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cardiotoxicity written by Wenyong Tan and published by BoD – Books on Demand. This book was released on 2018-11-14 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiotoxicity may be caused by radiotherapy and/or anticancer agents for many malignancies, adverse effects of some drugs in the context of medical intervention or heavy metal intake, especially during the anticancer therapy. This book intends to bring forward the recent development in toxicities from cancer treatment. It updates the possible mechanisms of cardiotoxicities of some anticancer agents and the suggested prevention and treatment strategies. This book contains many valuable contributions from the researchers in oncology and cardiology as well as the clinicians who are experts in this field.
Download or read book Acute Cocaine Intoxication written by Heinz Sorer and published by . This book was released on 1992 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Heart and Toxins written by Dr. Meenakshisundaram Sundaram Ramachandran and published by Elsevier. This book was released on 2014-08-12 with total page 668 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Heart and Toxins brings together global experts to provide the latest information and clinical trials that make the connection between genetic susceptibility, gene expression, and environmental factors in cardiovascular diseases. This unique reference, edited by renowned cardiologist Meenakshi Sundaram Ramachandran, solves the problem of managing multiple clinical cases of cardiovascular toxicity. It allows connections to be made between research, diagnosis, and treatment to avoid higher morbidity and mortality rates as a result of cardiovascular toxicity. Structured to bring together exploration into the epidemiology, molecular mechanism, pathogenesis, environmental factors and management in cardiovascular toxins” Included various topics on cardiovascular toxins such as plant, chemical, animal, nanomaterial and marine biology induced cardiac damage – which are new ideas discussed in detail Comprehensive chapters on the cardiovascular toxicity from drugs, radiotherapy and radiological imaging Enables you to manage multiple clinical cases of cardiovascular toxicity Outlined conclusions at the end of each chapter providing “key learning points” to help you organize the chapter’s details without losing insight
Download or read book Karch s Pathology of Drug Abuse written by Steven B. Karch MD and published by CRC Press. This book was released on 2001-12-26 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt: AUTHORITATIVE INFORMATION FROM THE SOURCE YOU TRUST The third edition of Karch's Pathology of Drug Abuse continues to provide a comprehensive yet accessible guide to the pathology, toxicology, and pharmacology of commonly abused drugs. As in previous editions, the focus remains on the investigation of drug-related deaths and on practical app
Download or read book Oxford Textbook of Critical Care written by Webb and published by Oxford University Press. This book was released on 2020-01-10 with total page 1961 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in paperback, the second edition of the Oxford Textbook of Critical Care is a comprehensive multi-disciplinary text covering all aspects of adult intensive care management. Uniquely this text takes a problem-orientated approach providing a key resource for daily clinical issues in the intensive care unit. The text is organized into short topics allowing readers to rapidly access authoritative information on specific clinical problems. Each topic refers to basic physiological principles and provides up-to-date treatment advice supported by references to the most vital literature. Where international differences exist in clinical practice, authors cover alternative views. Key messages summarise each topic in order to aid quick review and decision making. Edited and written by an international group of recognized experts from many disciplines, the second edition of the Oxford Textbook of Critical Careprovides an up-to-date reference that is relevant for intensive care units and emergency departments globally. This volume is the definitive text for all health care providers, including physicians, nurses, respiratory therapists, and other allied health professionals who take care of critically ill patients.
Download or read book Intensive Care Medicine written by Jean-Louis Vincent and published by Springer Science & Business Media. This book was released on 2009-02-20 with total page 913 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intensive Care Medicine compiles the most recent developments in experimental and clinical research and practice in one comprehensive reference book. The chapters are written by well recognized experts in the field of intensive care and emergency medicine. It is addressed to everyone involved in internal medicine, anesthesia, surgery, pediatrics, intensive care and emergency medicine.
Download or read book Physical Illness and Drugs of Abuse written by Adam J. Gordon and published by Cambridge University Press. This book was released on 2010-03-11 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive and critical review of recent literature regarding the relationships between physical illness and drugs of abuse, describing the association between each of the principal classes of illicit drugs (cocaine, marijuana, opioids, and common hallucinogens and stimulants) and the major categories of physical illness.
Download or read book Modulators of Oxidative Stress written by Hande Gurer-Orhan and published by MDPI. This book was released on 2020-11-03 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book starts with the editors' preface summarizing the contributions of each of the following thirteen articles dealing with chemical and pharmacological aspects of the molecular modulators of the oxidative stress in regard to various therapeutic approaches in cardiovascular and neurodegenerative diseases, cancer, and diabetes. The seven articles present data from original research studies enlightening the roles and mechanisms of action of small molecular weight compounds (natural and synthetic; ascorbic acid/vitamin C, deferoxamine, N-acetylcysteine, MitoVitE, α-tocopherol, trolox, and ezetimibe) or proteins (SIRT3) in modulation of oxidative stress. In the six review papers, the authors present and discuss the possible therapeutic potential of novel approaches and compounds that are promising and deserve further investigation, in modulation of oxidative stress.
Download or read book Mechanisms of AIDS and Cocaine Related Cardiovascular Disease written by Alysia Anne Chaves and published by . This book was released on 2003 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: The primary focus of this thesis deals with understanding pathophysiological aspects of retrovirus (HIV/AIDS) and cocaine related cardiovascular complications. Central goals were to define important interactions between the cardiovascular and immune systems and involvement of oxidant related pathways in relevant animal models and in human tissues. Additional components of this dissertation were to define optimal conditions for cardiovascular performance assessments (contractility and electrophysiology) in mouse models and to develop novel mechanistic insights so that therapy could be further optimized. Using a relevant mouse model of retroviral pathogenesis (LPBM5, 3murine AIDS4 model) we observed time dependent cardiomyopathy and first-time evidence of reactive nitrogen species in cardiac tissue in this setting; we also corroborated these phenomena in a well-defined set of human tissues from HIV/AIDS autopsy cases. In subsequent investigations we found that a modest exposure of bacterial lipopolysaccharide amplified abnormalities in cardiac structure and function observed in the murine AIDS model, and that this synergistic effect was associated with increased cardiac prevalence of activated monocytes and cardiac myocyte expression of toll-like receptor 4 (TLR4, an important component of cardiac innate immunity). These observations suggest that coincident infection in humans may promote HIV-related cardiac complications. In separate studies we investigated mechanistic aspects of cocaine related cardiovascular toxicity in mice. A single dose of cocaine (30mg/kg) caused acute and protracted electrical abnormalities and protracted endothelial dysfunction in mice, analogous to clinical phenomenon observed in humans. Isolated cell experiments demonstrated that cocaine induced toxicity is related to increased cellular production of oxidants (in the absence of hypoxia). In a pilot clinical study we also investigated the effects of a standardized grape product with respect to vascular performance in normal subjects. We found that this product produced beneficial effects on endothelial function (using a noninvasive ultrasound method of evaluation) and that these were not ethanol-dependent and could protect against detrimental influences of a standard high fat meal. Collectively these studies demonstrate an important role for oxidant related and immune system mediated processes in diverse settings of cardiac and vascular dysfunction.
Download or read book Drug Induced Liver Injury written by and published by Academic Press. This book was released on 2019-07-13 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. Includes the authority and expertise of leading contributors in pharmacology Presents the latest release in the Advances in Pharmacology series
Download or read book Drug induced Valvular Heart Disease written by Steven Droogmans and published by Nova Biomedical Books. This book was released on 2011 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The notion that drugs can induce valvular heart disease (VHD) has occurred since the sixties and has received a lot of attention in recent years. Overstimulation of the serotonin 2B receptor (5-HT2B) leads to valvular fibroblast proliferation and thickening of the valvular leaflets with reduced mobility and regurgitation as a consequence. This new book focuses on different aspects of this distinct kind of valvulopathy including pathophysiology of drug-induced VHD, histopathological and echocardiographic characteristics, drugs associated with VHD, the influence of cumulative drug dose and risk factors and others.
