Download or read book Cardiotonic Drugs written by Carl V. Leier and published by Marcel Dekker. This book was released on 1991 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cardiac Glycosides written by and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 411 pages. Available in PDF, EPUB and Kindle. Book excerpt: The pharmacokinetics of digitalis glycosides have been the subject of extensive re view (IISALO, 1977; ARONSON, 1980; PERRIER et ai., 1977). Research on glycoside kinetics has progressed at a rapid pace, requiring continuing reevaluation of the state of our understanding of this problem. The present article focuses on the effect of disease states (renal, gastrointestinal, thyroid, and cardiac) on the absorption, distribution, and clearance of a number of digitalis glycosides. Evidence is critically reviewed, and interpreted with respect to possible clinical implications. A. Renal Insufficiency I. Strophanthin Strophanthin disposition in renal failure has been evaluated in only two studies. KRAMER et ai. (1970) determined an elimination half-life of 14 h in normals as com pared to 60 h in anuric patients. Similar results were reported by BRASS and Pm LIPPS (1970) using tritiated strophanthin. They found a half-life value of 18 h in healthy individuals as compared to 68 h in anuric patients. The findings clearly in dicate that the elimination half-life of strophanthin is prolonged in renal failure.
Download or read book The Role of Inotropic Agents in the Treatment of Heart Failure Summary Proceedings written by MES Medical Education Services (Canada) and published by Mississauga, Ont. : MES Medical Education Serices (Canada). This book was released on 1990 with total page 20 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Inotropic Agents Advances in Research and Application 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 31 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inotropic Agents: Advances in Research and Application: 2011 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Inotropic Agents in a compact format. The editors have built Inotropic Agents: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Inotropic Agents in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Inotropic Agents: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Download or read book Effects of Some Cardiotonic Agents and Metabolic Substrates on Ventricular Strip Contractility written by Robert E. Nichols (M.S.) and published by . This book was released on 1963 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cardiac Glycosides written by G. Bodem and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: In spite of old vintage and 200 years of clinical use, digitalis remains an interesting therapeutic agent, to clinicians as well as to the pharmacologist, the biochemist, and colleagues in other diciplines of theoretic medicine. When a drug, however, has so many attractive facets, it seems proper and aJvis able for the success of a scientific meeting to focus on a number of well-defined aspects. This symposium was devoted to pharmacokinetics, drug metabolism, analytic procedures, blood level determinations, and their interpretation both for thera peutic and toxic situations. Considerable progress has been made during the last years in this area of digitalis research. The time was suitable for a critical reap praisal of facts and theories and for future planning. Our main intention was to relate analytic data and biochemical findings to clinical problems and questions. Despite the undoubtedly basic character of clinical pharmacology, it is neverthe less an applied science which should help to develop the rational basis of thera peutics. We are particularly grateful to the active participants who bore the burden of preparing presentations and - even worse - manuscripts. At the same time we are well-aware that many other active research groups would have been able to contribute in this way, but our program was limited because of the short time available. Their knowledge is included in the discussion parts of the meeting, so we hope a well-balanced description of the present state of affairs emerged in this volume.
Download or read book Cardiac Glycosides 1785 1985 written by E. Erdmann and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: The bicentenary of William Withering's now famous medical report entitled "An Account of the Foxglove and Some of its Medical Uses" has given us the occasion to analyze the state of the art. Cardiac glycosides in 1985 are considered tobe the basis for medical treatment of myocardial failure, together with diuretics and vasodilators in the more severe cases. Nevertheless, the controversy as to their exact place in the treatment of heart failure with sinus rhythm has never ceased. Although cardiac glycosides are of unquestionable value in tachycardia caused by atrial fibrillation or atrial flutter, the chronic use of these drugs in sinus rhythm is not generally accepted. The development of tolerance has been reported. It is of interest that Withering hirnself wrote: "-let it (foxglove) be continued until it either acts on the kidneys, the stomach, the pulse, or the bowels; Iet it be stopped upon the first appearance of any of these effects, and I will maintain that the patient will not suffer from its exhibition, nor the practitioner be disappointed in any reasonable expectation. " In West Germany alone, more than three million patients (about 5% of the total population) are constantly taking cardiac glycosides. These drugs are the most prescribed medicaments in many countries. Thus, we considered it worthwhile and necessary to review in a critical way today's knowledge about the foxglove; to report new findings and to evaluate old Statements.
Download or read book Inotropic Stimulation and Myocardial Energetics written by H. Just and published by Springer Science & Business Media. This book was released on 2013-03-14 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inotropic stimulation of the myocardium, as well as vasodilation and diuresis as essential principles in the treatment of congestive heart failure have recently met with considerable criticism and reevaluation. It is generally agreed that unloading of the heart, either through vasodilation and/or diuresis, improves the working conditions of the dilated, failing heart. It reduces myocar dial oxygen consumption through reduction of chamber radius and, thereby, wall tension as the major determinants of myocardial oxygen consumption. Inotropic stimulation, quite in contrast, does not conserve oxygen. It rather consumes energy and that may be disadvantageous in situations of compromised oxygen supply and energy metabolism of the working myocardium. However, under conditions of suf ficient oxygen supply and metabolic support inotropic stimulation may bring about in creased pumping and subsequent improvement of myocardial failure. In recent years it could convincingly be demonstrated that vasodilation leads to symp tomatic improvement of congestive heart failure, improvement of exercise tolerance, and it prolongs life - especially in the case of ACE-inhibitors and the combination of hydra lazine with long-acting nitrates. Quite in contrast, equally beneficial effects could not be demonstrated for inotropic agents in congestive heart failure. Only for the cardiac glyco sides has it been shown that beneficial effects can be achieved, especially if atrial fibril lation with absolute arrhythmia is present. The influence of the cardiac glycosides on the latter represents an effect which is independent of the inotropic action.
Download or read book Heart Failure An Issue of Medical Clinics written by Prakash C. Deedwania and published by Elsevier Health Sciences. This book was released on 2012-10-31 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: This important issue of Medical Clinics provides essential updates in heart failure. The following topics are covered: epidemiology, pathophysiology, and general approach for heart failure; symptoms, signs, diagnostic studies, and prognostic significance of systolic versus diastolic heart failure; the appropriate use of biomarkers; oral versus intravenous diuretic therapy; guideline-based therapy including RAAS blockade, beta-blockade, and aldosterone antagonist, appropriate use of AICD and biventricular pacing; role of ventricular assist device; pathophysiological consideration and management approaches in acute decompensated heart failure; pathophysiology and current approaches to cardiorenal syndrome; heart failure with other comorbidities including diabetes, obesity, anemia, and cancer; heart failure and atrial fibrillation; and the role of disease management strategies in heart failure.
Download or read book Digitalis and Other Cardiotonic Drugs written by Eli Rodin Movitt and published by . This book was released on 1949 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Drug Discovery and Evaluation Pharmacological Assays written by Hans Vogel and published by Springer Science & Business Media. This book was released on 2007-10-30 with total page 2118 pages. Available in PDF, EPUB and Kindle. Book excerpt: The new edition of this successful reference offers both cutting-edge and classic pharmacological methods. Thoroughly revised and expanded to two volumes, it offers an updated selection of the most frequently used assays for reliably detecting the pharmacological effects of potential drugs. Every chapter has been updated, and numerous assays have been added. Each of the more than 1,000 assays comprises a detailed protocol outlining purpose and rationale, and a critical assessment of the results and their pharmacological and clinical relevance.
Download or read book Investigation of Antiarrhythmic Agents and Cardiotonic Agents written by 蘇銘嘉 and published by . This book was released on 1997 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Handbook of Renal independent Cardiac Glycosides written by Norbert Rietbrock and published by Ellis Horwood. This book was released on 1989 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cardiac Glycoside Receptors and Positive Inotropy written by E. Erdmann and published by Steinkopff. This book was released on 2013-12-21 with total page 163 pages. Available in PDF, EPUB and Kindle. Book excerpt: Symposium, Munich, October 26-29, 1983
Download or read book The Role of PPAR delta in the Action of Cardiotonic Agents written by 游步青 and published by . This book was released on 2009 with total page 139 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Carbocyclic Partial Analogs of Forskolin as Potential Cardiotonic Agents written by Daniel L. Boring and published by . This book was released on 1989 with total page 606 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Studies of the Effect of Certain Cardiotonic Agents on the Cardiac Output in Dogs as Determined by the Dye Dilution Method written by Jack Robert Schmid and published by . This book was released on 1954 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt:
