Download or read book Cardiac Adrenergic Mechanisms and Effects of Drugs on Coronary Flow and Heart Action written by Richard A. Gillis and published by . This book was released on 1965 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "The search for drugs to relieve angina pectoris has been primarily a search for agents which enhance coronary flow without significantly increasing cardiac oxygen demand. Glyceryltrinitrate (nitroglycerin) has long been used clinically in angina pectoris and remains the standard by which the potency of other agents may be classified. The exact cause of the benefit derived from nitroglycerin in cardiac ischemic disease is far from clear. Usually it is attributed to improved myocardial oxygenation resulting from coronary dilatation and/or reduced peripheral resistance with a reduction in myocardial oxygen requirement. [...]" --
Download or read book Regulation of Coronary Blood Flow written by Michitoshi Inoue and published by Springer Science & Business Media. This book was released on 2013-11-09 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research centering on blood flow in the heart continues to hold an important position, especially since a better understanding of the subject may help reduce the incidence of coronary arterial disease and heart attacks. This book summarizes recent advances in the field; it is the product of fruitful cooperation among international scientists who met in Japan in May, 1990 to discuss the regulation of coronary blood flow.
Download or read book Pharmacology of the Coronary Circulation written by Natalii︠a︡ V Kaverina and published by . This book was released on 1965 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Diseases associated with impairment of the coronary circulation are very common. Hence, the treatment of such diseases is a matter of considerable importance. It is now considered one of the main problems of clinical medicine. The basis for solving the problem is to enlarge our knowledge of the mechanisms of action of the drugs used to treat coronary insufficiency and to find new effective agents. Owing to the complexity of physiological regulation of the coronary circulation, there are many difficulties of a procedural order in studying it experimentally. This was one of the reasons why ideas on the action of many pharmacological agents were derived until recently from the results of experiments involving the isolated heart. When applied to the intact organism, these ideas proved to be inexact and, at times, wrong. Some ideas on the effects of certain drugs were based on experiments involving the intact organism, but the data proved to be inexact due to the inadequacy of the method selected by the authors to determine the mechanism of action of a given substance. Another reason for misconceptions of the effects of some drugs stemmed from insufficient knowledge and contradictory opinions expressed by various investigators on many aspects of the coronary circulation. Now, however, advances in experimental techniques have produced new facts bearing on the physiological regulation of the cardiac blood supply. This has given rise to the need to reexamine some matters concerned with the influence of pharmacological agents on the coronary circulation, relying on modern ideas concerning its physiological regulation and using adequate experimental techniques. Most drugs have complex mechanisms of action owing to the intimate relationship between the processes regulating the cardiac blood supply. Elucidation of these mechanisms requires the use of various techniques, each of which must be suited to the particular aspect under study. This approach will result in a reappraisal of the action of several pharmacological agents on the coronary circulation. Moreover, we believe that the data in this book will be helpful in making more efficient use of these agents in the treatment of various forms of coronary insufficiency."--Introduction
Download or read book Factors Influencing Adrenergic Mechanisms in the Heart written by M. Szentiványi and published by Elsevier. This book was released on 2013-10-22 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Physiological Sciences, Volume 27: Factors Influencing Adrenergic Mechanisms in the Heart is a collection of papers presented at the 1980 satellite symposium of the 28th International Congress of Physiological Science, held in Visegrád, Hungary. This symposium covered the achievements that modify the traditional views of adrenergic regulation of cardiac muscle and coronary blood vessels. This volume is composed 18 chapters and begins with a discussion of the effect of adrenaline on some aspects of electrical and mechanical activity in the frog heart. The subsequent chapters describe the heart rate changes in neurogenic hypertension, the developmental changes of the catecholamine-induced chronotropic responses related to the blood pressure responses, and the inverse reciprocal regulation of cardiac post-synaptic a- and b-adreneceptors by thyroid hormones. Other chapters deal with the mechanism of adenosine-induced inhibition of adrenergic neurotransmission in the ventricular myocardium; the comparative morphological studies of localized exogenous adenosine in heart muscle; adenosine sensitivity of canine coronaries; and the significance of nickel ion in the coronary vascular tone regulation. These chapters are followed by discussions of the physiological and pathological effects of beta modulator release and the histological study of experimental diabetic angiopathy. The last chapters examine some aspects of myocardial noradrenaline metabolism in the ischemic heart and the activity of alpha-adrenoceptor without employing beta blocking agents.
Download or read book The Influence of Drugs Affecting Cardiac Adrenergic Mechanisms on the Movement of Radioactive Noradrenaline in the Perfused Heart written by Krishan K. Agrawal and published by . This book was released on 1965 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "The primary object of this investigation was to study further the movement of labelled noradrenaline in the isolated perfused rabbit heart, with special reference to its significance in cardiac drug action. Since the movment (uptake and outflow) of noradrenaline might be influenced by changes in heart functions, e.g. coronary flow, heart rate and cardiac contractility, attempts were made to cerrelate movement of noradrenaline with changes in these functions. It is now clearly established that the heart can take up exogenous noradrenaline and that the absorbed noradrenaline appears to be localised at similar sites to those of the physiologically occurring amine. It has also been reported that radioactive labelled noradrenaline is retained by the heart for a long time in some type of inactive bound form [...]" --
Download or read book Pharmacology of the Coronary Circulation written by Natalii︠a︡ V. Kaverina and published by . This book was released on 1965 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Diseases associated with impairment of the coronary circulation are very common. Hence, the treatment of such diseases is a matter of considerable importance. It is now considered one of the main problems of clinical medicine. The basis for solving the problem is to enlarge our knowledge of the mechanisms of action of the drugs used to treat coronary insufficiency and to find new effective agents. Owing to the complexity of physiological regulation of the coronary circulation, there are many difficulties of a procedural order in studying it experimentally. This was one of the reasons why ideas on the action of many pharmacological agents were derived until recently from the results of experiments involving the isolated heart. When applied to the intact organism, these ideas proved to be inexact and, at times, wrong. Some ideas on the effects of certain drugs were based on experiments involving the intact organism, but the data proved to be inexact due to the inadequacy of the method selected by the authors to determine the mechanism of action of a given substance. Another reason for misconceptions of the effects of some drugs stemmed from insufficient knowledge and contradictory opinions expressed by various investigators on many aspects of the coronary circulation. Now, however, advances in experimental techniques have produced new facts bearing on the physiological regulation of the cardiac blood supply. This has given rise to the need to reexamine some matters concerned with the influence of pharmacological agents on the coronary circulation, relying on modern ideas concerning its physiological regulation and using adequate experimental techniques. Most drugs have complex mechanisms of action owing to the intimate relationship between the processes regulating the cardiac blood supply. Elucidation of these mechanisms requires the use of various techniques, each of which must be suited to the particular aspect under study. This approach will result in a reappraisal of the action of several pharmacological agents on the coronary circulation. Moreover, we believe that the data in this book will be helpful in making more efficient use of these agents in the treatment of various forms of coronary insufficiency."--Introduction.
Download or read book Cardiac Adrenergic Mechanisms in Coronary Drug Responses microform written by Garvey, Henry Lloyd and published by National Library of Canada. This book was released on 1966 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "Experimental animal studies on the effects of drugs on the coronary circulation have usually been employed to provide quantitative and qualitative data for clinical trials of this group of agents in humans. Species variations in the responses to these drugs have been largely overlooked. [...]" --
Download or read book Cardiac Adrenergic Mechanisms in Coronary Drug Responses written by Lloyd H. Garvey and published by . This book was released on 1966 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "Experimental animal studies on the effects of drugs on the coronary circulation have usually been employed to provide quantitative and qualitative data for clinical trials of this group of agents in humans. Species variations in the responses to these drugs have been largely overlooked. [...]" --
Download or read book How Tobacco Smoke Causes Disease written by United States. Public Health Service. Office of the Surgeon General and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Download or read book Coronary Microvascular Dysfunction written by Filippo Crea and published by Springer Science & Business Media. This book was released on 2013-08-15 with total page 263 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past two decades a number of studies have shown that abnormalities in the function and structure of coronary microcirculation can be detected in several cardiovascular diseases. On the basis of the clinical setting in which it occurs, coronary microvascular dysfunction (CMD) can be classified into four types: CMD in the absence of any other cardiac disease; CMD in myocardial diseases; CMD in obstructive epicardial coronary artery disease; and iatrogenic CMD. In some instances CMD represents an epiphenomenon, whereas in others it represents an important marker of risk or may contribute to the pathogenesis of myocardial ischemia, thus becoming a possible therapeutic target. This book provides an update on coronary physiology and a systematic assessment of microvascular abnormalities in cardiovascular diseases, in the hope that it will assist clinicians in prevention, detection and management of CMD in their everyday activity.
Download or read book Caffeine in Food and Dietary Supplements written by Leslie A. Pray and published by . This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Caffeine in Food and Dietary Supplements is the summary of a workshop convened by the Institute of Medicine in August 2013 to review the available science on safe levels of caffeine consumption in foods, beverages, and dietary supplements and to identify data gaps. Scientists with expertise in food safety, nutrition, pharmacology, psychology, toxicology, and related disciplines; medical professionals with pediatric and adult patient experience in cardiology, neurology, and psychiatry; public health professionals; food industry representatives; regulatory experts; and consumer advocates discussed the safety of caffeine in food and dietary supplements, including, but not limited to, caffeinated beverage products, and identified data gaps. Caffeine, a central nervous stimulant, is arguably the most frequently ingested pharmacologically active substance in the world. Occurring naturally in more than 60 plants, including coffee beans, tea leaves, cola nuts and cocoa pods, caffeine has been part of innumerable cultures for centuries. But the caffeine-in-food landscape is changing. There are an array of new caffeine-containing energy products, from waffles to sunflower seeds, jelly beans to syrup, even bottled water, entering the marketplace. Years of scientific research have shown that moderate consumption by healthy adults of products containing naturally-occurring caffeine is not associated with adverse health effects. The changing caffeine landscape raises concerns about safety and whether any of these new products might be targeting populations not normally associated with caffeine consumption, namely children and adolescents, and whether caffeine poses a greater health risk to those populations than it does for healthy adults. This report delineates vulnerable populations who may be at risk from caffeine exposure; describes caffeine exposure and risk of cardiovascular and other health effects on vulnerable populations, including additive effects with other ingredients and effects related to pre-existing conditions; explores safe caffeine exposure levels for general and vulnerable populations; and identifies data gaps on caffeine stimulant effects.
Download or read book The ESC Textbook of Preventive Cardiology written by Stephan Gielen and published by European Society of Cardiology. This book was released on 2015 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: "EACPR, European Association for Cardiovascular Prevention and Rehabilitation -- European Society of Cardiology."
Download or read book Anesthetic Pharmacology written by Alex S. Evers and published by Cambridge University Press. This book was released on 2011-03-10 with total page 2902 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years our understanding of molecular mechanisms of drug action and interindividual variability in drug response has grown enormously. Meanwhile, the practice of anesthesiology has expanded to the preoperative environment and numerous locations outside the OR. Anesthetic Pharmacology: Basic Principles and Clinical Practice, 2nd edition, is an outstanding therapeutic resource in anesthesia and critical care: Section 1 introduces the principles of drug action, Section 2 presents the molecular, cellular and integrated physiology of the target organ/functional system and Section 3 reviews the pharmacology and toxicology of anesthetic drugs. The new Section 4, Therapeutics of Clinical Practice, provides integrated and comparative pharmacology and the practical application of drugs in daily clinical practice. Edited by three highly acclaimed academic anesthetic pharmacologists, with contributions from an international team of experts, and illustrated in full colour, this is a sophisticated, user-friendly resource for all practitioners providing care in the perioperative period.
Download or read book Oxford Desk Reference Critical Care written by Carl Waldmann and published by OUP Oxford. This book was released on 2008-11-27 with total page 632 pages. Available in PDF, EPUB and Kindle. Book excerpt: Critical care medicine is an evolving speciality in which the amount of available information is growing daily and spread across a myriad of books, journals and websites. This essential guide brings together this information in an easy-to-use format. Up-to-date, relevant, and evidence-based information on the management of the critically ill is combined in one resource, ideal for the use of Intensive Care Units, High Dependency Units, acute medical or surgical wards, Accident and Emergency departments and operating theatres. The book is designed such that each subject will form a self-contained topic in its own right, laid out across two or four pages to facilitate the key aim of rapid and easy access to information. This makes the information included simple to find, read and absorb, so that the book can be consulted in the clinic or ward setting for information on the optimum management of a particular condition. With chapters written by internationally renowned critical care specialists and edited by the three of the leading figures in UK Critical Care, this book should be an essential resource for all critical care physicians.
Download or read book Drug Discovery and Evaluation Pharmacological Assays written by Hans Vogel and published by Springer Science & Business Media. This book was released on 2007-10-30 with total page 2118 pages. Available in PDF, EPUB and Kindle. Book excerpt: The new edition of this successful reference offers both cutting-edge and classic pharmacological methods. Thoroughly revised and expanded to two volumes, it offers an updated selection of the most frequently used assays for reliably detecting the pharmacological effects of potential drugs. Every chapter has been updated, and numerous assays have been added. Each of the more than 1,000 assays comprises a detailed protocol outlining purpose and rationale, and a critical assessment of the results and their pharmacological and clinical relevance.
Download or read book ABC of Hypertension written by D. Gareth Beevers and published by John Wiley & Sons. This book was released on 2010-07-15 with total page 89 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hypertension is a condition which affects millions of peopleworldwide and its treatment greatly reduces the risk of strokes andheart attacks. This fully revised and updated edition of the ABCof Hypertension is an established guide providing all thenon-specialist needs to know about the measurement of bloodpressure and the investigation and management of hypertensivepatients. This new edition provides comprehensively updated andrevised information on how and whom to treat. The ABC of Hypertension will prove invaluable to generalpractitioners who may be screening large numbers of patients forhypertension, as well as nurse practitioners, midwives and otherhealthcare professionals.
Download or read book The ESC Textbook of Cardiovascular Medicine written by A. John Camm and published by . This book was released on 2019 with total page 3198 pages. Available in PDF, EPUB and Kindle. Book excerpt:
